Acvr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Acvr1
Entrez Gene ID	79558
Full Name	activin A receptor type 1
General protein information	Preferred Names activin A receptor type 1 Names activin receptor type-1 ACTR-I ALK2-B SKR1 TGF-B superfamily receptor type I TSR-I activin A receptor, type I activin receptor type I activin type I receptor serine/threonine-protein kinase receptor R1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q21
Summary	potential transmembrane protein serine kinase that acts as an activin receptor [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006234214.3	XP_006234276.1	activin receptor type-1 isoform X3
XM_017592054.1	XP_017447543.1	activin receptor type-1 isoform X1
XM_008761867.1	XP_008760089.1	activin receptor type-1 isoform X2
XM_008761864.2	XP_008760086.1	activin receptor type-1 isoform X1
NM_024486.1	NP_077812.1	activin receptor type-1 precursor

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	ACVR1	XP_001089146.1
Gallus gallus (chicken)	ACVR1	NP_989891.1
Xenopus tropicalis (tropical clawed frog)	acvr1	NP_001017357.1
Bos taurus (cattle)	ACVR1	NP_788836.2
Danio rerio (zebrafish)	acvr1l	NP_571420.1
Drosophila melanogaster (fruit fly)	sax	NP_001246193.1
Homo sapiens (human)	ACVR1	NP_001096.1
Pan troglodytes (chimpanzee)	ACVR1	XP_001145316.1
Canis lupus familiaris (dog)	ACVR1	XP_005640253.1
Mus musculus (house mouse)	Acvr1	NP_001103674.1
Rattus norvegicus (Norway rat)	Acvr1	NP_077812.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007729	XP_308147.4

Gene Ontology
Bibliography

Related articles in PubMed

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.
Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB
American journal of physiology. Heart and circulatory physiology310(8)H984-94(2016 Apr)

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.
Benn A, Bredow C, Casanova I, Vukičević S, Knaus P
Journal of cell science129(1)206-18(2016 Jan)

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.
Romero D, Terzic A, Conley BA, Craft CS, Jovanovic B, Bergan RC, Vary CP
Carcinogenesis31(3)359-66(2010 Mar)

Dominant-negative ALK2 allele associates with congenital heart defects.
Smith KA, Joziasse IC, Chocron S, van Dinther M, Guryev V, Verhoeven MC, Rehmann H, van der Smagt JJ, Doevendans PA, Cuppen E, Mulder BJ, Ten Dijke P, Bakkers J
Circulation119(24)3062-9(2009 Jun)

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
Lavery K, Swain P, Falb D, Alaoui-Ismaili MH
The Journal of biological chemistry283(30)20948-58(2008 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Acvr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Acvr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07082	NM_024486.1 Latest version!	Rattus norvegicus activin A receptor type 1 (Acvr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa25866	XM_017592054.1 Latest version!	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa25866	XM_008761864.2 Latest version!	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa25867	XM_008761867.1 Latest version!	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa25868	XM_006234214.3 Latest version!	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Acvr1 ( NM_024486.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077812.1 Rattus norvegicus activin A receptor type 1 (Acvr1), mRNA.

Price & Availability↑

CloneID	ORa07082
Clone ID Related Accession (Same CDS sequence)	NM_024486.1
Accession Version	NM_024486.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L19341.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L19341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMN01906355 [ECO:0000348] ##Evidence-Data-END##

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGATG AGGAGCCCAA GGTCAACCCG AAGCTTTACA TGTGTGTGTG TGAGGGCCTC 
TCCTGCGGGA ACGAGGACCA CTGTGAGGGC CAGCAGTGTT TTTCCTCCCT GAGCGTCAAT 
GATGGCTTCC GCGTCTACCA GAAGGGCTGC TTTCAGGTCT ATGAGCAGGG GAAGATGACG 
TGTAAGACCC CGCCGTCGCC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGCAAC 
AGGAACGTCA CGGCCCGGCT GCCCACTAAA GGGAAATCCT TCCCTGGATC GCAGAACTTC 
CACCTGGAAG TTGGCCTTAT CATCCTCTCC GTGGTGTTTG CGGTATGCCT TTTCGCTTGC 
ATCCTTGGCG TTGCTCTCAG GAAGTTTAAA AGGCGCAATC AAGAGCGCCT GAACCCCAGA 
GACGTGGAGT ACGGTACTAT CGAAGGGCTC ATCACCACCA ACGTCGGAGA TAGCACTCTA 
GCGGAATTAC TAGATCACTC ATGTACATCA GGAAGTGGCT CCGGTCTTCC TTTTCTGGTA 
CAGAGAACTG TGGCTCGACA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 
GAAGTGTGGA GGGGCAGCTG GCAAGGCGAA AATGTTGCTG TGAAGATCTT CTCCTCCCGT 
GATGAGAAGT CGTGGTTCAG GGAGACAGAA TTGTACAACA CGGTTATGCT GAGGCATGAG 
AATATCTTAG GTTTCATTGC TTCAGACATG ACCTCTAGAC ACTCCAGTAC CCAGCTGTGG 
CTCATTACAC ATTACCACGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACCACTCTG 
GACACGGTTA GCTGCCTTCG GATCGTGTTG TCCATAGCCA GCGGCCTTGC ACACTTGCAC 
ATAGAGATAT TTGGGACCCA GGGGAAGTCT GCCATCGCCC ACCGAGATCT AAAGAGCAAA 
AACATCCTCG TGAAGAAGAA CGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 
CATTCCCAGA GCACGAATCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 
TACATGGCCC CTGAAGTGCT TGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 
AGGGTCGATA TTTGGGCCTT TGGCCTCGTT CTGTGGGAAG TGGCCAGGAG GATGGTGAGC 
AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TTGTTCCCAA TGACCCAAGT 
TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 
TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAATG CTGGTACCAG 
AACCCATCCG CCAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATTGATAAC 
TCCCTAGACA AATTAAAAAC TGACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077812.1
CDS	148..1677
Translation	MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Target ORF information:

RefSeq Version	NM_024486.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1 (Acvr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024486.1

ORF Insert Sequence:

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGATG AGGAGCCCAA GGTCAACCCG AAGCTTTACA TGTGTGTGTG TGAGGGCCTC 
TCCTGCGGGA ACGAGGACCA CTGTGAGGGC CAGCAGTGTT TTTCCTCCCT GAGCGTCAAT 
GATGGCTTCC GCGTCTACCA GAAGGGCTGC TTTCAGGTCT ATGAGCAGGG GAAGATGACG 
TGTAAGACCC CGCCGTCGCC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGCAAC 
AGGAACGTCA CGGCCCGGCT GCCCACTAAA GGGAAATCCT TCCCTGGATC GCAGAACTTC 
CACCTGGAAG TTGGCCTTAT CATCCTCTCC GTGGTGTTTG CGGTATGCCT TTTCGCTTGC 
ATCCTTGGCG TTGCTCTCAG GAAGTTTAAA AGGCGCAATC AAGAGCGCCT GAACCCCAGA 
GACGTGGAGT ACGGTACTAT CGAAGGGCTC ATCACCACCA ACGTCGGAGA TAGCACTCTA 
GCGGAATTAC TAGATCACTC ATGTACATCA GGAAGTGGCT CCGGTCTTCC TTTTCTGGTA 
CAGAGAACTG TGGCTCGACA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 
GAAGTGTGGA GGGGCAGCTG GCAAGGCGAA AATGTTGCTG TGAAGATCTT CTCCTCCCGT 
GATGAGAAGT CGTGGTTCAG GGAGACAGAA TTGTACAACA CGGTTATGCT GAGGCATGAG 
AATATCTTAG GTTTCATTGC TTCAGACATG ACCTCTAGAC ACTCCAGTAC CCAGCTGTGG 
CTCATTACAC ATTACCACGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACCACTCTG 
GACACGGTTA GCTGCCTTCG GATCGTGTTG TCCATAGCCA GCGGCCTTGC ACACTTGCAC 
ATAGAGATAT TTGGGACCCA GGGGAAGTCT GCCATCGCCC ACCGAGATCT AAAGAGCAAA 
AACATCCTCG TGAAGAAGAA CGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 
CATTCCCAGA GCACGAATCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 
TACATGGCCC CTGAAGTGCT TGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 
AGGGTCGATA TTTGGGCCTT TGGCCTCGTT CTGTGGGAAG TGGCCAGGAG GATGGTGAGC 
AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TTGTTCCCAA TGACCCAAGT 
TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 
TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAATG CTGGTACCAG 
AACCCATCCG CCAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATTGATAAC 
TCCCTAGACA AATTAAAAAC TGACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr1 ( XM_017592054.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447543.1 Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa25866
Clone ID Related Accession (Same CDS sequence)	XM_017592054.1 , XM_008761864.2
Accession Version	XM_017592054.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGCAC TAACTCTTCA TTCCCCAACC CAGTATCAGC CAGATGTACT TCCCAGTACC 
TTAGATGAGG AGCCCAAGGT CAACCCGAAG CTTTACATGT GTGTGTGTGA GGGCCTCTCC 
TGCGGGAACG AGGACCACTG TGAGGGCCAG CAGTGTTTTT CCTCCCTGAG CGTCAATGAT 
GGCTTCCGCG TCTACCAGAA GGGCTGCTTT CAGGTCTATG AGCAGGGGAA GATGACGTGT 
AAGACCCCGC CGTCGCCTGG CCAGGCTGTG GAGTGCTGCC AAGGGGACTG GTGCAACAGG 
AACGTCACGG CCCGGCTGCC CACTAAAGGG AAATCCTTCC CTGGATCGCA GAACTTCCAC 
CTGGAAGTTG GCCTTATCAT CCTCTCCGTG GTGTTTGCGG TATGCCTTTT CGCTTGCATC 
CTTGGCGTTG CTCTCAGGAA GTTTAAAAGG CGCAATCAAG AGCGCCTGAA CCCCAGAGAC 
GTGGAGTATG GTACTATCGA AGGGCTCATC ACCACCAACG TCGGAGATAG CACTCTAGCG 
GAATTACTAG ATCACTCGTG TACATCAGGA AGTGGCTCCG GTCTTCCTTT TCTGGTACAG 
AGAACTGTGG CTCGACAGAT AACCCTGTTG GAGTGTGTCG GGAAGGGCCG GTATGGAGAA 
GTGTGGAGGG GCAGCTGGCA AGGCGAAAAT GTTGCTGTGA AGATCTTCTC CTCCCGTGAT 
GAGAAGTCGT GGTTCAGGGA GACAGAATTG TACAACACGG TGATGCTGAG GCATGAGAAT 
ATCTTAGGTT TCATTGCTTC AGACATGACC TCTAGACACT CCAGTACCCA GCTGTGGCTC 
ATTACACATT ACCACGAAAT GGGATCGTTG TATGACTACC TTCAGCTCAC CACTCTGGAC 
ACGGTTAGCT GCCTTCGGAT CGTGTTGTCC ATAGCCAGCG GCCTTGCACA CTTGCACATA 
GAGATATTTG GGACCCAGGG GAAGTCTGCC ATCGCCCACC GAGATCTAAA GAGCAAAAAC 
ATCCTCGTGA AGAAGAACGG ACAGTGCTGC ATAGCAGATT TGGGCCTGGC AGTCATGCAT 
TCCCAGAGCA CGAATCAGCT TGATGTGGGA AACAACCCCC GTGTGGGGAC CAAGCGCTAC 
ATGGCCCCTG AAGTGCTTGA TGAAACCATC CAAGTGGATT GCTTTGATTC TTATAAGAGG 
GTCGATATTT GGGCCTTTGG CCTCGTTCTG TGGGAAGTGG CCAGGAGGAT GGTGAGCAAT 
GGTATAGTGG AAGATTACAA GCCACCATTC TATGATGTTG TTCCCAATGA CCCAAGTTTT 
GAAGATATGA GGAAAGTTGT CTGTGTGGAT CAACAGAGGC CAAACATACC TAACAGATGG 
TTCTCAGACC CGACATTAAC TTCTCTGGCG AAGCTGATGA AAGAATGCTG GTACCAGAAC 
CCATCCGCCA GACTCACAGC TCTACGTATC AAAAAGACTT TGACCAAAAT TGATAACTCC 
CTAGACAAAT TAAAAACTGA CTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447543.1
CDS	382..1968
Translation	MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Target ORF information:

RefSeq Version	XM_017592054.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017592054.1

ORF Insert Sequence:

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGCAC TAACTCTTCA TTCCCCAACC CAGTATCAGC CAGATGTACT TCCCAGTACC 
TTAGATGAGG AGCCCAAGGT CAACCCGAAG CTTTACATGT GTGTGTGTGA GGGCCTCTCC 
TGCGGGAACG AGGACCACTG TGAGGGCCAG CAGTGTTTTT CCTCCCTGAG CGTCAATGAT 
GGCTTCCGCG TCTACCAGAA GGGCTGCTTT CAGGTCTATG AGCAGGGGAA GATGACGTGT 
AAGACCCCGC CGTCGCCTGG CCAGGCTGTG GAGTGCTGCC AAGGGGACTG GTGCAACAGG 
AACGTCACGG CCCGGCTGCC CACTAAAGGG AAATCCTTCC CTGGATCGCA GAACTTCCAC 
CTGGAAGTTG GCCTTATCAT CCTCTCCGTG GTGTTTGCGG TATGCCTTTT CGCTTGCATC 
CTTGGCGTTG CTCTCAGGAA GTTTAAAAGG CGCAATCAAG AGCGCCTGAA CCCCAGAGAC 
GTGGAGTATG GTACTATCGA AGGGCTCATC ACCACCAACG TCGGAGATAG CACTCTAGCG 
GAATTACTAG ATCACTCGTG TACATCAGGA AGTGGCTCCG GTCTTCCTTT TCTGGTACAG 
AGAACTGTGG CTCGACAGAT AACCCTGTTG GAGTGTGTCG GGAAGGGCCG GTATGGAGAA 
GTGTGGAGGG GCAGCTGGCA AGGCGAAAAT GTTGCTGTGA AGATCTTCTC CTCCCGTGAT 
GAGAAGTCGT GGTTCAGGGA GACAGAATTG TACAACACGG TGATGCTGAG GCATGAGAAT 
ATCTTAGGTT TCATTGCTTC AGACATGACC TCTAGACACT CCAGTACCCA GCTGTGGCTC 
ATTACACATT ACCACGAAAT GGGATCGTTG TATGACTACC TTCAGCTCAC CACTCTGGAC 
ACGGTTAGCT GCCTTCGGAT CGTGTTGTCC ATAGCCAGCG GCCTTGCACA CTTGCACATA 
GAGATATTTG GGACCCAGGG GAAGTCTGCC ATCGCCCACC GAGATCTAAA GAGCAAAAAC 
ATCCTCGTGA AGAAGAACGG ACAGTGCTGC ATAGCAGATT TGGGCCTGGC AGTCATGCAT 
TCCCAGAGCA CGAATCAGCT TGATGTGGGA AACAACCCCC GTGTGGGGAC CAAGCGCTAC 
ATGGCCCCTG AAGTGCTTGA TGAAACCATC CAAGTGGATT GCTTTGATTC TTATAAGAGG 
GTCGATATTT GGGCCTTTGG CCTCGTTCTG TGGGAAGTGG CCAGGAGGAT GGTGAGCAAT 
GGTATAGTGG AAGATTACAA GCCACCATTC TATGATGTTG TTCCCAATGA CCCAAGTTTT 
GAAGATATGA GGAAAGTTGT CTGTGTGGAT CAACAGAGGC CAAACATACC TAACAGATGG 
TTCTCAGACC CGACATTAAC TTCTCTGGCG AAGCTGATGA AAGAATGCTG GTACCAGAAC 
CCATCCGCCA GACTCACAGC TCTACGTATC AAAAAGACTT TGACCAAAAT TGATAACTCC 
CTAGACAAAT TAAAAACTGA CTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr1 ( XM_008761864.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760086.1 Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa25866
Clone ID Related Accession (Same CDS sequence)	XM_017592054.1 , XM_008761864.2
Accession Version	XM_008761864.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008761864.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGCAC TAACTCTTCA TTCCCCAACC CAGTATCAGC CAGATGTACT TCCCAGTACC 
TTAGATGAGG AGCCCAAGGT CAACCCGAAG CTTTACATGT GTGTGTGTGA GGGCCTCTCC 
TGCGGGAACG AGGACCACTG TGAGGGCCAG CAGTGTTTTT CCTCCCTGAG CGTCAATGAT 
GGCTTCCGCG TCTACCAGAA GGGCTGCTTT CAGGTCTATG AGCAGGGGAA GATGACGTGT 
AAGACCCCGC CGTCGCCTGG CCAGGCTGTG GAGTGCTGCC AAGGGGACTG GTGCAACAGG 
AACGTCACGG CCCGGCTGCC CACTAAAGGG AAATCCTTCC CTGGATCGCA GAACTTCCAC 
CTGGAAGTTG GCCTTATCAT CCTCTCCGTG GTGTTTGCGG TATGCCTTTT CGCTTGCATC 
CTTGGCGTTG CTCTCAGGAA GTTTAAAAGG CGCAATCAAG AGCGCCTGAA CCCCAGAGAC 
GTGGAGTATG GTACTATCGA AGGGCTCATC ACCACCAACG TCGGAGATAG CACTCTAGCG 
GAATTACTAG ATCACTCGTG TACATCAGGA AGTGGCTCCG GTCTTCCTTT TCTGGTACAG 
AGAACTGTGG CTCGACAGAT AACCCTGTTG GAGTGTGTCG GGAAGGGCCG GTATGGAGAA 
GTGTGGAGGG GCAGCTGGCA AGGCGAAAAT GTTGCTGTGA AGATCTTCTC CTCCCGTGAT 
GAGAAGTCGT GGTTCAGGGA GACAGAATTG TACAACACGG TGATGCTGAG GCATGAGAAT 
ATCTTAGGTT TCATTGCTTC AGACATGACC TCTAGACACT CCAGTACCCA GCTGTGGCTC 
ATTACACATT ACCACGAAAT GGGATCGTTG TATGACTACC TTCAGCTCAC CACTCTGGAC 
ACGGTTAGCT GCCTTCGGAT CGTGTTGTCC ATAGCCAGCG GCCTTGCACA CTTGCACATA 
GAGATATTTG GGACCCAGGG GAAGTCTGCC ATCGCCCACC GAGATCTAAA GAGCAAAAAC 
ATCCTCGTGA AGAAGAACGG ACAGTGCTGC ATAGCAGATT TGGGCCTGGC AGTCATGCAT 
TCCCAGAGCA CGAATCAGCT TGATGTGGGA AACAACCCCC GTGTGGGGAC CAAGCGCTAC 
ATGGCCCCTG AAGTGCTTGA TGAAACCATC CAAGTGGATT GCTTTGATTC TTATAAGAGG 
GTCGATATTT GGGCCTTTGG CCTCGTTCTG TGGGAAGTGG CCAGGAGGAT GGTGAGCAAT 
GGTATAGTGG AAGATTACAA GCCACCATTC TATGATGTTG TTCCCAATGA CCCAAGTTTT 
GAAGATATGA GGAAAGTTGT CTGTGTGGAT CAACAGAGGC CAAACATACC TAACAGATGG 
TTCTCAGACC CGACATTAAC TTCTCTGGCG AAGCTGATGA AAGAATGCTG GTACCAGAAC 
CCATCCGCCA GACTCACAGC TCTACGTATC AAAAAGACTT TGACCAAAAT TGATAACTCC 
CTAGACAAAT TAAAAACTGA CTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760086.1
CDS	6461..8047
Translation	MVDGAMILSVLMMMALPSPSMEALTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Target ORF information:

RefSeq Version	XM_008761864.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008761864.2

ORF Insert Sequence:

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGCAC TAACTCTTCA TTCCCCAACC CAGTATCAGC CAGATGTACT TCCCAGTACC 
TTAGATGAGG AGCCCAAGGT CAACCCGAAG CTTTACATGT GTGTGTGTGA GGGCCTCTCC 
TGCGGGAACG AGGACCACTG TGAGGGCCAG CAGTGTTTTT CCTCCCTGAG CGTCAATGAT 
GGCTTCCGCG TCTACCAGAA GGGCTGCTTT CAGGTCTATG AGCAGGGGAA GATGACGTGT 
AAGACCCCGC CGTCGCCTGG CCAGGCTGTG GAGTGCTGCC AAGGGGACTG GTGCAACAGG 
AACGTCACGG CCCGGCTGCC CACTAAAGGG AAATCCTTCC CTGGATCGCA GAACTTCCAC 
CTGGAAGTTG GCCTTATCAT CCTCTCCGTG GTGTTTGCGG TATGCCTTTT CGCTTGCATC 
CTTGGCGTTG CTCTCAGGAA GTTTAAAAGG CGCAATCAAG AGCGCCTGAA CCCCAGAGAC 
GTGGAGTATG GTACTATCGA AGGGCTCATC ACCACCAACG TCGGAGATAG CACTCTAGCG 
GAATTACTAG ATCACTCGTG TACATCAGGA AGTGGCTCCG GTCTTCCTTT TCTGGTACAG 
AGAACTGTGG CTCGACAGAT AACCCTGTTG GAGTGTGTCG GGAAGGGCCG GTATGGAGAA 
GTGTGGAGGG GCAGCTGGCA AGGCGAAAAT GTTGCTGTGA AGATCTTCTC CTCCCGTGAT 
GAGAAGTCGT GGTTCAGGGA GACAGAATTG TACAACACGG TGATGCTGAG GCATGAGAAT 
ATCTTAGGTT TCATTGCTTC AGACATGACC TCTAGACACT CCAGTACCCA GCTGTGGCTC 
ATTACACATT ACCACGAAAT GGGATCGTTG TATGACTACC TTCAGCTCAC CACTCTGGAC 
ACGGTTAGCT GCCTTCGGAT CGTGTTGTCC ATAGCCAGCG GCCTTGCACA CTTGCACATA 
GAGATATTTG GGACCCAGGG GAAGTCTGCC ATCGCCCACC GAGATCTAAA GAGCAAAAAC 
ATCCTCGTGA AGAAGAACGG ACAGTGCTGC ATAGCAGATT TGGGCCTGGC AGTCATGCAT 
TCCCAGAGCA CGAATCAGCT TGATGTGGGA AACAACCCCC GTGTGGGGAC CAAGCGCTAC 
ATGGCCCCTG AAGTGCTTGA TGAAACCATC CAAGTGGATT GCTTTGATTC TTATAAGAGG 
GTCGATATTT GGGCCTTTGG CCTCGTTCTG TGGGAAGTGG CCAGGAGGAT GGTGAGCAAT 
GGTATAGTGG AAGATTACAA GCCACCATTC TATGATGTTG TTCCCAATGA CCCAAGTTTT 
GAAGATATGA GGAAAGTTGT CTGTGTGGAT CAACAGAGGC CAAACATACC TAACAGATGG 
TTCTCAGACC CGACATTAAC TTCTCTGGCG AAGCTGATGA AAGAATGCTG GTACCAGAAC 
CCATCCGCCA GACTCACAGC TCTACGTATC AAAAAGACTT TGACCAAAAT TGATAACTCC 
CTAGACAAAT TAAAAACTGA CTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr1 ( XM_008761867.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008760089.1 Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X2, mRNA.

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CloneID	ORa25867
Clone ID Related Accession (Same CDS sequence)	XM_008761867.1
Accession Version	XM_008761867.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1536bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAATG GTGTCTCACT AACTCTTCAT TCCCCAACCC AGTATCAGCC AGATGTACTT 
CCCAGTACCT TAGATGAGGA GCCCAAGGTC AACCCGAAGC TTTACATGTG TGTGTGTGAG 
GGCCTCTCCT GCGGGAACGA GGACCACTGT GAGGGCCAGC AGTGTTTTTC CTCCCTGAGC 
GTCAATGATG GCTTCCGCGT CTACCAGAAG GGCTGCTTTC AGGTCTATGA GCAGGGGAAG 
ATGACGTGTA AGACCCCGCC GTCGCCTGGC CAGGCTGTGG AGTGCTGCCA AGGGGACTGG 
TGCAACAGGA ACGTCACGGC CCGGCTGCCC ACTAAAGGGA AATCCTTCCC TGGATCGCAG 
AACTTCCACC TGGAAGTTGG CCTTATCATC CTCTCCGTGG TGTTTGCGGT ATGCCTTTTC 
GCTTGCATCC TTGGCGTTGC TCTCAGGAAG TTTAAAAGGC GCAATCAAGA GCGCCTGAAC 
CCCAGAGACG TGGAGTATGG TACTATCGAA GGGCTCATCA CCACCAACGT CGGAGATAGC 
ACTCTAGCGG AATTACTAGA TCACTCGTGT ACATCAGGAA GTGGCTCCGG TCTTCCTTTT 
CTGGTACAGA GAACTGTGGC TCGACAGATA ACCCTGTTGG AGTGTGTCGG GAAGGGCCGG 
TATGGAGAAG TGTGGAGGGG CAGCTGGCAA GGCGAAAATG TTGCTGTGAA GATCTTCTCC 
TCCCGTGATG AGAAGTCGTG GTTCAGGGAG ACAGAATTGT ACAACACGGT GATGCTGAGG 
CATGAGAATA TCTTAGGTTT CATTGCTTCA GACATGACCT CTAGACACTC CAGTACCCAG 
CTGTGGCTCA TTACACATTA CCACGAAATG GGATCGTTGT ATGACTACCT TCAGCTCACC 
ACTCTGGACA CGGTTAGCTG CCTTCGGATC GTGTTGTCCA TAGCCAGCGG CCTTGCACAC 
TTGCACATAG AGATATTTGG GACCCAGGGG AAGTCTGCCA TCGCCCACCG AGATCTAAAG 
AGCAAAAACA TCCTCGTGAA GAAGAACGGA CAGTGCTGCA TAGCAGATTT GGGCCTGGCA 
GTCATGCATT CCCAGAGCAC GAATCAGCTT GATGTGGGAA ACAACCCCCG TGTGGGGACC 
AAGCGCTACA TGGCCCCTGA AGTGCTTGAT GAAACCATCC AAGTGGATTG CTTTGATTCT 
TATAAGAGGG TCGATATTTG GGCCTTTGGC CTCGTTCTGT GGGAAGTGGC CAGGAGGATG 
GTGAGCAATG GTATAGTGGA AGATTACAAG CCACCATTCT ATGATGTTGT TCCCAATGAC 
CCAAGTTTTG AAGATATGAG GAAAGTTGTC TGTGTGGATC AACAGAGGCC AAACATACCT 
AACAGATGGT TCTCAGACCC GACATTAACT TCTCTGGCGA AGCTGATGAA AGAATGCTGG 
TACCAGAACC CATCCGCCAG ACTCACAGCT CTACGTATCA AAAAGACTTT GACCAAAATT 
GATAACTCCC TAGACAAATT AAAAACTGAC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008760089.1
CDS	58..1593
Translation	MRNGVSLTLHSPTQYQPDVLPSTLDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Target ORF information:

RefSeq Version	XM_008761867.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008761867.1

ORF Insert Sequence:

ATGAGAAATG GTGTCTCACT AACTCTTCAT TCCCCAACCC AGTATCAGCC AGATGTACTT 
CCCAGTACCT TAGATGAGGA GCCCAAGGTC AACCCGAAGC TTTACATGTG TGTGTGTGAG 
GGCCTCTCCT GCGGGAACGA GGACCACTGT GAGGGCCAGC AGTGTTTTTC CTCCCTGAGC 
GTCAATGATG GCTTCCGCGT CTACCAGAAG GGCTGCTTTC AGGTCTATGA GCAGGGGAAG 
ATGACGTGTA AGACCCCGCC GTCGCCTGGC CAGGCTGTGG AGTGCTGCCA AGGGGACTGG 
TGCAACAGGA ACGTCACGGC CCGGCTGCCC ACTAAAGGGA AATCCTTCCC TGGATCGCAG 
AACTTCCACC TGGAAGTTGG CCTTATCATC CTCTCCGTGG TGTTTGCGGT ATGCCTTTTC 
GCTTGCATCC TTGGCGTTGC TCTCAGGAAG TTTAAAAGGC GCAATCAAGA GCGCCTGAAC 
CCCAGAGACG TGGAGTATGG TACTATCGAA GGGCTCATCA CCACCAACGT CGGAGATAGC 
ACTCTAGCGG AATTACTAGA TCACTCGTGT ACATCAGGAA GTGGCTCCGG TCTTCCTTTT 
CTGGTACAGA GAACTGTGGC TCGACAGATA ACCCTGTTGG AGTGTGTCGG GAAGGGCCGG 
TATGGAGAAG TGTGGAGGGG CAGCTGGCAA GGCGAAAATG TTGCTGTGAA GATCTTCTCC 
TCCCGTGATG AGAAGTCGTG GTTCAGGGAG ACAGAATTGT ACAACACGGT GATGCTGAGG 
CATGAGAATA TCTTAGGTTT CATTGCTTCA GACATGACCT CTAGACACTC CAGTACCCAG 
CTGTGGCTCA TTACACATTA CCACGAAATG GGATCGTTGT ATGACTACCT TCAGCTCACC 
ACTCTGGACA CGGTTAGCTG CCTTCGGATC GTGTTGTCCA TAGCCAGCGG CCTTGCACAC 
TTGCACATAG AGATATTTGG GACCCAGGGG AAGTCTGCCA TCGCCCACCG AGATCTAAAG 
AGCAAAAACA TCCTCGTGAA GAAGAACGGA CAGTGCTGCA TAGCAGATTT GGGCCTGGCA 
GTCATGCATT CCCAGAGCAC GAATCAGCTT GATGTGGGAA ACAACCCCCG TGTGGGGACC 
AAGCGCTACA TGGCCCCTGA AGTGCTTGAT GAAACCATCC AAGTGGATTG CTTTGATTCT 
TATAAGAGGG TCGATATTTG GGCCTTTGGC CTCGTTCTGT GGGAAGTGGC CAGGAGGATG 
GTGAGCAATG GTATAGTGGA AGATTACAAG CCACCATTCT ATGATGTTGT TCCCAATGAC 
CCAAGTTTTG AAGATATGAG GAAAGTTGTC TGTGTGGATC AACAGAGGCC AAACATACCT 
AACAGATGGT TCTCAGACCC GACATTAACT TCTCTGGCGA AGCTGATGAA AGAATGCTGG 
TACCAGAACC CATCCGCCAG ACTCACAGCT CTACGTATCA AAAAGACTTT GACCAAAATT 
GATAACTCCC TAGACAAATT AAAAACTGAC TGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Acvr1 ( XM_006234214.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234276.1 Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa25868
Clone ID Related Accession (Same CDS sequence)	XM_006234214.3
Accession Version	XM_006234214.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1530bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	activin receptor type-1 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234214.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGATG AGGAGCCCAA GGTCAACCCG AAGCTTTACA TGTGTGTGTG TGAGGGCCTC 
TCCTGCGGGA ACGAGGACCA CTGTGAGGGC CAGCAGTGTT TTTCCTCCCT GAGCGTCAAT 
GATGGCTTCC GCGTCTACCA GAAGGGCTGC TTTCAGGTCT ATGAGCAGGG GAAGATGACG 
TGTAAGACCC CGCCGTCGCC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGCAAC 
AGGAACGTCA CGGCCCGGCT GCCCACTAAA GGGAAATCCT TCCCTGGATC GCAGAACTTC 
CACCTGGAAG TTGGCCTTAT CATCCTCTCC GTGGTGTTTG CGGTATGCCT TTTCGCTTGC 
ATCCTTGGCG TTGCTCTCAG GAAGTTTAAA AGGCGCAATC AAGAGCGCCT GAACCCCAGA 
GACGTGGAGT ATGGTACTAT CGAAGGGCTC ATCACCACCA ACGTCGGAGA TAGCACTCTA 
GCGGAATTAC TAGATCACTC GTGTACATCA GGAAGTGGCT CCGGTCTTCC TTTTCTGGTA 
CAGAGAACTG TGGCTCGACA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 
GAAGTGTGGA GGGGCAGCTG GCAAGGCGAA AATGTTGCTG TGAAGATCTT CTCCTCCCGT 
GATGAGAAGT CGTGGTTCAG GGAGACAGAA TTGTACAACA CGGTGATGCT GAGGCATGAG 
AATATCTTAG GTTTCATTGC TTCAGACATG ACCTCTAGAC ACTCCAGTAC CCAGCTGTGG 
CTCATTACAC ATTACCACGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACCACTCTG 
GACACGGTTA GCTGCCTTCG GATCGTGTTG TCCATAGCCA GCGGCCTTGC ACACTTGCAC 
ATAGAGATAT TTGGGACCCA GGGGAAGTCT GCCATCGCCC ACCGAGATCT AAAGAGCAAA 
AACATCCTCG TGAAGAAGAA CGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 
CATTCCCAGA GCACGAATCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 
TACATGGCCC CTGAAGTGCT TGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 
AGGGTCGATA TTTGGGCCTT TGGCCTCGTT CTGTGGGAAG TGGCCAGGAG GATGGTGAGC 
AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TTGTTCCCAA TGACCCAAGT 
TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 
TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAATG CTGGTACCAG 
AACCCATCCG CCAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATTGATAAC 
TCCCTAGACA AATTAAAAAC TGACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234276.1
CDS	1752..3281
Translation	MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC

Target ORF information:

RefSeq Version	XM_006234214.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus activin A receptor type 1 (Acvr1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234214.3

ORF Insert Sequence:

ATGGTCGATG GAGCAATGAT CCTTTCTGTG CTAATGATGA TGGCTCTCCC TTCCCCGAGT 
ATGGAAGATG AGGAGCCCAA GGTCAACCCG AAGCTTTACA TGTGTGTGTG TGAGGGCCTC 
TCCTGCGGGA ACGAGGACCA CTGTGAGGGC CAGCAGTGTT TTTCCTCCCT GAGCGTCAAT 
GATGGCTTCC GCGTCTACCA GAAGGGCTGC TTTCAGGTCT ATGAGCAGGG GAAGATGACG 
TGTAAGACCC CGCCGTCGCC TGGCCAGGCT GTGGAGTGCT GCCAAGGGGA CTGGTGCAAC 
AGGAACGTCA CGGCCCGGCT GCCCACTAAA GGGAAATCCT TCCCTGGATC GCAGAACTTC 
CACCTGGAAG TTGGCCTTAT CATCCTCTCC GTGGTGTTTG CGGTATGCCT TTTCGCTTGC 
ATCCTTGGCG TTGCTCTCAG GAAGTTTAAA AGGCGCAATC AAGAGCGCCT GAACCCCAGA 
GACGTGGAGT ATGGTACTAT CGAAGGGCTC ATCACCACCA ACGTCGGAGA TAGCACTCTA 
GCGGAATTAC TAGATCACTC GTGTACATCA GGAAGTGGCT CCGGTCTTCC TTTTCTGGTA 
CAGAGAACTG TGGCTCGACA GATAACCCTG TTGGAGTGTG TCGGGAAGGG CCGGTATGGA 
GAAGTGTGGA GGGGCAGCTG GCAAGGCGAA AATGTTGCTG TGAAGATCTT CTCCTCCCGT 
GATGAGAAGT CGTGGTTCAG GGAGACAGAA TTGTACAACA CGGTGATGCT GAGGCATGAG 
AATATCTTAG GTTTCATTGC TTCAGACATG ACCTCTAGAC ACTCCAGTAC CCAGCTGTGG 
CTCATTACAC ATTACCACGA AATGGGATCG TTGTATGACT ACCTTCAGCT CACCACTCTG 
GACACGGTTA GCTGCCTTCG GATCGTGTTG TCCATAGCCA GCGGCCTTGC ACACTTGCAC 
ATAGAGATAT TTGGGACCCA GGGGAAGTCT GCCATCGCCC ACCGAGATCT AAAGAGCAAA 
AACATCCTCG TGAAGAAGAA CGGACAGTGC TGCATAGCAG ATTTGGGCCT GGCAGTCATG 
CATTCCCAGA GCACGAATCA GCTTGATGTG GGAAACAACC CCCGTGTGGG GACCAAGCGC 
TACATGGCCC CTGAAGTGCT TGATGAAACC ATCCAAGTGG ATTGCTTTGA TTCTTATAAG 
AGGGTCGATA TTTGGGCCTT TGGCCTCGTT CTGTGGGAAG TGGCCAGGAG GATGGTGAGC 
AATGGTATAG TGGAAGATTA CAAGCCACCA TTCTATGATG TTGTTCCCAA TGACCCAAGT 
TTTGAAGATA TGAGGAAAGT TGTCTGTGTG GATCAACAGA GGCCAAACAT ACCTAACAGA 
TGGTTCTCAG ACCCGACATT AACTTCTCTG GCGAAGCTGA TGAAAGAATG CTGGTACCAG 
AACCCATCCG CCAGACTCAC AGCTCTACGT ATCAAAAAGA CTTTGACCAA AATTGATAAC 
TCCCTAGACA AATTAAAAAC TGACTGTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy.
American journal of physiology. Heart and circulatory physiology310(8)H984-94(2016 Apr)
Shahid M,Spagnolli E,Ernande L,Thoonen R,Kolodziej SA,Leyton PA,Cheng J,Tainsh RE,Mayeur C,Rhee DK,Wu MX,Scherrer-Crosbie M,Buys ES,Zapol WM,Bloch KD,Bloch DB

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.
Journal of cell science129(1)206-18(2016 Jan)
Benn A,Bredow C,Casanova I,Vukičević S,Knaus P

Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.
Carcinogenesis31(3)359-66(2010 Mar)
Romero D,Terzic A,Conley BA,Craft CS,Jovanovic B,Bergan RC,Vary CP

Dominant-negative ALK2 allele associates with congenital heart defects.
Circulation119(24)3062-9(2009 Jun)
Smith KA,Joziasse IC,Chocron S,van Dinther M,Guryev V,Verhoeven MC,Rehmann H,van der Smagt JJ,Doevendans PA,Cuppen E,Mulder BJ,Ten Dijke P,Bakkers J

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
The Journal of biological chemistry283(30)20948-58(2008 Jul)
Lavery K,Swain P,Falb D,Alaoui-Ismaili MH

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Acvr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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