| Gene Symbol | Vkorc1l1 |
| Entrez Gene ID | 399684 |
| Full Name | vitamin K epoxide reductase complex, subunit 1-like 1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Vkorc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Vkorc1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vkorc1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa13535 Clone ID Related Accession (Same CDS sequence) NM_203338.1 Accession Version NM_203338.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1536854400000 Organism Rattus norvegicus(Norway rat) Product vitamin K epoxide reductase complex subunit 1-like protein 1 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY423048.1. ##Evidence-Data-START## Transcript exon combination :: AY423048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_976083.1 CDS 51..581 Translation 
Target ORF information:
RefSeq Version NM_203338.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_203338.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG AThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa52809 Clone ID Related Accession (Same CDS sequence) XM_017598418.1 Accession Version XM_017598418.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 384bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA
CAAACGACTG GTTTACTTGA ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_017453907.1 CDS 44..427 Translation
Target ORF information:
RefSeq Version XM_017598418.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017598418.1
ORF Insert Sequence:
1
61
121
181
241
301
361ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA
CAAACGACTG GTTTACTTGA ATGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
The Journal of biological chemistry289(13)9396-407(2014 Mar)
Tie JK,Jin DY,Stafford DW
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
The Journal of biological chemistry288(40)28733-42(2013 Oct)
Hammed A,Matagrin B,Spohn G,Prouillac C,Benoit E,Lattard V
Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
The Journal of biological chemistry286(17)15085-94(2011 Apr)
Westhofen P,Watzka M,Marinova M,Hass M,Kirfel G,Müller J,Bevans CG,Müller CR,Oldenburg J
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature427(6974)537-41(2004 Feb)
Rost S,Fregin A,Ivaskevicius V,Conzelmann E,Hörtnagel K,Pelz HJ,Lappegard K,Seifried E,Scharrer I,Tuddenham EG,Müller CR,Strom TM,Oldenburg J
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