Dtx3l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dtx3l
Entrez Gene ID	498089
Full Name	deltex E3 ubiquitin ligase 3L
Synonyms	RGD1565144
General protein information	Preferred Names deltex E3 ubiquitin ligase 3L Names E3 ubiquitin-protein ligase DTX3L deltex 3 like, E3 ubiquitin ligase deltex 3-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001109053.1	NP_001102523.1	E3 ubiquitin-protein ligase DTX3L
XM_017598167.1	XP_017453656.1	E3 ubiquitin-protein ligase DTX3L isoform X1
XM_006248414.3	XP_006248476.1	E3 ubiquitin-protein ligase DTX3L isoform X2

Pathways from BioSystems

Homologies

Homo sapiens (human)	DTX3L	NP_612144.1
Pan troglodytes (chimpanzee)	DTX3L	XP_526285.1
Mus musculus (house mouse)	Dtx3l	NP_001013389.2
Canis lupus familiaris (dog)	DTX3L	XP_535762.2
Rattus norvegicus (Norway rat)	Dtx3l	NP_001102523.1
Bos taurus (cattle)	DTX3L	NP_001179325.1
Macaca mulatta (Rhesus monkey)	DTX3L	XP_001112746.1
Gallus gallus (chicken)	DTX3L	XP_422114.4

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.
Yang CS, Jividen K, Spencer A, Dworak N, Ni L, Oostdyk LT, Chatterjee M, Kuśmider B, Reon B, Parlak M, Gorbunova V, Abbas T, Jeffery E, Sherman NE, Paschal BM
Molecular cell66(4)503-516.e5(2017 May)

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Zhang Y, Mao D, Roswit WT, Jin X, Patel AC, Patel DA, Agapov E, Wang Z, Tidwell RM, Atkinson JJ, Huang G, McCarthy R, Yu J, Yun NE, Paessler S, Lawson TG, Omattage NS, Brett TJ, Holtzman MJ
Nature immunology16(12)1215-27(2015 Dec)

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Holleman J, Marchese A
Molecular biology of the cell25(12)1892-904(2014 Jun)

BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.
Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J, Shipp MA
Molecular and cellular biology33(4)845-57(2013 Feb)

BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.
Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP, Shipp MA
Molecular cell36(1)110-20(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dtx3l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dtx3l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13829	NM_001109053.1 Latest version!	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa34317	XM_006248414.3 Latest version!	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa57741	XM_017598167.1 Latest version!	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dtx3l ( NM_001109053.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102523.1 Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), mRNA.

Price & Availability↑

CloneID	ORa13829
Clone ID Related Accession (Same CDS sequence)	NM_001109053.1
Accession Version	NM_001109053.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2256bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase DTX3L
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473967.1. On or before Oct 4, 2007 this sequence version replaced XM_573295.2, XM_001071264.1. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGAACTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACATCCC AGTGATGGGC CCGTTTTTAA CTCTGTTGAC 
TCAGTTGTCC AAAAGGTCTT TCTCGCTGTG ACCGCTGAGC TGAACTGTGA ACTGCTCTCC 
AAAGAGCAGA GAGCACAGAT TACTGCTGTC TGCCCTCATA TCAAAAGCAT GGAGGGCAGT 
GACGGAATTA AGAAGGTGTG TGGCAACTTC AAAGATATTG AAAAGATACA TCACTTCCTG 
AGTTCGCAGC TTTTGGAAAG TGAGCCGACA CGAAAGTACG TCCCACAGAA ATACACACCT 
TCCGATGTGG AGAGGGAGCC CCCCAGTCAG AGAAGTTTTG AAGTTTCTGT GCTTTTCCTT 
GAATATTTCA AACATATTTA TCCGGGTAGA ATAGAATCCA TAGAGAAAAA ATTTGGTGTA 
AACATCAAAA TCCAAGATAG TTCTCCGTAT ATGGTCTCTA TAGGCTTCAC CTCCAGACAA 
TCAGGCAACT TAGAAGAAGC TTGTCAGTCT TTTGTCAGAG ACTTTCAGAA ATGCACGCAG 
TCTCTGAAGC AAGATTGTAT CTCTTTAGAG GACCAACAGA GAGCAAAGAA GGTCAGGCAG 
GAGCTGAGTC GCTGCTTCCC AAAGCTCTTG ATAAAGGAAC AGGGAAGGAT GCTAACTCTC 
CTGGGCTCTG CTGCTGACAT TGCAGCTGCC GCAGAAAAAG TCTCCCAAAC TCTTGTCCCA 
GCACCTGTGA AAATAGTAGC CACACCTGTG AAAATAGCCA CACCTGTGAA AATAGCCACG 
TCTGGGTACA TGACAGGGAT CGAGGTCGAT TCGACCCGCT TTAAGCTTCT AGAACCTGAG 
CTGCTCCAGG AAATCGCAGA GATCGAGCAG AAGTTTAACA CTTGTGGCAA AGTCCAGGAA 
AAAGGCCAGA AAACCTGCAT TCTCTTTGTC CCCAAGGATA AAGAGTTAGA CCTGTCTGTG 
CAATCTTACA CAAGTTTTAC TGAGGCCTTC CAGCATGCCA CGTGCCAGTT GAGGACAGAA 
GTTCTGTCGC TGAAACAGCT GGGCAAGGAG AAAGCTCAAT TGCACAAGAC CAAGTTTGCT 
GACGACTTTA AAATAAAACA CCCAAACGTG CACTTCGTGA TATCTCAAGA GTCAGTGACC 
TTGACTGGTT TGCCCAATCA CCTTGGGCAG GCAATGCAGT ATGTTGCCAA AAGGATAGGA 
ATGCCCACGT TGTTGTCGTC TGGAGAGAAA TTGGCTATGG ATCATGAAAC GCCCATGGAG 
GTCCACAGGA ATGACTCAGA TGTGGCGTTA CTTTCTTTCG GAAGCTCTGC TAGCAGCCCT 
ACGGCCTCGA AGGGGAACAA GGACGAGGAC AACTGCGTCA TCTGCATGGA CACCATCAGG 
AACAAGCAGG TGCTCCCTAA GTGCAAGCAT GAATTCTGCT CCTCTTGTAT CAGCAAAGCC 
ATGTCATTCA AGCCTGTCTG TCCTGTGTGT CTGACTCCCT ACGGTGTCCA GAAAGGGAAC 
CAGCCAGAGG GAACCATGGC TCACACCATT CAAAAAGACT CACTTCCGGG TTATGAAGGC 
TGCGGGACTA TTGTGATTCA GTACAGTTTT GGAGATGGCA TACAAACAAA GGAGCACCCA 
AACCCAGGAA AAGCTTACTC TGGAACTTAT CGGGTTGCAT ATTTGCCTGA TAATGCGGAG 
GGGAGAAAGG TTTTGCATCT GCTCCGAAAA GCCTTTGATC AGAAGCTGAT TTTCACAGTA 
GGAGAATCTC GGGTATTAGG AATCTCGAAT GTCATTACAT GGAATGATAT TCATCACAAA 
ACAGCCAAGT TTGGAGGACC ATCAAATTTC GGCTACCCTG ATCCTGATTA CCTGAAACGT 
GTCAAGGAGG AGCTGAAATC AAAAGGGATC GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102523.1
CDS	115..2370
Translation	MASSPDPPSPLLVRLPESIPRAHMKLEIYFQSRASGGGECSVHPVGPGAPDTFEVKFLEKADKENVLKRGKHKLLVDDKSVPIVLETIKKPEEDLRPRPPSLTQPAETPSSRTPSLTESLDEALGDKIHPSDGPVFNSVDSVVQKVFLAVTAELNCELLSKEQRAQITAVCPHIKSMEGSDGIKKVCGNFKDIEKIHHFLSSQLLESEPTRKYVPQKYTPSDVEREPPSQRSFEVSVLFLEYFKHIYPGRIESIEKKFGVNIKIQDSSPYMVSIGFTSRQSGNLEEACQSFVRDFQKCTQSLKQDCISLEDQQRAKKVRQELSRCFPKLLIKEQGRMLTLLGSAADIAAAAEKVSQTLVPAPVKIVATPVKIATPVKIATSGYMTGIEVDSTRFKLLEPELLQEIAEIEQKFNTCGKVQEKGQKTCILFVPKDKELDLSVQSYTSFTEAFQHATCQLRTEVLSLKQLGKEKAQLHKTKFADDFKIKHPNVHFVISQESVTLTGLPNHLGQAMQYVAKRIGMPTLLSSGEKLAMDHETPMEVHRNDSDVALLSFGSSASSPTASKGNKDEDNCVICMDTIRNKQVLPKCKHEFCSSCISKAMSFKPVCPVCLTPYGVQKGNQPEGTMAHTIQKDSLPGYEGCGTIVIQYSFGDGIQTKEHPNPGKAYSGTYRVAYLPDNAEGRKVLHLLRKAFDQKLIFTVGESRVLGISNVITWNDIHHKTAKFGGPSNFGYPDPDYLKRVKEELKSKGIE

Target ORF information:

RefSeq Version	NM_001109053.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001109053.1

ORF Insert Sequence:

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGAACTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACATCCC AGTGATGGGC CCGTTTTTAA CTCTGTTGAC 
TCAGTTGTCC AAAAGGTCTT TCTCGCTGTG ACCGCTGAGC TGAACTGTGA ACTGCTCTCC 
AAAGAGCAGA GAGCACAGAT TACTGCTGTC TGCCCTCATA TCAAAAGCAT GGAGGGCAGT 
GACGGAATTA AGAAGGTGTG TGGCAACTTC AAAGATATTG AAAAGATACA TCACTTCCTG 
AGTTCGCAGC TTTTGGAAAG TGAGCCGACA CGAAAGTACG TCCCACAGAA ATACACACCT 
TCCGATGTGG AGAGGGAGCC CCCCAGTCAG AGAAGTTTTG AAGTTTCTGT GCTTTTCCTT 
GAATATTTCA AACATATTTA TCCGGGTAGA ATAGAATCCA TAGAGAAAAA ATTTGGTGTA 
AACATCAAAA TCCAAGATAG TTCTCCGTAT ATGGTCTCTA TAGGCTTCAC CTCCAGACAA 
TCAGGCAACT TAGAAGAAGC TTGTCAGTCT TTTGTCAGAG ACTTTCAGAA ATGCACGCAG 
TCTCTGAAGC AAGATTGTAT CTCTTTAGAG GACCAACAGA GAGCAAAGAA GGTCAGGCAG 
GAGCTGAGTC GCTGCTTCCC AAAGCTCTTG ATAAAGGAAC AGGGAAGGAT GCTAACTCTC 
CTGGGCTCTG CTGCTGACAT TGCAGCTGCC GCAGAAAAAG TCTCCCAAAC TCTTGTCCCA 
GCACCTGTGA AAATAGTAGC CACACCTGTG AAAATAGCCA CACCTGTGAA AATAGCCACG 
TCTGGGTACA TGACAGGGAT CGAGGTCGAT TCGACCCGCT TTAAGCTTCT AGAACCTGAG 
CTGCTCCAGG AAATCGCAGA GATCGAGCAG AAGTTTAACA CTTGTGGCAA AGTCCAGGAA 
AAAGGCCAGA AAACCTGCAT TCTCTTTGTC CCCAAGGATA AAGAGTTAGA CCTGTCTGTG 
CAATCTTACA CAAGTTTTAC TGAGGCCTTC CAGCATGCCA CGTGCCAGTT GAGGACAGAA 
GTTCTGTCGC TGAAACAGCT GGGCAAGGAG AAAGCTCAAT TGCACAAGAC CAAGTTTGCT 
GACGACTTTA AAATAAAACA CCCAAACGTG CACTTCGTGA TATCTCAAGA GTCAGTGACC 
TTGACTGGTT TGCCCAATCA CCTTGGGCAG GCAATGCAGT ATGTTGCCAA AAGGATAGGA 
ATGCCCACGT TGTTGTCGTC TGGAGAGAAA TTGGCTATGG ATCATGAAAC GCCCATGGAG 
GTCCACAGGA ATGACTCAGA TGTGGCGTTA CTTTCTTTCG GAAGCTCTGC TAGCAGCCCT 
ACGGCCTCGA AGGGGAACAA GGACGAGGAC AACTGCGTCA TCTGCATGGA CACCATCAGG 
AACAAGCAGG TGCTCCCTAA GTGCAAGCAT GAATTCTGCT CCTCTTGTAT CAGCAAAGCC 
ATGTCATTCA AGCCTGTCTG TCCTGTGTGT CTGACTCCCT ACGGTGTCCA GAAAGGGAAC 
CAGCCAGAGG GAACCATGGC TCACACCATT CAAAAAGACT CACTTCCGGG TTATGAAGGC 
TGCGGGACTA TTGTGATTCA GTACAGTTTT GGAGATGGCA TACAAACAAA GGAGCACCCA 
AACCCAGGAA AAGCTTACTC TGGAACTTAT CGGGTTGCAT ATTTGCCTGA TAATGCGGAG 
GGGAGAAAGG TTTTGCATCT GCTCCGAAAA GCCTTTGATC AGAAGCTGAT TTTCACAGTA 
GGAGAATCTC GGGTATTAGG AATCTCGAAT GTCATTACAT GGAATGATAT TCATCACAAA 
ACAGCCAAGT TTGGAGGACC ATCAAATTTC GGCTACCCTG ATCCTGATTA CCTGAAACGT 
GTCAAGGAGG AGCTGAAATC AAAAGGGATC GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dtx3l ( XM_006248414.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006248476.1 Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa34317
Clone ID Related Accession (Same CDS sequence)	XM_006248414.3
Accession Version	XM_006248414.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1980bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase DTX3L isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006248414.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGACCTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACCCAGT GATGGGCCCG TTTTTAACTC TGTTGACTCA 
GTTGTCCAAA AGGTCTTTCT CGCTGTGACC GCTGAGCTGA ACTGTGAACT GCTCTCCAAA 
GAGCAGAGAG CACAGATTAC TGCTGTCTGC CCTCATATCA AAAGCATGGA GGGCAGTGAC 
GGAATTAAGA AGGTGTGTGG CAACTTCAAA GATATTGAAA AGATACATCA CTTCCTGAGT 
TCGCAGCTTT TGGAAAGTGA GCCGACACGA AAGTACGTCC CACAGAAATA CACACCTTCC 
GATGTGGAGA GGGAGCCCCC CAGTCAGAGA AGTTTTGAAG TTTCTGTGCT TTTCCTTGAA 
TATTTCAAAC ATATTTATCC GGGTAGAATA GAATCCATAG AGAAAAAATT TGGTGTAAAC 
ATCAAAATCC AAGATAGTTC TCCGTATATG GTCTCTATAG GCTTCACCTC CAGACAATCA 
GGCAACTTAG AAGAAGCTTG TCAGTCTTTT GTCAGAGACT TTCAGAAATG CACGCAGTCT 
CTGAAGCAAG ATTGTATCTC TTTAGAGGAC CAACAGAGAG CAAAGAAGGT CAGGCAGGAG 
CTGAGTCGCT GCTTCCCAAA GCTCTTGATA AAGGAACAGG GAAGGATGCT AACTCTCCTG 
GGCTCTGCTG CTGACATTGC AGCTGCCGCA GAAAAAGTCT CCCAAACTCT TGTCCCAGCA 
CCTGTGAAAA TAGTAGCCAC ACCTGTGAAA ATAGCCACAC CTGTGAAAAT AGCCACGTCT 
GGGTACATGA CAGGGATCGA GGTCGATTCG ACCCGCTTTA AGCTTCTAGA ACCTGAGCTG 
CTCCAGGAAA TCGCAGAGAT CGAGCAGAAG TTTAACACTT GTGGCAAAGT CCAGGAAAAA 
GGCCAGAAAA CCTGCATTCT CTTTGTCCCC AAGGATAAAG AGTTAGACCT GTCTGTGCAA 
TCTTACACAA GTTTTACTGA GGCCTTCCAG CATGCCACGT GCCAGTTGAG GACAGAAGTT 
CTGTCGCTGA AACAGCTGGG CAAGGAGAAA GCTCAATTGC ACAAGACCAA GTTTGCTGAC 
GACTTTAAAA TAAAACACCC AAACGTGCAC TTCGTGATAT CTCAAGAGTC AGTGACCTTG 
ACTGGTTTGC CCAATCACCT TGGGCAGGCA ATGCAGTATG TTGCCAAAAG GATAGGAATG 
CCCACGTTGT TGTCGTCTGG AGAGAAATTG GCTATGGATC ATGAAACGCC CATGGAGGTC 
CACAGGAATG ACTCAGATGT GGCGTTACTT TCTTTCGGAA GCTCTGCTAG CAGCCCTACG 
GCCTCGAAGG GGAACAAGGA CGAGGACAAC TGCGTCATCT GCATGGACAC CATCAGGAAC 
AAGCAGGTGC TCCCTAAGTG CAAGCATGAA TTCTGCTCCT CTTGTATCAG CAAAGCCATG 
TCATTCAAGC CTGTCTGTCC TGTGTGTCTG ACTCCCTACG GTGTCCAGAA AGGGAACCAG 
CCAGAGGGAA CCATGGCTCA CACCATTCAA AAAGACTCAC TTCCGGGTTA TGAAGGCTGC 
GGGACTATTG TGATTCAGTA CAGTTTTGGA GATGGCATAC AAACATTTCG GCTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006248476.1
CDS	33..2012
Translation	MASSPDPPSPLLVRLPESIPRAHMKLEIYFQSRASGGGECSVHPVGPGAPDTFEVKFLEKADKENVLKRGKHKLLVDDKSVPIVLETIKKPEEDLRPRPPSLTQPAETPSSRPPSLTESLDEALGDKIPSDGPVFNSVDSVVQKVFLAVTAELNCELLSKEQRAQITAVCPHIKSMEGSDGIKKVCGNFKDIEKIHHFLSSQLLESEPTRKYVPQKYTPSDVEREPPSQRSFEVSVLFLEYFKHIYPGRIESIEKKFGVNIKIQDSSPYMVSIGFTSRQSGNLEEACQSFVRDFQKCTQSLKQDCISLEDQQRAKKVRQELSRCFPKLLIKEQGRMLTLLGSAADIAAAAEKVSQTLVPAPVKIVATPVKIATPVKIATSGYMTGIEVDSTRFKLLEPELLQEIAEIEQKFNTCGKVQEKGQKTCILFVPKDKELDLSVQSYTSFTEAFQHATCQLRTEVLSLKQLGKEKAQLHKTKFADDFKIKHPNVHFVISQESVTLTGLPNHLGQAMQYVAKRIGMPTLLSSGEKLAMDHETPMEVHRNDSDVALLSFGSSASSPTASKGNKDEDNCVICMDTIRNKQVLPKCKHEFCSSCISKAMSFKPVCPVCLTPYGVQKGNQPEGTMAHTIQKDSLPGYEGCGTIVIQYSFGDGIQTFRLP

Target ORF information:

RefSeq Version	XM_006248414.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006248414.3

ORF Insert Sequence:

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGACCTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACCCAGT GATGGGCCCG TTTTTAACTC TGTTGACTCA 
GTTGTCCAAA AGGTCTTTCT CGCTGTGACC GCTGAGCTGA ACTGTGAACT GCTCTCCAAA 
GAGCAGAGAG CACAGATTAC TGCTGTCTGC CCTCATATCA AAAGCATGGA GGGCAGTGAC 
GGAATTAAGA AGGTGTGTGG CAACTTCAAA GATATTGAAA AGATACATCA CTTCCTGAGT 
TCGCAGCTTT TGGAAAGTGA GCCGACACGA AAGTACGTCC CACAGAAATA CACACCTTCC 
GATGTGGAGA GGGAGCCCCC CAGTCAGAGA AGTTTTGAAG TTTCTGTGCT TTTCCTTGAA 
TATTTCAAAC ATATTTATCC GGGTAGAATA GAATCCATAG AGAAAAAATT TGGTGTAAAC 
ATCAAAATCC AAGATAGTTC TCCGTATATG GTCTCTATAG GCTTCACCTC CAGACAATCA 
GGCAACTTAG AAGAAGCTTG TCAGTCTTTT GTCAGAGACT TTCAGAAATG CACGCAGTCT 
CTGAAGCAAG ATTGTATCTC TTTAGAGGAC CAACAGAGAG CAAAGAAGGT CAGGCAGGAG 
CTGAGTCGCT GCTTCCCAAA GCTCTTGATA AAGGAACAGG GAAGGATGCT AACTCTCCTG 
GGCTCTGCTG CTGACATTGC AGCTGCCGCA GAAAAAGTCT CCCAAACTCT TGTCCCAGCA 
CCTGTGAAAA TAGTAGCCAC ACCTGTGAAA ATAGCCACAC CTGTGAAAAT AGCCACGTCT 
GGGTACATGA CAGGGATCGA GGTCGATTCG ACCCGCTTTA AGCTTCTAGA ACCTGAGCTG 
CTCCAGGAAA TCGCAGAGAT CGAGCAGAAG TTTAACACTT GTGGCAAAGT CCAGGAAAAA 
GGCCAGAAAA CCTGCATTCT CTTTGTCCCC AAGGATAAAG AGTTAGACCT GTCTGTGCAA 
TCTTACACAA GTTTTACTGA GGCCTTCCAG CATGCCACGT GCCAGTTGAG GACAGAAGTT 
CTGTCGCTGA AACAGCTGGG CAAGGAGAAA GCTCAATTGC ACAAGACCAA GTTTGCTGAC 
GACTTTAAAA TAAAACACCC AAACGTGCAC TTCGTGATAT CTCAAGAGTC AGTGACCTTG 
ACTGGTTTGC CCAATCACCT TGGGCAGGCA ATGCAGTATG TTGCCAAAAG GATAGGAATG 
CCCACGTTGT TGTCGTCTGG AGAGAAATTG GCTATGGATC ATGAAACGCC CATGGAGGTC 
CACAGGAATG ACTCAGATGT GGCGTTACTT TCTTTCGGAA GCTCTGCTAG CAGCCCTACG 
GCCTCGAAGG GGAACAAGGA CGAGGACAAC TGCGTCATCT GCATGGACAC CATCAGGAAC 
AAGCAGGTGC TCCCTAAGTG CAAGCATGAA TTCTGCTCCT CTTGTATCAG CAAAGCCATG 
TCATTCAAGC CTGTCTGTCC TGTGTGTCTG ACTCCCTACG GTGTCCAGAA AGGGAACCAG 
CCAGAGGGAA CCATGGCTCA CACCATTCAA AAAGACTCAC TTCCGGGTTA TGAAGGCTGC 
GGGACTATTG TGATTCAGTA CAGTTTTGGA GATGGCATAC AAACATTTCG GCTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dtx3l ( XM_017598167.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017453656.1 Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa57741
Clone ID Related Accession (Same CDS sequence)	XM_017598167.1
Accession Version	XM_017598167.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2253bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase DTX3L isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005110.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGACCTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACCCAGT GATGGGCCCG TTTTTAACTC TGTTGACTCA 
GTTGTCCAAA AGGTCTTTCT CGCTGTGACC GCTGAGCTGA ACTGTGAACT GCTCTCCAAA 
GAGCAGAGAG CACAGATTAC TGCTGTCTGC CCTCATATCA AAAGCATGGA GGGCAGTGAC 
GGAATTAAGA AGGTGTGTGG CAACTTCAAA GATATTGAAA AGATACATCA CTTCCTGAGT 
TCGCAGCTTT TGGAAAGTGA GCCGACACGA AAGTACGTCC CACAGAAATA CACACCTTCC 
GATGTGGAGA GGGAGCCCCC CAGTCAGAGA AGTTTTGAAG TTTCTGTGCT TTTCCTTGAA 
TATTTCAAAC ATATTTATCC GGGTAGAATA GAATCCATAG AGAAAAAATT TGGTGTAAAC 
ATCAAAATCC AAGATAGTTC TCCGTATATG GTCTCTATAG GCTTCACCTC CAGACAATCA 
GGCAACTTAG AAGAAGCTTG TCAGTCTTTT GTCAGAGACT TTCAGAAATG CACGCAGTCT 
CTGAAGCAAG ATTGTATCTC TTTAGAGGAC CAACAGAGAG CAAAGAAGGT CAGGCAGGAG 
CTGAGTCGCT GCTTCCCAAA GCTCTTGATA AAGGAACAGG GAAGGATGCT AACTCTCCTG 
GGCTCTGCTG CTGACATTGC AGCTGCCGCA GAAAAAGTCT CCCAAACTCT TGTCCCAGCA 
CCTGTGAAAA TAGTAGCCAC ACCTGTGAAA ATAGCCACAC CTGTGAAAAT AGCCACGTCT 
GGGTACATGA CAGGGATCGA GGTCGATTCG ACCCGCTTTA AGCTTCTAGA ACCTGAGCTG 
CTCCAGGAAA TCGCAGAGAT CGAGCAGAAG TTTAACACTT GTGGCAAAGT CCAGGAAAAA 
GGCCAGAAAA CCTGCATTCT CTTTGTCCCC AAGGATAAAG AGTTAGACCT GTCTGTGCAA 
TCTTACACAA GTTTTACTGA GGCCTTCCAG CATGCCACGT GCCAGTTGAG GACAGAAGTT 
CTGTCGCTGA AACAGCTGGG CAAGGAGAAA GCTCAATTGC ACAAGACCAA GTTTGCTGAC 
GACTTTAAAA TAAAACACCC AAACGTGCAC TTCGTGATAT CTCAAGAGTC AGTGACCTTG 
ACTGGTTTGC CCAATCACCT TGGGCAGGCA ATGCAGTATG TTGCCAAAAG GATAGGAATG 
CCCACGTTGT TGTCGTCTGG AGAGAAATTG GCTATGGATC ATGAAACGCC CATGGAGGTC 
CACAGGAATG ACTCAGATGT GGCGTTACTT TCTTTCGGAA GCTCTGCTAG CAGCCCTACG 
GCCTCGAAGG GGAACAAGGA CGAGGACAAC TGCGTCATCT GCATGGACAC CATCAGGAAC 
AAGCAGGTGC TCCCTAAGTG CAAGCATGAA TTCTGCTCCT CTTGTATCAG CAAAGCCATG 
TCATTCAAGC CTGTCTGTCC TGTGTGTCTG ACTCCCTACG GTGTCCAGAA AGGGAACCAG 
CCAGAGGGAA CCATGGCTCA CACCATTCAA AAAGACTCAC TTCCGGGTTA TGAAGGCTGC 
GGGACTATTG TGATTCAGTA CAGTTTTGGA GATGGCATAC AAACAAAGGA GCACCCAAAC 
CCAGGAAAAG CTTACTCTGG AACTTGTCGA GTTGCATATT TGCCTGATAA TGCGGAGGGG 
AGAAAGGTTT TGCATCTGCT CCGAAAAGCC TTTGATCAGA AGCTGATTTT CACAGTAGGA 
GAATCTCGGG TATTAGGAAT CTCGAATGTC ATTACATGGA ATGATATTCA TCACAAAACA 
GCCAAGTTTG GAGGACCATC AAATTTCGGC TACCCTGATC CTGATTACCT GAAACGTGTC 
AAGGAGGAGC TGAAATCAAA AGGGATCGAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017453656.1
CDS	33..2285
Translation	MASSPDPPSPLLVRLPESIPRAHMKLEIYFQSRASGGGECSVHPVGPGAPDTFEVKFLEKADKENVLKRGKHKLLVDDKSVPIVLETIKKPEEDLRPRPPSLTQPAETPSSRPPSLTESLDEALGDKIPSDGPVFNSVDSVVQKVFLAVTAELNCELLSKEQRAQITAVCPHIKSMEGSDGIKKVCGNFKDIEKIHHFLSSQLLESEPTRKYVPQKYTPSDVEREPPSQRSFEVSVLFLEYFKHIYPGRIESIEKKFGVNIKIQDSSPYMVSIGFTSRQSGNLEEACQSFVRDFQKCTQSLKQDCISLEDQQRAKKVRQELSRCFPKLLIKEQGRMLTLLGSAADIAAAAEKVSQTLVPAPVKIVATPVKIATPVKIATSGYMTGIEVDSTRFKLLEPELLQEIAEIEQKFNTCGKVQEKGQKTCILFVPKDKELDLSVQSYTSFTEAFQHATCQLRTEVLSLKQLGKEKAQLHKTKFADDFKIKHPNVHFVISQESVTLTGLPNHLGQAMQYVAKRIGMPTLLSSGEKLAMDHETPMEVHRNDSDVALLSFGSSASSPTASKGNKDEDNCVICMDTIRNKQVLPKCKHEFCSSCISKAMSFKPVCPVCLTPYGVQKGNQPEGTMAHTIQKDSLPGYEGCGTIVIQYSFGDGIQTKEHPNPGKAYSGTCRVAYLPDNAEGRKVLHLLRKAFDQKLIFTVGESRVLGISNVITWNDIHHKTAKFGGPSNFGYPDPDYLKRVKEELKSKGIE

Target ORF information:

RefSeq Version	XM_017598167.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus deltex E3 ubiquitin ligase 3L (Dtx3l), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598167.1

ORF Insert Sequence:

ATGGCCTCCA GTCCGGACCC GCCGTCCCCA CTACTCGTAA GGCTGCCGGA GTCCATCCCC 
CGAGCGCACA TGAAGCTGGA GATATATTTC CAGAGCCGGG CCTCCGGAGG CGGGGAGTGC 
TCTGTTCATC CCGTGGGGCC CGGCGCCCCG GACACCTTCG AGGTGAAGTT CCTTGAAAAA 
GCAGATAAGG AGAATGTGTT GAAAAGGGGA AAACACAAGC TGTTGGTTGA TGACAAATCT 
GTGCCTATTG TCCTGGAAAC TATTAAAAAG CCAGAAGAGG ACCTGAGACC CAGACCTCCA 
TCACTGACAC AGCCAGCTGA GACACCAAGC TCCCGACCTC CGTCCTTGAC AGAGTCCCTG 
GATGAAGCAC TGGGTGATAA GATACCCAGT GATGGGCCCG TTTTTAACTC TGTTGACTCA 
GTTGTCCAAA AGGTCTTTCT CGCTGTGACC GCTGAGCTGA ACTGTGAACT GCTCTCCAAA 
GAGCAGAGAG CACAGATTAC TGCTGTCTGC CCTCATATCA AAAGCATGGA GGGCAGTGAC 
GGAATTAAGA AGGTGTGTGG CAACTTCAAA GATATTGAAA AGATACATCA CTTCCTGAGT 
TCGCAGCTTT TGGAAAGTGA GCCGACACGA AAGTACGTCC CACAGAAATA CACACCTTCC 
GATGTGGAGA GGGAGCCCCC CAGTCAGAGA AGTTTTGAAG TTTCTGTGCT TTTCCTTGAA 
TATTTCAAAC ATATTTATCC GGGTAGAATA GAATCCATAG AGAAAAAATT TGGTGTAAAC 
ATCAAAATCC AAGATAGTTC TCCGTATATG GTCTCTATAG GCTTCACCTC CAGACAATCA 
GGCAACTTAG AAGAAGCTTG TCAGTCTTTT GTCAGAGACT TTCAGAAATG CACGCAGTCT 
CTGAAGCAAG ATTGTATCTC TTTAGAGGAC CAACAGAGAG CAAAGAAGGT CAGGCAGGAG 
CTGAGTCGCT GCTTCCCAAA GCTCTTGATA AAGGAACAGG GAAGGATGCT AACTCTCCTG 
GGCTCTGCTG CTGACATTGC AGCTGCCGCA GAAAAAGTCT CCCAAACTCT TGTCCCAGCA 
CCTGTGAAAA TAGTAGCCAC ACCTGTGAAA ATAGCCACAC CTGTGAAAAT AGCCACGTCT 
GGGTACATGA CAGGGATCGA GGTCGATTCG ACCCGCTTTA AGCTTCTAGA ACCTGAGCTG 
CTCCAGGAAA TCGCAGAGAT CGAGCAGAAG TTTAACACTT GTGGCAAAGT CCAGGAAAAA 
GGCCAGAAAA CCTGCATTCT CTTTGTCCCC AAGGATAAAG AGTTAGACCT GTCTGTGCAA 
TCTTACACAA GTTTTACTGA GGCCTTCCAG CATGCCACGT GCCAGTTGAG GACAGAAGTT 
CTGTCGCTGA AACAGCTGGG CAAGGAGAAA GCTCAATTGC ACAAGACCAA GTTTGCTGAC 
GACTTTAAAA TAAAACACCC AAACGTGCAC TTCGTGATAT CTCAAGAGTC AGTGACCTTG 
ACTGGTTTGC CCAATCACCT TGGGCAGGCA ATGCAGTATG TTGCCAAAAG GATAGGAATG 
CCCACGTTGT TGTCGTCTGG AGAGAAATTG GCTATGGATC ATGAAACGCC CATGGAGGTC 
CACAGGAATG ACTCAGATGT GGCGTTACTT TCTTTCGGAA GCTCTGCTAG CAGCCCTACG 
GCCTCGAAGG GGAACAAGGA CGAGGACAAC TGCGTCATCT GCATGGACAC CATCAGGAAC 
AAGCAGGTGC TCCCTAAGTG CAAGCATGAA TTCTGCTCCT CTTGTATCAG CAAAGCCATG 
TCATTCAAGC CTGTCTGTCC TGTGTGTCTG ACTCCCTACG GTGTCCAGAA AGGGAACCAG 
CCAGAGGGAA CCATGGCTCA CACCATTCAA AAAGACTCAC TTCCGGGTTA TGAAGGCTGC 
GGGACTATTG TGATTCAGTA CAGTTTTGGA GATGGCATAC AAACAAAGGA GCACCCAAAC 
CCAGGAAAAG CTTACTCTGG AACTTGTCGA GTTGCATATT TGCCTGATAA TGCGGAGGGG 
AGAAAGGTTT TGCATCTGCT CCGAAAAGCC TTTGATCAGA AGCTGATTTT CACAGTAGGA 
GAATCTCGGG TATTAGGAAT CTCGAATGTC ATTACATGGA ATGATATTCA TCACAAAACA 
GCCAAGTTTG GAGGACCATC AAATTTCGGC TACCCTGATC CTGATTACCT GAAACGTGTC 
AAGGAGGAGC TGAAATCAAA AGGGATCGAG TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.
Molecular cell66(4)503-516.e5(2017 May)
Yang CS,Jividen K,Spencer A,Dworak N,Ni L,Oostdyk LT,Chatterjee M,Kuśmider B,Reon B,Parlak M,Gorbunova V,Abbas T,Jeffery E,Sherman NE,Paschal BM

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Nature immunology16(12)1215-27(2015 Dec)
Zhang Y,Mao D,Roswit WT,Jin X,Patel AC,Patel DA,Agapov E,Wang Z,Tidwell RM,Atkinson JJ,Huang G,McCarthy R,Yu J,Yun NE,Paessler S,Lawson TG,Omattage NS,Brett TJ,Holtzman MJ

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Molecular biology of the cell25(12)1892-904(2014 Jun)
Holleman J,Marchese A

BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.
Molecular and cellular biology33(4)845-57(2013 Feb)
Yan Q,Xu R,Zhu L,Cheng X,Wang Z,Manis J,Shipp MA

BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.
Molecular cell36(1)110-20(2009 Oct)
Yan Q,Dutt S,Xu R,Graves K,Juszczynski P,Manis JP,Shipp MA

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Dtx3l cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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