Slc24a3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc24a3
Entrez Gene ID	85267
Full Name	solute carrier family 24 member 3
Synonyms	Nckx3
General protein information	Preferred Names solute carrier family 24 member 3 Names sodium/potassium/calcium exchanger 3 Na(+)/K(+)/Ca(2+)-exchange protein 3 potassium-dependent sodium-calcium exchanger NCKX3 (SLC24A3) solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q41
Summary	transmembrane ion transporter protein; functions as a potassium-dependent sodium/calcium exchanger (one calcium and one potassium in exchange for four sodium ions) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053505.2	NP_445957.2	sodium/potassium/calcium exchanger 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC24A3	XP_003953735.1
Mus musculus (house mouse)	Slc24a3	NP_444425.1
Canis lupus familiaris (dog)	SLC24A3	XP_005634784.1
Rattus norvegicus (Norway rat)	Slc24a3	NP_445957.1
Gallus gallus (chicken)	SLC24A3	XP_004940202.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010975	XP_001688244.1
Drosophila melanogaster (fruit fly)	CG2893	NP_001015260.3
Homo sapiens (human)	SLC24A3	NP_065740.2
Macaca mulatta (Rhesus monkey)	SLC24A3	XP_001090485.2
Bos taurus (cattle)	SLC24A3	XP_002692183.1
Danio rerio (zebrafish)	slc24a3	XP_685302.4

Gene Ontology
Bibliography

Related articles in PubMed

Uterine expression of sodium/potassium/calcium exchanger 3 and its regulation by sex-steroid hormones during the estrous cycle of rats.
Yang H, Yoo YM, Jung EM, Choi KC, Jeung EB
Molecular reproduction and development77(11)971-7(2010 Nov)

Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.
Lytton J
The Biochemical journal406(3)365-82(2007 Sep)

Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle.
Dong H, Jiang Y, Triggle CR, Li X, Lytton J
American journal of physiology. Heart and circulatory physiology291(3)H1226-35(2006 Sep)

Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes.
Kiedrowski L, Czyz A, Li XF, Lytton J
Neuroreport13(12)1529-32(2002 Aug)

Molecular cloning of a third member of the potassium-dependent sodium-calcium exchanger gene family, NCKX3.
Kraev A, Quednau BD, Leach S, Li XF, Dong H, Winkfein R, Perizzolo M, Cai X, Yang R, Philipson KD, Lytton J
The Journal of biological chemistry276(25)23161-72(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Slc24a3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc24a3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43868	NM_053505.2 Latest version!	Rattus norvegicus solute carrier family 24 member 3 (Slc24a3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc24a3 ( NM_053505.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445957.2 Rattus norvegicus solute carrier family 24 member 3 (Slc24a3), mRNA.

Price & Availability↑

CloneID	ORa43868
Clone ID Related Accession (Same CDS sequence)	NM_053505.2
Accession Version	NM_053505.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569168000000
Organism	Rattus norvegicus(Norway rat)
Product	sodium/potassium/calcium exchanger 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07054086.1, AY009158.1 and AABR07054090.1. On Sep 23, 2014 this sequence version replaced NM_053505.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AY009158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGCCGC CGGGCGACCA GGACCGCGCG CGCCGCCGCA GCCGCCGCCG GCGGAGGGAC 
CTTCTGCTGA GCCAGCTCTG CTTCCTGGCT TCGGTGGCGC TGCTGCTCTG GTCGCTGTCG 
AGCCTGCGAG AGCAGAAGGA ACTTGACCTC ATGGATCTCA TCGGGGAAGA TAGAAAATGG 
ATGGTGGGGA GGAAGCTGAT GCAGGTGAAT GATACACTGA CTTCTGAAGA TGCAGGACTC 
CGGAGCAGCA AGAACTGCAC AGAGCCAGCC CTGCATGAAT TCCCCAGGGA CATCTTCTCC 
AATGAAGACC GACGACAAGG AGCGGTGGTA CTCCACGTGC TCTGTGCCAT GTATATGTTC 
TATGCACTGG CCATCGTGTG CGATGACTTC TTCGTCCCAT CCTTGGAAAA GATCTGTGAG 
CGCCTCCACC TCAGTGAAGA TGTGGCAGGA GCCACCTTCA TGGCAGCAGG CAGCTCGGCC 
CCGGAGCTCT TCACATCGGT CATAGGAGTC TTCATCACAA AGGGGGATGT GGGAGTCGGC 
ACCATCGTGG GCTCTGCTGT GTTCAACATC CTGTGCATCA TTGGCGTCTG CGGGCTCTTT 
GCAGGACAGG TCGTGGCTCT TTCTTCCTGG TGCCTGCTGA GGGATTCCAT CTACTACACA 
CTGTCTGTGG TCGCACTCAT TGTGTTCATT TATGATGAAA AGGTTTCTTG GTGGGAATCT 
CTAGTCCTTG TGCTGATGTA CCTCATCTAT ATCATCATCA TGAAATACAA TGCGTGCATA 
CACCAGTGCT TCGAAAGGAG GACGAAAGGT GCTGGGAACA TGGTCAACGG ACTGGCCAAC 
AACGCCGAAA TCGATGACAG CAGCAACTGC GATGCCACTG TGGTGCTACT TAAGAAAGCC 
AATTTCCACC GCAAAGCGTC AGTGATCATG GTGGATGAGC TGCTGTCTGC CTACCCACAC 
CAGCTCTCTT TCTCTGAGGC TGGCCTTCGA ATAATGATCA CAAGCCACTT TCCTCCCAAG 
ACCCGGCTCT CCATGGCCAG TCGCATGTTA ATCAATGAGA GACAAAGACT GATAAACAGC 
AGGGCATATA CCAATGGGGA ATCTGAAGTG GCCATCAAAA TCCCAATTAA GCACACTGTG 
GAGAATGGAA CAGGGCCCAG CAGTGCCCCA GACAGGGGTG TGAATGGAAC CCGGAGGGAC 
GACATAGTTG CTGAGGCTGA CAATGAGACA GAGAACGAGA ATGAAGACGA GAACAATGAG 
AATGACGAGG AGGAGGATGA AGATGATGAT GAAGGCCCCT ACACGCCATT CGACCCCCCC 
TCTGGCAAAC TGGAAACTGT GAAATGGGCA TTCACCTGGC CCCTGAGTTT TGTCTTGTAC 
TTCACTGTCC CCAACTGTAA CAAGCCCCAC TGGGAGAAGT GGTTTATGGT GACGTTTGCT 
TCCTCTACAC TGTGGATTGC AGCCTTCTCC TACATGATGG TGTGGATGGT TACCATCATC 
GGCTACACCC TAGGGATCCC TGATGTCATC ATGGGGATCA CCTTCCTGGC TGCCGGAACC 
AGCGTGCCCG ACTGCATGGC CAGCCTCATT GTAGCCAGAC AAGGGATGGG GGACATGGCT 
GTGTCCAATT CCATTGGGAG CAACGTGTTT GACATCTTGA TTGGGCTTGG CCTTCCCTGG 
GCTCTGCAGA CTCTGGCTGT GGATTATGGA TCCTATATTC GGCTGAACAG CAGAGGGCTC 
ATCTACTCCG TGGGCTTGCT CCTGGCCTCT GTCTTTGTCA CGGTGTTTGG CGTTCACCTG 
AACAAGTGGC AGCTGGACAA GAAGCTGGGC TGTGGATGCC TCTTCCTGTA TGGCGTGTTC 
CTCTGCTTCT CCATCATGAC GGAGTTCAAC GTGTTCACCT TTGTGAACTT GCCCATGTGT 
GGGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445957.2
CDS	59..1987
Translation	MPPPGDQDRARRRSRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLIGEDRKWMVGRKLMQVNDTLTSEDAGLRSSKNCTEPALHEFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPYTPFDPPSGKLETVKWAFTWPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSIMTEFNVFTFVNLPMCGD

Target ORF information:

RefSeq Version	NM_053505.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 24 member 3 (Slc24a3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053505.2

ORF Insert Sequence:

ATGCCGCCGC CGGGCGACCA GGACCGCGCG CGCCGCCGCA GCCGCCGCCG GCGGAGGGAC 
CTTCTGCTGA GCCAGCTCTG CTTCCTGGCT TCGGTGGCGC TGCTGCTCTG GTCGCTGTCG 
AGCCTGCGAG AGCAGAAGGA ACTTGACCTC ATGGATCTCA TCGGGGAAGA TAGAAAATGG 
ATGGTGGGGA GGAAGCTGAT GCAGGTGAAT GATACACTGA CTTCTGAAGA TGCAGGACTC 
CGGAGCAGCA AGAACTGCAC AGAGCCAGCC CTGCATGAAT TCCCCAGGGA CATCTTCTCC 
AATGAAGACC GACGACAAGG AGCGGTGGTA CTCCACGTGC TCTGTGCCAT GTATATGTTC 
TATGCACTGG CCATCGTGTG CGATGACTTC TTCGTCCCAT CCTTGGAAAA GATCTGTGAG 
CGCCTCCACC TCAGTGAAGA TGTGGCAGGA GCCACCTTCA TGGCAGCAGG CAGCTCGGCC 
CCGGAGCTCT TCACATCGGT CATAGGAGTC TTCATCACAA AGGGGGATGT GGGAGTCGGC 
ACCATCGTGG GCTCTGCTGT GTTCAACATC CTGTGCATCA TTGGCGTCTG CGGGCTCTTT 
GCAGGACAGG TCGTGGCTCT TTCTTCCTGG TGCCTGCTGA GGGATTCCAT CTACTACACA 
CTGTCTGTGG TCGCACTCAT TGTGTTCATT TATGATGAAA AGGTTTCTTG GTGGGAATCT 
CTAGTCCTTG TGCTGATGTA CCTCATCTAT ATCATCATCA TGAAATACAA TGCGTGCATA 
CACCAGTGCT TCGAAAGGAG GACGAAAGGT GCTGGGAACA TGGTCAACGG ACTGGCCAAC 
AACGCCGAAA TCGATGACAG CAGCAACTGC GATGCCACTG TGGTGCTACT TAAGAAAGCC 
AATTTCCACC GCAAAGCGTC AGTGATCATG GTGGATGAGC TGCTGTCTGC CTACCCACAC 
CAGCTCTCTT TCTCTGAGGC TGGCCTTCGA ATAATGATCA CAAGCCACTT TCCTCCCAAG 
ACCCGGCTCT CCATGGCCAG TCGCATGTTA ATCAATGAGA GACAAAGACT GATAAACAGC 
AGGGCATATA CCAATGGGGA ATCTGAAGTG GCCATCAAAA TCCCAATTAA GCACACTGTG 
GAGAATGGAA CAGGGCCCAG CAGTGCCCCA GACAGGGGTG TGAATGGAAC CCGGAGGGAC 
GACATAGTTG CTGAGGCTGA CAATGAGACA GAGAACGAGA ATGAAGACGA GAACAATGAG 
AATGACGAGG AGGAGGATGA AGATGATGAT GAAGGCCCCT ACACGCCATT CGACCCCCCC 
TCTGGCAAAC TGGAAACTGT GAAATGGGCA TTCACCTGGC CCCTGAGTTT TGTCTTGTAC 
TTCACTGTCC CCAACTGTAA CAAGCCCCAC TGGGAGAAGT GGTTTATGGT GACGTTTGCT 
TCCTCTACAC TGTGGATTGC AGCCTTCTCC TACATGATGG TGTGGATGGT TACCATCATC 
GGCTACACCC TAGGGATCCC TGATGTCATC ATGGGGATCA CCTTCCTGGC TGCCGGAACC 
AGCGTGCCCG ACTGCATGGC CAGCCTCATT GTAGCCAGAC AAGGGATGGG GGACATGGCT 
GTGTCCAATT CCATTGGGAG CAACGTGTTT GACATCTTGA TTGGGCTTGG CCTTCCCTGG 
GCTCTGCAGA CTCTGGCTGT GGATTATGGA TCCTATATTC GGCTGAACAG CAGAGGGCTC 
ATCTACTCCG TGGGCTTGCT CCTGGCCTCT GTCTTTGTCA CGGTGTTTGG CGTTCACCTG 
AACAAGTGGC AGCTGGACAA GAAGCTGGGC TGTGGATGCC TCTTCCTGTA TGGCGTGTTC 
CTCTGCTTCT CCATCATGAC GGAGTTCAAC GTGTTCACCT TTGTGAACTT GCCCATGTGT 
GGGGACTAA