Cdkn2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cdkn2c
Entrez Gene ID	54238
Full Name	cyclin-dependent kinase inhibitor 2C
Synonyms	p18
General protein information	Preferred Names cyclin-dependent kinase inhibitor 2C Names cyclin-dependent kinase 4 inhibitor C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q35
Summary	cyclin-dependent kinase inhibitor that may be involved in cell cycle regulation during terminal differentiation of oligodendrocytes [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_131902.3	NP_571977.1	cyclin-dependent kinase 4 inhibitor C

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	CDKN2C	XP_001110979.1
Bos taurus (cattle)	CDKN2C	NP_001094524.1
Rattus norvegicus (Norway rat)	Cdkn2c	NP_571977.1
Gallus gallus (chicken)	CDKN2C	XP_004936837.1
Homo sapiens (human)	CDKN2C	NP_001253.1
Pan troglodytes (chimpanzee)	CDKN2C	XP_524704.2
Canis lupus familiaris (dog)	CDKN2C	XP_849772.1
Mus musculus (house mouse)	Cdkn2c	NP_031697.1
Danio rerio (zebrafish)	cdkn2c	NP_001186923.1
Xenopus tropicalis (tropical clawed frog)	cdkn2c	NP_001116932.1

Gene Ontology
Bibliography

Related articles in PubMed

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.
Pei XH, Bai F, Smith MD, Xiong Y
Cancer research67(7)3162-70(2007 Apr)

Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.
Tokumoto YM, Apperly JA, Gao FB, Raff MC
Developmental biology245(1)224-34(2002 May)

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome.
Korshunov A, Golanov A
Archives of pathology & laboratory medicine126(1)42-8(2002 Jan)

The Pezcoller lecture: cancer cell cycles revisited.
Sherr CJ
Cancer research60(14)3689-95(2000 Jul)

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.
Schreiber M, Muller WJ, Singh G, Graham FL
Oncogene18(9)1663-76(1999 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cdkn2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cdkn2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00469	NM_131902.3 Latest version!	Rattus norvegicus cyclin-dependent kinase inhibitor 2C (Cdkn2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cdkn2c ( NM_131902.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_571977.1 Rattus norvegicus cyclin-dependent kinase inhibitor 2C (Cdkn2c), mRNA.

Price & Availability↑

CloneID	ORa00469
Clone ID Related Accession (Same CDS sequence)	NM_131902.3
Accession Version	NM_131902.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 507bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Rattus norvegicus(Norway rat)
Product	cyclin-dependent kinase 4 inhibitor C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088864.1. On Jan 12, 2005 this sequence version replaced NM_131902.2. ##Evidence-Data-START## Transcript exon combination :: BC088864.1, AF474980.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAACGCTC AAAATGGATT TGGGAGAACT 
GCGCTGCAGG TTATGAAACT TGGGAATCCG GAGATTGCCA GGAGACTTCT CCTCAGAGGT 
GCTAATCCCA ATTTGAAAGA CCGAACTGGT TTTGCTGTCA TTCACGATGC TGCCAGAGCA 
GGTTTCCTGG ACACTGTACA GGCTTTGCTG GAGTTCCAAG CTGATGTTAA CATCGAAGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCC TGTGGTGGAG 
TTCCTAATGA AGCACACAGC CTGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TTCGACTTGG CCAGGTTCTA TGGAAGAAAT GAGGTCATCA GCCTGATGGA GGCGAATGGG 
GTTGGGGGAG CCACGAGCCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571977.1
CDS	533..1039
Translation	MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPNLKDRTGFAVIHDAARAGFLDTVQALLEFQADVNIEDNEGNLPLHLAAKEGHLPVVEFLMKHTACNVGHRNHKGDTAFDLARFYGRNEVISLMEANGVGGATSLQ

Target ORF information:

RefSeq Version	NM_131902.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cyclin-dependent kinase inhibitor 2C (Cdkn2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131902.3

ORF Insert Sequence:

ATGGCCGAGC CTTGGGGGAA CGAGTTGGCG TCCGCAGCTG CCAGGGGGGA CCTAGAGCAA 
CTTACTAGTT TGTTGCAAAA TAATGTAAAC GTCAACGCTC AAAATGGATT TGGGAGAACT 
GCGCTGCAGG TTATGAAACT TGGGAATCCG GAGATTGCCA GGAGACTTCT CCTCAGAGGT 
GCTAATCCCA ATTTGAAAGA CCGAACTGGT TTTGCTGTCA TTCACGATGC TGCCAGAGCA 
GGTTTCCTGG ACACTGTACA GGCTTTGCTG GAGTTCCAAG CTGATGTTAA CATCGAAGAT 
AATGAAGGGA ACCTGCCCTT GCACTTGGCT GCCAAAGAAG GCCACCTCCC TGTGGTGGAG 
TTCCTAATGA AGCACACAGC CTGCAATGTG GGGCATCGGA ACCATAAGGG GGACACCGCC 
TTCGACTTGG CCAGGTTCTA TGGAAGAAAT GAGGTCATCA GCCTGATGGA GGCGAATGGG 
GTTGGGGGAG CCACGAGCCT GCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers.
Cancer research67(7)3162-70(2007 Apr)
Pei XH,Bai F,Smith MD,Xiong Y

Posttranscriptional regulation of p18 and p27 Cdk inhibitor proteins and the timing of oligodendrocyte differentiation.
Developmental biology245(1)224-34(2002 May)
Tokumoto YM,Apperly JA,Gao FB,Raff MC

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome.
Archives of pathology & laboratory medicine126(1)42-8(2002 Jan)
Korshunov A,Golanov A

The Pezcoller lecture: cancer cell cycles revisited.
Cancer research60(14)3689-95(2000 Jul)
Sherr CJ

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.
Oncogene18(9)1663-76(1999 Mar)
Schreiber M,Muller WJ,Singh G,Graham FL