Cyba cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cyba
Entrez Gene ID	79129
Full Name	cytochrome b-245 alpha chain
Synonyms	Phox,p22-phox
General protein information	Preferred Names cytochrome b-245 alpha chain Names cytochrome b-245 light chain alpha-subunit p22 cytochrome b(558) alpha chain cytochrome b-245, alpha polypeptide cytochrome b558 alpha-subunit cytochrome b558 subunit alpha neutrophil cytochrome b 22 kDa polypeptide p22 phagocyte B-cytochrome p22phox superoxide-generating NADPH oxidase light chain subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q12
Summary	alpha subunit of cytochrome b558, a component of NAD(P)H oxidase, may play a role in production of reactive oxygen species in endothelial cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024160.1	NP_077074.1	cytochrome b-245 light chain

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYBA	NP_000092.2
Pan troglodytes (chimpanzee)	CYBA	XP_523459.1
Mus musculus (house mouse)	Cyba	NP_031832.2
Macaca mulatta (Rhesus monkey)	LOC696748	XP_001089060.1
Bos taurus (cattle)	CYBA	NP_776459.1
Rattus norvegicus (Norway rat)	Cyba	NP_077074.1
Canis lupus familiaris (dog)	CYBA	NP_001093760.1
Danio rerio (zebrafish)	cyba	NP_956873.1
Xenopus tropicalis (tropical clawed frog)	cyba	NP_001016480.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.
Naito Y, Sawada H, Oboshi M, Okuno K, Yasumura S, Okuhara Y, Eguchi A, Nishimura K, Soyama Y, Asakura M, Ishihara M, Tsujino T, Masuyama T
Heart and vessels32(11)1410-1414(2017 Nov)

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG
The Journal of experimental medicine214(4)1111-1128(2017 04)

Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
Zahid HM, Ferdaus MZ, Ohara H, Isomura M, Nabika T
Scientific reports636739(2016 11)

Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases.
Yao H, Ferdaus MZ, Zahid HM, Ohara H, Nakahara T, Nabika T
PloS one10(9)e0138551(2015)

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
Noubade R, Wong K, Ota N, Rutz S, Eidenschenk C, Valdez PA, Ding J, Peng I, Sebrell A, Caplazi P, DeVoss J, Soriano RH, Sai T, Lu R, Modrusan Z, Hackney J, Ouyang W
Nature509(7499)235-9(2014 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cyba gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cyba cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06883	NM_024160.1 Latest version!	Rattus norvegicus cytochrome b-245 alpha chain (Cyba), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cyba ( NM_024160.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077074.1 Rattus norvegicus cytochrome b-245 alpha chain (Cyba), mRNA.

Price & Availability↑

CloneID	ORa06883
Clone ID Related Accession (Same CDS sequence)	NM_024160.1
Accession Version	NM_024160.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome b-245 light chain
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U18729.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U18729.1, DV721628.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGCAGA TCGAGTGGGC CATGTGGGCC AACGAACAGG CGCTGGCATC TGGCCTGATC 
CTCATCACAG GGGGCATCGT GGCTACTGCG GGACGCTTCA CGCAGTGGTA CTTTGGTGCT 
TACTCTATTG TTGCAGGAGT GCTCATCTGT CTGCTGGAGT ACCCCCGGGG AAAGAGGAAA 
AAGGGCTCCA CCATGGAGCG GTGTGGACAG AAGTACCTGA CCGCTGTGGT GAAGCTGTTC 
GGGCCCCTCA CCAGAAATTA CTACGTCCGG GCTGTCCTCC ACTTACTGCT GTCCGTGCCT 
GCAGGCTTCC TGCTGGCCAC CATCCTGGGG ACCGTCTGCT TGGCCATTGC CAGTGTGATC 
TACCTGCTGG CAGCCATCCG GGGTGAGCAG TGGACTCCCA TTGAGCCTAA ACCCAAGGAG 
CGGCCGCAGG TTGGAGGCAC CATCAAGCAG CCACCTACCA ACCCCCCACC CCGGCCACCA 
GCGGAGGTCC GCAAGAAGCC AAGTGAGGCC GAAGAGGAGG CAGCCTCGGC AGGAGGACCC 
CAGGTTAACC CAATTCCAGT GACAGATGAG GTCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077074.1
CDS	45..623
Translation	MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVLICLLEYPRGKRKKGSTMERCGQKYLTAVVKLFGPLTRNYYVRAVLHLLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEAEEEAASAGGPQVNPIPVTDEVV

Target ORF information:

RefSeq Version	NM_024160.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome b-245 alpha chain (Cyba), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024160.1

ORF Insert Sequence:

ATGGGGCAGA TCGAGTGGGC CATGTGGGCC AACGAACAGG CGCTGGCATC TGGCCTGATC 
CTCATCACAG GGGGCATCGT GGCTACTGCG GGACGCTTCA CGCAGTGGTA CTTTGGTGCT 
TACTCTATTG TTGCAGGAGT GCTCATCTGT CTGCTGGAGT ACCCCCGGGG AAAGAGGAAA 
AAGGGCTCCA CCATGGAGCG GTGTGGACAG AAGTACCTGA CCGCTGTGGT GAAGCTGTTC 
GGGCCCCTCA CCAGAAATTA CTACGTCCGG GCTGTCCTCC ACTTACTGCT GTCCGTGCCT 
GCAGGCTTCC TGCTGGCCAC CATCCTGGGG ACCGTCTGCT TGGCCATTGC CAGTGTGATC 
TACCTGCTGG CAGCCATCCG GGGTGAGCAG TGGACTCCCA TTGAGCCTAA ACCCAAGGAG 
CGGCCGCAGG TTGGAGGCAC CATCAAGCAG CCACCTACCA ACCCCCCACC CCGGCCACCA 
GCGGAGGTCC GCAAGAAGCC AAGTGAGGCC GAAGAGGAGG CAGCCTCGGC AGGAGGACCC 
CAGGTTAACC CAATTCCAGT GACAGATGAG GTCGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered expression of intestinal duodenal cytochrome b and divalent metal transporter 1 might be associated with cardio-renal anemia syndrome.
Heart and vessels32(11)1410-1414(2017 Nov)
Naito Y,Sawada H,Oboshi M,Okuno K,Yasumura S,Okuhara Y,Eguchi A,Nishimura K,Soyama Y,Asakura M,Ishihara M,Tsujino T,Masuyama T

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine214(4)1111-1128(2017 04)
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG

Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain.
Scientific reports636739(2016 11)
Zahid HM,Ferdaus MZ,Ohara H,Isomura M,Nabika T

Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases.
PloS one10(9)e0138551(2015)
Yao H,Ferdaus MZ,Zahid HM,Ohara H,Nakahara T,Nabika T

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity.
Nature509(7499)235-9(2014 May)
Noubade R,Wong K,Ota N,Rutz S,Eidenschenk C,Valdez PA,Ding J,Peng I,Sebrell A,Caplazi P,DeVoss J,Soriano RH,Sai T,Lu R,Modrusan Z,Hackney J,Ouyang W

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Cyba cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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