Scn9a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scn9a
Entrez Gene ID	78956
Full Name	sodium voltage-gated channel alpha subunit 9
Synonyms	Nav1.7,PN1,Scn2a
General protein information	Preferred Names sodium voltage-gated channel alpha subunit 9 Names sodium channel protein type 9 subunit alpha peripheral sodium channel 1 sodium channel protein type IX subunit alpha sodium channel, voltage-gated, type 9, alpha polypeptide sodium channel, voltage-gated, type IX, alpha subunit voltage-gated sodium channel subunit alpha Nav1.7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q21
Summary	voltage-dependent sodium channel alpha subunit which may be the major channel in the peripheral nervous system [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133289.1	NP_579823.1	sodium channel protein type 9 subunit alpha

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Scn9a	NP_061340.2
Gallus gallus (chicken)	SCN9A	XP_004942840.1
Macaca mulatta (Rhesus monkey)	SCN9A	XP_001101662.2
Rattus norvegicus (Norway rat)	Scn9a	NP_579823.1
Homo sapiens (human)	SCN9A	NP_002968.1
Xenopus tropicalis (tropical clawed frog)	scn2a	XP_002939316.2
Pan troglodytes (chimpanzee)	SCN9A	XP_003309333.2
Bos taurus (cattle)	SCN9A	NP_001104257.1
Canis lupus familiaris (dog)	SCN9A	XP_005640317.1

Gene Ontology
Bibliography

Related articles in PubMed

Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
Sun S, Sun J, Jiang W, Wang W, Ni L
BioMed research international20196973932(2019)

Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing the Expression and Activity of Voltage-Gated Sodium Channel in Rat Dorsal Root Ganglia.
Ri-Ge-le A, Guo ZL, Wang Q, Zhang BJ, Kong DW, Yang WQ, Yu YB, Zhang L
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association126(10)632-639(2018 Nov)

MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 Following Spared Nerve Injury in Rats.
Cai W, Zhao Q, Shao J, Zhang J, Li L, Ren X, Su S, Bai Q, Li M, Chen X, Wang J, Cao J, Zang W
Scientific reports8(1)16750(2018 11)

Increased Na
Sun J, Li N, Duan G, Liu Y, Guo S, Wang C, Zhu C, Zhang X
Molecular pain141744806918782323(2018 Jan-Dec)

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay.
Fouillet A, Watson JF, Piekarz AD, Huang X, Li B, Priest B, Nisenbaum E, Sher E, Ursu D
Molecular pain131744806917745179(2017 Jan-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Scn9a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scn9a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13842	NM_133289.1 Latest version!	Rattus norvegicus sodium voltage-gated channel alpha subunit 9 (Scn9a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scn9a ( NM_133289.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579823.1 Rattus norvegicus sodium voltage-gated channel alpha subunit 9 (Scn9a), mRNA.

Price & Availability↑

CloneID	ORa13842
Clone ID Related Accession (Same CDS sequence)	NM_133289.1
Accession Version	NM_133289.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5955bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572796800000
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel protein type 9 subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF000368.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF000368.1, U79568.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGATGC TGCCTCCTCC AGGACCTCAG AGTTTCGTTC ACTTCACAAA ACAGTCCCTT 
GCCCTCATTG AACAGCGTAT TTCTGAAGAA AAAGCCAAGG AACACAAAGA CGAAAAGAAA 
GATGATGAGG AAGAAGGCCC CAAGCCCAGC AGTGACTTGG AAGCTGGGAA ACAGCTCCCC 
TTCATCTATG GAGACATTCC CCCTGGAATG GTGTCAGAGC CCCTGGAGGA CCTGGACCCA 
TACTATGCTG ACAAAAAAAC TTTTATAGTA TTGAACAAAG GGAAAGCAAT CTTCCGTTTC 
AACGCCACCC CTGCTTTGTA CATGCTGTCT CCCTTCAGTC CTCTAAGAAG AATATCTATT 
AAGATCTTAG TGCACTCCTT ATTCAGCATG CTAATCATGT GCACAATTCT GACGAACTGC 
ATATTCATGA CCTTGAGCAA CCCTCCAGAA TGGACCAAAA ATGTAGAGTA CACTTTTACT 
GGGATATATA CTTTTGAATC ACTCATAAAA ATCCTTGCAA GAGGCTTTTG CGTGGGAGAA 
TTCACCTTCC TCCGTGACCC TTGGAACTGG CTGGACTTTG TTGTCATTGT TTTTGCGTAT 
TTAACAGAAT TTGTAAACCT AGGCAATGTT TCAGCTCTTC GAACTTTCAG AGTCTTGAGA 
GCTTTGAAAA CTATTTCTGT AATCCCAGGA CTAAAGACCA TCGTGGGGGC CCTGATCCAG 
TCAGTGAAGA AGCTCTCTGA CGTCATGATC CTCACTGTGT TCTGTCTCAG TGTGTTTGCA 
CTAATTGGAC TACAGCTGTT TATGGGCAAC TTGAAGCATA AATGTTTCAG GAAGGAACTC 
GAAGAGAATG AAACATTAGA AAGTATCATG AATACTGCTG AGAGTGAAGA AGAATTGAAA 
AAATATTTTT ATTACTTGGA GGGATCCAAA GATGCTCTAC TCTGCGGCTT CAGCACAGAT 
TCAGGGCAGT GTCCAGAAGG CTACATCTGT GTGAAGGCTG GCAGAAACCC GGATTATGGC 
TACACGAGCT TTGACACATT CAGCTGGGCC TTCTTGGCCT TGTTTCGGCT AATGACTCAG 
GACTACTGGG AGAACCTTTA CCAACAGACT CTGCGTGCTG CTGGCAAAAC CTACATGATT 
TTCTTTGTCG TGGTTATTTT TCTGGGCTCC TTTTACCTGA TAAACTTGAT CCTGGCTGTG 
GTAGCCATGG CGTATGAGGA ACAGAACCAG GCCAACATCG AAGAAGCTAA ACAGAAAGAG 
TTAGAATTTC AGCAGATGTT AGACCGACTC AAAAAGGAGC AGGAAGAAGC TGAGGCGATC 
GCTGCAGCTG CTGCTGAGTT CACGAGTATA GGGCGGAGCA GGATCATGGG ACTCTCTGAG 
AGCTCTTCAG AAACCTCCAG GCTGAGCTCA AAGAGTGCCA AGGAGAGAAG AAACCGAAGA 
AAGAAAAAGA AACAGAAGAT GTCCAGTGGC GAGGAAAAGG GTGACGATGA GAAGCTGTCC 
AAGTCAGGAT CAGAGGAAAG CATCCGAAAG AAAAGTTTCC ATCTCGGTGT GGAAGGGCAC 
CACCGGACCC GGGAAAAGAG GCTGTCCACC CCCAACCAGT CGCCACTCAG CATTCGCGGG 
TCCCTGTTTT CTGCCAGGCG CAGCAGCAGG ACGAGTCTCT TCAGTTTTAA GGGGCGAGGA 
AGAGATCTGG GATCTGAGAC AGAATTCGCT GATGATGAGC ATAGCATTTT TGGAGACAAC 
GAGAGCAGAA GGGGTTCACT ATTCGTACCC CATAGACCCC GGGAGCGGCG CAGCAGTAAC 
ATCAGTCAGG CCAGTAGGTC CCCGCCAGTG CTACCGGTGA ACGGGAAGAT GCACAGTGCA 
GTGGACTGCA ATGGCGTCGT GTCGCTTGTT GATGGACCCT CAGCCCTCAT GCTCCCCAAT 
GGACAGCTTC TTCCAGAGGT GATAATAGAT AAGGCAACTT CCGACGACAG CGGCACGACT 
AATCAGATGC GCAAAAAAAG GCTCTCTAGT TCTTACTTCT TGTCTGAGGA CATGCTGAAT 
GACCCGCATC TCAGGCAAAG GGCCATGAGC AGGGCGAGCA TACTGACCAA CACTGTGGAA 
GAACTTGAAG AATCTAGACA AAAATGTCCA CCATGGTGGT ACAGATTTGC TCACACATTT 
TTAATCTGGA ATTGCTCTCC ATATTGGATA AAATTCAAAA AGCTCATCTA TTTTATTGTG 
ATGGATCCTT TTGTAGATCT TGCAATTACC ATTTGCATAG TTTTAAACAC CTTATTTATG 
GCTATGGAGC ACCACCCAAT GACTGAAGAA TTCAAAAATG TCCTTGCAGT GGGGAACTTG 
ATCTTTACAG GGATCTTCGC AGCTGAAATG GTACTGAAGT TAATAGCCAT GGACCCCTAT 
GAGTATTTCC AAGTAGGGTG GAATATTTTT GACAGCCTAA TTGTGACGCT GAGTTTGATA 
GAGCTTTTCC TAGCAGATGT GGAAGGATTA TCAGTTCTGC GGTCATTCAG ATTGCTCCGA 
GTCTTCAAGT TGGCAAAGTC CTGGCCCACA CTGAACATGC TCATTAAGAT CATCGGCAAC 
TCGGTGGGCG CACTGGGCAA CCTGACCCTG GTGCTGGCCA TCATCGTCTT CATTTTTGCC 
GTGGTCGGCA TGCAGCTGTT TGGAAAGAGC TACAAGGAGT GTGTCTGCAA GATCAATGTG 
GACTGCAAGC TGCCGCGCTG GCACATGAAC GACTTCTTCC ACTCCTTCCT CATCGTGTTC 
CGAGTGCTGT GTGGGGAGTG GATAGAGACC ATGTGGGACT GCATGGAGGT CGCGGGCCAG 
ACCATGTGCC TTATTGTTTA CATGATGGTC ATGGTGATTG GGAACCTTGT GGTCCTGAAC 
CTGTTTCTGG CTCTTTTGCT GAGTTCCTTT AGTTCTGACA ATCTTACAGC AATTGAGGAA 
GACACCGATG CAAACAACCT CCAGATCGCA GTGGCCAGAA TTAAGAGGGG AATCAATTAC 
GTGAAACAGA CCCTGCGTGA ATTCATTCTA AAATCATTTT CCAAAAAGCC AAAGGGCTCC 
AAGGACACAA AACGAACAGC AGATCCCAAC AACAAGAAAG AAAACTATAT TTCAAACCGT 
ACCCTTGCGG AGATGAGCAA GGATCACAAT TTCCTCAAAG AAAAGGATAG GATCAGTGGT 
TATGGCAGCA GTCTAGACAA AAGCTTTATG GATGAAAATG ATTACCAGTC CTTTATCCAT 
AACCCCAGCC TCACAGTGAC AGTGCCAATT GCACCTGGGG AGTCTGATTT GGAGATTATG 
AACACAGAAG AGCTTAGCAG TGACTCAGAC AGTGACTACA GCAAAGAGAA ACGGAACCGA 
TCAAGCTCTT CTGAGTGCAG CACTGTTGAC AACCCTCTGC CAGGAGAAGA GGAGGCTGAA 
GCAGAGCCCG TAAACGCAGA TGAGCCTGAA GCCTGCTTTA CAGATGGTTG TGTGAGGAGA 
TTTCCATGCT GCCAAGTTAA TGTAGACTCT GGGAAAGGGA AAGTTTGGTG GACCATCAGG 
AAGACGTGCT ACAGGATAGT TGAACACAGC TGGTTTGAAA GCTTCATCGT TCTCATGATC 
CTGCTCAGCA GTGGAGCTCT GGCTTTTGAA GATATCTATA TTGAAAAGAA AAAGACCATT 
AAGATTATCC TGGAGTATGC TGACAAGATA TTCACCTACA TCTTCATTCT GGAAATGCTT 
CTAAAATGGG TCGCATATGG GTATAAAACA TATTTCACTA ATGCCTGGTG TTGGCTGGAC 
TTCTTAATTG TTGATGTGTC TCTAGTTACT TTAGTAGCCA ACACTCTTGG CTACTCAGAC 
CTTGGCCCCA TTAAATCTCT ACGGACACTG AGGGCCCTAA GACCCCTAAG AGCCTTGTCT 
AGATTTGAAG GAATGAGGGT AGTGGTCAAC GCACTCATAG GAGCAATCCC TTCCATCATG 
AACGTGCTTC TCGTGTGCCT TATATTCTGG CTAATATTTA GCATCATGGG AGTCAATCTG 
TTTGCTGGCA AGTTCTATGA GTGTGTCAAC ACCACCGATG GGTCACGATT TCCTACATCT 
CAAGTTGCAA ACCGTTCTGA GTGTTTTGCC CTGATGAACG TTAGTGGAAA TGTGCGATGG 
AAAAACCTGA AAGTAAACTT CGACAACGTT GGGCTTGGTT ACCTGTCGCT GCTTCAAGTT 
GCAACATTCA AGGGCTGGAT GGATATTATG TATGCAGCAG TTGACTCTGT TAATGTAAAT 
GAACAGCCGA AATACGAATA CAGTCTCTAC ATGTACATTT ACTTTGTCAT CTTCATCATC 
TTCGGCTCAT TCTTCACGTT GAACCTGTTC ATTGGTGTCA TCATAGATAA TTTCAACCAA 
CAGAAAAAAA AGCTTGGAGG TCAAGATATC TTTATGACAG AAGAACAGAA GAAATACTAT 
AATGCAATGA AGAAGCTTGG GTCCAAAAAA CCACAAAAAC CAATTCCAAG GCCAGGGAAC 
AAATTCCAAG GATGTATATT TGACTTAGTG ACAAACCAAG CTTTTGATAT CACCATCATG 
GTTCTTATAT GCCTCAACAT GGTAACCATG ATGGTAGAAA AAGAGGGGCA AACTGAGTAC 
ATGGATTATG TTTTACACTG GATCAACATG GTCTTCATTA TCCTGTTCAC TGGGGAGTGT 
GTGCTGAAGC TAATCTCCCT CAGACATTAC TACTTCACTG TGGGTTGGAA CATTTTTGAT 
TTTGTGGTAG TGATCCTCTC CATTGTAGGA ATGTTTCTCG CTGAGATGAT AGAGAAGTAT 
TTCGTGTCCC CTACCCTGTT CCGAGTCATC CGCCTGGCCA GGATTGGACG AATCCTACGC 
CTGATCAAAG GCGCCAAGGG GATCCGCACT CTGCTCTTTG CTTTGATGAT GTCCCTTCCT 
GCGCTGTTCA ACATCGGCCT CCTGCTTTTC CTGGTCATGT TCATCTACGC CATCTTTGGG 
ATGTCCAACT TTGCCTACGT TAAAAAGGAG GCTGGAATTA ATGACATGTT CAACTTTGAG 
ACTTTTGGCA ACAGCATGAT CTGCTTGTTC CAAATCACCA CCTCTGCCGG CTGGGACGGA 
CTGCTGGCCC CCATCCTCAA CAGCGCACCT CCCGACTGTG ACCCTAAAAA AGTTCACCCA 
GGAAGTTCAG TGGAAGGGGA CTGTGGGAAC CCATCCGTGG GGATTTTTTA CTTTGTCAGC 
TACATCATCA TATCCTTCCT GGTGGTGGTG AACATGTACA TCGCTGTCAT CCTGGAGAAC 
TTCAGCGTCG CCACCGAAGA GAGCACTGAG CCTCTGAGTG AGGACGACTT TGAGATGTTC 
TACGAGGTCT GGGAGAAGTT CGACCCTGAC GCCACTCAGT TCATAGAGTT CTGCAAGCTC 
TCTGACTTTG CAGCTGCCCT GGATCCTCCC CTCCTCATCG CAAAGCCAAA CAAAGTCCAG 
CTCATTGCCA TGGACCTGCC CATGGTGAGT GGAGACCGCA TCCACTGCCT GGACATCTTG 
TTTGCTTTTA CAAAGCGGGT CCTGGGTGAG GGTGGAGAGA TGGATTCTCT TCGTTCACAG 
ATGGAAGAAA GGTTCATGTC AGCCAATCCT TCTAAAGTGT CCTATGAACC CATCACGACC 
ACACTGAAGA GAAAACAAGA GGAGGTGTCC GCGACTATCA TTCAGCGTGC TTACAGACGG 
TATCGCCTCA GACAACACGT CAAGAATATA TCGAGTATAT ACATAAAAGA TGGAGACAGG 
GATGATGATT TGCCCAATAA AGAAGATACA GTTTTTGATA ACGTGAACGA GAACTCAAGT 
CCGGAAAAGA CAGATGTAAC TGCCTCAACC ATCTCGCCAC CTTCCTATGA CAGTGTCACA 
AAGCCAGATC AAGAGAAATA TGAAACAGAC AAAACAGAGA AGGAAGACAA AGAGAAAGAT 
GAAAGCAGGA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579823.1
CDS	1..5955
Translation	MAMLPPPGPQSFVHFTKQSLALIEQRISEEKAKEHKDEKKDDEEEGPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKAIFRFNATPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTLSNPPEWTKNVEYTFTGIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRKELEENETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEFTSIGRSRIMGLSESSSETSRLSSKSAKERRNRRKKKKQKMSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRTREKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLIWNCSPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGNLIFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKKENYISNRTLAEMSKDHNFLKEKDRISGYGSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEIMNTEELSSDSDSDYSKEKRNRSSSSECSTVDNPLPGEEEAEAEPVNADEPEACFTDGCVRRFPCCQVNVDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIFILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFPTSQVANRSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTEYMDYVLHWINMVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEEVSATIIQRAYRRYRLRQHVKNISSIYIKDGDRDDDLPNKEDTVFDNVNENSSPEKTDVTASTISPPSYDSVTKPDQEKYETDKTEKEDKEKDESRK

Target ORF information:

RefSeq Version	NM_133289.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel alpha subunit 9 (Scn9a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133289.1

ORF Insert Sequence:

ATGGCGATGC TGCCTCCTCC AGGACCTCAG AGTTTCGTTC ACTTCACAAA ACAGTCCCTT 
GCCCTCATTG AACAGCGTAT TTCTGAAGAA AAAGCCAAGG AACACAAAGA CGAAAAGAAA 
GATGATGAGG AAGAAGGCCC CAAGCCCAGC AGTGACTTGG AAGCTGGGAA ACAGCTCCCC 
TTCATCTATG GAGACATTCC CCCTGGAATG GTGTCAGAGC CCCTGGAGGA CCTGGACCCA 
TACTATGCTG ACAAAAAAAC TTTTATAGTA TTGAACAAAG GGAAAGCAAT CTTCCGTTTC 
AACGCCACCC CTGCTTTGTA CATGCTGTCT CCCTTCAGTC CTCTAAGAAG AATATCTATT 
AAGATCTTAG TGCACTCCTT ATTCAGCATG CTAATCATGT GCACAATTCT GACGAACTGC 
ATATTCATGA CCTTGAGCAA CCCTCCAGAA TGGACCAAAA ATGTAGAGTA CACTTTTACT 
GGGATATATA CTTTTGAATC ACTCATAAAA ATCCTTGCAA GAGGCTTTTG CGTGGGAGAA 
TTCACCTTCC TCCGTGACCC TTGGAACTGG CTGGACTTTG TTGTCATTGT TTTTGCGTAT 
TTAACAGAAT TTGTAAACCT AGGCAATGTT TCAGCTCTTC GAACTTTCAG AGTCTTGAGA 
GCTTTGAAAA CTATTTCTGT AATCCCAGGA CTAAAGACCA TCGTGGGGGC CCTGATCCAG 
TCAGTGAAGA AGCTCTCTGA CGTCATGATC CTCACTGTGT TCTGTCTCAG TGTGTTTGCA 
CTAATTGGAC TACAGCTGTT TATGGGCAAC TTGAAGCATA AATGTTTCAG GAAGGAACTC 
GAAGAGAATG AAACATTAGA AAGTATCATG AATACTGCTG AGAGTGAAGA AGAATTGAAA 
AAATATTTTT ATTACTTGGA GGGATCCAAA GATGCTCTAC TCTGCGGCTT CAGCACAGAT 
TCAGGGCAGT GTCCAGAAGG CTACATCTGT GTGAAGGCTG GCAGAAACCC GGATTATGGC 
TACACGAGCT TTGACACATT CAGCTGGGCC TTCTTGGCCT TGTTTCGGCT AATGACTCAG 
GACTACTGGG AGAACCTTTA CCAACAGACT CTGCGTGCTG CTGGCAAAAC CTACATGATT 
TTCTTTGTCG TGGTTATTTT TCTGGGCTCC TTTTACCTGA TAAACTTGAT CCTGGCTGTG 
GTAGCCATGG CGTATGAGGA ACAGAACCAG GCCAACATCG AAGAAGCTAA ACAGAAAGAG 
TTAGAATTTC AGCAGATGTT AGACCGACTC AAAAAGGAGC AGGAAGAAGC TGAGGCGATC 
GCTGCAGCTG CTGCTGAGTT CACGAGTATA GGGCGGAGCA GGATCATGGG ACTCTCTGAG 
AGCTCTTCAG AAACCTCCAG GCTGAGCTCA AAGAGTGCCA AGGAGAGAAG AAACCGAAGA 
AAGAAAAAGA AACAGAAGAT GTCCAGTGGC GAGGAAAAGG GTGACGATGA GAAGCTGTCC 
AAGTCAGGAT CAGAGGAAAG CATCCGAAAG AAAAGTTTCC ATCTCGGTGT GGAAGGGCAC 
CACCGGACCC GGGAAAAGAG GCTGTCCACC CCCAACCAGT CGCCACTCAG CATTCGCGGG 
TCCCTGTTTT CTGCCAGGCG CAGCAGCAGG ACGAGTCTCT TCAGTTTTAA GGGGCGAGGA 
AGAGATCTGG GATCTGAGAC AGAATTCGCT GATGATGAGC ATAGCATTTT TGGAGACAAC 
GAGAGCAGAA GGGGTTCACT ATTCGTACCC CATAGACCCC GGGAGCGGCG CAGCAGTAAC 
ATCAGTCAGG CCAGTAGGTC CCCGCCAGTG CTACCGGTGA ACGGGAAGAT GCACAGTGCA 
GTGGACTGCA ATGGCGTCGT GTCGCTTGTT GATGGACCCT CAGCCCTCAT GCTCCCCAAT 
GGACAGCTTC TTCCAGAGGT GATAATAGAT AAGGCAACTT CCGACGACAG CGGCACGACT 
AATCAGATGC GCAAAAAAAG GCTCTCTAGT TCTTACTTCT TGTCTGAGGA CATGCTGAAT 
GACCCGCATC TCAGGCAAAG GGCCATGAGC AGGGCGAGCA TACTGACCAA CACTGTGGAA 
GAACTTGAAG AATCTAGACA AAAATGTCCA CCATGGTGGT ACAGATTTGC TCACACATTT 
TTAATCTGGA ATTGCTCTCC ATATTGGATA AAATTCAAAA AGCTCATCTA TTTTATTGTG 
ATGGATCCTT TTGTAGATCT TGCAATTACC ATTTGCATAG TTTTAAACAC CTTATTTATG 
GCTATGGAGC ACCACCCAAT GACTGAAGAA TTCAAAAATG TCCTTGCAGT GGGGAACTTG 
ATCTTTACAG GGATCTTCGC AGCTGAAATG GTACTGAAGT TAATAGCCAT GGACCCCTAT 
GAGTATTTCC AAGTAGGGTG GAATATTTTT GACAGCCTAA TTGTGACGCT GAGTTTGATA 
GAGCTTTTCC TAGCAGATGT GGAAGGATTA TCAGTTCTGC GGTCATTCAG ATTGCTCCGA 
GTCTTCAAGT TGGCAAAGTC CTGGCCCACA CTGAACATGC TCATTAAGAT CATCGGCAAC 
TCGGTGGGCG CACTGGGCAA CCTGACCCTG GTGCTGGCCA TCATCGTCTT CATTTTTGCC 
GTGGTCGGCA TGCAGCTGTT TGGAAAGAGC TACAAGGAGT GTGTCTGCAA GATCAATGTG 
GACTGCAAGC TGCCGCGCTG GCACATGAAC GACTTCTTCC ACTCCTTCCT CATCGTGTTC 
CGAGTGCTGT GTGGGGAGTG GATAGAGACC ATGTGGGACT GCATGGAGGT CGCGGGCCAG 
ACCATGTGCC TTATTGTTTA CATGATGGTC ATGGTGATTG GGAACCTTGT GGTCCTGAAC 
CTGTTTCTGG CTCTTTTGCT GAGTTCCTTT AGTTCTGACA ATCTTACAGC AATTGAGGAA 
GACACCGATG CAAACAACCT CCAGATCGCA GTGGCCAGAA TTAAGAGGGG AATCAATTAC 
GTGAAACAGA CCCTGCGTGA ATTCATTCTA AAATCATTTT CCAAAAAGCC AAAGGGCTCC 
AAGGACACAA AACGAACAGC AGATCCCAAC AACAAGAAAG AAAACTATAT TTCAAACCGT 
ACCCTTGCGG AGATGAGCAA GGATCACAAT TTCCTCAAAG AAAAGGATAG GATCAGTGGT 
TATGGCAGCA GTCTAGACAA AAGCTTTATG GATGAAAATG ATTACCAGTC CTTTATCCAT 
AACCCCAGCC TCACAGTGAC AGTGCCAATT GCACCTGGGG AGTCTGATTT GGAGATTATG 
AACACAGAAG AGCTTAGCAG TGACTCAGAC AGTGACTACA GCAAAGAGAA ACGGAACCGA 
TCAAGCTCTT CTGAGTGCAG CACTGTTGAC AACCCTCTGC CAGGAGAAGA GGAGGCTGAA 
GCAGAGCCCG TAAACGCAGA TGAGCCTGAA GCCTGCTTTA CAGATGGTTG TGTGAGGAGA 
TTTCCATGCT GCCAAGTTAA TGTAGACTCT GGGAAAGGGA AAGTTTGGTG GACCATCAGG 
AAGACGTGCT ACAGGATAGT TGAACACAGC TGGTTTGAAA GCTTCATCGT TCTCATGATC 
CTGCTCAGCA GTGGAGCTCT GGCTTTTGAA GATATCTATA TTGAAAAGAA AAAGACCATT 
AAGATTATCC TGGAGTATGC TGACAAGATA TTCACCTACA TCTTCATTCT GGAAATGCTT 
CTAAAATGGG TCGCATATGG GTATAAAACA TATTTCACTA ATGCCTGGTG TTGGCTGGAC 
TTCTTAATTG TTGATGTGTC TCTAGTTACT TTAGTAGCCA ACACTCTTGG CTACTCAGAC 
CTTGGCCCCA TTAAATCTCT ACGGACACTG AGGGCCCTAA GACCCCTAAG AGCCTTGTCT 
AGATTTGAAG GAATGAGGGT AGTGGTCAAC GCACTCATAG GAGCAATCCC TTCCATCATG 
AACGTGCTTC TCGTGTGCCT TATATTCTGG CTAATATTTA GCATCATGGG AGTCAATCTG 
TTTGCTGGCA AGTTCTATGA GTGTGTCAAC ACCACCGATG GGTCACGATT TCCTACATCT 
CAAGTTGCAA ACCGTTCTGA GTGTTTTGCC CTGATGAACG TTAGTGGAAA TGTGCGATGG 
AAAAACCTGA AAGTAAACTT CGACAACGTT GGGCTTGGTT ACCTGTCGCT GCTTCAAGTT 
GCAACATTCA AGGGCTGGAT GGATATTATG TATGCAGCAG TTGACTCTGT TAATGTAAAT 
GAACAGCCGA AATACGAATA CAGTCTCTAC ATGTACATTT ACTTTGTCAT CTTCATCATC 
TTCGGCTCAT TCTTCACGTT GAACCTGTTC ATTGGTGTCA TCATAGATAA TTTCAACCAA 
CAGAAAAAAA AGCTTGGAGG TCAAGATATC TTTATGACAG AAGAACAGAA GAAATACTAT 
AATGCAATGA AGAAGCTTGG GTCCAAAAAA CCACAAAAAC CAATTCCAAG GCCAGGGAAC 
AAATTCCAAG GATGTATATT TGACTTAGTG ACAAACCAAG CTTTTGATAT CACCATCATG 
GTTCTTATAT GCCTCAACAT GGTAACCATG ATGGTAGAAA AAGAGGGGCA AACTGAGTAC 
ATGGATTATG TTTTACACTG GATCAACATG GTCTTCATTA TCCTGTTCAC TGGGGAGTGT 
GTGCTGAAGC TAATCTCCCT CAGACATTAC TACTTCACTG TGGGTTGGAA CATTTTTGAT 
TTTGTGGTAG TGATCCTCTC CATTGTAGGA ATGTTTCTCG CTGAGATGAT AGAGAAGTAT 
TTCGTGTCCC CTACCCTGTT CCGAGTCATC CGCCTGGCCA GGATTGGACG AATCCTACGC 
CTGATCAAAG GCGCCAAGGG GATCCGCACT CTGCTCTTTG CTTTGATGAT GTCCCTTCCT 
GCGCTGTTCA ACATCGGCCT CCTGCTTTTC CTGGTCATGT TCATCTACGC CATCTTTGGG 
ATGTCCAACT TTGCCTACGT TAAAAAGGAG GCTGGAATTA ATGACATGTT CAACTTTGAG 
ACTTTTGGCA ACAGCATGAT CTGCTTGTTC CAAATCACCA CCTCTGCCGG CTGGGACGGA 
CTGCTGGCCC CCATCCTCAA CAGCGCACCT CCCGACTGTG ACCCTAAAAA AGTTCACCCA 
GGAAGTTCAG TGGAAGGGGA CTGTGGGAAC CCATCCGTGG GGATTTTTTA CTTTGTCAGC 
TACATCATCA TATCCTTCCT GGTGGTGGTG AACATGTACA TCGCTGTCAT CCTGGAGAAC 
TTCAGCGTCG CCACCGAAGA GAGCACTGAG CCTCTGAGTG AGGACGACTT TGAGATGTTC 
TACGAGGTCT GGGAGAAGTT CGACCCTGAC GCCACTCAGT TCATAGAGTT CTGCAAGCTC 
TCTGACTTTG CAGCTGCCCT GGATCCTCCC CTCCTCATCG CAAAGCCAAA CAAAGTCCAG 
CTCATTGCCA TGGACCTGCC CATGGTGAGT GGAGACCGCA TCCACTGCCT GGACATCTTG 
TTTGCTTTTA CAAAGCGGGT CCTGGGTGAG GGTGGAGAGA TGGATTCTCT TCGTTCACAG 
ATGGAAGAAA GGTTCATGTC AGCCAATCCT TCTAAAGTGT CCTATGAACC CATCACGACC 
ACACTGAAGA GAAAACAAGA GGAGGTGTCC GCGACTATCA TTCAGCGTGC TTACAGACGG 
TATCGCCTCA GACAACACGT CAAGAATATA TCGAGTATAT ACATAAAAGA TGGAGACAGG 
GATGATGATT TGCCCAATAA AGAAGATACA GTTTTTGATA ACGTGAACGA GAACTCAAGT 
CCGGAAAAGA CAGATGTAAC TGCCTCAACC ATCTCGCCAC CTTCCTATGA CAGTGTCACA 
AAGCCAGATC AAGAGAAATA TGAAACAGAC AAAACAGAGA AGGAAGACAA AGAGAAAGAT 
GAAAGCAGGA AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
BioMed research international20196973932(2019)
Sun S,Sun J,Jiang W,Wang W,Ni L

Tanshinone IIA Improves Painful Diabetic Neuropathy by Suppressing the Expression and Activity of Voltage-Gated Sodium Channel in Rat Dorsal Root Ganglia.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association126(10)632-639(2018 Nov)
Ri-Ge-le A,Guo ZL,Wang Q,Zhang BJ,Kong DW,Yang WQ,Yu YB,Zhang L

MicroRNA-182 Alleviates Neuropathic Pain by Regulating Nav1.7 Following Spared Nerve Injury in Rats.
Scientific reports8(1)16750(2018 11)
Cai W,Zhao Q,Shao J,Zhang J,Li L,Ren X,Su S,Bai Q,Li M,Chen X,Wang J,Cao J,Zang W

Increased Na
Molecular pain141744806918782323(2018 Jan-Dec)
Sun J,Li N,Duan G,Liu Y,Guo S,Wang C,Zhu C,Zhang X

Characterisation of Nav1.7 functional expression in rat dorsal root ganglia neurons by using an electrical field stimulation assay.
Molecular pain131744806917745179(2017 Jan-Dec)
Fouillet A,Watson JF,Piekarz AD,Huang X,Li B,Priest B,Nisenbaum E,Sher E,Ursu D

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Scn9a cDNA ORF clone, Rattus norvegicus(Norway rat)

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