Unc13a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Unc13a
Entrez Gene ID	64829
Full Name	unc-13 homolog A
Synonyms	Munc13-1,Unc13h1
General protein information	Preferred Names unc-13 homolog A Names protein unc-13 homolog A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14
Summary	brain specific protein that may have role during neurotransmitter release [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022861.1	NP_074052.1	protein unc-13 homolog A

Pathways from BioSystems

Homologies

Bos taurus (cattle)	UNC13A	XP_002688619.2
Rattus norvegicus (Norway rat)	Unc13a	NP_074052.1
Danio rerio (zebrafish)	si:dkey-110c1.7	NP_001038630.1
Xenopus tropicalis (tropical clawed frog)	LOC100492289	XP_002938873.2
Homo sapiens (human)	UNC13A	NP_001073890.2
Gallus gallus (chicken)	LOC430487	XP_428042.4
Canis lupus familiaris (dog)	UNC13A	XP_005633256.1
Caenorhabditis elegans (roundworm)	unc-13	NP_001021874.1
Mus musculus (house mouse)	Unc13a	NP_001025044.2
Drosophila melanogaster (fruit fly)	unc-13	NP_651949.2

Gene Ontology
Bibliography

Related articles in PubMed

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.
Wang S, Li Y, Gong J, Ye S, Yang X, Zhang R, Ma C
Nature communications10(1)69(2019 01)

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation.
Das J, Kedei N, Kelsey JS, You Y, Pany S, Mitchell GA, Lewin NE, Blumberg PM
Biochemistry57(5)732-741(2018 02)

Synaptic weight set by Munc13-1 supramolecular assemblies.
Sakamoto H, Ariyoshi T, Kimpara N, Sugao K, Taiko I, Takikawa K, Asanuma D, Namiki S, Hirose K
Nature neuroscience21(1)41-49(2018 01)

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
eLife6(2017 05)

Inhibitory role of Munc13-1 in antigen-induced mast cell degranulation.
Higashio H, Satoh YI, Saino T
Biomedical research (Tokyo, Japan)38(6)321-329(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Unc13a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc13a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06387	NM_022861.1 Latest version!	Rattus norvegicus unc-13 homolog A (Unc13a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Unc13a ( NM_022861.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_074052.1 Rattus norvegicus unc-13 homolog A (Unc13a), mRNA.

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CloneID	ORa06387
Clone ID Related Accession (Same CDS sequence)	NM_022861.1
Accession Version	NM_022861.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5208bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	protein unc-13 homolog A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U24070.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U24070.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCTCTGC TGTGCGTGGG AGTCAAAAAA GCCAAGTTTG ACGGTGCCCA AGAGAAGTTC 
AACACATACG TGACGCTGAA GGTGCAGAAC GTGAAGAGCA CTACCATAGC TGTACGCGGC 
AGCCAGCCTA GCTGGGAGCA GGACTTCATG TTTGAGATCA ACCGCCTGGA TCTGGGCCTG 
ACGGTGGAGG TGTGGAACAA GGGTCTCATC TGGGACACAA TGGTGGGTAC TGTGTGGATC 
CCACTTCGGA CCATCCGTCA GTCCAATGAG GAGGGTCCGG GAGAATGGCT GACACTGGAC 
TCTCAGGCCA TCATGGCGGA CAGTGAGATC TGTGGGACCA AGGACCCCAC CTTCCACCGC 
ATCCTCCTGG ACGCACATTT TGAGCTGCCT TTGGACATCC CCGAGGAGGA GGCGCGCTAC 
TGGGCCAAGA AGCTGGAGCA GCTGAATGCC ATGCGTGACC AAGATGAGTA CTCCTTTCAG 
GACCAGCAGG ACAAGCCACT GCCGGTGCCC AGCAGCCAGT GCTGCAACTG GAATTACTTT 
GGCTGGGGAG AACAGAATGA TGATCCCGAC AGTGCCGTGG ATGACCGGGA CAGTGATTAT 
AGGAGTGAGA CGAGCAACAG CATCCCACCG CCTTACTACA CGACTTCGCA GCCCAATGCT 
TCGGTGCACC AGTACTCCGT GCGGCCACCC CCTCTGGGGT CCCGGGAGTC CTACAGCGAC 
TCCATGCACA GCTATGAAGA GTTCTCTGAG CCGCGGGCAC TCAGTCCCAC AGGCAGCAGC 
CGCTATGCTT CCAGTGGGGA GCTGAGCCAG GGCAGCTCCC AGCTGAGTGA GGACTTCGAC 
CCGGATGAGC ACAGCCTACA GGGCTCAGAG CTGGATGACG AGAGGGACCG AGATTCTTAT 
CACTCCTGCC ACAGCTCTGT GAGCTACCAC AAGGACTCAC CCCGCTGGGA CCAGGATGAG 
GAGGACCTGG AGGACCTGGA GGACCTGGAA GATGAGGAGT TGCCCGAGGA AGAGGAGTTG 
GAAGAGGAGG AGTTGGAGGA GGAGGAGGAG TTGGAGGAAG AGGAATTGGA GTTGGAGGAG 
GAGGAGGAGG TGCCTGATGA CCTGGCCAGC TATACCCAGC AGGAGGACAC CACTGTGGCT 
GAGCCCAAAG AGTTCAAGCG GATCAGCTTC CCAACAGCTG CACCTCAGAA GGAAGACAAA 
GTTTCAGCTG TGCCCATTGA GGCCCCCGAT GTGTCCAAAG GCATCCCCAA GGCAGCCACA 
CCTGAAGAGA AGGCAGCTGC GGAGTGTGCA CAGGAAGCGG AGCCCCCCAA GTCTGAGGAG 
AGTTTCAGAT CTCGAGAGGC TGAGGAGGGC CAGGAAGGGC AGGATGCCAT GTCCAGGGCC 
AAAGCCAACT GGTTGCGAGC CTTCAACAAG GTGCGCATGC AGCTGCAGGA GGCCCGAGGA 
GAAGGAGAGA TGTCCAAGTC TCTGTGGTTC AAAGGCGGCC CTGGTGGTGG CCTTATCATC 
ATTGACAGCA TGCCAGACAT CAGGAAGCGG AAGCCCATTC CCCTCGTGAG CGACCTGGCT 
ATGTCTCTGG TCCAGTCACG GAAGGCGGGC ATCACCTCGG CCTTGGCCTC CAGCACGTTG 
AACAATGAAG AGTTGAAAAA CCACGTTTAC AAGAAGACCC TGCAAGCCTT AATCTACCCC 
ATCTCCTGCA CCACGCCGCA CAACTTCGAG GTGTGGACGG CCACCACTCC CACCTACTGC 
TACGAGTGCG AGGGGCTGCT GTGGGGCATC GCGCGGCAGG GCATGCGCTG CACCGAGTGC 
GGCGTTAAGT GCCACGAGAA GTGCCAAGAC CTGCTCAACG CGGACTGCCT GCAGCGGGCG 
GCTGAGAAGA GTTCTAAGCA TGGCGCTGAA GACCGCACGC AGAACATCAT CATGGTGCTG 
AAGGACCGCA TGAAGATCCG CGAGCGCAAC AAGCCTGAGA TCTTCGAGCT GATCCAGGAG 
GTCTTCGCGG TCACCAAGAG CGCACACACA CAGCAGATGA AGGCCGTCAA GCAGAGTGTG 
CTGGATGGCA CATCCAAGTG GTCTGCCAAA ATTAGCATCA CGGTGGTCTG TGCCCAGGGC 
TTGCAGGCCA AGGACAAGAC AGGATCCAGT GACCCTTATG TCACCGTCCA GGTTGGGAAG 
ACCAAGAAAA GGACAAAAAC CATCTACGGG AACCTTAACC CAGTGTGGGA AGAGAATTTC 
CACTTTGAAT GTCACAACTC CTCTGACCGG ATCAAGGTGC GTGTGTTGGA TGAAGACGAT 
GACATCAAAT CCCGTGTGAA GCAAAGGTTT AAGAGGGAGT CTGATGACTT CCTAGGGCAG 
ACAATCATCG AGGTGCGGAC GCTTAGCGGC GAGATGGATG TGTGGTACAA TCTGGACAAG 
AGAACAGACA AGTCTGCTGT GTCGGGCGCC ATTCGGCTTC ACATCAGTGT GGAGATCAAA 
GGGGAGGAGA AGGTGGCACC CTACCATGTC CAGTACACCT GTCTGCATGA GAACCTGTTC 
CATTTTGTGA CGGATGTACA GAACAATGGC GTGGTGAAGA TTCCCGATGC CAAAGGTGAC 
GACGCCTGGA AGGTTTACTA TGATGAGACT GCCCAGGAGA TCGTGGATGA GTTTGCCATG 
CGCTATGGCG TTGAATCCAT CTACCAAGCC ATGACCCACT TTGCCTGCCT CTCCTCCAAG 
TACATGTGCC CTGGGGTACC CGCTGTCATG AGCACCCTGC TTGCCAACAT CAACGCCTAC 
TACGCACACA CCACCGCCTC CACCAACGTG TCTGCCTCCG ACCGCTTCGC TGCCTCCAAT 
TTCGGGAAAG AGCGCTTTGT GAAACTTCTG GACCAGCTGC ACAACTCCCT GCGGATTGAC 
CTGTCCATGT ACCGGAACAA CTTCCCGGCC AGCAGCCCCG AGCGGCTGCA GGATCTCAAG 
TCCACAGTGG ACCTGCTTAC CAGCATCACC TTCTTCCGGA TGAAGGTTCA GGAACTGCAG 
AGTCCGCCAC GTGCCAGTCA GGTGGTGAAG GACTGCGTGA AGGCGTGCCT CAACTCCACC 
TACGAGTACA TCTTCAACAA CTGTCATGAG CTCTATGGCC GGGAGTACCA GACAGACCCG 
GCCAAGAAGG GGGAGGTCCC CCCGGAGGAG CAAGGCCCTA GCATCAAGAA CCTGGATTTC 
TGGTCCAAGC TCATCACCCT CATCGTGTCT ATCATTGAGG AGGATAAGAA CTCCTACACA 
CCCTGCCTCA ATCAGTTTCC CCAGGAGCTG AATGTGGGGA AGATCAGTGC TGAGGTGATG 
TGGAGCCTGT TTGCCCAGGA CATGAAGTAC GCCATGGAGG AACACGACAA GCACCGGCTG 
TGTAAGAGCG CAGACTACAT GAACCTGCAT TTCAAGGTCA AGTGGTTGTA CAACGAGTAC 
GTGGCTGAAC TGCCCACCTT CAAGGACCGC GTGCCGGAGT ACCCTGCGTG GTTTGAGCCC 
TTCGTCATCC AGTGGTTAGA TGAGAATGAG GAGGTGTCCC GGGACTTCCT GCATGGTGCA 
CTCGAGCGGG ACAAGAAGGA TGGGTTCCAG CAGACATCGG AGCACGCCCT GTTCTCTTGC 
TCGGTAGTGG ACGTCTTCTC CCAGCTCAAC CAGAGCTTTG AGATCATCAA GAAGCTGGAG 
TGTCCTGACC CCCAGATTGT GGGCCACTAC ATGCGGCGCT TTGCCAAGAC CATTAGCAAT 
GTGCTTCTCC AGTACGCCGA CATCGTCTCC AAGGACTTCG CTTCCTACTG CTCCAAGGAG 
AAGGAGAAAG TGCCCTGCAT CCTCATGAAC AACACACAGC AGCTGCGGGT GCAGCTGGAG 
AAGATGTTCG AGGCGATGGG TGGGAAGGAG CTGGACGCCG AGGCCAGCGG AACCCTGAAG 
GAGCTGCAGG TGAAACTCAA CAATGTCCTG GATGAACTCA GCCACGTGTT TGCCACCAGC 
TTCCAGCCAC ACATCGAGGA GTGTGTCAGA CAAATGGGTG ACATCCTAAG CCAAGTGAAG 
GGCACGGGCA ACGTGCCCGC CAGTGCCTGC AGCAGCGTGG CACAGGACGC AGACAACGTG 
CTACAGCCCA TCATGGATCT TCTGGACAGC AACCTCACCC TGTTTGCCAA AATCTGTGAG 
AAGACGGTTC TGAAGCGGGT GCTGAAGGAG CTGTGGAAGC TGGTGATGAA CACCATGGAG 
AGGACCATTG TCCTGCCGCC ACTCACTGAC CAGACGATGA TTGGTACCCT CTTGAGAAAA 
CATGGCAAGG GCCTAGAAAA GGGCAGGGTG AAACTGCCAA GCCACTCAGA CGGGACACAA 
ATGATCTTCA ATGCCGCCAA GGAGCTGGGC CAGCTGTCCA AACTGAAGGA TCACATGGTG 
CGAGAAGAAG CCAAGAGCTT GACCCCGAAG CAGTGTGCCG TGGTTGAACT GGCCCTGGAC 
ACCATCAAGC AATACTTCCA CGCGGGGGGC GTGGGCCTCA AGAAGACCTT TCTCGAGAAA 
AGCCCGGACC TTCAGTCCCT GCGCTACGCC CTGTCGCTCT ACACACAGGC CACCGACCTG 
CTCATCAAAA CCTTCGTGCA GACGCAGTCA GCGCAGGTCC ATGGTGGAAA GGGGACTAGG 
TTTACCCTTA GTGAAGACGT TTGTCCTGAG ATGGGCTCGG GTGTGGAAGA CCCTGTAGGT 
GAAGTATCCG TCCACGTGGA GCTGTTCACG CATCCGGGAA CTGGGGAACA GAAGGTCACA 
GTGAAGGTGG TGGCCGCCAA CGACCTCAAG TGGCAGACTT CTGGCATCTT CCGTCCGTTC 
ATTGAGGTCA ACATCGTTGG ACCTCAGCTC AGCGACAAGA AACGAAAGTT CGCCACCAAA 
TCGAAAAACA ACAGCTGGGC GCCCAAATAT AACGAGAGCT TCCAGTTCTC CCTGAGCGCC 
GACGCGGGAC CCGAGTGCTA CGAGTTGCAG GTGTGCGTGA AGGACTACTG CTTCGCGCGC 
GAGGACCGCA CGGTGGAGCT GGCGGTGCTG CAGCTGCGGG AGCTGGCTCA GCGCGGGAGC 
GCCGCGTGCT GGCTGCCGCT CGGCCGCCGC ATCCACATGG ACGACACGGG GCTCACAGTG 
CTGCGTATCC TGTCGCAGCG CAGCAATGAC GAGGTGGCCA AGGAGTTCGT CAAGCTCAAG 
TCCGACACGC GCTCGGCCGA GGAGGGCGGT GCCGCGCCTG CGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_074052.1
CDS	1109..6316
Translation	MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQAIMADSEICGTKDPTFHRILLDAHFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDQQDKPLPVPSSQCCNWNYFGWGEQNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPRALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSELDDERDRDSYHSCHSSVSYHKDSPRWDQDEEDLEDLEDLEDEELPEEEELEEEELEEEEELEEEELELEEEEEVPDDLASYTQQEDTTVAEPKEFKRISFPTAAPQKEDKVSAVPIEAPDVSKGIPKAATPEEKAAAECAQEAEPPKSEESFRSREAEEGQEGQDAMSRAKANWLRAFNKVRMQLQEARGEGEMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEVFAVTKSAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVLDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVAELPTFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIVSKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASGTLKELQVKLNNVLDELSHVFATSFQPHIEECVRQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMERTIVLPPLTDQTMIGTLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQVHGGKGTRFTLSEDVCPEMGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFIEVNIVGPQLSDKKRKFATKSKNNSWAPKYNESFQFSLSADAGPECYELQVCVKDYCFAREDRTVELAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP

Target ORF information:

RefSeq Version	NM_022861.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus unc-13 homolog A (Unc13a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022861.1

ORF Insert Sequence:

ATGTCTCTGC TGTGCGTGGG AGTCAAAAAA GCCAAGTTTG ACGGTGCCCA AGAGAAGTTC 
AACACATACG TGACGCTGAA GGTGCAGAAC GTGAAGAGCA CTACCATAGC TGTACGCGGC 
AGCCAGCCTA GCTGGGAGCA GGACTTCATG TTTGAGATCA ACCGCCTGGA TCTGGGCCTG 
ACGGTGGAGG TGTGGAACAA GGGTCTCATC TGGGACACAA TGGTGGGTAC TGTGTGGATC 
CCACTTCGGA CCATCCGTCA GTCCAATGAG GAGGGTCCGG GAGAATGGCT GACACTGGAC 
TCTCAGGCCA TCATGGCGGA CAGTGAGATC TGTGGGACCA AGGACCCCAC CTTCCACCGC 
ATCCTCCTGG ACGCACATTT TGAGCTGCCT TTGGACATCC CCGAGGAGGA GGCGCGCTAC 
TGGGCCAAGA AGCTGGAGCA GCTGAATGCC ATGCGTGACC AAGATGAGTA CTCCTTTCAG 
GACCAGCAGG ACAAGCCACT GCCGGTGCCC AGCAGCCAGT GCTGCAACTG GAATTACTTT 
GGCTGGGGAG AACAGAATGA TGATCCCGAC AGTGCCGTGG ATGACCGGGA CAGTGATTAT 
AGGAGTGAGA CGAGCAACAG CATCCCACCG CCTTACTACA CGACTTCGCA GCCCAATGCT 
TCGGTGCACC AGTACTCCGT GCGGCCACCC CCTCTGGGGT CCCGGGAGTC CTACAGCGAC 
TCCATGCACA GCTATGAAGA GTTCTCTGAG CCGCGGGCAC TCAGTCCCAC AGGCAGCAGC 
CGCTATGCTT CCAGTGGGGA GCTGAGCCAG GGCAGCTCCC AGCTGAGTGA GGACTTCGAC 
CCGGATGAGC ACAGCCTACA GGGCTCAGAG CTGGATGACG AGAGGGACCG AGATTCTTAT 
CACTCCTGCC ACAGCTCTGT GAGCTACCAC AAGGACTCAC CCCGCTGGGA CCAGGATGAG 
GAGGACCTGG AGGACCTGGA GGACCTGGAA GATGAGGAGT TGCCCGAGGA AGAGGAGTTG 
GAAGAGGAGG AGTTGGAGGA GGAGGAGGAG TTGGAGGAAG AGGAATTGGA GTTGGAGGAG 
GAGGAGGAGG TGCCTGATGA CCTGGCCAGC TATACCCAGC AGGAGGACAC CACTGTGGCT 
GAGCCCAAAG AGTTCAAGCG GATCAGCTTC CCAACAGCTG CACCTCAGAA GGAAGACAAA 
GTTTCAGCTG TGCCCATTGA GGCCCCCGAT GTGTCCAAAG GCATCCCCAA GGCAGCCACA 
CCTGAAGAGA AGGCAGCTGC GGAGTGTGCA CAGGAAGCGG AGCCCCCCAA GTCTGAGGAG 
AGTTTCAGAT CTCGAGAGGC TGAGGAGGGC CAGGAAGGGC AGGATGCCAT GTCCAGGGCC 
AAAGCCAACT GGTTGCGAGC CTTCAACAAG GTGCGCATGC AGCTGCAGGA GGCCCGAGGA 
GAAGGAGAGA TGTCCAAGTC TCTGTGGTTC AAAGGCGGCC CTGGTGGTGG CCTTATCATC 
ATTGACAGCA TGCCAGACAT CAGGAAGCGG AAGCCCATTC CCCTCGTGAG CGACCTGGCT 
ATGTCTCTGG TCCAGTCACG GAAGGCGGGC ATCACCTCGG CCTTGGCCTC CAGCACGTTG 
AACAATGAAG AGTTGAAAAA CCACGTTTAC AAGAAGACCC TGCAAGCCTT AATCTACCCC 
ATCTCCTGCA CCACGCCGCA CAACTTCGAG GTGTGGACGG CCACCACTCC CACCTACTGC 
TACGAGTGCG AGGGGCTGCT GTGGGGCATC GCGCGGCAGG GCATGCGCTG CACCGAGTGC 
GGCGTTAAGT GCCACGAGAA GTGCCAAGAC CTGCTCAACG CGGACTGCCT GCAGCGGGCG 
GCTGAGAAGA GTTCTAAGCA TGGCGCTGAA GACCGCACGC AGAACATCAT CATGGTGCTG 
AAGGACCGCA TGAAGATCCG CGAGCGCAAC AAGCCTGAGA TCTTCGAGCT GATCCAGGAG 
GTCTTCGCGG TCACCAAGAG CGCACACACA CAGCAGATGA AGGCCGTCAA GCAGAGTGTG 
CTGGATGGCA CATCCAAGTG GTCTGCCAAA ATTAGCATCA CGGTGGTCTG TGCCCAGGGC 
TTGCAGGCCA AGGACAAGAC AGGATCCAGT GACCCTTATG TCACCGTCCA GGTTGGGAAG 
ACCAAGAAAA GGACAAAAAC CATCTACGGG AACCTTAACC CAGTGTGGGA AGAGAATTTC 
CACTTTGAAT GTCACAACTC CTCTGACCGG ATCAAGGTGC GTGTGTTGGA TGAAGACGAT 
GACATCAAAT CCCGTGTGAA GCAAAGGTTT AAGAGGGAGT CTGATGACTT CCTAGGGCAG 
ACAATCATCG AGGTGCGGAC GCTTAGCGGC GAGATGGATG TGTGGTACAA TCTGGACAAG 
AGAACAGACA AGTCTGCTGT GTCGGGCGCC ATTCGGCTTC ACATCAGTGT GGAGATCAAA 
GGGGAGGAGA AGGTGGCACC CTACCATGTC CAGTACACCT GTCTGCATGA GAACCTGTTC 
CATTTTGTGA CGGATGTACA GAACAATGGC GTGGTGAAGA TTCCCGATGC CAAAGGTGAC 
GACGCCTGGA AGGTTTACTA TGATGAGACT GCCCAGGAGA TCGTGGATGA GTTTGCCATG 
CGCTATGGCG TTGAATCCAT CTACCAAGCC ATGACCCACT TTGCCTGCCT CTCCTCCAAG 
TACATGTGCC CTGGGGTACC CGCTGTCATG AGCACCCTGC TTGCCAACAT CAACGCCTAC 
TACGCACACA CCACCGCCTC CACCAACGTG TCTGCCTCCG ACCGCTTCGC TGCCTCCAAT 
TTCGGGAAAG AGCGCTTTGT GAAACTTCTG GACCAGCTGC ACAACTCCCT GCGGATTGAC 
CTGTCCATGT ACCGGAACAA CTTCCCGGCC AGCAGCCCCG AGCGGCTGCA GGATCTCAAG 
TCCACAGTGG ACCTGCTTAC CAGCATCACC TTCTTCCGGA TGAAGGTTCA GGAACTGCAG 
AGTCCGCCAC GTGCCAGTCA GGTGGTGAAG GACTGCGTGA AGGCGTGCCT CAACTCCACC 
TACGAGTACA TCTTCAACAA CTGTCATGAG CTCTATGGCC GGGAGTACCA GACAGACCCG 
GCCAAGAAGG GGGAGGTCCC CCCGGAGGAG CAAGGCCCTA GCATCAAGAA CCTGGATTTC 
TGGTCCAAGC TCATCACCCT CATCGTGTCT ATCATTGAGG AGGATAAGAA CTCCTACACA 
CCCTGCCTCA ATCAGTTTCC CCAGGAGCTG AATGTGGGGA AGATCAGTGC TGAGGTGATG 
TGGAGCCTGT TTGCCCAGGA CATGAAGTAC GCCATGGAGG AACACGACAA GCACCGGCTG 
TGTAAGAGCG CAGACTACAT GAACCTGCAT TTCAAGGTCA AGTGGTTGTA CAACGAGTAC 
GTGGCTGAAC TGCCCACCTT CAAGGACCGC GTGCCGGAGT ACCCTGCGTG GTTTGAGCCC 
TTCGTCATCC AGTGGTTAGA TGAGAATGAG GAGGTGTCCC GGGACTTCCT GCATGGTGCA 
CTCGAGCGGG ACAAGAAGGA TGGGTTCCAG CAGACATCGG AGCACGCCCT GTTCTCTTGC 
TCGGTAGTGG ACGTCTTCTC CCAGCTCAAC CAGAGCTTTG AGATCATCAA GAAGCTGGAG 
TGTCCTGACC CCCAGATTGT GGGCCACTAC ATGCGGCGCT TTGCCAAGAC CATTAGCAAT 
GTGCTTCTCC AGTACGCCGA CATCGTCTCC AAGGACTTCG CTTCCTACTG CTCCAAGGAG 
AAGGAGAAAG TGCCCTGCAT CCTCATGAAC AACACACAGC AGCTGCGGGT GCAGCTGGAG 
AAGATGTTCG AGGCGATGGG TGGGAAGGAG CTGGACGCCG AGGCCAGCGG AACCCTGAAG 
GAGCTGCAGG TGAAACTCAA CAATGTCCTG GATGAACTCA GCCACGTGTT TGCCACCAGC 
TTCCAGCCAC ACATCGAGGA GTGTGTCAGA CAAATGGGTG ACATCCTAAG CCAAGTGAAG 
GGCACGGGCA ACGTGCCCGC CAGTGCCTGC AGCAGCGTGG CACAGGACGC AGACAACGTG 
CTACAGCCCA TCATGGATCT TCTGGACAGC AACCTCACCC TGTTTGCCAA AATCTGTGAG 
AAGACGGTTC TGAAGCGGGT GCTGAAGGAG CTGTGGAAGC TGGTGATGAA CACCATGGAG 
AGGACCATTG TCCTGCCGCC ACTCACTGAC CAGACGATGA TTGGTACCCT CTTGAGAAAA 
CATGGCAAGG GCCTAGAAAA GGGCAGGGTG AAACTGCCAA GCCACTCAGA CGGGACACAA 
ATGATCTTCA ATGCCGCCAA GGAGCTGGGC CAGCTGTCCA AACTGAAGGA TCACATGGTG 
CGAGAAGAAG CCAAGAGCTT GACCCCGAAG CAGTGTGCCG TGGTTGAACT GGCCCTGGAC 
ACCATCAAGC AATACTTCCA CGCGGGGGGC GTGGGCCTCA AGAAGACCTT TCTCGAGAAA 
AGCCCGGACC TTCAGTCCCT GCGCTACGCC CTGTCGCTCT ACACACAGGC CACCGACCTG 
CTCATCAAAA CCTTCGTGCA GACGCAGTCA GCGCAGGTCC ATGGTGGAAA GGGGACTAGG 
TTTACCCTTA GTGAAGACGT TTGTCCTGAG ATGGGCTCGG GTGTGGAAGA CCCTGTAGGT 
GAAGTATCCG TCCACGTGGA GCTGTTCACG CATCCGGGAA CTGGGGAACA GAAGGTCACA 
GTGAAGGTGG TGGCCGCCAA CGACCTCAAG TGGCAGACTT CTGGCATCTT CCGTCCGTTC 
ATTGAGGTCA ACATCGTTGG ACCTCAGCTC AGCGACAAGA AACGAAAGTT CGCCACCAAA 
TCGAAAAACA ACAGCTGGGC GCCCAAATAT AACGAGAGCT TCCAGTTCTC CCTGAGCGCC 
GACGCGGGAC CCGAGTGCTA CGAGTTGCAG GTGTGCGTGA AGGACTACTG CTTCGCGCGC 
GAGGACCGCA CGGTGGAGCT GGCGGTGCTG CAGCTGCGGG AGCTGGCTCA GCGCGGGAGC 
GCCGCGTGCT GGCTGCCGCT CGGCCGCCGC ATCCACATGG ACGACACGGG GCTCACAGTG 
CTGCGTATCC TGTCGCAGCG CAGCAATGAC GAGGTGGCCA AGGAGTTCGT CAAGCTCAAG 
TCCGACACGC GCTCGGCCGA GGAGGGCGGT GCCGCGCCTG CGCCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly.
Nature communications10(1)69(2019 01)
Wang S,Li Y,Gong J,Ye S,Yang X,Zhang R,Ma C

Critical Role of Trp-588 of Presynaptic Munc13-1 for Ligand Binding and Membrane Translocation.
Biochemistry57(5)732-741(2018 02)
Das J,Kedei N,Kelsey JS,You Y,Pany S,Mitchell GA,Lewin NE,Blumberg PM

Synaptic weight set by Munc13-1 supramolecular assemblies.
Nature neuroscience21(1)41-49(2018 01)
Sakamoto H,Ariyoshi T,Kimpara N,Sugao K,Taiko I,Takikawa K,Asanuma D,Namiki S,Hirose K

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
eLife6(2017 05)
Sitarska E,Xu J,Park S,Liu X,Quade B,Stepien K,Sugita K,Brautigam CA,Sugita S,Rizo J

Inhibitory role of Munc13-1 in antigen-induced mast cell degranulation.
Biomedical research (Tokyo, Japan)38(6)321-329(2017)
Higashio H,Satoh YI,Saino T

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Unc13a cDNA ORF clone, Rattus norvegicus(Norway rat)

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