| Gene Symbol | Wars2 |
| Entrez Gene ID | 690654 |
| Full Name | tryptophanyl tRNA synthetase 2 (mitochondrial) |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Wars2 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Wars2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wars2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa05991 Clone ID Related Accession (Same CDS sequence) NM_001168641.1 Accession Version NM_001168641.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1083bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1535126400000 Organism Rattus norvegicus(Norway rat) Product tryptophan--tRNA ligase, mitochondrial Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07012640.1 and AABR07012643.1. On or before Dec 13, 2009 this sequence version replaced XM_001065089.1, XM_001075111.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: FQ081211.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCGCTGT TCTCCGTGCG GAAGGCGCGT GAGTGCTGGC GCTTCATCCG GGCACTTCAT
AAAGGACCCA CAGCTACTGC GGCTCCCCAG AAGGAGAGCG GGGAGCGAGT GTTCTCTGGC
ATTCAGCCTA CAGGAATCCC CCACCTGGGA AATTACCTTG GAGCCATCGA GAGCTGGGTG
AAGTTACAGG AGGAGTATGA CACGGTGATA TACAGCATTG TGGACCTCCA CTCCATCACT
GTCCCCCAAG ACCCCGGCAT CCTGCAGCAG AGCATCCTGG ACATGACTGC CGTGCTCCTT
GCCTGCGGCA TAGACCCAGA GAGAAGTATC CTTTTCCAGC AGTCTCAGGT GTCTGAACAC
ACTCAGTTAA GTTGGATCCT CACCTGCATG GTGAGACTGC CTCGACTACA GCATTTACAC
CAGTGGAAGG CGAAGGCTGC GAGGCAGAAG CATGATGGGA CAGTAGGCCT GCTCACATAC
CCTGTACTCC AGGCGGCAGA CATTCTGTGC TACAAGTCCA CACACGTTCC TGTCGGGGAA
GATCAAGTCC AGCACATGGA ACTAGTTCAG GATCTAGCTC GGAGTTTCAA CCAGAAGTAT
GGCGAGCTCT TTCCACTGCC CAGGTCTATT CTCACATCCA TGAAGAAAGT GAAATCTCTT
CGTGACCCTT CTGCCAAGAT GTCAAAATCG GACCCTGACA AACTGGCCAC TGTCCAAATA
ACAGACAGCC CAGAGGAGAT TGTACGGAAA TTCCGCAAGG CTGTGACGGA CTTCACGTCA
GAAGTCACCT ACGAGCCGGA CAGCAGACCT GGTGTCTCCA ACATGGTGGC GATCCATGCG
GCCGTGTCAG GCCTCTCGGT GGAGGAGGTG GTGCGCAATA GTGCAGGCGT GGACACTGCA
CGCTACAAGC TGCTAGTGGC CGACGCTGTG ATTGAGAAAT TTGCTCCAAT CAGAAGTGAA
ATTGAAAAAC TGAAAATGGA TAAGGACCAT TTAAGAAAGG TTTTACTTGT GGGATCTGCA
AAAGCCAAAG AATTAGCCTC TCCTGTGTTC GAGGAGGTGA AGAAGTTGGT GGGGATTCTG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001162112.1 CDS 11..1093 Translation 
Target ORF information:
RefSeq Version NM_001168641.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus tryptophanyl tRNA synthetase 2 (mitochondrial) (Wars2), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001168641.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCGCTGT TCTCCGTGCG GAAGGCGCGT GAGTGCTGGC GCTTCATCCG GGCACTTCAT
AAAGGACCCA CAGCTACTGC GGCTCCCCAG AAGGAGAGCG GGGAGCGAGT GTTCTCTGGC
ATTCAGCCTA CAGGAATCCC CCACCTGGGA AATTACCTTG GAGCCATCGA GAGCTGGGTG
AAGTTACAGG AGGAGTATGA CACGGTGATA TACAGCATTG TGGACCTCCA CTCCATCACT
GTCCCCCAAG ACCCCGGCAT CCTGCAGCAG AGCATCCTGG ACATGACTGC CGTGCTCCTT
GCCTGCGGCA TAGACCCAGA GAGAAGTATC CTTTTCCAGC AGTCTCAGGT GTCTGAACAC
ACTCAGTTAA GTTGGATCCT CACCTGCATG GTGAGACTGC CTCGACTACA GCATTTACAC
CAGTGGAAGG CGAAGGCTGC GAGGCAGAAG CATGATGGGA CAGTAGGCCT GCTCACATAC
CCTGTACTCC AGGCGGCAGA CATTCTGTGC TACAAGTCCA CACACGTTCC TGTCGGGGAA
GATCAAGTCC AGCACATGGA ACTAGTTCAG GATCTAGCTC GGAGTTTCAA CCAGAAGTAT
GGCGAGCTCT TTCCACTGCC CAGGTCTATT CTCACATCCA TGAAGAAAGT GAAATCTCTT
CGTGACCCTT CTGCCAAGAT GTCAAAATCG GACCCTGACA AACTGGCCAC TGTCCAAATA
ACAGACAGCC CAGAGGAGAT TGTACGGAAA TTCCGCAAGG CTGTGACGGA CTTCACGTCA
GAAGTCACCT ACGAGCCGGA CAGCAGACCT GGTGTCTCCA ACATGGTGGC GATCCATGCG
GCCGTGTCAG GCCTCTCGGT GGAGGAGGTG GTGCGCAATA GTGCAGGCGT GGACACTGCA
CGCTACAAGC TGCTAGTGGC CGACGCTGTG ATTGAGAAAT TTGCTCCAAT CAGAAGTGAA
ATTGAAAAAC TGAAAATGGA TAAGGACCAT TTAAGAAAGG TTTTACTTGT GGGATCTGCA
AAAGCCAAAG AATTAGCCTC TCCTGTGTTC GAGGAGGTGA AGAAGTTGGT GGGGATTCTG
TAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa25105 Clone ID Related Accession (Same CDS sequence) XM_006233028.3 Accession Version XM_006233028.3 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1002bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product tryptophan--tRNA ligase, mitochondrial isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233028.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGGCGCTGT TCTCCGTGCG GAAGGCGCGT GAGTGCTGGC GCTTCATCCG GGCACTTCAT
AAAGGACCCA CAGCTACTGC GGCTCCCCAG AAGGAGAGCG GGGAGCGAGT GTTCTCTGGC
ATTCAGCCTA CAGGAATCCC CCACCTGGGA AATTACCTTG GAGCCATCGA GAGCTGGGTG
AAGTTACAGG AGGAGTATGA CACGGTGATA TACAGCATTG TGGACCTCCA CTCCATCACT
GTCCCCCAAG ACCCCGGCAT CCTGCAGCAG AGCATCCTGG ACATGACTGC CGTGCTCCTT
GCCTGCGGCA TAGACCCAGA GAGAAGTATC CTTTTCCAGC AGTCTCAGGC GAAGGCTGCG
AGGCAGAAGC ATGATGGGAC AGTAGGCCTG CTCACATACC CTGTACTCCA GGCGGCAGAC
ATTCTGTGCT ACAAGTCCAC ACACGTTCCT GTCGGGGAAG ATCAAGTCCA GCACATGGAA
CTAGTTCAGG ATCTAGCTCG GAGTTTCAAC CAGAAGTATG GCGAGCTCTT TCCACTGCCC
AGGTCTATTC TCACATCCAT GAAGAAAGTG AAATCTCTTC GTGACCCTTC TGCCAAGATG
TCAAAATCGG ACCCTGACAA ACTGGCCACT GTCCAAATAA CAGACAGCCC AGAGGAGATT
GTACGGAAAT TCCGCAAGGC TGTGACGGAC TTCACGTCAG AAGTCACCTA CGAGCCGGAC
AGCAGACCTG GTGTCTCCAA CATGGTGGCG ATCCATGCGG CCGTGTCAGG CCTCTCGGTG
GAGGAGGTGG TGCGCAATAG TGCAGGCGTG GACACTGCAC GCTACAAGCT GCTAGTGGCC
GACGCTGTGA TTGAGAAATT TGCTCCAATC AGAAGTGAAA TTGAAAAACT GAAAATGGAT
AAGGACCATT TAAGAAAGGT TTTACTTGTG GGATCTGCAA AAGCCAAAGA ATTAGCCTCT
CCTGTGTTCG AGGAGGTGAA GAAGTTGGTG GGGATTCTGT AGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_006233090.1 CDS 1960..2961 Translation
Target ORF information:
RefSeq Version XM_006233028.3 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus tryptophanyl tRNA synthetase 2 (mitochondrial) (Wars2), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_006233028.3
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961ATGGCGCTGT TCTCCGTGCG GAAGGCGCGT GAGTGCTGGC GCTTCATCCG GGCACTTCAT
AAAGGACCCA CAGCTACTGC GGCTCCCCAG AAGGAGAGCG GGGAGCGAGT GTTCTCTGGC
ATTCAGCCTA CAGGAATCCC CCACCTGGGA AATTACCTTG GAGCCATCGA GAGCTGGGTG
AAGTTACAGG AGGAGTATGA CACGGTGATA TACAGCATTG TGGACCTCCA CTCCATCACT
GTCCCCCAAG ACCCCGGCAT CCTGCAGCAG AGCATCCTGG ACATGACTGC CGTGCTCCTT
GCCTGCGGCA TAGACCCAGA GAGAAGTATC CTTTTCCAGC AGTCTCAGGC GAAGGCTGCG
AGGCAGAAGC ATGATGGGAC AGTAGGCCTG CTCACATACC CTGTACTCCA GGCGGCAGAC
ATTCTGTGCT ACAAGTCCAC ACACGTTCCT GTCGGGGAAG ATCAAGTCCA GCACATGGAA
CTAGTTCAGG ATCTAGCTCG GAGTTTCAAC CAGAAGTATG GCGAGCTCTT TCCACTGCCC
AGGTCTATTC TCACATCCAT GAAGAAAGTG AAATCTCTTC GTGACCCTTC TGCCAAGATG
TCAAAATCGG ACCCTGACAA ACTGGCCACT GTCCAAATAA CAGACAGCCC AGAGGAGATT
GTACGGAAAT TCCGCAAGGC TGTGACGGAC TTCACGTCAG AAGTCACCTA CGAGCCGGAC
AGCAGACCTG GTGTCTCCAA CATGGTGGCG ATCCATGCGG CCGTGTCAGG CCTCTCGGTG
GAGGAGGTGG TGCGCAATAG TGCAGGCGTG GACACTGCAC GCTACAAGCT GCTAGTGGCC
GACGCTGTGA TTGAGAAATT TGCTCCAATC AGAAGTGAAA TTGAAAAACT GAAAATGGAT
AAGGACCATT TAAGAAAGGT TTTACTTGTG GGATCTGCAA AAGCCAAAGA ATTAGCCTCT
CCTGTGTTCG AGGAGGTGAA GAAGTTGGTG GGGATTCTGT AGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity.
Physiological research66(6)917-924(2017 12)
Pravenec M,Zídek V,Landa V,Mlejnek P,Šilhavý J,Šimáková M,Trnovská J,Škop V,Marková I,Malínská H,Hüttl M,Kazdová L,Bardová K,Tauchmannová K,Vrbacký M,Nůsková H,Mráček T,Kopecký J,Houštěk J
Mutations of the aminoacyl-tRNA-synthetases SARS and WARS2 are implicated in the etiology of autosomal recessive intellectual disability.
Human mutation38(6)621-636(2017 06)
Musante L,Püttmann L,Kahrizi K,Garshasbi M,Hu H,Stehr H,Lipkowitz B,Otto S,Jensen LR,Tzschach A,Jamali P,Wienker T,Najmabadi H,Ropers HH,Kuss AW
Wars2 is a determinant of angiogenesis.
Nature communications712061(2016 07)
Wang M,Sips P,Khin E,Rotival M,Sun X,Ahmed R,Widjaja AA,Schafer S,Yusoff P,Choksi PK,Ko NS,Singh MK,Epstein D,Guan Y,Houštěk J,Mracek T,Nuskova H,Mikell B,Tan J,Pesce F,Kolar F,Bottolo L,Mancini M,Hubner N,Pravenec M,Petretto E,MacRae C,Cook SA
T2-TrpRS inhibits preretinal neovascularization and enhances physiological vascular regrowth in OIR as assessed by a new method of quantification.
Investigative ophthalmology & visual science47(5)2125-34(2006 May)
Banin E,Dorrell MI,Aguilar E,Ritter MR,Aderman CM,Smith AC,Friedlander J,Friedlander M
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M
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