Slc5a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc5a2
Entrez Gene ID	64522
Full Name	solute carrier family 5 member 2
Synonyms	Sglt2
General protein information	Preferred Names solute carrier family 5 member 2 Names sodium/glucose cotransporter 2 Na(+)/glucose cotransporter 2 low affinity Na-dependent glucose transporter (SGLT2) low affinity sodium-glucose cotransporter solute carrier family 5 (sodium/glucose cotransporter), member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q37
Summary	a Na(+)-coupled glucose transporter involved in reabsorption of filtered glucose in the kidney [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022590.2	NP_072112.2	sodium/glucose cotransporter 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slc5a2	NP_573517.1
Bos taurus (cattle)	SLC5A2	NP_976236.1
Rattus norvegicus (Norway rat)	Slc5a2	NP_072112.2
Pan troglodytes (chimpanzee)	SLC5A2	XP_003315117.1
Macaca mulatta (Rhesus monkey)	SLC5A2	XP_001113206.1
Danio rerio (zebrafish)	slc5a2	NP_998091.1
Xenopus tropicalis (tropical clawed frog)	slc5a2	XP_002940641.2
Homo sapiens (human)	SLC5A2	NP_003032.1
Canis lupus familiaris (dog)	SLC5A2	XP_005621284.1

Gene Ontology
Bibliography

Related articles in PubMed

SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2.
Zhou Y, Fan J, Zheng C, Yin P, Wu H, Li X, Luo N, Yu X, Chen C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1091327-1338(2019 Jan)

Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat.
Masuda T, Watanabe Y, Fukuda K, Watanabe M, Onishi A, Ohara K, Imai T, Koepsell H, Muto S, Vallon V, Nagata D
American journal of physiology. Renal physiology315(3)F653-F664(2018 09)

Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.
Lee TM, Chang NC, Lin SZ
Free radical biology & medicine104298-310(2017 03)

Sodium Glucose Cotransporter 2 (SGLT2) Plays as a Physiological Glucose Sensor and Regulates Cellular Contractility in Rat Mesangial Cells.
Wakisaka M, Nagao T, Yoshinari M
PloS one11(3)e0151585(2016)

Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease.
Zhang Y, Thai K, Kepecs DM, Gilbert RE
PloS one11(1)e0144640(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Slc5a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc5a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06068	NM_022590.2 Latest version!	Rattus norvegicus solute carrier family 5 member 2 (Slc5a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc5a2 ( NM_022590.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_072112.2 Rattus norvegicus solute carrier family 5 member 2 (Slc5a2), mRNA.

Price & Availability↑

CloneID	ORa06068
Clone ID Related Accession (Same CDS sequence)	NM_022590.2
Accession Version	NM_022590.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2013bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	sodium/glucose cotransporter 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U29881.1, AB070850.1 and AB070976.1. On Nov 1, 2005 this sequence version replaced NM_022590.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U29881.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN02642745 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGGAC ACGTAGAGGA AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTCAT TGCCGCGTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCTTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCGG GGACTGGTGC AGCAAGTGGC TTGGCCGTGG CTGGATTTGA GTGGAATGCG 
CTCTTTGTGG TGTTGCTCCT CGGCTGGCTC TTCGTGCCTG TGTATCTGAC CGCCGGAGTG 
ATTACCATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC GCCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCCGGA 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCTGTCAT CGCACTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCAGGTCT CTTCGACAAA TACCTGGGAG CAGTGACTTC ACTGACGGTG 
TCCAAGGATC CAGCTGTTGG CAACATCTCC AGCACCTGCT ATCAGCCGAG GCCCGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCGT GGCCTGCGCT GCTTCTGGGG 
CTTACCATTG TCTCAGGCTG GTACTGGTGC AGTGACCAGG TAATTGTGCA GCGCTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAGGCT GGATGCATCC TGTGTGGTTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATTAGCC GCATTCTTTA CCCAGATGAG 
GTGGCCTGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT TGTTGTGAAG CTCATGCCCA ATGGTCTGCG TGGACTCATG 
CTGGCAGTCA TGCTGGCCGC CCTCATGTCT TCTCTAGCGT CCATCTTTAA CAGCAGCAGC 
ACACTCTTCA CCATGGATAT CTACACACGC CTGCGGCCTC GGGCGGGTGA TAGGGAGCTG 
CTGCTGGTTG GAAGGCTTTG GGTGGTGTTC ATTGTGGCAG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCACAGGG CGGCCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAC 
CTGGCGCCTC CAGTGTCCGC TGTCTTTGTG CTGGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGTGCTT TCTGGGGACT CATTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCACGGG CAGCTGTGTG CGACCCTCTG CATGCCCAGC CATCTTCTGC 
CGGGTACACT ACCTCTACTT CGCCATCATT CTCTTCTTCT GCTCCGGCTT CCTCACACTC 
GCAATCTCCC TGTGCACCGC ACCCATCCCT CAGAAGCATC TCCACCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAT CTGGATGCTG AAGAGTTAGA GGGTCCAGCC 
CCTCCTCCTG TGCAGAACGG GTGCCAGGAA TGTGCAATGG GGATTGAAGA GGTCCAGTCC 
CCAGCTCCAG GCCTGCTCCG CCAGTGCTTG CTCTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCACCCAC TACCGAGGAG GTGGCTGCAA CCACCAGGCG GCTAGAGGAC 
ATCAGTGAGG ATCCCAGCTG GGCCCGAGTA GTCAACCTCA ATGCCCTGCT CATGATGACT 
GTGGCTGTGT TCCTCTGGGG CTTTTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_072112.2
CDS	6..2018
Translation	MEGHVEEGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAVTSLTVSKDPAVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLIGGLLMGLARLIPEFFFGTGSCVRPSACPAIFCRVHYLYFAIILFFCSGFLTLAISLCTAPIPQKHLHRLVFSLRHSKEEREDLDAEELEGPAPPPVQNGCQECAMGIEEVQSPAPGLLRQCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPSWARVVNLNALLMMTVAVFLWGFYA

Target ORF information:

RefSeq Version	NM_022590.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 5 member 2 (Slc5a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022590.2

ORF Insert Sequence:

ATGGAGGGAC ACGTAGAGGA AGGCTCTGAA CTTGGGGAGC AGAAGGTCCT GATTGATAAT 
CCTGCTGACA TTCTGGTCAT TGCCGCGTAT TTCCTGCTGG TCATTGGTGT TGGCTTGTGG 
TCTATGTTCA GAACCAATAG AGGCACAGTT GGTGGCTACT TCTTGGCAGG ACGGAGCATG 
GTGTGGTGGC CGGTTGGAGC CTCTCTGTTC GCCAGCAACA TCGGCAGCGG TCATTTTGTG 
GGCCTGGCGG GGACTGGTGC AGCAAGTGGC TTGGCCGTGG CTGGATTTGA GTGGAATGCG 
CTCTTTGTGG TGTTGCTCCT CGGCTGGCTC TTCGTGCCTG TGTATCTGAC CGCCGGAGTG 
ATTACCATGC CTCAGTACCT CCGCAAGCGC TTTGGTGGGC GCCGTATTCG CCTCTACCTG 
TCCGTGCTCT CGCTTTTTTT GTACATTTTC ACCAAGATCT CGGTGGATAT GTTCTCCGGA 
GCAGTATTCA TTCAACAGGC CCTGGGCTGG AACATTTACG CTTCTGTCAT CGCACTCTTG 
GGCATCACCA TGATTTATAC TGTGACAGGA GGGCTGGCGG CACTGATGTA CACAGACACT 
GTGCAGACCT TCGTCATTCT TGCCGGGGCC TTCATCCTCA CTGGTTATGC TTTCCATGAA 
GTGGGCGGGT ACTCAGGTCT CTTCGACAAA TACCTGGGAG CAGTGACTTC ACTGACGGTG 
TCCAAGGATC CAGCTGTTGG CAACATCTCC AGCACCTGCT ATCAGCCGAG GCCCGACTCC 
TATCACCTGC TGCGTGACCC TGTGACAGGA GACCTGCCGT GGCCTGCGCT GCTTCTGGGG 
CTTACCATTG TCTCAGGCTG GTACTGGTGC AGTGACCAGG TAATTGTGCA GCGCTGCCTG 
GCTGGAAAGA ATCTGACTCA CATCAAGGCT GGATGCATCC TGTGTGGTTA CCTGAAGCTG 
ATGCCCATGT TCCTCATGGT CATGCCAGGC ATGATTAGCC GCATTCTTTA CCCAGATGAG 
GTGGCCTGTG TGGTACCTGA GGTGTGTAAG CGGGTGTGTG GCACTGAGGT GGGCTGCTCT 
AACATCGCCT ACCCACGGCT TGTTGTGAAG CTCATGCCCA ATGGTCTGCG TGGACTCATG 
CTGGCAGTCA TGCTGGCCGC CCTCATGTCT TCTCTAGCGT CCATCTTTAA CAGCAGCAGC 
ACACTCTTCA CCATGGATAT CTACACACGC CTGCGGCCTC GGGCGGGTGA TAGGGAGCTG 
CTGCTGGTTG GAAGGCTTTG GGTGGTGTTC ATTGTGGCAG TGTCCGTGGC TTGGCTGCCA 
GTGGTGCAGG CAGCACAGGG CGGCCAGCTC TTCGATTACA TTCAGTCTGT CTCCAGCTAC 
CTGGCGCCTC CAGTGTCCGC TGTCTTTGTG CTGGCACTCT TTGTGCCCCG TGTTAATGAG 
AAGGGTGCTT TCTGGGGACT CATTGGGGGC CTGCTGATGG GCCTAGCTCG TCTCATACCC 
GAGTTCTTCT TTGGCACGGG CAGCTGTGTG CGACCCTCTG CATGCCCAGC CATCTTCTGC 
CGGGTACACT ACCTCTACTT CGCCATCATT CTCTTCTTCT GCTCCGGCTT CCTCACACTC 
GCAATCTCCC TGTGCACCGC ACCCATCCCT CAGAAGCATC TCCACCGCCT GGTTTTCAGT 
CTCCGGCACA GCAAGGAGGA GCGGGAGGAT CTGGATGCTG AAGAGTTAGA GGGTCCAGCC 
CCTCCTCCTG TGCAGAACGG GTGCCAGGAA TGTGCAATGG GGATTGAAGA GGTCCAGTCC 
CCAGCTCCAG GCCTGCTCCG CCAGTGCTTG CTCTGGTTCT GTGGGATGAG CAAGAGTGGG 
TCAGGGAGTC CTCCACCCAC TACCGAGGAG GTGGCTGCAA CCACCAGGCG GCTAGAGGAC 
ATCAGTGAGG ATCCCAGCTG GGCCCGAGTA GTCAACCTCA ATGCCCTGCT CATGATGACT 
GTGGCTGTGT TCCTCTGGGG CTTTTATGCA TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1091327-1338(2019 Jan)
Zhou Y,Fan J,Zheng C,Yin P,Wu H,Li X,Luo N,Yu X,Chen C

Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat.
American journal of physiology. Renal physiology315(3)F653-F664(2018 09)
Masuda T,Watanabe Y,Fukuda K,Watanabe M,Onishi A,Ohara K,Imai T,Koepsell H,Muto S,Vallon V,Nagata D

Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.
Free radical biology & medicine104298-310(2017 03)
Lee TM,Chang NC,Lin SZ

Sodium Glucose Cotransporter 2 (SGLT2) Plays as a Physiological Glucose Sensor and Regulates Cellular Contractility in Rat Mesangial Cells.
PloS one11(3)e0151585(2016)
Wakisaka M,Nagao T,Yoshinari M

Sodium-Glucose Linked Cotransporter-2 Inhibition Does Not Attenuate Disease Progression in the Rat Remnant Kidney Model of Chronic Kidney Disease.
PloS one11(1)e0144640(2016)
Zhang Y,Thai K,Kepecs DM,Gilbert RE