Cxcr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cxcr4
Entrez Gene ID	60628
Full Name	C-X-C motif chemokine receptor 4
General protein information	Preferred Names C-X-C motif chemokine receptor 4 Names C-X-C chemokine receptor type 4 CXC chemokine receptor CXC-R4 CXCR-4 LESTR SDF-1 receptor chemokine (C-X-C motif) receptor 4 chemokine receptor (LCR1) fusin leukocyte-derived seven transmembrane domain receptor stromal cell-derived factor 1 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	G protein-coupled receptor for the chemokine stromal cell-derived factor-1; may have a role in brain development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_022205.3	NP_071541.2	C-X-C chemokine receptor type 4

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	CXCR4	NP_989948.2
Danio rerio (zebrafish)	cxcr4a	NP_571957.2
Danio rerio (zebrafish)	cxcr4b	NP_571909.1
Pan troglodytes (chimpanzee)	CXCR4	NP_001009047.1
Mus musculus (house mouse)	Cxcr4	NP_034041.2
Rattus norvegicus (Norway rat)	Cxcr4	NP_071541.2
Xenopus tropicalis (tropical clawed frog)	cxcr4	NP_001090831.1
Homo sapiens (human)	CXCR4	NP_003458.1
Macaca mulatta (Rhesus monkey)	CXCR4	NP_001036110.1
Canis lupus familiaris (dog)	CXCR4	NP_001041491.1
Bos taurus (cattle)	CXCR4	NP_776726.1

Gene Ontology
Bibliography

Related articles in PubMed

Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats.
Li T, Wang H, Wang J, Chen Y, Yang C, Zhao M, Wang G, Yang Z
Neuroscience research14448-55(2019 Jul)

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway.
Huang X, Mao W, Zhang T, Wang M, Wang X, Li Y, Zhang L, Yao D, Cai X, Wang L
BMC complementary and alternative medicine18(1)330(2018 Dec)

Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4.
Zhan LY, Lei SQ, Zhang BH, Li WL, Wang HX, Zhao B, Cui SS, Ding H, Huang QM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie107818-823(2018 Nov)

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways.
Tian Y, Yin H, Deng X, Tang B, Ren X, Jiang T
Molecular medicine reports18(5)4374-4380(2018 Nov)

Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4.
Scofield SLC, Daniels CR, Dalal S, Millard JA, Singh M, Singh K
Life sciences2118-16(2018 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cxcr4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cxcr4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12939	NM_022205.3 Latest version!	Rattus norvegicus C-X-C motif chemokine receptor 4 (Cxcr4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cxcr4 ( NM_022205.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071541.2 Rattus norvegicus C-X-C motif chemokine receptor 4 (Cxcr4), mRNA.

Price & Availability↑

CloneID	ORa12939
Clone ID Related Accession (Same CDS sequence)	NM_022205.3
Accession Version	NM_022205.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1050bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	C-X-C chemokine receptor type 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO557829.1 and BC089804.1. On Nov 23, 2005 this sequence version replaced NM_022205.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC089804.1, DY315507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAAATAT ACACTTCGGA TAACTACTCC GAAGAAGTAG GGTCTGGAGA CTATGACTCC 
AACAAGGAAC CCTGCTTCCG GGATGAAAAC GAAAACTTCA ACAGGATCTT CCTGCCCACC 
ATCTATTTTA TCATCTTCTT GACTGGCATA GTGGGCAATG GGTTGGTAAT CCTGGTCATG 
GGTTACCAGA AGAAGCTGAG GAGCATGACA GACAAGTACC GGCTGCACCT GTCCGTGGCT 
GACCTCCTCT TTGTCATCAC ACTCCCCTTC TGGGCAGTGG ACGCCATGGC TGACTGGTAC 
TTTGGGAAAT TTTTATGTAA GGCTGTGCAT ATCATCTACA CCGTCAACCT TTACAGCAGT 
GTTCTCATCC TGGCCTTCAT CAGCCTGGAC CGCTACCTTG CCATTGTCCA CGCCACCAAC 
AGCCAGAGGC CGAGGAAGCT GCTGGCTGAA AAGGCCGTCT ATGTGGGTGT CTGGATCCCC 
GCCCTCCTCC TGACTATCCC TGACATCATC TTCGCCGATG TCAGCCAGGG GGACGGCAGG 
TACATCTGTG ACCGCCTTTA CCCCGACAGC CTGTGGATGG TGGTGTTCCA GTTCCAGCAC 
ATCATGGTGG GTCTCATCCT GCCGGGCATC GTCATCCTGT CCTGTTACTG CATCATCATC 
TCCAAGCTGT CACACTCCAA GGGCCACCAG AAGCGCAAGG CCCTCAAGAC TACGGTCATC 
CTTATCCTGG CTTTCTTTGC CTGCTGGCTA CCGTATTACG TGGGGATCAG CATCGATTCC 
TTCATCCTTT TGGAGGTCAT CAAGCAAGGA TGTGAGTTCG AGAGCGTCGT GCACAAGTGG 
ATCTCCATCA CGGAGGCCCT CGCCTTCTTC CACTGTTGCC TGAACCCCAT CCTCTACGCC 
TTCCTCGGGG CCAAATTCAA GAGCTCCGCG CAGCATGCAC TCAATTCCAT GAGCAGAGGC 
TCCAGCCTCA AGATCCTTTC CAAAGGGAAA CGGGGTGGAC ACTCTTCCGT CTCCACAGAG 
TCAGAATCCT CAAGTTTTCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071541.2
CDS	76..1125
Translation	MEIYTSDNYSEEVGSGDYDSNKEPCFRDENENFNRIFLPTIYFIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAMADWYFGKFLCKAVHIIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDIIFADVSQGDGRYICDRLYPDSLWMVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYVGISIDSFILLEVIKQGCEFESVVHKWISITEALAFFHCCLNPILYAFLGAKFKSSAQHALNSMSRGSSLKILSKGKRGGHSSVSTESESSSFHSS

Target ORF information:

RefSeq Version	NM_022205.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-X-C motif chemokine receptor 4 (Cxcr4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022205.3

ORF Insert Sequence:

ATGGAAATAT ACACTTCGGA TAACTACTCC GAAGAAGTAG GGTCTGGAGA CTATGACTCC 
AACAAGGAAC CCTGCTTCCG GGATGAAAAC GAAAACTTCA ACAGGATCTT CCTGCCCACC 
ATCTATTTTA TCATCTTCTT GACTGGCATA GTGGGCAATG GGTTGGTAAT CCTGGTCATG 
GGTTACCAGA AGAAGCTGAG GAGCATGACA GACAAGTACC GGCTGCACCT GTCCGTGGCT 
GACCTCCTCT TTGTCATCAC ACTCCCCTTC TGGGCAGTGG ACGCCATGGC TGACTGGTAC 
TTTGGGAAAT TTTTATGTAA GGCTGTGCAT ATCATCTACA CCGTCAACCT TTACAGCAGT 
GTTCTCATCC TGGCCTTCAT CAGCCTGGAC CGCTACCTTG CCATTGTCCA CGCCACCAAC 
AGCCAGAGGC CGAGGAAGCT GCTGGCTGAA AAGGCCGTCT ATGTGGGTGT CTGGATCCCC 
GCCCTCCTCC TGACTATCCC TGACATCATC TTCGCCGATG TCAGCCAGGG GGACGGCAGG 
TACATCTGTG ACCGCCTTTA CCCCGACAGC CTGTGGATGG TGGTGTTCCA GTTCCAGCAC 
ATCATGGTGG GTCTCATCCT GCCGGGCATC GTCATCCTGT CCTGTTACTG CATCATCATC 
TCCAAGCTGT CACACTCCAA GGGCCACCAG AAGCGCAAGG CCCTCAAGAC TACGGTCATC 
CTTATCCTGG CTTTCTTTGC CTGCTGGCTA CCGTATTACG TGGGGATCAG CATCGATTCC 
TTCATCCTTT TGGAGGTCAT CAAGCAAGGA TGTGAGTTCG AGAGCGTCGT GCACAAGTGG 
ATCTCCATCA CGGAGGCCCT CGCCTTCTTC CACTGTTGCC TGAACCCCAT CCTCTACGCC 
TTCCTCGGGG CCAAATTCAA GAGCTCCGCG CAGCATGCAC TCAATTCCAT GAGCAGAGGC 
TCCAGCCTCA AGATCCTTTC CAAAGGGAAA CGGGGTGGAC ACTCTTCCGT CTCCACAGAG 
TCAGAATCCT CAAGTTTTCA CTCCAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Annexin 1 inhibits remifentanil-induced hyperalgesia and NMDA receptor phosphorylation via regulating spinal CXCL12/CXCR4 in rats.
Neuroscience research14448-55(2019 Jul)
Li T,Wang H,Wang J,Chen Y,Yang C,Zhao M,Wang G,Yang Z

Baicalin promotes apoptosis and inhibits proliferation and migration of hypoxia-induced pulmonary artery smooth muscle cells by up-regulating A2a receptor via the SDF-1/CXCR4 signaling pathway.
BMC complementary and alternative medicine18(1)330(2018 Dec)
Huang X,Mao W,Zhang T,Wang M,Wang X,Li Y,Zhang L,Yao D,Cai X,Wang L

Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie107818-823(2018 Nov)
Zhan LY,Lei SQ,Zhang BH,Li WL,Wang HX,Zhao B,Cui SS,Ding H,Huang QM

CXCL12 induces migration of oligodendrocyte precursor cells through the CXCR4‑activated MEK/ERK and PI3K/AKT pathways.
Molecular medicine reports18(5)4374-4380(2018 Nov)
Tian Y,Yin H,Deng X,Tang B,Ren X,Jiang T

Extracellular ubiquitin modulates cardiac fibroblast phenotype and function via its interaction with CXCR4.
Life sciences2118-16(2018 Oct)
Scofield SLC,Daniels CR,Dalal S,Millard JA,Singh M,Singh K

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Cxcr4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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