Mertk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mertk
Entrez Gene ID	65037
Full Name	MER proto-oncogene, tyrosine kinase
Synonyms	rdy
General protein information	Preferred Names MER proto-oncogene, tyrosine kinase Names tyrosine-protein kinase Mer Receptor tyrosine tinase gene probably the gene for Rdy c-mer proto-oncogene tyrosine kinase proto-oncogene c-Mer proto-oncogene tyrosine-protein kinase MER receptor tyrosine kinase MerTK retinal dystrophy
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q36
Summary	receptor tyrosine kinase; involved in the phagocytoses of the shed outer segments by retinal pigment epithelial (RPE) cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022943.1	NP_075232.1	tyrosine-protein kinase Mer precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MERTK	XP_515690.3
Mus musculus (house mouse)	Mertk	NP_032613.1
Gallus gallus (chicken)	MERTK	NP_990319.1
Homo sapiens (human)	MERTK	NP_006334.2
Bos taurus (cattle)	MERTK	NP_001178953.2
Rattus norvegicus (Norway rat)	Mertk	NP_075232.1
Danio rerio (zebrafish)	mertk	XP_002664277.3
Xenopus tropicalis (tropical clawed frog)	mertk	XP_002940444.2
Macaca mulatta (Rhesus monkey)	MERTK	XP_001086951.1
Canis lupus familiaris (dog)	MERTK	XP_005630494.1

Gene Ontology
Bibliography

Related articles in PubMed

MERTK mutation update in inherited retinal diseases.
Audo I, Mohand-Said S, Boulanger-Scemama E, Zanlonghi X, Condroyer C, Démontant V, Boyard F, Antonio A, Méjécase C, El Shamieh S, Sahel JA, Zeitz C
Human mutation39(7)887-913(2018 07)

Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.
Lorach H, Kang S, Dalal R, Bhuckory MB, Quan Y, Palanker D
Scientific reports8(1)11312(2018 07)

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.
Nomura K, Vilalta A, Allendorf DH, Hornik TC, Brown GC
Journal of immunology (Baltimore, Md. : 1950)198(12)4792-4801(2017 06)

Peng RM, Hong J, Jin Y, Sun YZ, Sun YQ, Zhang P
Molecular vision238-19(2017)

Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
Kohno H, Koso H, Okano K, Sundermeier TR, Saito S, Watanabe S, Tsuneoka H, Sakai T
Journal of neuroinflammation12188(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mertk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mertk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06480	NM_022943.1 Latest version!	Rattus norvegicus MER proto-oncogene, tyrosine kinase (Mertk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mertk ( NM_022943.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_075232.1 Rattus norvegicus MER proto-oncogene, tyrosine kinase (Mertk), mRNA.

Price & Availability↑

CloneID	ORa06480
Clone ID Related Accession (Same CDS sequence)	NM_022943.1
Accession Version	NM_022943.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2985bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1572105600000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase Mer precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF208235.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF208235.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTTCTGG CCCCACTACT GCTGGGGCTG CTGCTGCTAT CCGCACTCTG GAATGGAGGC 
ACTGCTGAAA AGGAGGAAGA AATCAAGCCA GATCAGCCAT TTTCAGGGCC TTTACCAGGG 
AGCCTACCAG CTGACCACAG GCCATTCTTC GCCCCTCACT CCAGTGGGGA CCAGCTGTCA 
CCATCCCAGA CTGGAAGATC ACATCCAGCA CACACAGCCA CTCCCCAGAT GACCTCTGCA 
GCATCAAACC TCCTGCCTCC TGTTGCATTT AAAAACACAA TTGGACGCAT AGTACTTTCG 
GAACATAAAA GTGTCAAATT TAATTGCTCG ATCAACATTC CTAACGTGTA TCAAGAAACA 
GCTGGCATTT CGTGGTGGAA AGATGGAAAG GAACTGCTTG GGGCACATCA TTCAATCACA 
CAGTTTTATC CTGATGAGGA AGGGGTATCA ATAATTGCAT TGTTCAGCAT AACCAGTGTG 
CAGCGCTCAG ACAATGGGTC GTACATCTGT AAGATGAAGG TGAACGATAG AGAGGTTGTG 
TCTGATCCCA TATACGTGGA AGTCCAAGGA CTCCCTTACT TTACTAAGCA GCCTGAGAGC 
GTGAATGTCA CCAGAAACAC AGCCTTCAAC CTCACCTGCC AGGCTGTGGG ACCCCCTGAG 
CCCGTCAACA TCTTCTGGGT TCAAAATAGC AGCCGTGTTA ATGAAAATCC AGAAAGGTCC 
CCGTCTGTCC TAACTGTCGC TGGTCTGACA GAGACCGCAG TCTTCAGCTG TGAGGCCCAC 
AACGACAAAG GACTGACGGT GTCCAAGGGT GTACAGATCA ACATCAAAGT CATCCCTTCC 
CCACCCACTG AAGTCCATAT CCTCAACAGC ACAGCGCACA GCATCCTGGT CTCCTGGGTC 
CCAGGGTTTG ATGGCTACTC CCCACTTCAG AACTGCAGCA TTCAGGTCAA GGAAGCTGAC 
CAGCTGAGTA ATGGCTCAGT CATGGTTTTT AATACCTCTG CTTCGCCACA TCTGTATGAA 
GTCCAGCAGC TGCAAGCCCT GGCTAATTAC AGCGTCACTG TGTCCTGTCG GAATGAGATT 
GGCTGGTCTG CAGTGAGCCC TTGGATCCTG GCCAGCACTA CAGAAGGAGC TCCAGCAGTG 
GCGCCTCTAA ACATCACTGT GTTTCTGAAC GAATCCAGCA ACAACCTGGA AATCAGATGG 
ACGAAGCCTC CAATTAAGCG GCAGGATGGG GAACTGGTGG GCTACCGGAT ATCTCACGTG 
TGGGAGAGTG CGGGGACTTC CAAAGAGCTT TCTGAAGAAG TCAGCCAGAA TGGCAGCTGG 
GCTCAGGTTC CTGTCCAAAT GCACAATGCC ACCTGCACAG TGAGAATCGC CGTCATCACT 
AAAGGGGGCA TTGGGCCCTT CAGTGAGCCA GTGGACGTAG CCATTCCGGA GCACAGTAGG 
GTAGATTACG CACCCTCATC AACCCCAGCC CCTGGCAACA CCGAGTCTAT GCTCATCATC 
CTGGGCTGCT TCTGCGGGTT TGTTCTCATG GGGTTGATTC TGTATCTTTC TCTGGCCATC 
AAAAGGAGAG TCCAGGAAAC AAAGTTTGGG GGTGCATTCT CCGAGGAGGA CTCCCAATTA 
GTTGTAAATT ACAGAGCAAA GAAGTCCTTC TGTCGGCGAG CCATCGAGCT TACCTTGCAA 
AGCCTGGGGG TGAGCGAGGA GCTGCAAAAC AAGCTAGAAG ATGTTGTGGT TGACAGAAAT 
CTTCTAATTC TTGGGAAAGT TCTGGGCGAA GGAGAGTTTG GGTCTGTAAT GGAAGGAAAT 
CTGAAGCAGG AAGATGGGAC TTCTCAGAAG GTGGCAGTGA AGACCATGAA GTTGGACAAC 
TTTTCTCTAC GGGAGATCGA GGAGTTTCTC AGCGAAGCAG CGTGCATGAA AGACTTCAAT 
CACCCAAACG TCATCCGGCT TCTAGGCGTG TGTATAGAAC TGAGCTCTCA AGGCATCCCG 
AAGCCCATGG TGATTTTACC CTTCATGAAA TACGGAGACC TCCACACCTT CCTGCTATAT 
TCCCGGATAG AATCAGTACC GAAGTCCATC CCCCTGCAGA CACTGCTGAA GTTCATGGTG 
GACATTGCCC AGGGAATGGA GTACCTGAGC AGCAGGAATT TTCTCCACAG GGATTTAGCT 
GCTCGGAATT GCATGTTGCG GGATGACATG ACTGTCTGCG TGGCAGACTT TGGCCTCTCT 
AAGAAGATTT ACAGTGGTGA TTATTACCGC CAAGGCCGCA TTGCCAAAAT GCCTGTGAAG 
TGGATCGCCA TAGAGAGCCT GGCGGACCGA GTCTACACAA GCAAGAGTGA CGTGTGGGCT 
TTTGGCGTGA CCATGTGGGA AATAGCAACA CGGGGAATGA CTCCCTATCC TGGAGTCCAG 
AACCATGAGA TGTACGATTA CCTTCTCCAC GGCCACAGGC TGAAGCAGCC CGAGGACTGC 
CTGGATGATC TGTATGAAAT CATGTACTCT TGCTGGAGTG CTGATCCCCT GGACCGACCC 
ACCTTCTCAG TGCTGAGGCT GCAGCTGGAA AAGCTCTCCG AGAGTTTGCC TGATGCCCAG 
GACAAAGAAT CCATCATCTA CATCAATACA CAGTTACTAG AGAGCTGCGA GGGCCTAGCC 
AACAGGTCCT CCCTCGCAGG GCTAGACATG AACATTGATC CTGACTCCAT CATTGCCTCT 
TGCACAGCAG GTGCTGCTGT CAGCGTGGTC ATGGCGGAAG TTCACGAGAA CAACCTTCAT 
GAGGAAAGAT ACATCTTAAA TGGGGGCAAC GAGGAATGGG AAGATGTGGC CTCCACTCCA 
TTTGCTACAG TCACAGCTGG AAAAGATGGT GTGTTACCAG AGGACAGACT CACCAAAAAT 
GGCATCTCCT GGTCTCACCA TAGTACGCTA CCCTTGGGGA GCCCATCACC AGATGAACTT 
CTGTTTGCAG ACGACTCCTC GGGAGACTCT GAAGTTCTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_075232.1
CDS	40..3024
Translation	MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLMGLILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVVVDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQTLLKFMVDIAQGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCWSADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDSIIASCTAGAAVSVVMAEVHENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKNGISWSHHSTLPLGSPSPDELLFADDSSGDSEVLM

Target ORF information:

RefSeq Version	NM_022943.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus MER proto-oncogene, tyrosine kinase (Mertk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022943.1

ORF Insert Sequence:

ATGGTTCTGG CCCCACTACT GCTGGGGCTG CTGCTGCTAT CCGCACTCTG GAATGGAGGC 
ACTGCTGAAA AGGAGGAAGA AATCAAGCCA GATCAGCCAT TTTCAGGGCC TTTACCAGGG 
AGCCTACCAG CTGACCACAG GCCATTCTTC GCCCCTCACT CCAGTGGGGA CCAGCTGTCA 
CCATCCCAGA CTGGAAGATC ACATCCAGCA CACACAGCCA CTCCCCAGAT GACCTCTGCA 
GCATCAAACC TCCTGCCTCC TGTTGCATTT AAAAACACAA TTGGACGCAT AGTACTTTCG 
GAACATAAAA GTGTCAAATT TAATTGCTCG ATCAACATTC CTAACGTGTA TCAAGAAACA 
GCTGGCATTT CGTGGTGGAA AGATGGAAAG GAACTGCTTG GGGCACATCA TTCAATCACA 
CAGTTTTATC CTGATGAGGA AGGGGTATCA ATAATTGCAT TGTTCAGCAT AACCAGTGTG 
CAGCGCTCAG ACAATGGGTC GTACATCTGT AAGATGAAGG TGAACGATAG AGAGGTTGTG 
TCTGATCCCA TATACGTGGA AGTCCAAGGA CTCCCTTACT TTACTAAGCA GCCTGAGAGC 
GTGAATGTCA CCAGAAACAC AGCCTTCAAC CTCACCTGCC AGGCTGTGGG ACCCCCTGAG 
CCCGTCAACA TCTTCTGGGT TCAAAATAGC AGCCGTGTTA ATGAAAATCC AGAAAGGTCC 
CCGTCTGTCC TAACTGTCGC TGGTCTGACA GAGACCGCAG TCTTCAGCTG TGAGGCCCAC 
AACGACAAAG GACTGACGGT GTCCAAGGGT GTACAGATCA ACATCAAAGT CATCCCTTCC 
CCACCCACTG AAGTCCATAT CCTCAACAGC ACAGCGCACA GCATCCTGGT CTCCTGGGTC 
CCAGGGTTTG ATGGCTACTC CCCACTTCAG AACTGCAGCA TTCAGGTCAA GGAAGCTGAC 
CAGCTGAGTA ATGGCTCAGT CATGGTTTTT AATACCTCTG CTTCGCCACA TCTGTATGAA 
GTCCAGCAGC TGCAAGCCCT GGCTAATTAC AGCGTCACTG TGTCCTGTCG GAATGAGATT 
GGCTGGTCTG CAGTGAGCCC TTGGATCCTG GCCAGCACTA CAGAAGGAGC TCCAGCAGTG 
GCGCCTCTAA ACATCACTGT GTTTCTGAAC GAATCCAGCA ACAACCTGGA AATCAGATGG 
ACGAAGCCTC CAATTAAGCG GCAGGATGGG GAACTGGTGG GCTACCGGAT ATCTCACGTG 
TGGGAGAGTG CGGGGACTTC CAAAGAGCTT TCTGAAGAAG TCAGCCAGAA TGGCAGCTGG 
GCTCAGGTTC CTGTCCAAAT GCACAATGCC ACCTGCACAG TGAGAATCGC CGTCATCACT 
AAAGGGGGCA TTGGGCCCTT CAGTGAGCCA GTGGACGTAG CCATTCCGGA GCACAGTAGG 
GTAGATTACG CACCCTCATC AACCCCAGCC CCTGGCAACA CCGAGTCTAT GCTCATCATC 
CTGGGCTGCT TCTGCGGGTT TGTTCTCATG GGGTTGATTC TGTATCTTTC TCTGGCCATC 
AAAAGGAGAG TCCAGGAAAC AAAGTTTGGG GGTGCATTCT CCGAGGAGGA CTCCCAATTA 
GTTGTAAATT ACAGAGCAAA GAAGTCCTTC TGTCGGCGAG CCATCGAGCT TACCTTGCAA 
AGCCTGGGGG TGAGCGAGGA GCTGCAAAAC AAGCTAGAAG ATGTTGTGGT TGACAGAAAT 
CTTCTAATTC TTGGGAAAGT TCTGGGCGAA GGAGAGTTTG GGTCTGTAAT GGAAGGAAAT 
CTGAAGCAGG AAGATGGGAC TTCTCAGAAG GTGGCAGTGA AGACCATGAA GTTGGACAAC 
TTTTCTCTAC GGGAGATCGA GGAGTTTCTC AGCGAAGCAG CGTGCATGAA AGACTTCAAT 
CACCCAAACG TCATCCGGCT TCTAGGCGTG TGTATAGAAC TGAGCTCTCA AGGCATCCCG 
AAGCCCATGG TGATTTTACC CTTCATGAAA TACGGAGACC TCCACACCTT CCTGCTATAT 
TCCCGGATAG AATCAGTACC GAAGTCCATC CCCCTGCAGA CACTGCTGAA GTTCATGGTG 
GACATTGCCC AGGGAATGGA GTACCTGAGC AGCAGGAATT TTCTCCACAG GGATTTAGCT 
GCTCGGAATT GCATGTTGCG GGATGACATG ACTGTCTGCG TGGCAGACTT TGGCCTCTCT 
AAGAAGATTT ACAGTGGTGA TTATTACCGC CAAGGCCGCA TTGCCAAAAT GCCTGTGAAG 
TGGATCGCCA TAGAGAGCCT GGCGGACCGA GTCTACACAA GCAAGAGTGA CGTGTGGGCT 
TTTGGCGTGA CCATGTGGGA AATAGCAACA CGGGGAATGA CTCCCTATCC TGGAGTCCAG 
AACCATGAGA TGTACGATTA CCTTCTCCAC GGCCACAGGC TGAAGCAGCC CGAGGACTGC 
CTGGATGATC TGTATGAAAT CATGTACTCT TGCTGGAGTG CTGATCCCCT GGACCGACCC 
ACCTTCTCAG TGCTGAGGCT GCAGCTGGAA AAGCTCTCCG AGAGTTTGCC TGATGCCCAG 
GACAAAGAAT CCATCATCTA CATCAATACA CAGTTACTAG AGAGCTGCGA GGGCCTAGCC 
AACAGGTCCT CCCTCGCAGG GCTAGACATG AACATTGATC CTGACTCCAT CATTGCCTCT 
TGCACAGCAG GTGCTGCTGT CAGCGTGGTC ATGGCGGAAG TTCACGAGAA CAACCTTCAT 
GAGGAAAGAT ACATCTTAAA TGGGGGCAAC GAGGAATGGG AAGATGTGGC CTCCACTCCA 
TTTGCTACAG TCACAGCTGG AAAAGATGGT GTGTTACCAG AGGACAGACT CACCAAAAAT 
GGCATCTCCT GGTCTCACCA TAGTACGCTA CCCTTGGGGA GCCCATCACC AGATGAACTT 
CTGTTTGCAG ACGACTCCTC GGGAGACTCT GAAGTTCTGA TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MERTK mutation update in inherited retinal diseases.
Human mutation39(7)887-913(2018 07)
Audo I,Mohand-Said S,Boulanger-Scemama E,Zanlonghi X,Condroyer C,Démontant V,Boyard F,Antonio A,Méjécase C,El Shamieh S,Sahel JA,Zeitz C

Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.
Scientific reports8(1)11312(2018 07)
Lorach H,Kang S,Dalal R,Bhuckory MB,Quan Y,Palanker D

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.
Journal of immunology (Baltimore, Md. : 1950)198(12)4792-4801(2017 06)
Nomura K,Vilalta A,Allendorf DH,Hornik TC,Brown GC

Molecular vision238-19(2017)
Peng RM,Hong J,Jin Y,Sun YZ,Sun YQ,Zhang P

Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
Journal of neuroinflammation12188(2015 Oct)
Kohno H,Koso H,Okano K,Sundermeier TR,Saito S,Watanabe S,Tsuneoka H,Sakai T

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Mertk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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