Mlh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mlh1
Entrez Gene ID	81685
Full Name	mutL homolog 1
General protein information	Preferred Names mutL homolog 1 Names DNA mismatch repair protein Mlh1 mismatch repair protein 1 mutL homolog 1, colon cancer, nonpolyposis type 2 mutL protein homolog 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q32
Summary	may be involved in DNA mismatch repair [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017595929.1	XP_017451418.1	DNA mismatch repair protein Mlh1 isoform X1
NM_031053.1	NP_112315.1	DNA mismatch repair protein Mlh1

Pathways from BioSystems

Homologies

Magnaporthe oryzae (rice blast fungus)	MGG_07121	XP_003715311.1
Rattus norvegicus (Norway rat)	Mlh1	NP_112315.1
Drosophila melanogaster (fruit fly)	Mlh1	NP_477022.1
Oryza sativa (rice)	Os01g0958900	NP_001045457.1
Xenopus tropicalis (tropical clawed frog)	mlh1	XP_002933455.2
Schizosaccharomyces pombe (fission yeast)	mlh1	NP_596199.1
Pan troglodytes (chimpanzee)	MLH1	XP_001170433.1
Canis lupus familiaris (dog)	MLH1	XP_534219.2
Danio rerio (zebrafish)	mlh1	NP_956953.1
Neurospora crassa	NCU08309	XP_962522.1
Kluyveromyces lactis	KLLA0D09955g	XP_453504.1
Gallus gallus (chicken)	MLH1	XP_418828.1
Saccharomyces cerevisiae (baker's yeast)	MLH1	NP_013890.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012192	XP_320342.4
Bos taurus (cattle)	MLH1	NP_001069462.2
Mus musculus (house mouse)	Mlh1	NP_081086.2
Homo sapiens (human)	MLH1	NP_000240.1
Arabidopsis thaliana (thale cress)	MLH1	NP_567345.2
Eremothecium gossypii	AGOS_AFL199C	NP_985351.1

Gene Ontology
Bibliography

Related articles in PubMed

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.
Finsterbusch F, Ravindranathan R, Dereli I, Stanzione M, Tränkner D, Tóth A
PLoS genetics12(10)e1006393(2016 Oct)

MCM9 Is Required for Mammalian DNA Mismatch Repair.
Traver S, Coulombe P, Peiffer I, Hutchins JR, Kitzmann M, Latreille D, Méchali M
Molecular cell59(5)831-9(2015 Sep)

Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
Kim J, Ishiguro K, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A, Ishiguro T, Pendas AM, Takeda N, Sakakibara Y, Kitajima TS, Tanno Y, Sakuno T, Watanabe Y
Nature517(7535)466-71(2015 Jan)

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
Holloway JK, Sun X, Yokoo R, Villeneuve AM, Cohen PE
The Journal of cell biology205(5)633-41(2014 Jun)

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
Ghodgaonkar MM, Lazzaro F, Olivera-Pimentel M, Artola-Borán M, Cejka P, Reijns MA, Jackson AP, Plevani P, Muzi-Falconi M, Jiricny J
Molecular cell50(3)323-32(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mlh1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mlh1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07475	NM_031053.1 Latest version!	Rattus norvegicus mutL homolog 1 (Mlh1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa62561	XM_017595929.1 Latest version!	Rattus norvegicus mutL homolog 1 (Mlh1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mlh1 ( NM_031053.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112315.1 Rattus norvegicus mutL homolog 1 (Mlh1), mRNA.

Price & Availability↑

CloneID	ORa07475
Clone ID Related Accession (Same CDS sequence)	NM_031053.1
Accession Version	NM_031053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2274bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577030400000
Organism	Rattus norvegicus(Norway rat)
Product	DNA mismatch repair protein Mlh1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U80054.1. On Jan 12, 2005 this sequence version replaced XM_346837.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U80054.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCATTTG TAGCAGGAGT TATTCGGCGC CTGGACGAGA CGGTAGTGAA TCGCATAGCG 
GCGGGAGAAG TTATCCAGCG GCCGGCCAAT GCTATCAAAG AGATGACTGA AAACTGTTTA 
GATGCAAAAT CTACAAATAT TCAAGTGATT GTTAGAGAAG GAGGCCTGAA GCTAATTCAG 
ATCCAAGACA ATGGCACTGG AATCAGGAAG GAAGATTTGG ATATTGTGTG TGAGAGGTTC 
ACTACAAGTA AACTGCAGAC CTTTGAGGAT TTAGCTATGA TTTCCACCTA TGGGTTTCGC 
GGAGAGGCTT TGGCAAGCAT AAGCCATGTG GCCCATGTCA CTATTACAAC CAAAACAGCT 
GATGGGAAAT GTGCATACAG AGCAAGTTAC TCAGATGGAA AGCTACAAGC CCCTCCTAAA 
CCGTGTGCAG GCAACCAGGG TACCCTGATC ACGGTGGAAG ACCTTTTTTA CAACATAATC 
ACAAGGAAGA AAGCTTTAAA AAATCCCAGT GAAGAGTACG GGAAGATTTT GGAAGTTGTT 
GGCAGGTACT CAATACACAA TTCAGGAATT AGTTTCTCAG TTAAAAAACA AGGCGAGACA 
GTCTCTGATG TCAGAACACT ACCCAATGCC ACGACCGTAG ACAACATTCG CTCCATCTTT 
GGAAATGCTG TTAGTCGAGA ACTGATCGAA GTTGGGTGTG AGGATAAAAC CCTAGCTTTC 
AAAATGAATG GCTATATCTC GAATGCAAAC TACTCAGTGA AGAAGTGCAT TTTCCTACTC 
TTCATCAACC ACCGGCTGGT GGAATCGGCT GCCCTGAAGA AAGCCATAGA AGCTGTATAT 
GCAGCATATT TACCCAAAAA CACGCACCCA TTCCTGTACC TCATTTTGGA AATCAGTCCC 
CAGAACGTGG ATGTCAATGT GCACCCCACC AAGCATGAAG TTCACTTTCT CCATGAGGAG 
AGTATTCTGG AGCGTGTGCA GCAGCACATC GAGAGCAAGC TATTGGGCTC CAATTCATCC 
AGGATGTATT TTACCCAGAC CTTGCTTCCA GGACTTGCTG GGCCCTCTGG GGAAGCCGTT 
AAATCCACGA CAGGCATAGC TTCCTCATCT ACTAGTGGAA GTGGCGACAA GGTTCACGCT 
TACCAAATGG TCCGTACAGA CTCTCGGGAC CAGAAGCTCG ATGCCTTTAT GCAGCCTGTA 
AGCAGGCGTC TGCCCAGCCA GCCCCAGGAC CCTGTCCCTG GGAACAGGAC AGAGGGCTCT 
CCTGAAAAAG CCATGCAGAA GGATCAGGAG ATATCTGAGC TCCCGGCCCC CATGGAAGCA 
GCTGCTGACA GTGCGAGTTT GGAGAGAGAA TCAGTGATTG GGGCTTCGGA AGTGGTGGCA 
CCCCAGCGGC ACCCCTCCAG TCCAGGCAGC TCCAGAAAGA GACATCCGGA GGACTCCGAT 
GTGGAAATGA TGGAAAATGA TTCCCGGAAG GAAATGACAG CTGCTTGCTA CCCCCGGAGG 
AGGATCATTA ACCTCACCAG TGTTTTGAGT CTCCAGGAAG AAATTAACGA CCGGGGTCAT 
GAGACTCTCC GGGAGATGCT CCGTAACCAT ACCTTTGTGG GCTGTGTGAA TCCTCAGTGG 
GCCTTGGCAC AGCACCAGAC CAAGCTCTAC CTCCTCAACA CTACCAAGCT CAGTGAAGAA 
CTCTTCTACC AGATACTCAT TTACGATTTT GCCAACTTCG GTGTTCTCAG GTTACCGGAA 
CCAGCACCAC TCTTTGACTT CGCCATGCTG GCCTTAGATA GTCCTGAAAG TGGCTGGACA 
GAGGAAGATG GCCCAAAGGA AGGACTTGCA GAATACATTG TTGAGTTTTT GAAGAAGAAA 
GCCAAGATGC TTGCAGACTA TTTCTCTGTG GAAATTGATG AGGAAGGGAA CCTGATTGGA 
TTACCTCTCC TGATTGATAG CTATGTGCCG CCTTTGGAGG GACTGCCTAT CTTCATTCTT 
CGACTGGCCA CTGAGGTGAA CTGGGATGAA GAGGAGTGTT TCGAAAGTCT CAGTAAAGAA 
TGTGCTGTGT TTTACTCCAT TCGGAAGCAA TACATACTGG AGGAGTCAGC CCTCTCAGGC 
CAGCAGAGTG ACATGCCTGG CTCCCCTTCA AAGCCCTGGA AGTGGACTGT GGAACACATT 
ATCTATAAAG CCTTCCGCTC ACACCTTCTG CCTCCGAAGC ATTTCACAGA AGATGGCAAT 
GTCCTGCAGC TCGCCAACCT GCCAGATCTG TGCAAAGTCT TCGAACGCTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112315.1
CDS	1..2274
Translation	MSFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMTENCLDAKSTNIQVIVREGGLKLIQIQDNGTGIRKEDLDIVCERFTTSKLQTFEDLAMISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPKPCAGNQGTLITVEDLFYNIITRKKALKNPSEEYGKILEVVGRYSIHNSGISFSVKKQGETVSDVRTLPNATTVDNIRSIFGNAVSRELIEVGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESAALKKAIEAVYAAYLPKNTHPFLYLILEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAVKSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQPQDPVPGNRTEGSPEKAMQKDQEISELPAPMEAAADSASLERESVIGASEVVAPQRHPSSPGSSRKRHPEDSDVEMMENDSRKEMTAACYPRRRIINLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLPEPAPLFDFAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAKMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLCKVFERC

Target ORF information:

RefSeq Version	NM_031053.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mutL homolog 1 (Mlh1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031053.1

ORF Insert Sequence:

ATGTCATTTG TAGCAGGAGT TATTCGGCGC CTGGACGAGA CGGTAGTGAA TCGCATAGCG 
GCGGGAGAAG TTATCCAGCG GCCGGCCAAT GCTATCAAAG AGATGACTGA AAACTGTTTA 
GATGCAAAAT CTACAAATAT TCAAGTGATT GTTAGAGAAG GAGGCCTGAA GCTAATTCAG 
ATCCAAGACA ATGGCACTGG AATCAGGAAG GAAGATTTGG ATATTGTGTG TGAGAGGTTC 
ACTACAAGTA AACTGCAGAC CTTTGAGGAT TTAGCTATGA TTTCCACCTA TGGGTTTCGC 
GGAGAGGCTT TGGCAAGCAT AAGCCATGTG GCCCATGTCA CTATTACAAC CAAAACAGCT 
GATGGGAAAT GTGCATACAG AGCAAGTTAC TCAGATGGAA AGCTACAAGC CCCTCCTAAA 
CCGTGTGCAG GCAACCAGGG TACCCTGATC ACGGTGGAAG ACCTTTTTTA CAACATAATC 
ACAAGGAAGA AAGCTTTAAA AAATCCCAGT GAAGAGTACG GGAAGATTTT GGAAGTTGTT 
GGCAGGTACT CAATACACAA TTCAGGAATT AGTTTCTCAG TTAAAAAACA AGGCGAGACA 
GTCTCTGATG TCAGAACACT ACCCAATGCC ACGACCGTAG ACAACATTCG CTCCATCTTT 
GGAAATGCTG TTAGTCGAGA ACTGATCGAA GTTGGGTGTG AGGATAAAAC CCTAGCTTTC 
AAAATGAATG GCTATATCTC GAATGCAAAC TACTCAGTGA AGAAGTGCAT TTTCCTACTC 
TTCATCAACC ACCGGCTGGT GGAATCGGCT GCCCTGAAGA AAGCCATAGA AGCTGTATAT 
GCAGCATATT TACCCAAAAA CACGCACCCA TTCCTGTACC TCATTTTGGA AATCAGTCCC 
CAGAACGTGG ATGTCAATGT GCACCCCACC AAGCATGAAG TTCACTTTCT CCATGAGGAG 
AGTATTCTGG AGCGTGTGCA GCAGCACATC GAGAGCAAGC TATTGGGCTC CAATTCATCC 
AGGATGTATT TTACCCAGAC CTTGCTTCCA GGACTTGCTG GGCCCTCTGG GGAAGCCGTT 
AAATCCACGA CAGGCATAGC TTCCTCATCT ACTAGTGGAA GTGGCGACAA GGTTCACGCT 
TACCAAATGG TCCGTACAGA CTCTCGGGAC CAGAAGCTCG ATGCCTTTAT GCAGCCTGTA 
AGCAGGCGTC TGCCCAGCCA GCCCCAGGAC CCTGTCCCTG GGAACAGGAC AGAGGGCTCT 
CCTGAAAAAG CCATGCAGAA GGATCAGGAG ATATCTGAGC TCCCGGCCCC CATGGAAGCA 
GCTGCTGACA GTGCGAGTTT GGAGAGAGAA TCAGTGATTG GGGCTTCGGA AGTGGTGGCA 
CCCCAGCGGC ACCCCTCCAG TCCAGGCAGC TCCAGAAAGA GACATCCGGA GGACTCCGAT 
GTGGAAATGA TGGAAAATGA TTCCCGGAAG GAAATGACAG CTGCTTGCTA CCCCCGGAGG 
AGGATCATTA ACCTCACCAG TGTTTTGAGT CTCCAGGAAG AAATTAACGA CCGGGGTCAT 
GAGACTCTCC GGGAGATGCT CCGTAACCAT ACCTTTGTGG GCTGTGTGAA TCCTCAGTGG 
GCCTTGGCAC AGCACCAGAC CAAGCTCTAC CTCCTCAACA CTACCAAGCT CAGTGAAGAA 
CTCTTCTACC AGATACTCAT TTACGATTTT GCCAACTTCG GTGTTCTCAG GTTACCGGAA 
CCAGCACCAC TCTTTGACTT CGCCATGCTG GCCTTAGATA GTCCTGAAAG TGGCTGGACA 
GAGGAAGATG GCCCAAAGGA AGGACTTGCA GAATACATTG TTGAGTTTTT GAAGAAGAAA 
GCCAAGATGC TTGCAGACTA TTTCTCTGTG GAAATTGATG AGGAAGGGAA CCTGATTGGA 
TTACCTCTCC TGATTGATAG CTATGTGCCG CCTTTGGAGG GACTGCCTAT CTTCATTCTT 
CGACTGGCCA CTGAGGTGAA CTGGGATGAA GAGGAGTGTT TCGAAAGTCT CAGTAAAGAA 
TGTGCTGTGT TTTACTCCAT TCGGAAGCAA TACATACTGG AGGAGTCAGC CCTCTCAGGC 
CAGCAGAGTG ACATGCCTGG CTCCCCTTCA AAGCCCTGGA AGTGGACTGT GGAACACATT 
ATCTATAAAG CCTTCCGCTC ACACCTTCTG CCTCCGAAGC ATTTCACAGA AGATGGCAAT 
GTCCTGCAGC TCGCCAACCT GCCAGATCTG TGCAAAGTCT TCGAACGCTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mlh1 ( XM_017595929.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451418.1 Rattus norvegicus mutL homolog 1 (Mlh1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa62561
Clone ID Related Accession (Same CDS sequence)	XM_017595929.1
Accession Version	XM_017595929.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1554bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	DNA mismatch repair protein Mlh1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAATGGCT ATATCTCGAA TGCAAACTAC TCAGTGAAGA AGTGCATTTT CCTACTCTTC 
ATCAACCACC GGCTGGTGGA ATCGGCTGCC CTGAAGAAAG CCATAGAAGC TGTATATGCA 
GCATATTTAC CCAAAAACAC GCACCCATTC CTGTACCTCA GTTTGGAAAT CAGTCCTCAG 
AACGTGGATG TCAATGTGCA CCCCACCAAG CATGAAGTTC ACTTTCTCCA TGAGGAGAGT 
ATTCTGGAGC GTGTGCAGCA GCACATCGAG AGCAAGCTAT TGGGCTCCAA TTCATCCAGG 
ATGTATTTTA CCCAGACCTT GCTTCCAGGA CTTGCTGGGC CCTCTGGGGA AGCCGTTAAA 
TCCACGACAG GCATAGCTTC CTCATCTACT AGTGGAAGTG GCGACAAGGT TCACGCTTAC 
CAGATGGTCC GTACAGACTC TCGGGACCAG AAGCTCGATG CCTTTATGCA GCCTGTAAGC 
AGGCGTCTGC CCAGCCAGCC CCAGGACCCT GTCCCTGGGA ACAGGACAGA GGGCTCTCCT 
GAAAAAGCCA TGCAGAAGGA TCAGGAGATG TCTGAGCTCC CGGCCGCCAT GGAAGCAGCT 
GCTGACAGTG CGAGTTTGGA GAGAGAATCA GTGATTGGGG CTTCGGAAGT GGCACCCCCA 
GCGGCACCCC CTTCCAGTCC AGGCAGCTCC AGAAAGAGAC ATCGGGAGGA CTCCGATGAG 
GAAATGATGG AAAATGATTC CCGGAAGGAA ATGACAGCTG CTTGCTACCC CCGGAGGAGG 
ATCATTAACC TCACCAGTGT TTTGAGTCTC CAGGAAGAAA TTAACGACCG GGGTCATGAG 
ACTCTCCGGG AGATGCTCCG TAACCATACC TTTGTGGGCT GTGTGAATCC TCAGTGGGCC 
TTGGCACAGC ACCAGACCAA GCTCTACCTC CTCAACACTA CCAAGCTCAG TGAAGAACTC 
TTCTACCAGA TACTCATTTA CGATTTTGCC AACTTCGGTG TTCTCAGGTT ATCGGAACCA 
GCACCACTCT TTGACCTCGC CATGCTGGCC TTAGACAGTC CTGAAAGTGG CTGGACAGAG 
GAAGATGGCC CAAAGGAAGG ACTTGCAGAA TACATTGTTG AGTTTTTGAA GAAGAAAGCC 
GAGATGCTTG CAGACTATTT CTCTGTGGAA ATTGATGAGG AAGGGAACCT GATTGGATTA 
CCTCTCCTGA TTGATAGCTA TGTGCCGCCT TTGGAGGGAC TGCCTATCTT CATTCTTCGA 
CTGGCCACTG AGGTGAACTG GGATGAAGAA AAGGAGTGTT TCGAAAGTCT CAGTAAAGAA 
TGTGCTGTGT TTTACTCCAT TCGGAAGCAA TACATACTGG AGGAGTCAGC CCTCTCAGGC 
CAGCAGAGTG ACATGCCTGG CTCCCCTTCA AAGCCCTGGA AGTGGACTGT GGAACACATT 
ATCTATAAAG CCTTCCGCTC ACACCTTCTG CCTCCGAAGC ATTTCACAGA AGATGGCAAT 
GTCCTGCAGC TCGCCAACCT GCCAGATCTG TACAAAGTCT TTGAGCGGTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451418.1
CDS	679..2232
Translation	MNGYISNANYSVKKCIFLLFINHRLVESAALKKAIEAVYAAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILERVQQHIESKLLGSNSSRMYFTQTLLPGLAGPSGEAVKSTTGIASSSTSGSGDKVHAYQMVRTDSRDQKLDAFMQPVSRRLPSQPQDPVPGNRTEGSPEKAMQKDQEMSELPAAMEAAADSASLERESVIGASEVAPPAAPPSSPGSSRKRHREDSDEEMMENDSRKEMTAACYPRRRIINLTSVLSLQEEINDRGHETLREMLRNHTFVGCVNPQWALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSVEIDEEGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAVFYSIRKQYILEESALSGQQSDMPGSPSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKVFERC

Target ORF information:

RefSeq Version	XM_017595929.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus mutL homolog 1 (Mlh1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595929.1

ORF Insert Sequence:

ATGAATGGCT ATATCTCGAA TGCAAACTAC TCAGTGAAGA AGTGCATTTT CCTACTCTTC 
ATCAACCACC GGCTGGTGGA ATCGGCTGCC CTGAAGAAAG CCATAGAAGC TGTATATGCA 
GCATATTTAC CCAAAAACAC GCACCCATTC CTGTACCTCA GTTTGGAAAT CAGTCCTCAG 
AACGTGGATG TCAATGTGCA CCCCACCAAG CATGAAGTTC ACTTTCTCCA TGAGGAGAGT 
ATTCTGGAGC GTGTGCAGCA GCACATCGAG AGCAAGCTAT TGGGCTCCAA TTCATCCAGG 
ATGTATTTTA CCCAGACCTT GCTTCCAGGA CTTGCTGGGC CCTCTGGGGA AGCCGTTAAA 
TCCACGACAG GCATAGCTTC CTCATCTACT AGTGGAAGTG GCGACAAGGT TCACGCTTAC 
CAGATGGTCC GTACAGACTC TCGGGACCAG AAGCTCGATG CCTTTATGCA GCCTGTAAGC 
AGGCGTCTGC CCAGCCAGCC CCAGGACCCT GTCCCTGGGA ACAGGACAGA GGGCTCTCCT 
GAAAAAGCCA TGCAGAAGGA TCAGGAGATG TCTGAGCTCC CGGCCGCCAT GGAAGCAGCT 
GCTGACAGTG CGAGTTTGGA GAGAGAATCA GTGATTGGGG CTTCGGAAGT GGCACCCCCA 
GCGGCACCCC CTTCCAGTCC AGGCAGCTCC AGAAAGAGAC ATCGGGAGGA CTCCGATGAG 
GAAATGATGG AAAATGATTC CCGGAAGGAA ATGACAGCTG CTTGCTACCC CCGGAGGAGG 
ATCATTAACC TCACCAGTGT TTTGAGTCTC CAGGAAGAAA TTAACGACCG GGGTCATGAG 
ACTCTCCGGG AGATGCTCCG TAACCATACC TTTGTGGGCT GTGTGAATCC TCAGTGGGCC 
TTGGCACAGC ACCAGACCAA GCTCTACCTC CTCAACACTA CCAAGCTCAG TGAAGAACTC 
TTCTACCAGA TACTCATTTA CGATTTTGCC AACTTCGGTG TTCTCAGGTT ATCGGAACCA 
GCACCACTCT TTGACCTCGC CATGCTGGCC TTAGACAGTC CTGAAAGTGG CTGGACAGAG 
GAAGATGGCC CAAAGGAAGG ACTTGCAGAA TACATTGTTG AGTTTTTGAA GAAGAAAGCC 
GAGATGCTTG CAGACTATTT CTCTGTGGAA ATTGATGAGG AAGGGAACCT GATTGGATTA 
CCTCTCCTGA TTGATAGCTA TGTGCCGCCT TTGGAGGGAC TGCCTATCTT CATTCTTCGA 
CTGGCCACTG AGGTGAACTG GGATGAAGAA AAGGAGTGTT TCGAAAGTCT CAGTAAAGAA 
TGTGCTGTGT TTTACTCCAT TCGGAAGCAA TACATACTGG AGGAGTCAGC CCTCTCAGGC 
CAGCAGAGTG ACATGCCTGG CTCCCCTTCA AAGCCCTGGA AGTGGACTGT GGAACACATT 
ATCTATAAAG CCTTCCGCTC ACACCTTCTG CCTCCGAAGC ATTTCACAGA AGATGGCAAT 
GTCCTGCAGC TCGCCAACCT GCCAGATCTG TACAAAGTCT TTGAGCGGTG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein.
PLoS genetics12(10)e1006393(2016 Oct)
Finsterbusch F,Ravindranathan R,Dereli I,Stanzione M,Tränkner D,Tóth A

MCM9 Is Required for Mammalian DNA Mismatch Repair.
Molecular cell59(5)831-9(2015 Sep)
Traver S,Coulombe P,Peiffer I,Hutchins JR,Kitzmann M,Latreille D,Méchali M

Meikin is a conserved regulator of meiosis-I-specific kinetochore function.
Nature517(7535)466-71(2015 Jan)
Kim J,Ishiguro K,Nambu A,Akiyoshi B,Yokobayashi S,Kagami A,Ishiguro T,Pendas AM,Takeda N,Sakakibara Y,Kitajima TS,Tanno Y,Sakuno T,Watanabe Y

Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites.
The Journal of cell biology205(5)633-41(2014 Jun)
Holloway JK,Sun X,Yokoo R,Villeneuve AM,Cohen PE

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.
Molecular cell50(3)323-32(2013 May)
Ghodgaonkar MM,Lazzaro F,Olivera-Pimentel M,Artola-Borán M,Cejka P,Reijns MA,Jackson AP,Plevani P,Muzi-Falconi M,Jiricny J

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Mlh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

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