Enpp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Enpp2
Entrez Gene ID	84050
Full Name	ectonucleotide pyrophosphatase/phosphodiesterase 2
General protein information	Preferred Names ectonucleotide pyrophosphatase/phosphodiesterase 2 Names ectonucleotide pyrophosphatase/phosphodiesterase family member 2 E-NPP 2 autotaxin extracellular lysophospholipase D lysoPLD phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q32
Summary	may regulate oligodendrocyte cell-extracellular matrix adhesive interactions during myelination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_057104.2	NP_476445.2	ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ENPP2	XP_519922.2
Rattus norvegicus (Norway rat)	Enpp2	NP_476445.2
Danio rerio (zebrafish)	enpp2	XP_005173554.1
Homo sapiens (human)	ENPP2	NP_006200.3
Mus musculus (house mouse)	Enpp2	NP_001129549.1
Gallus gallus (chicken)	ENPP2	NP_001185591.1
Danio rerio (zebrafish)	enpp2	NP_956897.1
Xenopus tropicalis (tropical clawed frog)	enpp2	NP_001015936.1
Macaca mulatta (Rhesus monkey)	ENPP2	XP_002805517.1
Canis lupus familiaris (dog)	ENPP2	XP_539147.2
Bos taurus (cattle)	ENPP2	NP_001073762.1

Gene Ontology
Bibliography

Related articles in PubMed

ENPP2 protects cardiomyocytes from erastin-induced ferroptosis.
Bai YT, Chang R, Wang H, Xiao FJ, Ge RL, Wang LS
Biochemical and biophysical research communications499(1)44-51(2018 04)

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.
Meng G, Tang X, Yang Z, Benesch MGK, Marshall A, Murray D, Hemmings DG, Wuest F, McMullen TPW, Brindley DN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)4064-4077(2017 09)

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Keune WJ, Hausmann J, Bolier R, Tolenaars D, Kremer A, Heidebrecht T, Joosten RP, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink RP, Perrakis A
Nature communications711248(2016 Apr)

Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
da Conceição RR, Laureano-Melo R, Oliveira KC, de Carvalho Melo MC, Kasamatsu TS, de Barros Maciel RM, de Souza JS, Giannocco G
Physiology & behavior157158-64(2016 Apr)

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Stein AJ, Bain G, Prodanovich P, Santini AM, Darlington J, Stelzer NM, Sidhu RS, Schaub J, Goulet L, Lonergan D, Calderon I, Evans JF, Hutchinson JH
Molecular pharmacology88(6)982-92(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Enpp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Enpp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11344	NM_057104.2 Latest version!	Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Enpp2 ( NM_057104.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_476445.2 Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), mRNA.

Price & Availability↑

CloneID	ORa11344
Clone ID Related Accession (Same CDS sequence)	NM_057104.2
Accession Version	NM_057104.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2589bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ131564.1. On Feb 3, 2006 this sequence version replaced NM_057104.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ131564.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906349, SAMN01906355 [ECO:0000350] ##Evidence-Data-END##

ATGGCAAGAC AAGGCTGTCT CGGGTCATTC CAGGTAATAT CCTTGTTCAC TTTTGCCATC 
AGTGTCAATA TCTGCTTAGG ATTCACAGCA AGTCGAATTA AGAGGGCAGA ATGGGATGAA 
GGACCTCCCA CAGTGCTGTC TGACTCTCCA TGGACCAACA CCTCTGGATC CTGCAAAGGT 
AGATGCTTTG AGCTTCAAGA GGTTGGCCCT CCAGACTGTC GGTGTGACAA CCTGTGTAAG 
AGCTACAGCA GCTGCTGCCA CGATTTCGAT GAGCTCTGTT TGAAAACAGC TCGAGGCTGG 
GAGTGCACCA AAGACAGATG TGGGGAAGTA CGAAACGAGG AAAATGCCTG TCACTGCTCA 
GAAGACTGCT TGTCCAGGGG AGACTGCTGT ACCAACTACC AAGTGGTCTG CAAAGGAGAA 
TCACACTGGG TAGATGATGA CTGCGAAGAA ATCAAAGTTC CCGAATGCCC TGCAGGGTTT 
GTCCGCCCTC CGTTAATCAT CTTCTCTGTG GATGGTTTCC GTGCATCATA CATGAAGAAA 
GGCAGCAAGG TTATGCCCAA CATTGAGAAA CTGCGGTCCT GTGGCACCCA TGCTCCCTAC 
ATGAGGCCTG TGTACCCCAC AAAAACCTTC CCTAATCTAT ATACGCTGGC CACTGGTTTA 
TATCCGGAAT CCCATGGAAT TGTCGGTAAT TCAATGTATG ATCCTGTCTT TGATGCTTCG 
TTCCATCTAC GAGGGCGAGA GAAGTTTAAT CATAGGTGGT GGGGAGGCCA ACCGCTATGG 
ATTACAGCCA CCAAGCAAGG GGTGAGAGCT GGAACATTCT TTTGGTCTGT GAGCATCCCT 
CATGAACGGA GGATCCTAAC CATTCTTCAG TGGCTTTCTC TGCCAGACAA CGAGAGGCCT 
TCAGTTTATG CCTTCTACTC AGAGCAGCCT GATTTTTCTG GACACAAGTA CGGCCCTTTT 
GGCCCTGAGA TGACAAATCC TCTGAGGGAG ATTGACAAGA CCGTGGGGCA GTTAATGGAT 
GGACTGAAAC AACTCAGGCT GCATCGCTGT GTGAACGTTA TCTTTGTTGG AGACCATGGA 
ATGGAAGATG TGACATGTGA CAGAACTGAG TTCTTGAGCA ACTATCTGAC TAATGTGGAT 
GACATTACTT TAGTGCCTGG AACTCTGGGA AGAATTCGAG CCAAATCTAT CAATAATTCT 
AAATATGACC CTAAAACCAT TATTGCTAAC CTCACGTGCA AAAAACCGGA TCAGCACTTT 
AAGCCTTACA TGAAACAGCA CCTTCCCAAA CGGTTGCACT ATGCCAACAA CAGAAGAATT 
GAAGACATCC ATTTATTGGT CGATCGAAGA TGGCATGTTG CAAGGAAACC TTTGGACGTT 
TATAAGAAAC CATCAGGAAA ATGTTTTTTC CAGGGTGACC ACGGCTTTGA TAACAAGGTC 
AATAGCATGC AGACTGTTTT CGTAGGTTAT GGCCCAACTT TTAAGTACAG GACTAAAGTG 
CCTCCATTTG AAAACATTGA ACTTTACAAT GTTATGTGCG ATCTCCTAGG CTTGAAGCCC 
GCTCCCAATA ATGGAACTCA TGGAAGCTTG AATCACCTAC TGCGTACAAA TACCTTTAGG 
CCAACCATGC CAGACGAAGT CAGCCGACCT AACTACCCAG GGATTATGTA CCTTCAGTCC 
GAGTTTGACC TGGGCTGCAC CTGTGACGAT AAGGTAGAGC CAAAGAACAA ATTGGAAGAA 
CTCAATAAAC GTCTTCATAC CAAAGGATCA ACAGAAGAGA GACATCTCCT GTATGGACGG 
CCTGCAGTGC TCTATCGGAC TAGCTATGAT ATCTTATACC ATACGGACTT TGAAAGTGGT 
TATAGTGAAA TATTCTTAAT GCCTCTCTGG ACATCGTATA CCATTTCTAA GCAGGCTGAG 
GTCTCCAGCA TCCCAGAACA CCTGACCAAC TGTGTTCGTC CTGATGTCCG TGTGTCTCCA 
GGATTCAGTC AGAACTGTTT AGCTTATAAA AATGATAAAC AGATGTCATA TGGATTCCTT 
TTTCCTCCCT ACCTGAGCTC CTCCCCAGAA GCTAAGTATG ATGCATTCCT CGTAACCAAC 
ATGGTTCCAA TGTACCCCGC CTTCAAACGT GTTTGGGCTT ATTTCCAAAG GGTTTTGGTG 
AAGAAATATG CTTCAGAAAG GAATGGAGTC AACGTAATAA GTGGACCGAT TTTTGACTAC 
AATTACGATG GCCTACGTGA CACTGAAGAT GAAATTAAAC AGTATGTGGA AGGCAGCTCT 
ATACCTGTCC CCACCCACTA CTACAGCATC ATCACCAGCT GCCTGGACTT CACTCAGCCT 
GCAGACAAGT GTGACGGTCC CCTCTCTGTG TCTTCCTTCA TCCTTCCTCA CCGACCCGAC 
AATGATGAGA GCTGTAATAG CTCCGAGGAT GAGTCGAAGT GGGTAGAGGA ACTCATGAAG 
ATGCACACAG CTCGGGTGCG GGACATTGAG CACCTCACTG GTCTGGATTT CTACCGGAAG 
ACTAGCCGTA GCTATTCGGA AATTCTGACC CTCAAGACAT ACCTGCATAC ATATGAGAGC 
GAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476445.2
CDS	92..2680
Translation	MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI

Target ORF information:

RefSeq Version	NM_057104.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ectonucleotide pyrophosphatase/phosphodiesterase 2 (Enpp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057104.2

ORF Insert Sequence:

ATGGCAAGAC AAGGCTGTCT CGGGTCATTC CAGGTAATAT CCTTGTTCAC TTTTGCCATC 
AGTGTCAATA TCTGCTTAGG ATTCACAGCA AGTCGAATTA AGAGGGCAGA ATGGGATGAA 
GGACCTCCCA CAGTGCTGTC TGACTCTCCA TGGACCAACA CCTCTGGATC CTGCAAAGGT 
AGATGCTTTG AGCTTCAAGA GGTTGGCCCT CCAGACTGTC GGTGTGACAA CCTGTGTAAG 
AGCTACAGCA GCTGCTGCCA CGATTTCGAT GAGCTCTGTT TGAAAACAGC TCGAGGCTGG 
GAGTGCACCA AAGACAGATG TGGGGAAGTA CGAAACGAGG AAAATGCCTG TCACTGCTCA 
GAAGACTGCT TGTCCAGGGG AGACTGCTGT ACCAACTACC AAGTGGTCTG CAAAGGAGAA 
TCACACTGGG TAGATGATGA CTGCGAAGAA ATCAAAGTTC CCGAATGCCC TGCAGGGTTT 
GTCCGCCCTC CGTTAATCAT CTTCTCTGTG GATGGTTTCC GTGCATCATA CATGAAGAAA 
GGCAGCAAGG TTATGCCCAA CATTGAGAAA CTGCGGTCCT GTGGCACCCA TGCTCCCTAC 
ATGAGGCCTG TGTACCCCAC AAAAACCTTC CCTAATCTAT ATACGCTGGC CACTGGTTTA 
TATCCGGAAT CCCATGGAAT TGTCGGTAAT TCAATGTATG ATCCTGTCTT TGATGCTTCG 
TTCCATCTAC GAGGGCGAGA GAAGTTTAAT CATAGGTGGT GGGGAGGCCA ACCGCTATGG 
ATTACAGCCA CCAAGCAAGG GGTGAGAGCT GGAACATTCT TTTGGTCTGT GAGCATCCCT 
CATGAACGGA GGATCCTAAC CATTCTTCAG TGGCTTTCTC TGCCAGACAA CGAGAGGCCT 
TCAGTTTATG CCTTCTACTC AGAGCAGCCT GATTTTTCTG GACACAAGTA CGGCCCTTTT 
GGCCCTGAGA TGACAAATCC TCTGAGGGAG ATTGACAAGA CCGTGGGGCA GTTAATGGAT 
GGACTGAAAC AACTCAGGCT GCATCGCTGT GTGAACGTTA TCTTTGTTGG AGACCATGGA 
ATGGAAGATG TGACATGTGA CAGAACTGAG TTCTTGAGCA ACTATCTGAC TAATGTGGAT 
GACATTACTT TAGTGCCTGG AACTCTGGGA AGAATTCGAG CCAAATCTAT CAATAATTCT 
AAATATGACC CTAAAACCAT TATTGCTAAC CTCACGTGCA AAAAACCGGA TCAGCACTTT 
AAGCCTTACA TGAAACAGCA CCTTCCCAAA CGGTTGCACT ATGCCAACAA CAGAAGAATT 
GAAGACATCC ATTTATTGGT CGATCGAAGA TGGCATGTTG CAAGGAAACC TTTGGACGTT 
TATAAGAAAC CATCAGGAAA ATGTTTTTTC CAGGGTGACC ACGGCTTTGA TAACAAGGTC 
AATAGCATGC AGACTGTTTT CGTAGGTTAT GGCCCAACTT TTAAGTACAG GACTAAAGTG 
CCTCCATTTG AAAACATTGA ACTTTACAAT GTTATGTGCG ATCTCCTAGG CTTGAAGCCC 
GCTCCCAATA ATGGAACTCA TGGAAGCTTG AATCACCTAC TGCGTACAAA TACCTTTAGG 
CCAACCATGC CAGACGAAGT CAGCCGACCT AACTACCCAG GGATTATGTA CCTTCAGTCC 
GAGTTTGACC TGGGCTGCAC CTGTGACGAT AAGGTAGAGC CAAAGAACAA ATTGGAAGAA 
CTCAATAAAC GTCTTCATAC CAAAGGATCA ACAGAAGAGA GACATCTCCT GTATGGACGG 
CCTGCAGTGC TCTATCGGAC TAGCTATGAT ATCTTATACC ATACGGACTT TGAAAGTGGT 
TATAGTGAAA TATTCTTAAT GCCTCTCTGG ACATCGTATA CCATTTCTAA GCAGGCTGAG 
GTCTCCAGCA TCCCAGAACA CCTGACCAAC TGTGTTCGTC CTGATGTCCG TGTGTCTCCA 
GGATTCAGTC AGAACTGTTT AGCTTATAAA AATGATAAAC AGATGTCATA TGGATTCCTT 
TTTCCTCCCT ACCTGAGCTC CTCCCCAGAA GCTAAGTATG ATGCATTCCT CGTAACCAAC 
ATGGTTCCAA TGTACCCCGC CTTCAAACGT GTTTGGGCTT ATTTCCAAAG GGTTTTGGTG 
AAGAAATATG CTTCAGAAAG GAATGGAGTC AACGTAATAA GTGGACCGAT TTTTGACTAC 
AATTACGATG GCCTACGTGA CACTGAAGAT GAAATTAAAC AGTATGTGGA AGGCAGCTCT 
ATACCTGTCC CCACCCACTA CTACAGCATC ATCACCAGCT GCCTGGACTT CACTCAGCCT 
GCAGACAAGT GTGACGGTCC CCTCTCTGTG TCTTCCTTCA TCCTTCCTCA CCGACCCGAC 
AATGATGAGA GCTGTAATAG CTCCGAGGAT GAGTCGAAGT GGGTAGAGGA ACTCATGAAG 
ATGCACACAG CTCGGGTGCG GGACATTGAG CACCTCACTG GTCTGGATTT CTACCGGAAG 
ACTAGCCGTA GCTATTCGGA AATTCTGACC CTCAAGACAT ACCTGCATAC ATATGAGAGC 
GAGATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ENPP2 protects cardiomyocytes from erastin-induced ferroptosis.
Biochemical and biophysical research communications499(1)44-51(2018 04)
Bai YT,Chang R,Wang H,Xiao FJ,Ge RL,Wang LS

Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(9)4064-4077(2017 09)
Meng G,Tang X,Yang Z,Benesch MGK,Marshall A,Murray D,Hemmings DG,Wuest F,McMullen TPW,Brindley DN

Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.
Nature communications711248(2016 Apr)
Keune WJ,Hausmann J,Bolier R,Tolenaars D,Kremer A,Heidebrecht T,Joosten RP,Sunkara M,Morris AJ,Matas-Rico E,Moolenaar WH,Oude Elferink RP,Perrakis A

Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal hypothyroidism.
Physiology & behavior157158-64(2016 Apr)
da Conceição RR,Laureano-Melo R,Oliveira KC,de Carvalho Melo MC,Kasamatsu TS,de Barros Maciel RM,de Souza JS,Giannocco G

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Molecular pharmacology88(6)982-92(2015 Dec)
Stein AJ,Bain G,Prodanovich P,Santini AM,Darlington J,Stelzer NM,Sidhu RS,Schaub J,Goulet L,Lonergan D,Calderon I,Evans JF,Hutchinson JH

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Enpp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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