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For each citation that was shared on social media (LinkedIn, Facebook, or Twitter) with the “@GenScript” tag, the author will be rewarded with a $10 Amazon gift card or 2,000 GS points.Regulation of PTP1B activation through disruption of redox-complex formation
Nat Chem Biol. 2020;Products/Services Used Details Operation Peptide Synthesis The pTyr loop-derived peptide (CKNRNRYRDVS) and pSer50 pTyr loop-derived peptide (CKNRNRYRDVpS) were from GenScript. Get A Quote Abstract
We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3ζ and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.Keywords
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