Lrp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrp4
Entrez Gene ID	83469
Full Name	LDL receptor related protein 4
Synonyms	Megf7
General protein information	Preferred Names LDL receptor related protein 4 Names low-density lipoprotein receptor-related protein 4 LRP-4 multiple epidermal growth factor-like domains 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24
Summary	mouse homolog has similarity to the low density lipoprotein receptor family, however, it does not bind very low density lipoprotein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031322.3	NP_112612.2	low-density lipoprotein receptor-related protein 4 precursor
XM_008762038.2	XP_008760260.1	low-density lipoprotein receptor-related protein 4 isoform X1

Pathways from BioSystems

Homologies

Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000037	XP_311125.5
Macaca mulatta (Rhesus monkey)	LRP4	XP_001111133.2
Mus musculus (house mouse)	Lrp4	NP_766256.3
Rattus norvegicus (Norway rat)	Lrp4	NP_112612.2
Pan troglodytes (chimpanzee)	LRP4	XP_508403.4
Danio rerio (zebrafish)	lrp4	XP_005169124.1
Gallus gallus (chicken)	LRP4	XP_421114.4
Drosophila melanogaster (fruit fly)	CG8909	NP_001162769.1
Xenopus tropicalis (tropical clawed frog)	lrp4	XP_002941898.2
Homo sapiens (human)	LRP4	NP_002325.2
Canis lupus familiaris (dog)	LRP4	XP_005631328.1
Bos taurus (cattle)	LRP4	NP_001071311.1

Gene Ontology
Bibliography

Related articles in PubMed

Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract Alleviates β-Glycerophosphate-Induced Vascular Smooth Muscle Cell Calcification By Inhibiting Wnt/β-Catenin Pathway.
Wang J, Qiu X, Xu T, Sheng Z, Yao L
Blood purification47 Suppl 117-23(2019)

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.
Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y
FEBS letters587(23)3749-54(2013 Nov)

The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.
Witzemann V, Chevessier F, Pacifici PG, Yampolsky P
Mechanisms of development130(6-8)402-11(2013 Jun-Aug)

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.
Yumoto N, Kim N, Burden SJ
Nature489(7416)438-42(2012 Sep)

Structural basis of agrin-LRP4-MuSK signaling.
Zong Y, Zhang B, Gu S, Lee K, Zhou J, Yao G, Figueiredo D, Perry K, Mei L, Jin R
Genes & development26(3)247-58(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lrp4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrp4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07813	NM_031322.3 Latest version!	Rattus norvegicus LDL receptor related protein 4 (Lrp4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
ORa43754	XM_008762038.2 Latest version!	Rattus norvegicus LDL receptor related protein 4 (Lrp4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrp4 ( NM_031322.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112612.2 Rattus norvegicus LDL receptor related protein 4 (Lrp4), mRNA.

Price & Availability↑

CloneID	ORa07813
Clone ID Related Accession (Same CDS sequence)	NM_031322.3
Accession Version	NM_031322.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5718bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1562169600000
Organism	Rattus norvegicus(Norway rat)
Product	low-density lipoprotein receptor-related protein 4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB073317.3. On Apr 16, 2011 this sequence version replaced NM_031322.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB073317.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGGCGGT GGTGGGGCGC GCTGCTGCTC GGCGCCCTGC TCTGCGCACA CGGCACAGCC 
AGCAATCTGG AGTGTGCGTG TGGTCGGAGC CACTTCACAT GTGCAGTGAG CGCGCTCGGC 
GAATGTACCT GCATCCCCGC CCAGTGGCAG TGTGATGGTG ACAATGACTG TGGAGACCAC 
AGCGATGAGG ATGGCTGTAC GCTGCCTACC TGTTCCCCTC TGGACTTCCA CTGTGACAAC 
GGCAAGTGCA TCCGACGCTC CTGGGTGTGT GATGGGGACA ATGACTGTGA AGATGACTCC 
GATGAGCAGG ACTGTCCCCC CCGGGAGTGT GAGGAGGACG AGTTCCCCTG CCAGAACGGC 
TACTGCATCC GGAGTCTGTG GCACTGTGAT GGGGACAATG ACTGTGGTGA CAACAGTGAC 
GAACAGTGCG ACATGCGCAA GTGCTCAGAC AAGGAATTCC GCTGCAGTGA TGGGAGCTGC 
ATTGCTGAGC ATTGGTACTG TGATGGAGAC ACAGACTGCA AAGACGGCTC TGATGAGGAA 
AGCTGCCCCT CAGCAGTACC CTCTCCTCCT TGCAACCTGG AAGAGTTCCA GTGTGCCTAC 
GGCCGCCGCA TCCTTGACAT CTACCACTGT GACGGGGATG ATGACTGCGG AGACTGGTCA 
GACGAGTCCG ACTGCTCCTC CCACCAGCCC TGCCGCTCTG GGGAATTCAT GTGTGACAGT 
GGCCTGTGCG TCAACGCAGG CTGGCGCTGT GATGGTGATG CGGACTGCGA TGACCAGTCT 
GATGAACGTA ACTGCACCAC CTCCATGTGC ACAGCTGAAC AGTTTCGCTG TCGGTCAGGC 
CGCTGTGTCC GTCTGTCCTG GCGCTGTGAT GGGGAGGATG ACTGCGCGGA CAACAGTGAT 
GAAGAAAACT GTGAGAACAC AGGAAGCCCC CAATGCGCCT CTGACCAGTT CCTGTGTTGG 
AATGGGCGTT GTATTGGGCA GAGGAAGCTC TGCAATGGGG TCAATGACTG CGGCGACAAC 
AGTGACGAAA GCCCACAGCA GAACTGTCGG CCCCGGACGG GTGAGGAGAA CTGCAATGTT 
AACAACGGTG GCTGTGCCCA GAAGTGTCAG ATGATTCGAG GGGCAGTGCA GTGTACCTGC 
CACACAGGCT ACCGGCTCAC AGAGGATGGG AGAACGTGCC AGGATGTGAA TGAATGTGCT 
GAGGAGGGAT ACTGCAGCCA GGGCTGCACA AACAGCGAAG GGGCTTTCCA GTGCTGGTGC 
GAAGCCGGTT ATGAGCTGCG GCCCGATCGG CGCAGCTGCA AGGCTCTGGG GCCGGAACCT 
GTGCTACTGT TTGCCAATCG CATCGACATC CGGCAGGTGC TCCCGCACCG CTCCGAATAC 
ACGCTGCTAC TGAACAACCT GGAGAACGCC ATTGCCCTTG ACTTTCATCA TCGGCGGGAG 
CTGGTCTTCT GGTCTGATGT CACCCTGGAC CGCATCCTCC GTGCCAACCT TAATGGCAGC 
AATGTGGAGG AGGTGGTGTC TACTGGGCTA GAGAGCCCAG GCGGCTTGGC TGTGGATTGG 
GTCCATGACA AGCTCTACTG GACTGACTCC GGGACGTCGA GGATTGAGGT GGCTAATCTG 
GACGGGGCCC ACCGGAAGGT GCTGCTGTGG CAGAGCCTGG AGAAGCCCAG GGCCATTGCC 
CTGCACCCCA TGGAGGGAAC CATCTATTGG ACAGACTGGG GCAACACCCC CCGCATCGAG 
GCCTCCAGCA TGGACGGCTC TGGACGTCGC ATCATTGCTG ACACTCATCT TTTCTGGCCC 
AACGGCCTCA CCATCGACTA CGCTGGACGC CGTATGTACT GGGTGGACGC TAAGCACCAC 
GTCATCGAGA GAGCCAATCT AGATGGGAGT CACCGCAAGG CTGTCATTAG CCAGGGCCTC 
CCACATCCCT TTGCCATCAC AGTGTTTGAA GACAGCTTGT ATTGGACAGA CTGGCACACC 
AAGAGCATCA ATAGTGCCAA CAAGTTCACT GGGAAGAACC AGGAGATCAT TCGCAACAAG 
CTCCACTTTC CTATGGACAT TCATACCTTG CACCCCCAGC GCCAGCCTGC AGGGAAAAAC 
CGCTGCGGGG ACAACAACGG AGGTTGCACT CACCTGTGTC TACCCAGTGG CCAGAACTAC 
ACTTGTGCCT GCCCCACCGG CTTCCGAAAA ATCAACAGCC ACGCCTGTGC CCAGAGTCTT 
GACAAGTTCC TGCTTTTTGC CCGAAGGATG GACATCCGTC GGATCAGCTT CGACACAGAG 
GACCTGTCCG ACGATGTCAT CCCACTGGCT GACGTGCGCA GTGCTGTGGC CCTTGACTGG 
GACTCCCGGG ATGACCACGT GTACTGGACA GATGTCAGCA CTGATACCAT CAGCAGGGCC 
AAGTGGGATG GAACAGGACA GAAGGTGGTA GTTGACACCA GTTTGGAGAG CCCTGCTGGC 
CTGGCAATTG ATTGGGTCAC CAACAAACTC TACTGGACAG ATGCAGGTAC AGACCGGATT 
GAAGTGGCCA ACACGGACGG CAGCATGAGG ACAGTGCTCA TCTGGGAGAA CCTTGATCGT 
CCTCGGGACA TCGTGGTAGA ACCCATGGGC GGGTACATGT ATTGGACTGA CTGGGGTGCA 
AGTCCCAAGA TTGAACGAGC TGGCATGGAT GCCTCCAACC GACAAGTCAT CATCTCTTCG 
AATCTGACAT GGCCTAATGG ATTAGCTATT GACTATGGGT CCCAGCGGCT GTACTGGGCT 
GATGCCGGCA TGAAGACTAT TGAATTTGCT GGGCTGGATG GCAGCAAGAG GAAGGTACTA 
ATTGGAAGTC AACTCCCCCA CCCTTTCGGG CTGACTCTAT ACGGACAGCG CATCTATTGG 
ACTGACTGGC AGACCAAAAG TATCCAAAGT GCTGACCGGC TGACTGGGCT AGACCGGGAG 
ACTCTGCAGG AGAACCTGGA GAATCTTATG GACATCCATG TCTTCCACCG CCAGAGGCCT 
CCAGTGACGA CACCATGTGC TGTGGAGAAT GGCGGCTGCA GCCATTTGTG TCTTCGGTCC 
CCAAGTCCGA GCGGCTTCAG CTGTACCTGC CCCACAGGTA TCAACCTGCT GCTTGATGGC 
AAGACATGCT CACCAGGCAT GAACAGTTTC CTCATCTTCG CCAGGAGGAT TGATGTTCGC 
ATGGTCTCCT TGGACATCCC TTATTTTGCT GATGTGGTGG TACCCATCAA CATGACCATG 
AAGAACACCA TTGCCATTGG AGTGGACCCG CTGGAAGGAA AAGTGTACTG GTCTGACAGC 
ACACTGCACA GGATCAGCCG TGCCAGCCTG GATGGCTCAC AGCACGAGGA CATCATCACT 
ACAGGTTTGC AGACCACAGA TGGACTTGCA GTGGATGCCA TCGGCCGGAA AGTGTATTGG 
ACAGACACGG GAACGAATCG GATTGAAGTT GGCAACCTGG ATGGGTCTAT GCGGAAAGTG 
TTGGTGTGGC AGAACCTTGA CAGTCCCCGG GCCATTGTGC TATACCATGA AATGGGGTTC 
ATGTACTGGA CAGACTGGGG GGAGAATGCC AAACTAGAGC GTTCCGGGAT GGATGGCTCA 
GACCGTACTG TGCTCATCAA CAACAACCTA GGGTGGCCTA ACGGACTGAC TGTGGACAAG 
ACCAGCTCCC AACTGCTGTG GGCTGATGCC CATACTGAGA GAATTGAGGT GGCTGACCTG 
AACGGTGCCA ATCGGCATAC ATTGGTGTCA CCAGTGCAGC ACCCATATGG CCTCACTCTG 
CTTGACTCTT ACATCTACTG GACTGACTGG CAGACCCGTA GCATCCACCG GGCCGACAAG 
AGTACTGGCA GCAATGTTAT CCTCGTGAGG TCCAACCTGC CAGGCCTCAT GGACATCCAA 
GCTGTTGACC GGGCACAGCC ACTGGGTTTT AATAAGTGTG GTTCGAGAAA TGGCGGCTGC 
TCCCACCTCT GTTTACCTCG GCCCTCTGGT TTCTCCTGTG CCTGCCCCAC TGGCATTCAG 
CTGAAGGGGG ATGGGAAGAC CTGTGACCCC TCTCCGGAGA CCTACCTGCT CTTCTCTAGC 
CGGGGCTCCA TTCGCCGTAT CTCACTGGAC ACCGATGACC ACACAGACGT GCATGTCCCT 
GTTCCTGGGC TCAACAATGT CATCTCCCTA GACTATGACA GTGTGGATGG AAAGGTCTAT 
TACACAGACG TGTTCCTGGA TGTTATCAGG CGAGCAGACC TGAATGGCAG CAACATGGAG 
ACTGTTATTG GGCATGGGCT GAAGACCACT GATGGGCTGG CAGTGGACTG GGTTGCCAGA 
AACCTGTACT GGACAGATAC AGGCCGAAAT ACCATCGAAG CATCTCGGCT AGATGGTTCC 
TGTCGCAAAG TGCTAATCAA CAACAGTCTG GACGAGCCCC GGGCCATTGC TGTTTTCCCC 
AGAAAGGGGT ACCTCTTCTG GACAGACTGG GGCCACATTG CCAAGATTGA ACGGGCAAAC 
CTGGATGGTT CTGAGAGGAA GGTCCTCATC AATGCAGACC TAGGCTGGCC CAATGGCCTT 
ACCTTGGACT ATGATACCCG CAGGATCTAC TGGGTAGATG CACATCTGGA TCGGATTGAG 
AGTGCTGACC TCAATGGGAA GCTGAGGCAG GTCTTGGTCA GCCATGTGTC CCACCCCTTT 
GCCCTCACAC AGCAGGACAG GTGGATCTAC TGGACAGACT GGCAGACCAA ATCCATCCAG 
CGTGTCGACA AGTACTCAGG CCGCAACAAG GAGACAGTGC TGGCCAATGT GGAGGGACTC 
ATGGATATCA TCGTGGTGTC CCCTCAACGG CAGACAGGGA CCAATGCCTG TGGTGTGAAC 
AATGGTGGCT GTAGCCACCT CTGCTTTGCC AGAGCCTCTG ACTTTGTGTG CGCCTGTCCT 
GATGAGCCAG ACAGTCATCC CTGCTCCCTC GTGCCTGGCC TCATGCCTCC TGCTCCCAGA 
GCTACCAGCC TGAATGAAAA GAGCCCAGTG CTCCCCAACA CATTGCCCAC CACCTTACAT 
TCTTCTACCA CCAGGACCCG CACATCTCCA GAGGGGGCAG AAGGAAGATG CTCTGAAAGG 
GACGCCCAGC TGGGCCTCTG TGCACATTCC AATGAAGCTG TACCTGCTGC TCCAGGTGAA 
GGACTGCATG TCAGCTACGC CGTTGGTGGA CTCCTCAGCG TCCTGCTGAT TTTGTTGGTG 
ACTGCAGCTT TGATGCTATA CAGACACAGA AAATCCAAAT TCACGGATCC TGGAATGGGA 
AACCTGACCT ACAGCAACCC CTCCTACCGA ACTTCCACTC AGGAAGTGAA AATTGAAGCA 
GCTCCCAAAC CAGCCATGTA TAATCAGCTG TGCTATAAGA AAGAGGGTGG ACCTGACCAC 
AGCTACACCA AGGAGAAGAT CAAGATTGTA GAGGGAATTC ACCTCCTGGC TGGGCATGAT 
GCTGAATGGG GTGACCTCAA GCAACTGCGC AGCTCCAGGG GGGGCCTTCT ACGGGATCAC 
GTATGCATGA AGACAGACAC GGTGTCCATC CAGGCCAGCT CTGGCTCCCT AGATGACACG 
GAGACAGAGC AGCTGCTGCA GGAAGAGCAG TCTGAGTGTA GCAGTGTTCA CACTGCAACC 
ACTCCAGAGA GACGGGGCTC TCTGCCAGAC ACAGGCTGGA AACATGAACG CAAGCTCTCC 
TCAGAAAGCC AGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112612.2
CDS	14..5731
Translation	MRRWWGALLLGALLCAHGTASNLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRRILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCVNAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMIRGAVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQGCTNSEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASNRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRSPSPSGFSCTCPTGINLLLDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCSHLCFARASDFVCACPDEPDSHPCSLVPGLMPPAPRATSLNEKSPVLPNTLPTTLHSSTTRTRTSPEGAEGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSYAVGGLLSVLLILLVTAALMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAAPKPAMYNQLCYKKEGGPDHSYTKEKIKIVEGIHLLAGHDAEWGDLKQLRSSRGGLLRDHVCMKTDTVSIQASSGSLDDTETEQLLQEEQSECSSVHTATTPERRGSLPDTGWKHERKLSSESQV

Target ORF information:

RefSeq Version	NM_031322.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LDL receptor related protein 4 (Lrp4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031322.3

ORF Insert Sequence:

ATGAGGCGGT GGTGGGGCGC GCTGCTGCTC GGCGCCCTGC TCTGCGCACA CGGCACAGCC 
AGCAATCTGG AGTGTGCGTG TGGTCGGAGC CACTTCACAT GTGCAGTGAG CGCGCTCGGC 
GAATGTACCT GCATCCCCGC CCAGTGGCAG TGTGATGGTG ACAATGACTG TGGAGACCAC 
AGCGATGAGG ATGGCTGTAC GCTGCCTACC TGTTCCCCTC TGGACTTCCA CTGTGACAAC 
GGCAAGTGCA TCCGACGCTC CTGGGTGTGT GATGGGGACA ATGACTGTGA AGATGACTCC 
GATGAGCAGG ACTGTCCCCC CCGGGAGTGT GAGGAGGACG AGTTCCCCTG CCAGAACGGC 
TACTGCATCC GGAGTCTGTG GCACTGTGAT GGGGACAATG ACTGTGGTGA CAACAGTGAC 
GAACAGTGCG ACATGCGCAA GTGCTCAGAC AAGGAATTCC GCTGCAGTGA TGGGAGCTGC 
ATTGCTGAGC ATTGGTACTG TGATGGAGAC ACAGACTGCA AAGACGGCTC TGATGAGGAA 
AGCTGCCCCT CAGCAGTACC CTCTCCTCCT TGCAACCTGG AAGAGTTCCA GTGTGCCTAC 
GGCCGCCGCA TCCTTGACAT CTACCACTGT GACGGGGATG ATGACTGCGG AGACTGGTCA 
GACGAGTCCG ACTGCTCCTC CCACCAGCCC TGCCGCTCTG GGGAATTCAT GTGTGACAGT 
GGCCTGTGCG TCAACGCAGG CTGGCGCTGT GATGGTGATG CGGACTGCGA TGACCAGTCT 
GATGAACGTA ACTGCACCAC CTCCATGTGC ACAGCTGAAC AGTTTCGCTG TCGGTCAGGC 
CGCTGTGTCC GTCTGTCCTG GCGCTGTGAT GGGGAGGATG ACTGCGCGGA CAACAGTGAT 
GAAGAAAACT GTGAGAACAC AGGAAGCCCC CAATGCGCCT CTGACCAGTT CCTGTGTTGG 
AATGGGCGTT GTATTGGGCA GAGGAAGCTC TGCAATGGGG TCAATGACTG CGGCGACAAC 
AGTGACGAAA GCCCACAGCA GAACTGTCGG CCCCGGACGG GTGAGGAGAA CTGCAATGTT 
AACAACGGTG GCTGTGCCCA GAAGTGTCAG ATGATTCGAG GGGCAGTGCA GTGTACCTGC 
CACACAGGCT ACCGGCTCAC AGAGGATGGG AGAACGTGCC AGGATGTGAA TGAATGTGCT 
GAGGAGGGAT ACTGCAGCCA GGGCTGCACA AACAGCGAAG GGGCTTTCCA GTGCTGGTGC 
GAAGCCGGTT ATGAGCTGCG GCCCGATCGG CGCAGCTGCA AGGCTCTGGG GCCGGAACCT 
GTGCTACTGT TTGCCAATCG CATCGACATC CGGCAGGTGC TCCCGCACCG CTCCGAATAC 
ACGCTGCTAC TGAACAACCT GGAGAACGCC ATTGCCCTTG ACTTTCATCA TCGGCGGGAG 
CTGGTCTTCT GGTCTGATGT CACCCTGGAC CGCATCCTCC GTGCCAACCT TAATGGCAGC 
AATGTGGAGG AGGTGGTGTC TACTGGGCTA GAGAGCCCAG GCGGCTTGGC TGTGGATTGG 
GTCCATGACA AGCTCTACTG GACTGACTCC GGGACGTCGA GGATTGAGGT GGCTAATCTG 
GACGGGGCCC ACCGGAAGGT GCTGCTGTGG CAGAGCCTGG AGAAGCCCAG GGCCATTGCC 
CTGCACCCCA TGGAGGGAAC CATCTATTGG ACAGACTGGG GCAACACCCC CCGCATCGAG 
GCCTCCAGCA TGGACGGCTC TGGACGTCGC ATCATTGCTG ACACTCATCT TTTCTGGCCC 
AACGGCCTCA CCATCGACTA CGCTGGACGC CGTATGTACT GGGTGGACGC TAAGCACCAC 
GTCATCGAGA GAGCCAATCT AGATGGGAGT CACCGCAAGG CTGTCATTAG CCAGGGCCTC 
CCACATCCCT TTGCCATCAC AGTGTTTGAA GACAGCTTGT ATTGGACAGA CTGGCACACC 
AAGAGCATCA ATAGTGCCAA CAAGTTCACT GGGAAGAACC AGGAGATCAT TCGCAACAAG 
CTCCACTTTC CTATGGACAT TCATACCTTG CACCCCCAGC GCCAGCCTGC AGGGAAAAAC 
CGCTGCGGGG ACAACAACGG AGGTTGCACT CACCTGTGTC TACCCAGTGG CCAGAACTAC 
ACTTGTGCCT GCCCCACCGG CTTCCGAAAA ATCAACAGCC ACGCCTGTGC CCAGAGTCTT 
GACAAGTTCC TGCTTTTTGC CCGAAGGATG GACATCCGTC GGATCAGCTT CGACACAGAG 
GACCTGTCCG ACGATGTCAT CCCACTGGCT GACGTGCGCA GTGCTGTGGC CCTTGACTGG 
GACTCCCGGG ATGACCACGT GTACTGGACA GATGTCAGCA CTGATACCAT CAGCAGGGCC 
AAGTGGGATG GAACAGGACA GAAGGTGGTA GTTGACACCA GTTTGGAGAG CCCTGCTGGC 
CTGGCAATTG ATTGGGTCAC CAACAAACTC TACTGGACAG ATGCAGGTAC AGACCGGATT 
GAAGTGGCCA ACACGGACGG CAGCATGAGG ACAGTGCTCA TCTGGGAGAA CCTTGATCGT 
CCTCGGGACA TCGTGGTAGA ACCCATGGGC GGGTACATGT ATTGGACTGA CTGGGGTGCA 
AGTCCCAAGA TTGAACGAGC TGGCATGGAT GCCTCCAACC GACAAGTCAT CATCTCTTCG 
AATCTGACAT GGCCTAATGG ATTAGCTATT GACTATGGGT CCCAGCGGCT GTACTGGGCT 
GATGCCGGCA TGAAGACTAT TGAATTTGCT GGGCTGGATG GCAGCAAGAG GAAGGTACTA 
ATTGGAAGTC AACTCCCCCA CCCTTTCGGG CTGACTCTAT ACGGACAGCG CATCTATTGG 
ACTGACTGGC AGACCAAAAG TATCCAAAGT GCTGACCGGC TGACTGGGCT AGACCGGGAG 
ACTCTGCAGG AGAACCTGGA GAATCTTATG GACATCCATG TCTTCCACCG CCAGAGGCCT 
CCAGTGACGA CACCATGTGC TGTGGAGAAT GGCGGCTGCA GCCATTTGTG TCTTCGGTCC 
CCAAGTCCGA GCGGCTTCAG CTGTACCTGC CCCACAGGTA TCAACCTGCT GCTTGATGGC 
AAGACATGCT CACCAGGCAT GAACAGTTTC CTCATCTTCG CCAGGAGGAT TGATGTTCGC 
ATGGTCTCCT TGGACATCCC TTATTTTGCT GATGTGGTGG TACCCATCAA CATGACCATG 
AAGAACACCA TTGCCATTGG AGTGGACCCG CTGGAAGGAA AAGTGTACTG GTCTGACAGC 
ACACTGCACA GGATCAGCCG TGCCAGCCTG GATGGCTCAC AGCACGAGGA CATCATCACT 
ACAGGTTTGC AGACCACAGA TGGACTTGCA GTGGATGCCA TCGGCCGGAA AGTGTATTGG 
ACAGACACGG GAACGAATCG GATTGAAGTT GGCAACCTGG ATGGGTCTAT GCGGAAAGTG 
TTGGTGTGGC AGAACCTTGA CAGTCCCCGG GCCATTGTGC TATACCATGA AATGGGGTTC 
ATGTACTGGA CAGACTGGGG GGAGAATGCC AAACTAGAGC GTTCCGGGAT GGATGGCTCA 
GACCGTACTG TGCTCATCAA CAACAACCTA GGGTGGCCTA ACGGACTGAC TGTGGACAAG 
ACCAGCTCCC AACTGCTGTG GGCTGATGCC CATACTGAGA GAATTGAGGT GGCTGACCTG 
AACGGTGCCA ATCGGCATAC ATTGGTGTCA CCAGTGCAGC ACCCATATGG CCTCACTCTG 
CTTGACTCTT ACATCTACTG GACTGACTGG CAGACCCGTA GCATCCACCG GGCCGACAAG 
AGTACTGGCA GCAATGTTAT CCTCGTGAGG TCCAACCTGC CAGGCCTCAT GGACATCCAA 
GCTGTTGACC GGGCACAGCC ACTGGGTTTT AATAAGTGTG GTTCGAGAAA TGGCGGCTGC 
TCCCACCTCT GTTTACCTCG GCCCTCTGGT TTCTCCTGTG CCTGCCCCAC TGGCATTCAG 
CTGAAGGGGG ATGGGAAGAC CTGTGACCCC TCTCCGGAGA CCTACCTGCT CTTCTCTAGC 
CGGGGCTCCA TTCGCCGTAT CTCACTGGAC ACCGATGACC ACACAGACGT GCATGTCCCT 
GTTCCTGGGC TCAACAATGT CATCTCCCTA GACTATGACA GTGTGGATGG AAAGGTCTAT 
TACACAGACG TGTTCCTGGA TGTTATCAGG CGAGCAGACC TGAATGGCAG CAACATGGAG 
ACTGTTATTG GGCATGGGCT GAAGACCACT GATGGGCTGG CAGTGGACTG GGTTGCCAGA 
AACCTGTACT GGACAGATAC AGGCCGAAAT ACCATCGAAG CATCTCGGCT AGATGGTTCC 
TGTCGCAAAG TGCTAATCAA CAACAGTCTG GACGAGCCCC GGGCCATTGC TGTTTTCCCC 
AGAAAGGGGT ACCTCTTCTG GACAGACTGG GGCCACATTG CCAAGATTGA ACGGGCAAAC 
CTGGATGGTT CTGAGAGGAA GGTCCTCATC AATGCAGACC TAGGCTGGCC CAATGGCCTT 
ACCTTGGACT ATGATACCCG CAGGATCTAC TGGGTAGATG CACATCTGGA TCGGATTGAG 
AGTGCTGACC TCAATGGGAA GCTGAGGCAG GTCTTGGTCA GCCATGTGTC CCACCCCTTT 
GCCCTCACAC AGCAGGACAG GTGGATCTAC TGGACAGACT GGCAGACCAA ATCCATCCAG 
CGTGTCGACA AGTACTCAGG CCGCAACAAG GAGACAGTGC TGGCCAATGT GGAGGGACTC 
ATGGATATCA TCGTGGTGTC CCCTCAACGG CAGACAGGGA CCAATGCCTG TGGTGTGAAC 
AATGGTGGCT GTAGCCACCT CTGCTTTGCC AGAGCCTCTG ACTTTGTGTG CGCCTGTCCT 
GATGAGCCAG ACAGTCATCC CTGCTCCCTC GTGCCTGGCC TCATGCCTCC TGCTCCCAGA 
GCTACCAGCC TGAATGAAAA GAGCCCAGTG CTCCCCAACA CATTGCCCAC CACCTTACAT 
TCTTCTACCA CCAGGACCCG CACATCTCCA GAGGGGGCAG AAGGAAGATG CTCTGAAAGG 
GACGCCCAGC TGGGCCTCTG TGCACATTCC AATGAAGCTG TACCTGCTGC TCCAGGTGAA 
GGACTGCATG TCAGCTACGC CGTTGGTGGA CTCCTCAGCG TCCTGCTGAT TTTGTTGGTG 
ACTGCAGCTT TGATGCTATA CAGACACAGA AAATCCAAAT TCACGGATCC TGGAATGGGA 
AACCTGACCT ACAGCAACCC CTCCTACCGA ACTTCCACTC AGGAAGTGAA AATTGAAGCA 
GCTCCCAAAC CAGCCATGTA TAATCAGCTG TGCTATAAGA AAGAGGGTGG ACCTGACCAC 
AGCTACACCA AGGAGAAGAT CAAGATTGTA GAGGGAATTC ACCTCCTGGC TGGGCATGAT 
GCTGAATGGG GTGACCTCAA GCAACTGCGC AGCTCCAGGG GGGGCCTTCT ACGGGATCAC 
GTATGCATGA AGACAGACAC GGTGTCCATC CAGGCCAGCT CTGGCTCCCT AGATGACACG 
GAGACAGAGC AGCTGCTGCA GGAAGAGCAG TCTGAGTGTA GCAGTGTTCA CACTGCAACC 
ACTCCAGAGA GACGGGGCTC TCTGCCAGAC ACAGGCTGGA AACATGAACG CAAGCTCTCC 
TCAGAAAGCC AGGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrp4 ( XM_008762038.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760260.1 Rattus norvegicus LDL receptor related protein 4 (Lrp4), transcript variant X1, mRNA.

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CloneID	ORa43754
Clone ID Related Accession (Same CDS sequence)	XM_008762038.2
Accession Version	XM_008762038.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5430bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	low-density lipoprotein receptor-related protein 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008762038.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGCGGT GGTGGGGCGC GCTGCTGCTC GGCGCCCTGC TCTGCGCACA CGGCACAGCC 
AGCAATCTGG AGTGTGCGTG TGGTCGGAGC CACTTCACAT GTGCAGTGAG CGCGCTCGGC 
GAATGTACCT GCATCCCCGC CCAGTGGCAG TGTGATGGTG ACAATGACTG TGGAGACCAC 
AGCGATGAGG ATGGCTGTAC GCTGCCTACC TGTTCCCCTC TGGACTTCCA CTGTGACAAC 
GGCAAGTGCA TCCGACGCTC CTGGGTGTGT GATGGGGACA ATGACTGTGA AGATGACTCC 
GATGAGCAGG ACTGTCCCCC CCGGGAGTGT GAGGAGGACG AGTTCCCCTG CCAGAACGGC 
TACTGCATCC GGAGTCTGTG GCACTGTGAT GGGGACAATG ACTGTGGTGA CAACAGTGAC 
GAACAGTGCG ACATGCGCAA GTGCTCAGAC AAGGAATTCC GCTGCAGTGA TGGGAGCTGC 
ATTGCTGAGC ATTGGTACTG TGATGGAGAC ACAGACTGCA AAGACGGCTC TGATGAGGAA 
AGCTGCCCCT CAGCAGTACC CTCTCCTCCT TGCAACCTGG AAGAGTTCCA GTGTGCCTAC 
GGCCGCTGCA TCCTTGACAT CTACCACTGT GACGGGGATG ATGACTGCGG AGACTGGTCA 
GACGAGTCCG ACTGCTCCTC CCACCAGCCC TGCCGCTCTG GGGAATTCAT GTGTGACAGT 
GGCCTGTGCG TCAACGCAGG CTGGCGCTGT GATGGTGATG CGGACTGCGA TGACCAGTCT 
GATGAACGTA ACTGCACCAC CTCCATGTGC ACAGCTGAAC AGTTTCGCTG TCGGTCAGGC 
CGCTGTGTCC GTCTGTCCTG GCGCTGTGAT GGGGAGGATG ACTGCGCGGA CAACAGTGAT 
GAAGAAAACT GTGAGAACAC AGGAAGCCCC CAATGCGCCT CTGACCAGTT CCTGTGTTGG 
AATGGGCGTT GTATTGGGCA GAGGAAGCTC TGCAATGGGG TCAATGACTG CGGCGACAAC 
AGTGACGAAA GCCCACAGCA GAACTGTCGG CCCCGGACGG GTGAGGAGAA CTGCAATGTT 
AACAACGGTG GCTGTGCCCA GAAGTGTCAG ATGATTCGAG GGGCAGTGCA GTGTACCTGC 
CACACAGGCT ACCGGCTCAC AGAGGATGGG AGAACGTGCC AGGATGTGAA TGAATGTGCT 
GAGGAGGGAT ACTGCAGCCA GGGCTGCACA AACAGCGAAG GGGCTTTCCA GTGCTGGTGC 
GAAGCCGGTT ATGAGCTGCG GCCCGATCGG CGCAGCTGCA AGGCTCTGGG GCCGGAACCT 
GTGCTACTGT TTGCCAATCG CATCGACATC CGGCAGGTGC TCCCGCACCG CTCCGAATAC 
ACGCTGCTAC TGAACAACCT GGAGAACGCC ATTGCCCTTG ACTTTCATCA TCGGCGGGAG 
CTGGTCTTCT GGTCTGATGT CACCCTGGAC CGCATCCTCC GTGCCAACCT TAATGGCAGC 
AATGTGGAGG AGGTGGTGTC TACTGGGCTA GAGAGCCCAG GCGGCTTGGC TGTGGATTGG 
GTCCATGACA AGCTCTACTG GACTGACTCC GGGACGTCGA GGATTGAGGT GGCTAATCTG 
GACGGGGCCC ACCGGAAGGT GCTGCTGTGG CAGAGCCTGG AGAAGCCCAG GGCCATTGCC 
CTGCACCCCA TGGAGGGAAC CATCTATTGG ACAGACTGGG GCAACACCCC CCGCATCGAG 
GCCTCCAGCA TGGACGGCTC TGGACGTCGC ATCATTGCTG ACACTCATCT TTTCTGGCCC 
AACGGCCTCA CCATCGACTA CGCTGGACGC CGTATGTACT GGGTGGACGC TAAGCACCAC 
GTCATCGAGA GAGCCAATCT AGATGGGAGT CACCGCAAGG CTGTCATTAG CCAGGGCCTC 
CCACATCCCT TTGCCATCAC AGTGTTTGAA GACAGCTTGT ATTGGACAGA CTGGCACACC 
AAGAGCATCA ATAGTGCCAA CAAGTTCACT GGGAAGAACC AGGAGATCAT TCGCAACAAG 
CTCCACTTTC CTATGGACAT TCATACCTTG CACCCCCAGC GCCAGCCTGC AGGGAAAAAC 
CGCTGCGGGG ACAACAACGG AGGTTGCACT CACCTGTGTC TACCCAGTGG CCAGAACTAC 
ACTTGTGCCT GCCCCACCGG CTTCCGAAAA ATCAACAGCC ACGCCTGTGC CCAGAGTCTT 
GACAAGTTCC TGCTTTTTGC CCGAAGGATG GACATCCGTC GGATCAGCTT CGACACAGAG 
GACCTGTCCG ACGATGTCAT CCCACTGGCT GACGTGCGCA GTGCTGTGGC CCTTGACTGG 
GACTCCCGGG ATGACCACGT GTACTGGACA GATGTCAGCA CTGATACCAT CAGCAGGGCC 
AAGTGGGATG GAACAGGACA GAAGGTGGTA GTTGACACCA GTTTGGAGAG CCCTGCTGGC 
CTGGCAATTG ATTGGGTCAC CAACAAACTC TACTGGACAG ATGCAGGTAC AGACCGGATT 
GAAGTGGCCA ACACGGACGG CAGCATGAGG ACAGTGCTCA TCTGGGAGAA CCTTGATCGT 
CCTCGGGACA TCGTGGTAGA ACCCATGGGC GGGTACATGT ATTGGACTGA CTGGGGTGCA 
AGTCCCAAGA TTGAACGAGC TGGCATGGAT GCCTCCAACC GACAAGTCAT CATCTCTTCG 
AATCTGACAT GGCCTAATGG ATTAGCTATT GACTATGGGT CCCAGCGGCT GTACTGGGCT 
GATGCCGGCA TGAAGACTAT TGAATTTGCT GGGCTGGATG GCAGCAAGAG GAAGGTACTA 
ATTGGAAGTC AACTCCCCCA CCCTTTCGGG CTGACTCTAT ACGGACAGCG CATCTATTGG 
ACTGACTGGC AGACCAAAAG TATCCAAAGT GCTGACCGGC TGACTGGGCT AGACCGGGAG 
ACTCTGCAGG AGAACCTGGA GAATCTTATG GACATCCATG TCTTCCACCG CCAGAGGCCT 
CCAGTGACGA CACCATGTGC TGTGGAGAAT GGCGGCTGCA GCCATTTGTG TCTTCGGTCC 
CCAAGTCCGA GCGGCTTCAG CTGTACCTGC CCCACAGGTA TCAACCTGCT GCTTGATGGC 
AAGACATGCT CACCAGGCAT GAACAGTTTC CTCATCTTCG CCAGGAGGAT TGATGTTCGC 
ATGGTCTCCT TGGACATCCC TTATTTTGCT GATGTGGTGG TACCCATCAA CATGACCATG 
AAGAACACCA TTGCCATTGG AGTGGACCCG CTGGAAGGAA AAGTGTACTG GTCTGACAGC 
ACACTGCACA GGATCAGCCG TGCCAGCCTG GATGGCTCAC AGCACGAGGA CATCATCACT 
ACAGGTTTGC AGACCACAGA TGGACTTGCA GTGGATGCCA TCGGCCGGAA AGTGTATTGG 
ACAGACACGG GAACGAATCG GATTGAAGTT GGCAACCTGG ATGGGTCTAT GCGGAAAGTG 
TTGGTGTGGC AGAACCTTGA CAGTCCCCGG GCCATTGTGC TATACCATGA AATGGGGTTC 
ATGTACTGGA CAGACTGGGG GGAGAATGCC AAACTAGAGC GTTCCGGGAT GGATGGCTCA 
GACCGTACTG TGCTCATCAA CAACAACCTA GGGTGGCCTA ACGGACTGAC TGTGGACAAG 
ACCAGCTCCC AACTGCTGTG GGCTGATGCC CATACTGAGA GAATTGAGGT GGCTGACCTG 
AACGGTGCCA ATCGGCATAC ATTGGTGTCA CCAGTGCAGC ACCCATATGG CCTCACTCTG 
CTTGACTCTT ACATCTACTG GACTGACTGG CAGACCCGTA GCATCCACCG GGCCGACAAG 
AGTACTGGCA GCAATGTTAT CCTCGTGAGG TCCAACCTGC CAGGCCTCAT GGACATCCAA 
GCTGTTGACC GGGCACAGCC ACTGGGTTTT AATAAGTGTG GTTCGAGAAA TGGCGGCTGC 
TCCCACCTCT GTTTACCTCG GCCCTCTGGT TTCTCCTGTG CCTGCCCCAC TGGCATTCAG 
CTGAAGGGGG ATGGGAAGAC CTGTGACCCC TCTCCGGAGA CCTACCTGCT CTTCTCTAGC 
CGGGGCTCCA TTCGCCGTAT CTCACTGGAC ACCGATGACC ACACAGACGT GCATGTCCCT 
GTTCCTGGGC TCAACAATGT CATCTCCCTA GACTATGACA GTGTGGATGG AAAGGTCTAT 
TACACAGACG TGTTCCTGGA TGTTATCAGG CGAGCAGACC TGAATGGCAG CAACATGGAG 
ACTGTTATTG GGCATGGGCT GAAGACCACT GATGGGCTGG CAGTGGACTG GGTTGCCAGA 
AACCTGTACT GGACAGATAC AGGCCGAAAT ACCATCGAAG CATCTCGGCT AGATGGTTCC 
TGTCGCAAAG TGCTAATCAA CAACAGTCTG GACGAGCCCC GGGCCATTGC TGTTTTCCCC 
AGAAAGGGGT ACCTCTTCTG GACAGACTGG GGCCACATTG CCAAGATTGA ACGGGCAAAC 
CTGGATGGTT CTGAGAGGAA GGTCCTCATC AATGCAGACC TAGGCTGGCC CAATGGCCTT 
ACCTTGGACT ATGATACCCG CAGGATCTAC TGGGTAGATG CACATCTGGA TCGGATTGAG 
AGTGCTGACC TCAATGGGAA GCTGAGGCAG GTCTTGGTCA GCCATGTGTC CCACCCCTTT 
GCCCTCACAC AGCAGGACAG GTGGATCTAC TGGACAGACT GGCAGACCAA ATCCATCCAG 
CGTGTCGACA AGTACTCAGG CCGCAACAAG GAGACAGTGC TGGCCAATGT GGAGGGACTC 
ATGGATATCA TCGTGGTGTC CCCTCAACGG CAGACAGGGA CCAATGCCTG TGGTGTGAAC 
AATGGTGGCT GTAGCCACCT CTGCTTTGCC AGAGCCTCTG ACTTTGTGTG CGCCTGTCCT 
GATGAGCCAG ACAGTCATCC CTGCTCCCTC GTGCCTGGCC TCATGCCTCC TGCTCCCAGA 
GCTACCAGCC TGAATGAAAA GAGCCCAGTG CTCCCCAACA CATTGCCCAC CACCTTACAT 
TCTTCTACCA CCAGGACCCG CACATCTCCA GAGGGGGCAG AAGGAAGATG CTCTGAAAGG 
GACGCCCAGC TGGGCCTCTG TGCACATTCC AATGAAGCTG TACCTGCTGC TCCAGGTGAA 
GGACTGCATG TCAGCTACGC CGTTGGTGGA CTCCTCAGCG TCCTGCTGAT TTTGTTGGTG 
ACTGCAGCTT TGATGCTATA CAGACACAGA AAATCCAAAT TCACGGATCC TGGAATGGGA 
AACCTGACCT ACAGCAACCC CTCCTACCGA ACTTCCACTC AGGAAGTGAA AATTGAAGCA 
GCTCCCAAAC CAGCCATGTA TAATCAGCTG TGCTATAAGA AAGAGCAGCT CTTCCATCCC 
TCTGATAGCC TATCACCCTT TCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760260.1
CDS	229..5658
Translation	MRRWWGALLLGALLCAHGTASNLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCTLPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCVNAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCRSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMIRGAVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQGCTNSEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKINSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASNRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRSPSPSGFSCTCPTGINLLLDGKTCSPGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGKVYWSDSTLHRISRASLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCSHLCFARASDFVCACPDEPDSHPCSLVPGLMPPAPRATSLNEKSPVLPNTLPTTLHSSTTRTRTSPEGAEGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSYAVGGLLSVLLILLVTAALMLYRHRKSKFTDPGMGNLTYSNPSYRTSTQEVKIEAAPKPAMYNQLCYKKEQLFHPSDSLSPFLF

Target ORF information:

RefSeq Version	XM_008762038.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus LDL receptor related protein 4 (Lrp4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008762038.2

ORF Insert Sequence:

ATGAGGCGGT GGTGGGGCGC GCTGCTGCTC GGCGCCCTGC TCTGCGCACA CGGCACAGCC 
AGCAATCTGG AGTGTGCGTG TGGTCGGAGC CACTTCACAT GTGCAGTGAG CGCGCTCGGC 
GAATGTACCT GCATCCCCGC CCAGTGGCAG TGTGATGGTG ACAATGACTG TGGAGACCAC 
AGCGATGAGG ATGGCTGTAC GCTGCCTACC TGTTCCCCTC TGGACTTCCA CTGTGACAAC 
GGCAAGTGCA TCCGACGCTC CTGGGTGTGT GATGGGGACA ATGACTGTGA AGATGACTCC 
GATGAGCAGG ACTGTCCCCC CCGGGAGTGT GAGGAGGACG AGTTCCCCTG CCAGAACGGC 
TACTGCATCC GGAGTCTGTG GCACTGTGAT GGGGACAATG ACTGTGGTGA CAACAGTGAC 
GAACAGTGCG ACATGCGCAA GTGCTCAGAC AAGGAATTCC GCTGCAGTGA TGGGAGCTGC 
ATTGCTGAGC ATTGGTACTG TGATGGAGAC ACAGACTGCA AAGACGGCTC TGATGAGGAA 
AGCTGCCCCT CAGCAGTACC CTCTCCTCCT TGCAACCTGG AAGAGTTCCA GTGTGCCTAC 
GGCCGCTGCA TCCTTGACAT CTACCACTGT GACGGGGATG ATGACTGCGG AGACTGGTCA 
GACGAGTCCG ACTGCTCCTC CCACCAGCCC TGCCGCTCTG GGGAATTCAT GTGTGACAGT 
GGCCTGTGCG TCAACGCAGG CTGGCGCTGT GATGGTGATG CGGACTGCGA TGACCAGTCT 
GATGAACGTA ACTGCACCAC CTCCATGTGC ACAGCTGAAC AGTTTCGCTG TCGGTCAGGC 
CGCTGTGTCC GTCTGTCCTG GCGCTGTGAT GGGGAGGATG ACTGCGCGGA CAACAGTGAT 
GAAGAAAACT GTGAGAACAC AGGAAGCCCC CAATGCGCCT CTGACCAGTT CCTGTGTTGG 
AATGGGCGTT GTATTGGGCA GAGGAAGCTC TGCAATGGGG TCAATGACTG CGGCGACAAC 
AGTGACGAAA GCCCACAGCA GAACTGTCGG CCCCGGACGG GTGAGGAGAA CTGCAATGTT 
AACAACGGTG GCTGTGCCCA GAAGTGTCAG ATGATTCGAG GGGCAGTGCA GTGTACCTGC 
CACACAGGCT ACCGGCTCAC AGAGGATGGG AGAACGTGCC AGGATGTGAA TGAATGTGCT 
GAGGAGGGAT ACTGCAGCCA GGGCTGCACA AACAGCGAAG GGGCTTTCCA GTGCTGGTGC 
GAAGCCGGTT ATGAGCTGCG GCCCGATCGG CGCAGCTGCA AGGCTCTGGG GCCGGAACCT 
GTGCTACTGT TTGCCAATCG CATCGACATC CGGCAGGTGC TCCCGCACCG CTCCGAATAC 
ACGCTGCTAC TGAACAACCT GGAGAACGCC ATTGCCCTTG ACTTTCATCA TCGGCGGGAG 
CTGGTCTTCT GGTCTGATGT CACCCTGGAC CGCATCCTCC GTGCCAACCT TAATGGCAGC 
AATGTGGAGG AGGTGGTGTC TACTGGGCTA GAGAGCCCAG GCGGCTTGGC TGTGGATTGG 
GTCCATGACA AGCTCTACTG GACTGACTCC GGGACGTCGA GGATTGAGGT GGCTAATCTG 
GACGGGGCCC ACCGGAAGGT GCTGCTGTGG CAGAGCCTGG AGAAGCCCAG GGCCATTGCC 
CTGCACCCCA TGGAGGGAAC CATCTATTGG ACAGACTGGG GCAACACCCC CCGCATCGAG 
GCCTCCAGCA TGGACGGCTC TGGACGTCGC ATCATTGCTG ACACTCATCT TTTCTGGCCC 
AACGGCCTCA CCATCGACTA CGCTGGACGC CGTATGTACT GGGTGGACGC TAAGCACCAC 
GTCATCGAGA GAGCCAATCT AGATGGGAGT CACCGCAAGG CTGTCATTAG CCAGGGCCTC 
CCACATCCCT TTGCCATCAC AGTGTTTGAA GACAGCTTGT ATTGGACAGA CTGGCACACC 
AAGAGCATCA ATAGTGCCAA CAAGTTCACT GGGAAGAACC AGGAGATCAT TCGCAACAAG 
CTCCACTTTC CTATGGACAT TCATACCTTG CACCCCCAGC GCCAGCCTGC AGGGAAAAAC 
CGCTGCGGGG ACAACAACGG AGGTTGCACT CACCTGTGTC TACCCAGTGG CCAGAACTAC 
ACTTGTGCCT GCCCCACCGG CTTCCGAAAA ATCAACAGCC ACGCCTGTGC CCAGAGTCTT 
GACAAGTTCC TGCTTTTTGC CCGAAGGATG GACATCCGTC GGATCAGCTT CGACACAGAG 
GACCTGTCCG ACGATGTCAT CCCACTGGCT GACGTGCGCA GTGCTGTGGC CCTTGACTGG 
GACTCCCGGG ATGACCACGT GTACTGGACA GATGTCAGCA CTGATACCAT CAGCAGGGCC 
AAGTGGGATG GAACAGGACA GAAGGTGGTA GTTGACACCA GTTTGGAGAG CCCTGCTGGC 
CTGGCAATTG ATTGGGTCAC CAACAAACTC TACTGGACAG ATGCAGGTAC AGACCGGATT 
GAAGTGGCCA ACACGGACGG CAGCATGAGG ACAGTGCTCA TCTGGGAGAA CCTTGATCGT 
CCTCGGGACA TCGTGGTAGA ACCCATGGGC GGGTACATGT ATTGGACTGA CTGGGGTGCA 
AGTCCCAAGA TTGAACGAGC TGGCATGGAT GCCTCCAACC GACAAGTCAT CATCTCTTCG 
AATCTGACAT GGCCTAATGG ATTAGCTATT GACTATGGGT CCCAGCGGCT GTACTGGGCT 
GATGCCGGCA TGAAGACTAT TGAATTTGCT GGGCTGGATG GCAGCAAGAG GAAGGTACTA 
ATTGGAAGTC AACTCCCCCA CCCTTTCGGG CTGACTCTAT ACGGACAGCG CATCTATTGG 
ACTGACTGGC AGACCAAAAG TATCCAAAGT GCTGACCGGC TGACTGGGCT AGACCGGGAG 
ACTCTGCAGG AGAACCTGGA GAATCTTATG GACATCCATG TCTTCCACCG CCAGAGGCCT 
CCAGTGACGA CACCATGTGC TGTGGAGAAT GGCGGCTGCA GCCATTTGTG TCTTCGGTCC 
CCAAGTCCGA GCGGCTTCAG CTGTACCTGC CCCACAGGTA TCAACCTGCT GCTTGATGGC 
AAGACATGCT CACCAGGCAT GAACAGTTTC CTCATCTTCG CCAGGAGGAT TGATGTTCGC 
ATGGTCTCCT TGGACATCCC TTATTTTGCT GATGTGGTGG TACCCATCAA CATGACCATG 
AAGAACACCA TTGCCATTGG AGTGGACCCG CTGGAAGGAA AAGTGTACTG GTCTGACAGC 
ACACTGCACA GGATCAGCCG TGCCAGCCTG GATGGCTCAC AGCACGAGGA CATCATCACT 
ACAGGTTTGC AGACCACAGA TGGACTTGCA GTGGATGCCA TCGGCCGGAA AGTGTATTGG 
ACAGACACGG GAACGAATCG GATTGAAGTT GGCAACCTGG ATGGGTCTAT GCGGAAAGTG 
TTGGTGTGGC AGAACCTTGA CAGTCCCCGG GCCATTGTGC TATACCATGA AATGGGGTTC 
ATGTACTGGA CAGACTGGGG GGAGAATGCC AAACTAGAGC GTTCCGGGAT GGATGGCTCA 
GACCGTACTG TGCTCATCAA CAACAACCTA GGGTGGCCTA ACGGACTGAC TGTGGACAAG 
ACCAGCTCCC AACTGCTGTG GGCTGATGCC CATACTGAGA GAATTGAGGT GGCTGACCTG 
AACGGTGCCA ATCGGCATAC ATTGGTGTCA CCAGTGCAGC ACCCATATGG CCTCACTCTG 
CTTGACTCTT ACATCTACTG GACTGACTGG CAGACCCGTA GCATCCACCG GGCCGACAAG 
AGTACTGGCA GCAATGTTAT CCTCGTGAGG TCCAACCTGC CAGGCCTCAT GGACATCCAA 
GCTGTTGACC GGGCACAGCC ACTGGGTTTT AATAAGTGTG GTTCGAGAAA TGGCGGCTGC 
TCCCACCTCT GTTTACCTCG GCCCTCTGGT TTCTCCTGTG CCTGCCCCAC TGGCATTCAG 
CTGAAGGGGG ATGGGAAGAC CTGTGACCCC TCTCCGGAGA CCTACCTGCT CTTCTCTAGC 
CGGGGCTCCA TTCGCCGTAT CTCACTGGAC ACCGATGACC ACACAGACGT GCATGTCCCT 
GTTCCTGGGC TCAACAATGT CATCTCCCTA GACTATGACA GTGTGGATGG AAAGGTCTAT 
TACACAGACG TGTTCCTGGA TGTTATCAGG CGAGCAGACC TGAATGGCAG CAACATGGAG 
ACTGTTATTG GGCATGGGCT GAAGACCACT GATGGGCTGG CAGTGGACTG GGTTGCCAGA 
AACCTGTACT GGACAGATAC AGGCCGAAAT ACCATCGAAG CATCTCGGCT AGATGGTTCC 
TGTCGCAAAG TGCTAATCAA CAACAGTCTG GACGAGCCCC GGGCCATTGC TGTTTTCCCC 
AGAAAGGGGT ACCTCTTCTG GACAGACTGG GGCCACATTG CCAAGATTGA ACGGGCAAAC 
CTGGATGGTT CTGAGAGGAA GGTCCTCATC AATGCAGACC TAGGCTGGCC CAATGGCCTT 
ACCTTGGACT ATGATACCCG CAGGATCTAC TGGGTAGATG CACATCTGGA TCGGATTGAG 
AGTGCTGACC TCAATGGGAA GCTGAGGCAG GTCTTGGTCA GCCATGTGTC CCACCCCTTT 
GCCCTCACAC AGCAGGACAG GTGGATCTAC TGGACAGACT GGCAGACCAA ATCCATCCAG 
CGTGTCGACA AGTACTCAGG CCGCAACAAG GAGACAGTGC TGGCCAATGT GGAGGGACTC 
ATGGATATCA TCGTGGTGTC CCCTCAACGG CAGACAGGGA CCAATGCCTG TGGTGTGAAC 
AATGGTGGCT GTAGCCACCT CTGCTTTGCC AGAGCCTCTG ACTTTGTGTG CGCCTGTCCT 
GATGAGCCAG ACAGTCATCC CTGCTCCCTC GTGCCTGGCC TCATGCCTCC TGCTCCCAGA 
GCTACCAGCC TGAATGAAAA GAGCCCAGTG CTCCCCAACA CATTGCCCAC CACCTTACAT 
TCTTCTACCA CCAGGACCCG CACATCTCCA GAGGGGGCAG AAGGAAGATG CTCTGAAAGG 
GACGCCCAGC TGGGCCTCTG TGCACATTCC AATGAAGCTG TACCTGCTGC TCCAGGTGAA 
GGACTGCATG TCAGCTACGC CGTTGGTGGA CTCCTCAGCG TCCTGCTGAT TTTGTTGGTG 
ACTGCAGCTT TGATGCTATA CAGACACAGA AAATCCAAAT TCACGGATCC TGGAATGGGA 
AACCTGACCT ACAGCAACCC CTCCTACCGA ACTTCCACTC AGGAAGTGAA AATTGAAGCA 
GCTCCCAAAC CAGCCATGTA TAATCAGCTG TGCTATAAGA AAGAGCAGCT CTTCCATCCC 
TCTGATAGCC TATCACCCTT TCTCTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sclerostin/Receptor Related Protein 4 and Ginkgo Biloba Extract Alleviates β-Glycerophosphate-Induced Vascular Smooth Muscle Cell Calcification By Inhibiting Wnt/β-Catenin Pathway.
Blood purification47 Suppl 117-23(2019)
Wang J,Qiu X,Xu T,Sheng Z,Yao L

Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.
FEBS letters587(23)3749-54(2013 Nov)
Hoshi T,Tezuka T,Yokoyama K,Iemura S,Natsume T,Yamanashi Y

The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface.
Mechanisms of development130(6-8)402-11(2013 Jun-Aug)
Witzemann V,Chevessier F,Pacifici PG,Yampolsky P

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.
Nature489(7416)438-42(2012 Sep)
Yumoto N,Kim N,Burden SJ

Structural basis of agrin-LRP4-MuSK signaling.
Genes & development26(3)247-58(2012 Feb)
Zong Y,Zhang B,Gu S,Lee K,Zhou J,Yao G,Figueiredo D,Perry K,Mei L,Jin R

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Lrp4 cDNA ORF clone, Rattus norvegicus(Norway rat)

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