| Gene Symbol | Nkx6-1 |
| Entrez Gene ID | 65193 |
| Full Name | NK6 homeobox 1 |
| Synonyms | Nkx6.1,Nkx61,Nkx6a |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | pancreatic beta-cell-specific transcription factor important for the formation of the insulin-producing beta-cells [RGD, Feb 2006]. |
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Nkx6-1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Nkx6-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nkx6-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa12549 Clone ID Related Accession (Same CDS sequence) NM_031737.1 Accession Version NM_031737.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1098bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1568995200000 Organism Rattus norvegicus(Norway rat) Product homeobox protein Nkx-6.1 Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF004431.1. On Dec 17, 2003 this sequence version replaced XM_346455.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF004431.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906348, SAMN04563759 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTTAGCTG TGGGGGCGAT GGAGGGCCCC CGGCAGAGCG CGTTCCTGCT CAGCAGCCCG
CCCTTGGCCG CCCTGCACAG CATGGCCGAG ATGAAGACCC CGCTCTACCC TGCCGCCTAT
CCCCCGCTGC CCACCGGGCC CCCCTCCTCC TCGTCCTCGT CCTCCTCGTC CTCGTCGCCC
TCCCCACCTT TGGGCGCACA CAACCCGGGC GGTTTGAAGC CCCCGGCCGC GGGGGGCCTC
TCGTCCCTGG GCAGCCCCCC GCAGCAGCTT TCGGCGGCCA CTCCGCACGG CATCAACGAC
ATCCTGAGCC GGCCCTCCAT GCCGGTGGCC TCGGGGGCCG CCCTGCCCTC CGCCTCGCCC
TCGGGGTCTT CTTCCTCCTC CTCCTCGTCC GCCTCCGCCA CCTCGGCCTC TGCGGCCGCC
GCTGCTGCTG CCGCTGCCGC CGCCGCTGCC GCCTCATCGC CCGCCGGGCT GTTGGCCGGC
CTGCCCCGCT TCAGCAGCCT GAGCCCTCCG CCACCGCCGC CCGGGCTCTA CTTTAGCCCC
AGCGCCGCGG CCGTGGCCGC CGTGGGCCGG TACCCCAAGC CCCTGGCCGA GCTGCCCGGT
CGGACGCCCA TCTTCTGGCC TGGGGTGATG CAGAGCCCGC CTTGGAGGGA CGCGCGCCTT
GCCTGTACCC CCCATCAAGG ATCCATTTTG TTGGACAAAG ATGGGAAGAG AAAACACACC
AGACCCACAT TCTCCGGCCA GCAGATCTTC GCCCTGGAGA AGACTTTCGA ACAAACGAAG
TACTTGGCAG GACCAGAGAG AGCACGCTTG GCCTATTCTC TGGGGATGAC GGAGAGTCAG
GTCAAGGTCT GGTTCCAGAA TCGGCGGACC AAGTGGAGAA AGAAGCACGC AGCCGAGATG
GCCACCGCCA AGAAGAAGCA GGACTCGGAG ACTGAGCGGC TCAAGGGGAC TTCGGAGAAC
GAGGAGGACG ACGACGATTA CAACAAGCCC CTGGACCCGA ACTCTGACGA CGAGAAAATC
ACTCAGCTGC TGAAAAAGCA CAAATCCAGC GGAGGCAGCC TCCTGCTGCA CGCGTCGGAG
GCCGAGGGCT CGTCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_113925.1 CDS 789..1886 Translation 
Target ORF information:
RefSeq Version NM_031737.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus NK6 homeobox 1 (Nkx6-1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_031737.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGTTAGCTG TGGGGGCGAT GGAGGGCCCC CGGCAGAGCG CGTTCCTGCT CAGCAGCCCG
CCCTTGGCCG CCCTGCACAG CATGGCCGAG ATGAAGACCC CGCTCTACCC TGCCGCCTAT
CCCCCGCTGC CCACCGGGCC CCCCTCCTCC TCGTCCTCGT CCTCCTCGTC CTCGTCGCCC
TCCCCACCTT TGGGCGCACA CAACCCGGGC GGTTTGAAGC CCCCGGCCGC GGGGGGCCTC
TCGTCCCTGG GCAGCCCCCC GCAGCAGCTT TCGGCGGCCA CTCCGCACGG CATCAACGAC
ATCCTGAGCC GGCCCTCCAT GCCGGTGGCC TCGGGGGCCG CCCTGCCCTC CGCCTCGCCC
TCGGGGTCTT CTTCCTCCTC CTCCTCGTCC GCCTCCGCCA CCTCGGCCTC TGCGGCCGCC
GCTGCTGCTG CCGCTGCCGC CGCCGCTGCC GCCTCATCGC CCGCCGGGCT GTTGGCCGGC
CTGCCCCGCT TCAGCAGCCT GAGCCCTCCG CCACCGCCGC CCGGGCTCTA CTTTAGCCCC
AGCGCCGCGG CCGTGGCCGC CGTGGGCCGG TACCCCAAGC CCCTGGCCGA GCTGCCCGGT
CGGACGCCCA TCTTCTGGCC TGGGGTGATG CAGAGCCCGC CTTGGAGGGA CGCGCGCCTT
GCCTGTACCC CCCATCAAGG ATCCATTTTG TTGGACAAAG ATGGGAAGAG AAAACACACC
AGACCCACAT TCTCCGGCCA GCAGATCTTC GCCCTGGAGA AGACTTTCGA ACAAACGAAG
TACTTGGCAG GACCAGAGAG AGCACGCTTG GCCTATTCTC TGGGGATGAC GGAGAGTCAG
GTCAAGGTCT GGTTCCAGAA TCGGCGGACC AAGTGGAGAA AGAAGCACGC AGCCGAGATG
GCCACCGCCA AGAAGAAGCA GGACTCGGAG ACTGAGCGGC TCAAGGGGAC TTCGGAGAAC
GAGGAGGACG ACGACGATTA CAACAAGCCC CTGGACCCGA ACTCTGACGA CGAGAAAATC
ACTCAGCTGC TGAAAAAGCA CAAATCCAGC GGAGGCAGCC TCCTGCTGCA CGCGTCGGAG
GCCGAGGGCT CGTCCTGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats.
Scientific reports7(1)15674(2017 Nov)
Špaček T,Pavluch V,Alán L,Capková N,Engstová H,Dlasková A,Berková Z,Saudek F,Ježek P
Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos.
FEBS letters590(12)1791-803(2016 06)
Ray JD,Kener KB,Bitner BF,Wright BJ,Ballard MS,Barrett EJ,Hill JT,Moss LG,Tessem JS
Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.
Islets7(1)e1027854(2015)
Hobson A,Draney C,Stratford A,Becker TC,Lu D,Arlotto M,Tessem JS
Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.
Proceedings of the National Academy of Sciences of the United States of America111(14)5242-7(2014 Apr)
Tessem JS,Moss LG,Chao LC,Arlotto M,Lu D,Jensen MV,Stephens SB,Tontonoz P,Hohmeier HE,Newgard CB
Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor.
PloS one9(10)e109171(2014)
Zhao X,Chen Y,Zhu Q,Huang H,Teng P,Zheng K,Hu X,Xie B,Zhang Z,Sander M,Qiu M
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