Dusp10 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dusp10
Entrez Gene ID	63995
Full Name	dual specificity phosphatase 10
Synonyms	Mkp-5,Mkp5
General protein information	Preferred Names dual specificity phosphatase 10 Names dual specificity protein phosphatase 10
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q26

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105734.1	NP_001099204.1	dual specificity protein phosphatase 10

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	LOC100497288	XP_002940746.2
Rattus norvegicus (Norway rat)	Dusp10	NP_001099204.1
Danio rerio (zebrafish)	si:ch211-180b22.4	XP_003200822.1
Homo sapiens (human)	DUSP10	NP_009138.1
Macaca mulatta (Rhesus monkey)	DUSP10	XP_001101834.1
Bos taurus (cattle)	DUSP10	NP_001029897.2
Canis lupus familiaris (dog)	DUSP10	XP_545790.2
Gallus gallus (chicken)	DUSP10	NP_001026215.1
Pan troglodytes (chimpanzee)	DUSP10	XP_001173001.1
Mus musculus (house mouse)	Dusp10	NP_071302.2

Gene Ontology
Bibliography

Related articles in PubMed

DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.
Png CW, Weerasooriya M, Guo J, James SJ, Poh HM, Osato M, Flavell RA, Dong C, Yang H, Zhang Y
Oncogene35(2)206-17(2016 Jan)

The family-wide structure and function of human dual-specificity protein phosphatases.
Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang HS, Ryu SY, Park H, Kim DS, Kim SJ, Ryu SE
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)

Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology.
Papadopoulos P, Rosa-Neto P, Rochford J, Hamel E
PloS one8(7)e68612(2013)

Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase.
Choi HR, Kim WK, Kim EY, Han BS, Min JK, Chi SW, Park SG, Bae KH, Lee SC
PloS one8(8)e72340(2013)

Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells.
Chang CC, Zhang QY, Liu Z, Clynes RA, Suciu-Foca N, Vlad G
Journal of immunology (Baltimore, Md. : 1950)188(7)3042-52(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dusp10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dusp10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa11269	NM_001105734.1 Latest version!	Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dusp10 ( NM_001105734.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099204.1 Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA.

Price & Availability↑

CloneID	ORa11269
Clone ID Related Accession (Same CDS sequence)	NM_001105734.1
Accession Version	NM_001105734.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527350400000
Organism	Rattus norvegicus(Norway rat)
Product	dual specificity protein phosphatase 10
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473985.1. On or before Oct 3, 2007 this sequence version replaced XM_223030.4, XM_001064583.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTCCGT CCCCTTTAGA CGACAGGGTA GTAGTAGCAC TGTCTAGGCC TGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCCAGC TACCTGGGCT CTGCCAGCCC AGGCAGCAAT 
AACCACACTC CTGTCATTGC CACAGCCGTC GTGACCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCC CTGAATTGCG GATGCAGCAG CACTAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGATCAT CAGGCCCAGA CTCAAGCCAT CGCTGCAGGC 
ACTGCCACCA CTGCCATAGG AACCTCGACC ACCTGCCCTG CTAACCAGAT GGTCAACAAC 
AATGAAAATA TAGGCTCTTT AAGTCCATCG GGCGGGGTGG GCAGCCCCGT GTCAGGGACT 
CCCAAGCAGC TAGCCAGCAT CAAAATCATC TACCCCAATG ACCTGGCGAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCCAGCCAG GGTCCTGTCA TCATTGACTG CAGGCCTTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC AGATAAGATC 
AGCCGGCGGA GGCTGCAACA GGGCAAGATC ACTGTCTTAG ACTTGATTTC CTGTAGAGAA 
GGCAAAGACT CTTTCAAGAG GATTTTTTCC AAAGAAATCA TAGTTTATGA TGAGAATACC 
AATGAGCCGA GCCGTGTGAC GCCATCCCAA CCACTTCACA TAGTTCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCCCT GGTATTGAAA GGGGGACTCA GTAGTTTTAA ACAGAACCAT 
GGAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGTGGTGCC 
TCTGCGGCCT CGAGCGTGCT ACCTCAGTCT GTCCCCTCCA CCCCTGACAT CGAGAGCGCA 
GAGCTGACAC CCATCCTGCC CTTCCTGTTT CTTGGCAATG AGCAGGATGC TCAGGACCTA 
GACGCCATGC AGAGGCTCAA TGTCGGCTAT GTCATCAACG TCACCACACA CCTTCCTCTC 
TACCACTATG AGAAAGGCCT CTTCAACTAC AAGAGGCTGC CAGCCACAGA CAGCAACAAG 
CAGAACTTGC GGCAGTACTT TGAAGAGGCA TTCGAATTCA TTGAGGAAGC TCATCAGTGT 
GGGAAGGGCC TTCTCATCCA CTGCCAGGCC GGCGTGTCCC GTTCTGCCAC CATTGTCATC 
GCCTACCTGA TGAAGCACAC ACGGATGACC ATGACTGACG CTTACAAATT CGTCAAAGGC 
AAACGACCAA TTATCTCCCC GAACCTCAAC TTCATGGGGC AGTTGCTGGA ATTTGAGGAA 
GACCTAAACA ATGGCGTGAC ACCACGGATC CTTACACCAA AGCTGATGGG CATGGAGACA 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099204.1
CDS	157..1605
Translation	MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSASPGSNNHTPVIATAVVTLKAANLTYMPSSSGSARSLNCGCSSTSCCTVATYDKDHQAQTQAIAAGTATTAIGTSTTCPANQMVNNNENIGSLSPSGGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVTPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHGNLCDNSLQLQECREVGGGASAASSVLPQSVPSTPDIESAELTPILPFLFLGNEQDAQDLDAMQRLNVGYVINVTTHLPLYHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGMETVV

Target ORF information:

RefSeq Version	NM_001105734.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus dual specificity phosphatase 10 (Dusp10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105734.1

ORF Insert Sequence:

ATGCCTCCGT CCCCTTTAGA CGACAGGGTA GTAGTAGCAC TGTCTAGGCC TGTCCGACCT 
CAGGATCTCA ACCTTTGTTT AGACTCCAGC TACCTGGGCT CTGCCAGCCC AGGCAGCAAT 
AACCACACTC CTGTCATTGC CACAGCCGTC GTGACCCTCA AGGCTGCGAA TCTGACGTAT 
ATGCCCTCAT CCAGCGGCTC TGCCCGCTCC CTGAATTGCG GATGCAGCAG CACTAGCTGC 
TGCACTGTGG CAACCTACGA CAAGGATCAT CAGGCCCAGA CTCAAGCCAT CGCTGCAGGC 
ACTGCCACCA CTGCCATAGG AACCTCGACC ACCTGCCCTG CTAACCAGAT GGTCAACAAC 
AATGAAAATA TAGGCTCTTT AAGTCCATCG GGCGGGGTGG GCAGCCCCGT GTCAGGGACT 
CCCAAGCAGC TAGCCAGCAT CAAAATCATC TACCCCAATG ACCTGGCGAA GAAGATGACC 
AAATGCAGCA AGAGTCACCT GCCCAGCCAG GGTCCTGTCA TCATTGACTG CAGGCCTTTC 
ATGGAGTACA ACAAGAGTCA CATCCAAGGA GCTGTCCACA TTAACTGTGC AGATAAGATC 
AGCCGGCGGA GGCTGCAACA GGGCAAGATC ACTGTCTTAG ACTTGATTTC CTGTAGAGAA 
GGCAAAGACT CTTTCAAGAG GATTTTTTCC AAAGAAATCA TAGTTTATGA TGAGAATACC 
AATGAGCCGA GCCGTGTGAC GCCATCCCAA CCACTTCACA TAGTTCTCGA GTCCCTGAAG 
AGAGAAGGCA AAGAACCCCT GGTATTGAAA GGGGGACTCA GTAGTTTTAA ACAGAACCAT 
GGAAACCTCT GTGACAACTC CCTCCAGCTC CAAGAGTGCC GGGAGGTGGG GGGTGGTGCC 
TCTGCGGCCT CGAGCGTGCT ACCTCAGTCT GTCCCCTCCA CCCCTGACAT CGAGAGCGCA 
GAGCTGACAC CCATCCTGCC CTTCCTGTTT CTTGGCAATG AGCAGGATGC TCAGGACCTA 
GACGCCATGC AGAGGCTCAA TGTCGGCTAT GTCATCAACG TCACCACACA CCTTCCTCTC 
TACCACTATG AGAAAGGCCT CTTCAACTAC AAGAGGCTGC CAGCCACAGA CAGCAACAAG 
CAGAACTTGC GGCAGTACTT TGAAGAGGCA TTCGAATTCA TTGAGGAAGC TCATCAGTGT 
GGGAAGGGCC TTCTCATCCA CTGCCAGGCC GGCGTGTCCC GTTCTGCCAC CATTGTCATC 
GCCTACCTGA TGAAGCACAC ACGGATGACC ATGACTGACG CTTACAAATT CGTCAAAGGC 
AAACGACCAA TTATCTCCCC GAACCTCAAC TTCATGGGGC AGTTGCTGGA ATTTGAGGAA 
GACCTAAACA ATGGCGTGAC ACCACGGATC CTTACACCAA AGCTGATGGG CATGGAGACA 
GTTGTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis.
Oncogene35(2)206-17(2016 Jan)
Png CW,Weerasooriya M,Guo J,James SJ,Poh HM,Osato M,Flavell RA,Dong C,Yang H,Zhang Y

The family-wide structure and function of human dual-specificity protein phosphatases.
Acta crystallographica. Section D, Biological crystallography70(Pt 2)421-35(2014 Feb)
Jeong DG,Wei CH,Ku B,Jeon TJ,Chien PN,Kim JK,Park SY,Hwang HS,Ryu SY,Park H,Kim DS,Kim SJ,Ryu SE

Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology.
PloS one8(7)e68612(2013)
Papadopoulos P,Rosa-Neto P,Rochford J,Hamel E

Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase.
PloS one8(8)e72340(2013)
Choi HR,Kim WK,Kim EY,Han BS,Min JK,Chi SW,Park SG,Bae KH,Lee SC

Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)188(7)3042-52(2012 Apr)
Chang CC,Zhang QY,Liu Z,Clynes RA,Suciu-Foca N,Vlad G