| Gene Symbol | Sco1 |
| Entrez Gene ID | 497930 |
| Full Name | SCO1 cytochrome c oxidase assembly protein |
| Synonyms | RGD1559538 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Sco1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Sco1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sco1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa06500 Clone ID Related Accession (Same CDS sequence) NM_001173374.1 Accession Version NM_001173374.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 855bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1574092800000 Organism Rattus norvegicus(Norway rat) Product SCO cytochrome oxidase deficient homolog 1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK359925.1 and BC158882.1. On or before May 13, 2010 this sequence version replaced XM_001078805.2, XM_573117.3. ##Evidence-Data-START## Transcript exon combination :: BC158882.1, FQ209701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG
TTCCCTCGCG GCCATGGGCT CAGGGGTATG GCGGAGAGGC CGAGACCGGA GGAGGCGCGC
TGCTCCCTGG GGAGCCGAAA CTTCAGCGCC AGGCCGCCAC CGCCGGGTGC CGGGCCGGAG
CCCAAGGGCA GTCAAGCGGG GTCTCACCGC CCGAAGCTTG GGCCTGTTTC TTGGAAGTCT
TTAGCACTCA CTTTTGCCAT TGGAGGATCT TTATTGGCTG GAATGAAGTA CTTCAAGAAA
GAGAAGATAG AAAAGCTGGA GAAACAGCGG CATCGCAGCA TTGGGAAGCC TTTACTAGGG
GGACCATTTT CCCTCACAAC TCACAATGGA GAGCCCAAAA CTGACAAGGA CTTCCTGGGT
CAATGGGTAT TGATTTATTT TGGCTTCACT CATTGCCCTG ATATCTGTCC AGAAGAACTG
GAAAAAATGA TTGAAGTTGT GGAGGAAATA GACAGTATTC CATCCCTGCC AAATTTAACT
CCACTTTTCA TCACCATTGA CCCAGAAAGG GACACAAAAG AAGCCATCGC AACTTATGTG
AAAGAATTTT CTCCCAAATT GGTTGGTTTG ACTGGCACAA AGGAAGAGAT TGATGGAGTG
GCCAGAGCAT ACAGGGTGTA TTACAGTCCT GGCCCTAAGG ACGAGGATGA GGACTACATA
GTGGATCATA CAATAATAAT GTACTTGATT GGACCAGATG GAGAATTTCT TGATTATTTT
GGACAAAACA AGAAGAAGGC AGAAATAGCT GGCTCAATAG CTGCACATAT GAGGTCACAC
ATGAGGAAGA GGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001166845.1 CDS 38..892 Translation 
Target ORF information:
RefSeq Version NM_001173374.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus synthesis of cytochrome C oxidase 1 (Sco1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001173374.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841ATGGCGGCTC TTGTACGGTT AGCGGTGGTG CGTTCACAGT GTCGCCAGCT TTGGCATCTG
TTCCCTCGCG GCCATGGGCT CAGGGGTATG GCGGAGAGGC CGAGACCGGA GGAGGCGCGC
TGCTCCCTGG GGAGCCGAAA CTTCAGCGCC AGGCCGCCAC CGCCGGGTGC CGGGCCGGAG
CCCAAGGGCA GTCAAGCGGG GTCTCACCGC CCGAAGCTTG GGCCTGTTTC TTGGAAGTCT
TTAGCACTCA CTTTTGCCAT TGGAGGATCT TTATTGGCTG GAATGAAGTA CTTCAAGAAA
GAGAAGATAG AAAAGCTGGA GAAACAGCGG CATCGCAGCA TTGGGAAGCC TTTACTAGGG
GGACCATTTT CCCTCACAAC TCACAATGGA GAGCCCAAAA CTGACAAGGA CTTCCTGGGT
CAATGGGTAT TGATTTATTT TGGCTTCACT CATTGCCCTG ATATCTGTCC AGAAGAACTG
GAAAAAATGA TTGAAGTTGT GGAGGAAATA GACAGTATTC CATCCCTGCC AAATTTAACT
CCACTTTTCA TCACCATTGA CCCAGAAAGG GACACAAAAG AAGCCATCGC AACTTATGTG
AAAGAATTTT CTCCCAAATT GGTTGGTTTG ACTGGCACAA AGGAAGAGAT TGATGGAGTG
GCCAGAGCAT ACAGGGTGTA TTACAGTCCT GGCCCTAAGG ACGAGGATGA GGACTACATA
GTGGATCATA CAATAATAAT GTACTTGATT GGACCAGATG GAGAATTTCT TGATTATTTT
GGACAAAACA AGAAGAAGGC AGAAATAGCT GGCTCAATAG CTGCACATAT GAGGTCACAC
ATGAGGAAGA GGTAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis.
Cell reports10(6)933-943(2015 Feb)
Hlynialuk CJ,Ling B,Baker ZN,Cobine PA,Yu LD,Boulet A,Wai T,Hossain A,El Zawily AM,McFie PJ,Stone SJ,Diaz F,Moraes CT,Viswanathan D,Petris MJ,Leary SC
Mutations in COA6 cause cytochrome c oxidase deficiency and neonatal hypertrophic cardiomyopathy.
Human mutation36(1)34-8(2015 Jan)
Baertling F,A M van den Brand M,Hertecant JL,Al-Shamsi A,P van den Heuvel L,Distelmaier F,Mayatepek E,Smeitink JA,Nijtmans LG,Rodenburg RJ
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
The American journal of pathology177(5)2541-8(2010 Nov)
Brosel S,Yang H,Tanji K,Bonilla E,Schon EA
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Human molecular genetics19(1)170-80(2010 Jan)
Yang H,Brosel S,Acin-Perez R,Slavkovich V,Nishino I,Khan R,Goldberg IJ,Graziano J,Manfredi G,Schon EA
Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.
Human molecular genetics13(17)1839-48(2004 Sep)
Leary SC,Kaufman BA,Pellecchia G,Guercin GH,Mattman A,Jaksch M,Shoubridge EA
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