Kdm1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kdm1a
Entrez Gene ID	500569
Full Name	lysine demethylase 1A
Synonyms	Aof2,Kdm1,RGD1562975
General protein information	Preferred Names lysine demethylase 1A Names lysine-specific histone demethylase 1A amine oxidase (flavin containing) domain 2 lysine (K)-specific demethylase 1 lysine (K)-specific demethylase 1A neuroprotective protein 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
NM_001130098.1	NP_001123570.1	lysine-specific histone demethylase 1A

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os08g0143400	NP_001060976.1
Neurospora crassa	NCU09120	XP_958892.1
Canis lupus familiaris (dog)	KDM1A	XP_005617878.1
Mus musculus (house mouse)	Kdm1a	NP_598633.2
Gallus gallus (chicken)	KDM1A	XP_417719.4
Danio rerio (zebrafish)	kdm1a	NP_001229924.1
Caenorhabditis elegans (roundworm)	spr-5	NP_493366.1
Caenorhabditis elegans (roundworm)	lsd-1	NP_510000.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011661	XP_320852.4
Rattus norvegicus (Norway rat)	Kdm1a	NP_001123570.1
Drosophila melanogaster (fruit fly)	Su(var)3-3	NP_649194.1
Arabidopsis thaliana (thale cress)	LDL2	NP_187981.1
Magnaporthe oryzae (rice blast fungus)	MGG_09915	XP_003710013.1
Pan troglodytes (chimpanzee)	KDM1A	XP_513190.3
Bos taurus (cattle)	KDM1A	XP_002685762.1
Xenopus tropicalis (tropical clawed frog)	kdm1a	XP_002936640.1
Homo sapiens (human)	KDM1A	NP_001009999.1
Macaca mulatta (Rhesus monkey)	KDM1A	XP_001111525.2

Gene Ontology
Bibliography

Related articles in PubMed

LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.
Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan SJ, Karmodiya K, Padmanabhan H, Shetty AS, Balaji C, Kolthur-Seetharam U, Macklis JD, Galande S, Tole S
The Journal of neuroscience : the official journal of the Society for Neuroscience37(1)194-203(2017 01)

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity.
Tsutsumi T, Iwao K, Hayashi H, Kirihara T, Kawaji T, Inoue T, Hino S, Nakao M, Tanihara H
Investigative ophthalmology & visual science57(14)6461-6473(2016 11)

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.
Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM
Genes & development30(16)1822-36(2016 08)

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
Zhang F, Xu D, Yuan L, Sun Y, Xu Z
Nature communications55815(2014 Dec)

Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.
Han X, Gui B, Xiong C, Zhao L, Liang J, Sun L, Yang X, Yu W, Si W, Yan R, Yi X, Zhang D, Li W, Li L, Yang J, Wang Y, Sun YE, Zhang D, Meng A, Shang Y
Molecular cell55(3)482-94(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kdm1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kdm1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13231	NM_001130098.1 Latest version!	Rattus norvegicus lysine demethylase 1A (Kdm1a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kdm1a ( NM_001130098.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001123570.1 Rattus norvegicus lysine demethylase 1A (Kdm1a), mRNA.

Price & Availability↑

CloneID	ORa13231
Clone ID Related Accession (Same CDS sequence)	NM_001130098.1
Accession Version	NM_001130098.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2619bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	lysine-specific histone demethylase 1A
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF688598.1. On or before Jul 18, 2008 this sequence version replaced XM_575936.2, XM_001069483.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EF688598.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTTGTCTG GGAAGAAGGC GGCGGCGGCG GCAGCGGCGG CGGCGGCAGC AGCGGCTGGG 
ACAGAGGCCG GGCCCGGGGC GGCGGGCGGC GCCGAGAACG GCTCTGAGGT GGCCGCGCCG 
CCCGCGGGCC TGGCGGGCCC CGCCGACATT GCTACGGGGG CGGCGGGCGA GCGCACTCCC 
CGAAAGAAGG AGCCTCCGCG GGCCTCGCCG CCCGGAGGCC TGGCCGAGCC GCCTGGGTCC 
GCCGGGCCTC AGGCGGGGCC CACAGCCGGG CCCGGCTCCG CTACACCCAT GGAGACAGGA 
ATAGCCGAGA CCCCGGAGGG CCGACGGACC AGCCGACGCA AGCGGGCGAA GGTAGAATAC 
AGAGAAATGG ATGAAAGCTT GGCCAACCTC TCAGAAGATG AATATTATTC AGAAGAAGAA 
AGAAATGCCA AAGCAGAGAA GGAGAAGAAG CTTCCCCCGC CACCTCCTCA AGCCCCACCT 
GAGGAGGAAA ATGAAAGTGA GCCCGAGGAG CCGTCTGGGC AAGCAGGAGG ACTTCAAGAC 
GACAGTTCTG GAGGGTATGG AGACGGCCAA GCATCAGGTG TGGAGGGTGC AGCTTTCCAA 
AGCAGACTTC CCCATGACCG AATGACCTCT CAGGAAGCAG CGTGTTTCCC AGACATCATC 
AGTGGGCCTC AGCAGACACA GAAGGTTTTT CTGTTCATCA GGAATCGCAC ATTGCAGTTA 
TGGTTGGACA ACCCAAAGAT TCAGCTGACA TTTGAAGCTA CGCTCCAGCA GTTAGAAGCA 
CCTTATAACA GTGACACTGT ACTTGTCCAC CGAGTTCATA GTTACTTAGA GCGCCACGGT 
CTTATCAACT TCGGCATCTA CAAGAGGATA AAACCTTTAC CAATTAAAAA GACAGGAAAG 
GTGATTATTA TAGGCTCAGG TGTTTCTGGC TTGGCAGCAG CTCGACAACT ACAGAGTTTT 
GGGATGGATG TCACACTTCT GGAAGCCAGG GATCGCGTAG GTGGACGGGT CGCTACATTT 
CGAAAAGGAA ACTATGTAGC TGATCTTGGA GCCATGGTAG TAACAGGTCT TGGAGGAAAT 
CCCATGGCTG TCGTCAGCAA ACAAGTAAAT ATGGAACTGG CCAAGATCAA GCAAAAATGC 
CCACTTTATG AAGCCAATGG ACAAGCTGTT CCAAAAGAGA AAGATGAAAT GGTAGAACAA 
GAATTTAACC GGTTGCTTGA AGCCACCTCT TACCTTAGTC ATCAGTTAGA CTTCAACGTC 
CTCAATAATA AACCTGTGTC CCTTGGCCAG GCGTTGGAGG TTGTCATTCA GCTACAAGAA 
AAGCACGTCA AAGATGAGCA GATTGAACAC TGGAAGAAGA TAGTGAAAAC TCAGGAGGAA 
TTGAAAGAGC TTCTCAATAA GATGGTAAAC TTGAAGGAGA AAATTAAAGA GCTCCACCAG 
CAATACAAAG AAGCTTCAGA AGTGAAGCCG CCCAGAGATA TTACAGCTGA GTTCCTAGTG 
AAAAGCAAGC ACAGGGACCT GACTGCCCTC TGCAAGGAAT ATGATGAATT AGCTGAAACA 
CAAGGAAAGC TAGAAGAAAA ACTTCAAGAA TTGGAAGCCA ATCCCCCAAG TGATGTATAT 
CTCTCATCAA GAGACAGACA AATACTTGAC TGGCATTTTG CAAATCTTGA ATTTGCCAAC 
GCCACACCTC TCTCTACCCT CTCTCTTAAA CATTGGGATC AGGATGATGA CTTCGAGTTT 
ACTGGCAGCC ACCTGACAGT GAGGAATGGC TACTCGTGTG TGCCTGTGGC TTTAGCTGAA 
GGTTTGGACA TTAAACTGAA CACAGCAGTG CGGCAGGTTC GCTACACAGC CTCAGGATGT 
GAAGTGATTG CTGTGAACAC ACGCTCCACA AGTCAGACCT TCATTTATAA GTGTGACGCA 
GTGCTCTGTA CCCTTCCTTT GGGAGTGCTG AAGCAGCAGC CACCAGCTGT TCAGTTTGTG 
CCGCCTCTTC CTGAGTGGAA AACATCCGCA GTCCAAAGGA TGGGATTTGG CAACCTTAAC 
AAGGTGGTGC TATGTTTTGA CCGTGTGTTC TGGGATCCAA GTGTCAATTT GTTTGGGCAC 
GTTGGCAGTA CAACTGCTAG CAGGGGCGAG CTCTTCCTCT TCTGGAACTT ATATAAAGCT 
CCAATACTCT TGGCTCTGGT AGCAGGCGAA GCTGCTGGCA TTATGGAGAA CATTAGTGAT 
GATGTGATTG TCGGCCGGTG CCTGGCCATT CTCAAAGGGA TTTTTGGCAG CAGTGCAGTA 
CCACAGCCCA AGGAAACTGT GGTGTCTCGT TGGCGTGCTG ATCCCTGGGC CCGGGGCTCC 
TATTCTTATG TGGCTGCAGG ATCTTCTGGA AATGACTATG ATTTAATGGC TCAGCCAATC 
ACTCCTGGTC CCTCAATTCC AGGTGCCCCA CAGCCAATTC CAAGACTCTT CTTTGCTGGA 
GAACATACAA TCCGCAACTA CCCAGCTACG GTCCATGGTG CTCTGCTGAG TGGGCTTCGA 
GAAGCAGGAA GGATTGCCGA CCAGTTTTTG GGAGCCATGT ACACGTTGCC TCGTCAGGCC 
ACACCGGGTG TCCCTGCACA GCAGTCCCCA AGTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123570.1
CDS	145..2763
Translation	MLSGKKAAAAAAAAAAAAAGTEAGPGAAGGAENGSEVAAPPAGLAGPADIATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM

Target ORF information:

RefSeq Version	NM_001130098.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lysine demethylase 1A (Kdm1a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130098.1

ORF Insert Sequence:

ATGTTGTCTG GGAAGAAGGC GGCGGCGGCG GCAGCGGCGG CGGCGGCAGC AGCGGCTGGG 
ACAGAGGCCG GGCCCGGGGC GGCGGGCGGC GCCGAGAACG GCTCTGAGGT GGCCGCGCCG 
CCCGCGGGCC TGGCGGGCCC CGCCGACATT GCTACGGGGG CGGCGGGCGA GCGCACTCCC 
CGAAAGAAGG AGCCTCCGCG GGCCTCGCCG CCCGGAGGCC TGGCCGAGCC GCCTGGGTCC 
GCCGGGCCTC AGGCGGGGCC CACAGCCGGG CCCGGCTCCG CTACACCCAT GGAGACAGGA 
ATAGCCGAGA CCCCGGAGGG CCGACGGACC AGCCGACGCA AGCGGGCGAA GGTAGAATAC 
AGAGAAATGG ATGAAAGCTT GGCCAACCTC TCAGAAGATG AATATTATTC AGAAGAAGAA 
AGAAATGCCA AAGCAGAGAA GGAGAAGAAG CTTCCCCCGC CACCTCCTCA AGCCCCACCT 
GAGGAGGAAA ATGAAAGTGA GCCCGAGGAG CCGTCTGGGC AAGCAGGAGG ACTTCAAGAC 
GACAGTTCTG GAGGGTATGG AGACGGCCAA GCATCAGGTG TGGAGGGTGC AGCTTTCCAA 
AGCAGACTTC CCCATGACCG AATGACCTCT CAGGAAGCAG CGTGTTTCCC AGACATCATC 
AGTGGGCCTC AGCAGACACA GAAGGTTTTT CTGTTCATCA GGAATCGCAC ATTGCAGTTA 
TGGTTGGACA ACCCAAAGAT TCAGCTGACA TTTGAAGCTA CGCTCCAGCA GTTAGAAGCA 
CCTTATAACA GTGACACTGT ACTTGTCCAC CGAGTTCATA GTTACTTAGA GCGCCACGGT 
CTTATCAACT TCGGCATCTA CAAGAGGATA AAACCTTTAC CAATTAAAAA GACAGGAAAG 
GTGATTATTA TAGGCTCAGG TGTTTCTGGC TTGGCAGCAG CTCGACAACT ACAGAGTTTT 
GGGATGGATG TCACACTTCT GGAAGCCAGG GATCGCGTAG GTGGACGGGT CGCTACATTT 
CGAAAAGGAA ACTATGTAGC TGATCTTGGA GCCATGGTAG TAACAGGTCT TGGAGGAAAT 
CCCATGGCTG TCGTCAGCAA ACAAGTAAAT ATGGAACTGG CCAAGATCAA GCAAAAATGC 
CCACTTTATG AAGCCAATGG ACAAGCTGTT CCAAAAGAGA AAGATGAAAT GGTAGAACAA 
GAATTTAACC GGTTGCTTGA AGCCACCTCT TACCTTAGTC ATCAGTTAGA CTTCAACGTC 
CTCAATAATA AACCTGTGTC CCTTGGCCAG GCGTTGGAGG TTGTCATTCA GCTACAAGAA 
AAGCACGTCA AAGATGAGCA GATTGAACAC TGGAAGAAGA TAGTGAAAAC TCAGGAGGAA 
TTGAAAGAGC TTCTCAATAA GATGGTAAAC TTGAAGGAGA AAATTAAAGA GCTCCACCAG 
CAATACAAAG AAGCTTCAGA AGTGAAGCCG CCCAGAGATA TTACAGCTGA GTTCCTAGTG 
AAAAGCAAGC ACAGGGACCT GACTGCCCTC TGCAAGGAAT ATGATGAATT AGCTGAAACA 
CAAGGAAAGC TAGAAGAAAA ACTTCAAGAA TTGGAAGCCA ATCCCCCAAG TGATGTATAT 
CTCTCATCAA GAGACAGACA AATACTTGAC TGGCATTTTG CAAATCTTGA ATTTGCCAAC 
GCCACACCTC TCTCTACCCT CTCTCTTAAA CATTGGGATC AGGATGATGA CTTCGAGTTT 
ACTGGCAGCC ACCTGACAGT GAGGAATGGC TACTCGTGTG TGCCTGTGGC TTTAGCTGAA 
GGTTTGGACA TTAAACTGAA CACAGCAGTG CGGCAGGTTC GCTACACAGC CTCAGGATGT 
GAAGTGATTG CTGTGAACAC ACGCTCCACA AGTCAGACCT TCATTTATAA GTGTGACGCA 
GTGCTCTGTA CCCTTCCTTT GGGAGTGCTG AAGCAGCAGC CACCAGCTGT TCAGTTTGTG 
CCGCCTCTTC CTGAGTGGAA AACATCCGCA GTCCAAAGGA TGGGATTTGG CAACCTTAAC 
AAGGTGGTGC TATGTTTTGA CCGTGTGTTC TGGGATCCAA GTGTCAATTT GTTTGGGCAC 
GTTGGCAGTA CAACTGCTAG CAGGGGCGAG CTCTTCCTCT TCTGGAACTT ATATAAAGCT 
CCAATACTCT TGGCTCTGGT AGCAGGCGAA GCTGCTGGCA TTATGGAGAA CATTAGTGAT 
GATGTGATTG TCGGCCGGTG CCTGGCCATT CTCAAAGGGA TTTTTGGCAG CAGTGCAGTA 
CCACAGCCCA AGGAAACTGT GGTGTCTCGT TGGCGTGCTG ATCCCTGGGC CCGGGGCTCC 
TATTCTTATG TGGCTGCAGG ATCTTCTGGA AATGACTATG ATTTAATGGC TCAGCCAATC 
ACTCCTGGTC CCTCAATTCC AGGTGCCCCA CAGCCAATTC CAAGACTCTT CTTTGCTGGA 
GAACATACAA TCCGCAACTA CCCAGCTACG GTCCATGGTG CTCTGCTGAG TGGGCTTCGA 
GAAGCAGGAA GGATTGCCGA CCAGTTTTTG GGAGCCATGT ACACGTTGCC TCGTCAGGCC 
ACACCGGGTG TCCCTGCACA GCAGTCCCCA AGTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(1)194-203(2017 01)
Muralidharan B,Khatri Z,Maheshwari U,Gupta R,Roy B,Pradhan SJ,Karmodiya K,Padmanabhan H,Shetty AS,Balaji C,Kolthur-Seetharam U,Macklis JD,Galande S,Tole S

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity.
Investigative ophthalmology & visual science57(14)6461-6473(2016 11)
Tsutsumi T,Iwao K,Hayashi H,Kirihara T,Kawaji T,Inoue T,Hino S,Nakao M,Tanihara H

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.
Genes & development30(16)1822-36(2016 08)
Zeng X,Jedrychowski MP,Chen Y,Serag S,Lavery GG,Gygi SP,Spiegelman BM

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance.
Nature communications55815(2014 Dec)
Zhang F,Xu D,Yuan L,Sun Y,Xu Z

Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development.
Molecular cell55(3)482-94(2014 Aug)
Han X,Gui B,Xiong C,Zhao L,Liang J,Sun L,Yang X,Yu W,Si W,Yan R,Yi X,Zhang D,Li W,Li L,Yang J,Wang Y,Sun YE,Zhang D,Meng A,Shang Y

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Kdm1a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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