| Gene Symbol | Tdp2 |
| Entrez Gene ID | 498749 |
| Full Name | tyrosyl-DNA phosphodiesterase 2 |
| Synonyms | Ttrap |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Tdp2 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Tdp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tdp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa09118 Clone ID Related Accession (Same CDS sequence) NM_001034947.1 Accession Version NM_001034947.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1559750400000 Organism Rattus norvegicus(Norway rat) Product tyrosyl-DNA phosphodiesterase 2 Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC101920.1. On Oct 21, 2005 this sequence version replaced XM_574028.1. ##Evidence-Data-START## Transcript exon combination :: BC101920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCGTCTG GCAGCAGTTC CGATGCGGCG GAGTCGGCAG AGCCGGCGGC GGCGCCCGCA
GCAGCAGAGA CGGAGGAGGA TCAGGTGAAG AGGCGGCGGC TTCAGTCCCT GGGATTTGCG
TTGGTGACGA GCTGCGACAC TACGGTGGCT TCCACTTTCC TGTCGGAGAA CAACTGGCAG
ACGAAAAAAG CGTTGAGCGC CTTCTTCGAG CAGCCAGAGA ACGACCTAGC GCGGCCTCAC
CAGCCTCCGA CATCCTCCAA GTCCGAGGAC TATGTTGATC TAACCAATGA GGATGCAAAT
GATACCACCA TTTTAGAAAC CAGTCCATCT GGAACTCCTC TAGAAGATAG CAGCACTATC
TCTTTCATTA CCTGGAATAT TGATGGATTA GATGGATGCA ATCTCCCAGA GAGGGCTCGA
GGGGTGTGTT CCTGCCTTGC TTTGTACAGT CCGGACGTGG TATTTCTACA GGAAGTGATT
CCCTCCTACT GTGCCTACCT AAGGAAGAGA GCACGCACTT ACAACATTAT TACAGGTAAT
GAAGAAGGAT ATTTCACAGC TATATTATTG AAGAAAGGAA GAGTGAAATT TAAAGGTCAA
GAAATTATTC CTTTTCCAAA TACCAAAATG ATGAGAAACC TTCTGTGTGT AAATGTGAGT
TTGGGTGGAA ATGAATTTTG CCTTATGACA TCCCATTTGG AGAGCACAAG AAAACATTCT
GCTGAACGAA TAAATCAATT AAAAACTGTT TTTCAAAAAA TGCAAGAGGC TACAGATTCA
ACTACTGTTA TATTTGCAGG AGATACAAAT TTAAGAGATC AAGAAGTTAT CAAATGTGGT
GGTTTACCTG ACAATGTTTT TGATGCCTGG GAATTTTTGG GCAAACCTAA GCATTGCCGG
TATACATGGG ATACGAAAGC AAACGATAAT CTCAGGATTC CTGCCGCTTG TAAGCATCGT
TTTGATCGAA TATTCTTCAG AGCAGAAGAG GGACACCTTA TTCCCCAAAG TTTAGACCTA
ATTGGGTTGG AAAGACTGGA CTGTGGTAGA TTTCCTAGTG ATCACTGGGG GCTCCTGTGT
ACCTTGAATG TAGTATTGTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001030119.1 CDS 70..1170 Translation 
Target ORF information:
RefSeq Version NM_001034947.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus tyrosyl-DNA phosphodiesterase 2 (Tdp2), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001034947.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081ATGGCGTCTG GCAGCAGTTC CGATGCGGCG GAGTCGGCAG AGCCGGCGGC GGCGCCCGCA
GCAGCAGAGA CGGAGGAGGA TCAGGTGAAG AGGCGGCGGC TTCAGTCCCT GGGATTTGCG
TTGGTGACGA GCTGCGACAC TACGGTGGCT TCCACTTTCC TGTCGGAGAA CAACTGGCAG
ACGAAAAAAG CGTTGAGCGC CTTCTTCGAG CAGCCAGAGA ACGACCTAGC GCGGCCTCAC
CAGCCTCCGA CATCCTCCAA GTCCGAGGAC TATGTTGATC TAACCAATGA GGATGCAAAT
GATACCACCA TTTTAGAAAC CAGTCCATCT GGAACTCCTC TAGAAGATAG CAGCACTATC
TCTTTCATTA CCTGGAATAT TGATGGATTA GATGGATGCA ATCTCCCAGA GAGGGCTCGA
GGGGTGTGTT CCTGCCTTGC TTTGTACAGT CCGGACGTGG TATTTCTACA GGAAGTGATT
CCCTCCTACT GTGCCTACCT AAGGAAGAGA GCACGCACTT ACAACATTAT TACAGGTAAT
GAAGAAGGAT ATTTCACAGC TATATTATTG AAGAAAGGAA GAGTGAAATT TAAAGGTCAA
GAAATTATTC CTTTTCCAAA TACCAAAATG ATGAGAAACC TTCTGTGTGT AAATGTGAGT
TTGGGTGGAA ATGAATTTTG CCTTATGACA TCCCATTTGG AGAGCACAAG AAAACATTCT
GCTGAACGAA TAAATCAATT AAAAACTGTT TTTCAAAAAA TGCAAGAGGC TACAGATTCA
ACTACTGTTA TATTTGCAGG AGATACAAAT TTAAGAGATC AAGAAGTTAT CAAATGTGGT
GGTTTACCTG ACAATGTTTT TGATGCCTGG GAATTTTTGG GCAAACCTAA GCATTGCCGG
TATACATGGG ATACGAAAGC AAACGATAAT CTCAGGATTC CTGCCGCTTG TAAGCATCGT
TTTGATCGAA TATTCTTCAG AGCAGAAGAG GGACACCTTA TTCCCCAAAG TTTAGACCTA
ATTGGGTTGG AAAGACTGGA CTGTGGTAGA TTTCCTAGTG ATCACTGGGG GCTCCTGTGT
ACCTTGAATG TAGTATTGTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
Nature genetics46(5)516-21(2014 May)
Gómez-Herreros F,Schuurs-Hoeijmakers JH,McCormack M,Greally MT,Rulten S,Romero-Granados R,Counihan TJ,Chaila E,Conroy J,Ennis S,Delanty N,Cortés-Ledesma F,de Brouwer AP,Cavalleri GL,El-Khamisy SF,de Vries BB,Caldecott KW
An RNA virus hijacks an incognito function of a DNA repair enzyme.
Proceedings of the National Academy of Sciences of the United States of America109(36)14634-9(2012 Sep)
Virgen-Slane R,Rozovics JM,Fitzgerald KD,Ngo T,Chou W,van der Heden van Noort GJ,Filippov DV,Gershon PD,Semler BL
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
The Journal of biological chemistry287(36)30842-52(2012 Aug)
Gao R,Huang SY,Marchand C,Pommier Y
Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction.
BMC research notes5134(2012 Mar)
Adhikari S,Karmahapatra SK,Karve TM,Bandyopadhyay S,Woodrick J,Manthena PV,Glasgow E,Byers S,Saha T,Uren A
TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
The Journal of biological chemistry286(1)403-9(2011 Jan)
Zeng Z,Cortés-Ledesma F,El Khamisy SF,Caldecott KW
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