Slc6a8 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a8
Entrez Gene ID	50690
Full Name	solute carrier family 6 member 8
Synonyms	CHOT1,CHT1,CRT,CT1
General protein information	Preferred Names solute carrier family 6 member 8 Names sodium- and chloride-dependent creatine transporter 1 choline transporter creatine transporter 1 solute carrier family 6 (neurotransmitter transporter), member 8 solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq37
Summary	high-affinity widely expressed sodium-dependent creatine transporter [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017348.2	NP_059044.1	sodium- and chloride-dependent creatine transporter 1
XM_006229611.2	XP_006229673.1	sodium- and chloride-dependent creatine transporter 1 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC6A8	XP_529227.4
Danio rerio (zebrafish)	slc6a8	XP_695932.1
Macaca mulatta (Rhesus monkey)	SLC6A8	XP_001086826.2
Xenopus tropicalis (tropical clawed frog)	LOC100489909	XP_004916750.1
Rattus norvegicus (Norway rat)	Slc6a8	NP_059044.1
Bos taurus (cattle)	SLC6A8	NP_777036.1
Mus musculus (house mouse)	Slc6a8	NP_001136281.1
Homo sapiens (human)	SLC6A8	NP_005620.1
Canis lupus familiaris (dog)	SLC6A8	XP_005642051.1

Gene Ontology
Bibliography

Related articles in PubMed

CXCL12 Regulates the Cholinergic Locus and CHT1 Through Akt Signaling Pathway.
Yan J, Zhao W, Guo M, Han X, Feng Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)982-992(2016)

Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene.
DesRoches CL, Patel J, Wang P, Minassian B, Salomons GS, Marshall CR, Mercimek-Mahmutoglu S
Gene565(2)187-91(2015 Jul)

Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ-amyloid β interactions.
Kristofikova Z, Ripova D, Hegnerová K, Sirova J, Homola J
Neurochemical research38(9)1949-59(2013 Sep)

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.
Wong AC, Velamoor S, Skelton MR, Thorne PR, Vlajkovic SM
Histochemistry and cell biology137(5)599-613(2012 May)

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
Kim DW, Yeo SI, Ryu HJ, Kim JE, Song HK, Kwon OS, Choi SY, Kang TC
BMC neuroscience11141(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Slc6a8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12376	NM_017348.2 Latest version!	Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa23045	XM_006229611.2 Latest version!	Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a8 ( NM_017348.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_059044.1 Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), mRNA.

Price & Availability↑

CloneID	ORa12376
Clone ID Related Accession (Same CDS sequence)	NM_017348.2
Accession Version	NM_017348.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1908bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569081600000
Organism	Rattus norvegicus(Norway rat)
Product	sodium- and chloride-dependent creatine transporter 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DV213900.1 and X66494.1. On Mar 15, 2007 this sequence version replaced NM_017348.1. Sequence Note: The sequence X66494.1 is chimeric. Only the Slc6a8 sequence region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC168238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END##

ATGGCGAAGA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGAGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGATGGTGCC CCGTCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCCA GCAGCCGCCT TGCTGTGCCG CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCACTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACGTGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTAGAGA TCTTTCGCCA TGAAGACTGT GCCAATGCCA GCTTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGACG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTCTCCACAG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AAGTGACCCT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATCGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC TGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTTCAAAGGG AGATCTCCGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC AGCTAGTGGC 
ACTACCCTGC TTTGGCAAGC CTTTTGGGAG TGTGTGGTGG TGGCTTGGGT TTATGGAGCT 
GACCGCTTCA TGGACGATAT TGCCTGTATG ATTGGGTACC GACCTTGCCC TTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCACTGGTC TGCATGGGCA TCTTCATCTT CAATGTTGTG 
TACTACAAGC CACTGGTCTA CAACAATACC TACGTGTACC CATGGTGGGG TGAAGCTATG 
GGCTGGGCCT TTGCACTCTC TTCTATGCTC TGTGTGCCCC TCCACCTCCT GGGCTGTCTC 
CTCAGGGCAA AAGGAACCAT GGCAGAGCGA TGGCAGCACC TGACCCAGCC TATCTGGGGC 
CTCCATCACT TGGAATACAG AGCTCAGGAT GCAGATGTCA GGGGCCTGAC CACCCTGACT 
CCCGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_059044.1
CDS	587..2494
Translation	MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPSKGDGPAGLGAPSSRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	NM_017348.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017348.2

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGAGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGATGGTGCC CCGTCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCCA GCAGCCGCCT TGCTGTGCCG CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCACTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACGTGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTAGAGA TCTTTCGCCA TGAAGACTGT GCCAATGCCA GCTTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGACG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTCTCCACAG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AAGTGACCCT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGATC 
GTGTACTTCA CTGCTACATT CCCCTACGTG GTCCTCGTTG TGCTGCTGGT GCGAGGGGTG 
CTGCTGCCTG GAGCCCTGGA TGGTATCATC TACTATCTCA AGCCTGACTG GTCAAAGCTA 
GGGTCCCCTC AGGTATGGAT AGATGCTGGG ACCCAGATTT TCTTCTCTTA TGCCATCGGC 
CTGGGGGCCC TCACAGCCCT AGGCAGCTAC AATCGCTTCA ACAACAACTG CTACAAGGAT 
GCCATCATCC TGGCACTCAT CAACAGCGGG ACCAGCTTCT TTGCTGGCTT TGTGGTCTTC 
TCCATCCTGG GCTTCATGGC CACAGAGCAG GGTGTGCATA TCTCCAAGGT GGCAGAATCA 
GGGCCTGGTC TAGCCTTCAT TGCCTACCCA CGGGCTGTCA CACTGATGCC TGTGGCCCCA 
CTCTGGGCTG CCTTGTTCTT CTTCATGCTG CTGCTGCTCG GTCTGGACAG CCAGTTTGTA 
GGTGTGGAGG GCTTCATCAC TGGGCTCCTG GATCTCCTCC CGGCCTCCTA CTACTTCCGT 
TTTCAAAGGG AGATCTCCGT GGCCCTCTGT TGTGCCCTCT GCTTTGTCAT CGATCTCTCC 
ATGGTGACTG ATGGCGGGAT GTACGTCTTC CAGCTGTTTG ACTACTACTC AGCTAGTGGC 
ACTACCCTGC TTTGGCAAGC CTTTTGGGAG TGTGTGGTGG TGGCTTGGGT TTATGGAGCT 
GACCGCTTCA TGGACGATAT TGCCTGTATG ATTGGGTACC GACCTTGCCC TTGGATGAAA 
TGGTGCTGGT CCTTCTTCAC CCCACTGGTC TGCATGGGCA TCTTCATCTT CAATGTTGTG 
TACTACAAGC CACTGGTCTA CAACAATACC TACGTGTACC CATGGTGGGG TGAAGCTATG 
GGCTGGGCCT TTGCACTCTC TTCTATGCTC TGTGTGCCCC TCCACCTCCT GGGCTGTCTC 
CTCAGGGCAA AAGGAACCAT GGCAGAGCGA TGGCAGCACC TGACCCAGCC TATCTGGGGC 
CTCCATCACT TGGAATACAG AGCTCAGGAT GCAGATGTCA GGGGCCTGAC CACCCTGACT 
CCCGTGTCCG AGAGCAGCAA GGTCGTCGTG GTGGAGAGTG TCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Slc6a8 ( XM_006229611.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229673.1 Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa23045
Clone ID Related Accession (Same CDS sequence)	XM_006229611.2
Accession Version	XM_006229611.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1773bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	sodium- and chloride-dependent creatine transporter 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229611.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGAAGA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGAGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGATGGTGCC CCGTCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCCA GCAGCCGCCT TGCTGTGCCG CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCACTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACGTGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTAGAGA TCTTTCGCCA TGAAGACTGT GCCAATGCCA GCTTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGACG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTCTCCACAG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AAGTGACCCT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGGTA 
TGGATAGATG CTGGGACCCA GATTTTCTTC TCTTATGCCA TCGGCCTGGG GGCCCTCACA 
GCCCTAGGCA GCTACAATCG CTTCAACAAC AACTGCTACA AGGATGCCAT CATCCTGGCA 
CTCATCAACA GCGGGACCAG CTTCTTTGCT GGCTTTGTGG TCTTCTCCAT CCTGGGCTTC 
ATGGCCACAG AGCAGGGTGT GCATATCTCC AAGGTGGCAG AATCAGGGCC TGGTCTAGCC 
TTCATTGCCT ACCCACGGGC TGTCACACTG ATGCCTGTGG CCCCACTCTG GGCTGCCTTG 
TTCTTCTTCA TGCTGCTGCT GCTCGGTCTG GACAGCCAGT TTGTAGGTGT GGAGGGCTTC 
ATCACTGGGC TCCTGGATCT CCTCCCGGCC TCCTACTACT TCCGTTTTCA AAGGGAGATC 
TCCGTGGCCC TCTGTTGTGC CCTCTGCTTT GTCATCGATC TCTCCATGGT GACTGATGGC 
GGGATGTACG TCTTCCAGCT GTTTGACTAC TACTCAGCTA GTGGCACTAC CCTGCTTTGG 
CAAGCCTTTT GGGAGTGTGT GGTGGTGGCT TGGGTTTATG GAGCTGACCG CTTCATGGAC 
GATATTGCCT GTATGATTGG GTACCGACCT TGCCCTTGGA TGAAATGGTG CTGGTCCTTC 
TTCACCCCAC TGGTCTGCAT GGGCATCTTC ATCTTCAATG TTGTGTACTA CAAGCCACTG 
GTCTACAACA ATACCTACGT GTACCCATGG TGGGGTGAAG CTATGGGCTG GGCCTTTGCA 
CTCTCTTCTA TGCTCTGTGT GCCCCTCCAC CTCCTGGGCT GTCTCCTCAG GGCAAAAGGA 
ACCATGGCAG AGCGATGGCA GCACCTGACC CAGCCTATCT GGGGCCTCCA TCACTTGGAA 
TACAGAGCTC AGGATGCAGA TGTCAGGGGC CTGACCACCC TGACTCCCGT GTCCGAGAGC 
AGCAAGGTCG TCGTGGTGGA GAGTGTCATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229673.1
CDS	618..2390
Translation	MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPSKGDGPAGLGAPSSRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYKPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM

Target ORF information:

RefSeq Version	XM_006229611.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 8 (Slc6a8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229611.2

ORF Insert Sequence:

ATGGCGAAGA AGAGCGCTGA AAACGGTATC TATAGCGTGT CTGGAGACGA GAAGAAGGGT 
CCTCTCATCG TGTCCGGGCC CGATGGTGCC CCGTCCAAGG GCGATGGCCC TGCGGGCCTG 
GGGGCGCCCA GCAGCCGCCT TGCTGTGCCG CCGCGAGAGA CTTGGACACG CCAGATGGAC 
TTCATCATGT CGTGCGTGGG CTTCGCCGTG GGCCTCGGTA ACGTGTGGCG CTTCCCCTAC 
CTGTGCTACA AGAACGGCGG AGGTGTGTTC CTTATTCCCT ATGTCCTGAT TGCCCTGGTT 
GGAGGAATCC CCATTTTCTT CCTGGAAATC TCACTGGGCC AGTTCATGAA GGCCGGCAGC 
ATCAATGTCT GGAACATCTG TCCCCTATTC AAAGGTCTGG GCTATGCCTC CATGGTGATT 
GTCTTCTACT GCAACACTTA CTACATCATG GTGCTGGCCT GGGGCTTCTA TTACCTGGTC 
AAGTCCTTTA CTACCACTTT GCCATGGGCT ACGTGTGGCC ACACCTGGAA CACTCCTGAC 
TGTGTAGAGA TCTTTCGCCA TGAAGACTGT GCCAATGCCA GCTTGGCCAA CCTCACATGT 
GACCAGCTTG CTGACCGACG GTCCCCTGTC ATCGAGTTCT GGGAGAACAA AGTCTTGAGG 
CTCTCCACAG GGCTGGAGGT TCCAGGAGCC CTCAACTGGG AAGTGACCCT GTGCCTGCTG 
GCCTGCTGGG TGCTGGTCTA CTTCTGTGTG TGGAAGGGGG TCAAGTCAAC AGGAAAGGTA 
TGGATAGATG CTGGGACCCA GATTTTCTTC TCTTATGCCA TCGGCCTGGG GGCCCTCACA 
GCCCTAGGCA GCTACAATCG CTTCAACAAC AACTGCTACA AGGATGCCAT CATCCTGGCA 
CTCATCAACA GCGGGACCAG CTTCTTTGCT GGCTTTGTGG TCTTCTCCAT CCTGGGCTTC 
ATGGCCACAG AGCAGGGTGT GCATATCTCC AAGGTGGCAG AATCAGGGCC TGGTCTAGCC 
TTCATTGCCT ACCCACGGGC TGTCACACTG ATGCCTGTGG CCCCACTCTG GGCTGCCTTG 
TTCTTCTTCA TGCTGCTGCT GCTCGGTCTG GACAGCCAGT TTGTAGGTGT GGAGGGCTTC 
ATCACTGGGC TCCTGGATCT CCTCCCGGCC TCCTACTACT TCCGTTTTCA AAGGGAGATC 
TCCGTGGCCC TCTGTTGTGC CCTCTGCTTT GTCATCGATC TCTCCATGGT GACTGATGGC 
GGGATGTACG TCTTCCAGCT GTTTGACTAC TACTCAGCTA GTGGCACTAC CCTGCTTTGG 
CAAGCCTTTT GGGAGTGTGT GGTGGTGGCT TGGGTTTATG GAGCTGACCG CTTCATGGAC 
GATATTGCCT GTATGATTGG GTACCGACCT TGCCCTTGGA TGAAATGGTG CTGGTCCTTC 
TTCACCCCAC TGGTCTGCAT GGGCATCTTC ATCTTCAATG TTGTGTACTA CAAGCCACTG 
GTCTACAACA ATACCTACGT GTACCCATGG TGGGGTGAAG CTATGGGCTG GGCCTTTGCA 
CTCTCTTCTA TGCTCTGTGT GCCCCTCCAC CTCCTGGGCT GTCTCCTCAG GGCAAAAGGA 
ACCATGGCAG AGCGATGGCA GCACCTGACC CAGCCTATCT GGGGCCTCCA TCACTTGGAA 
TACAGAGCTC AGGATGCAGA TGTCAGGGGC CTGACCACCC TGACTCCCGT GTCCGAGAGC 
AGCAAGGTCG TCGTGGTGGA GAGTGTCATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CXCL12 Regulates the Cholinergic Locus and CHT1 Through Akt Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology40(5)982-992(2016)
Yan J,Zhao W,Guo M,Han X,Feng Z

Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene.
Gene565(2)187-91(2015 Jul)
DesRoches CL,Patel J,Wang P,Minassian B,Salomons GS,Marshall CR,Mercimek-Mahmutoglu S

Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ-amyloid β interactions.
Neurochemical research38(9)1949-59(2013 Sep)
Kristofikova Z,Ripova D,Hegnerová K,Sirova J,Homola J

Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.
Histochemistry and cell biology137(5)599-613(2012 May)
Wong AC,Velamoor S,Skelton MR,Thorne PR,Vlajkovic SM

Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
BMC neuroscience11141(2010 Oct)
Kim DW,Yeo SI,Ryu HJ,Kim JE,Song HK,Kwon OS,Choi SY,Kang TC