Fgd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgd1
Entrez Gene ID	363460
Full Name	FYVE, RhoGEF and PH domain containing 1
General protein information	Preferred Names FYVE, RhoGEF and PH domain containing 1 Names FYVE, RhoGEF and PH domain-containing protein 1 FYVE, RhoGEF and PH domain-containing protein 1-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001037546.1	NP_001032635.1	FYVE, RhoGEF and PH domain-containing protein 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgd1	NP_001032635.1
Macaca mulatta (Rhesus monkey)	FGD1	XP_002806297.1
Mus musculus (house mouse)	Fgd1	NP_032027.2
Bos taurus (cattle)	FGD1	NP_001096014.1
Homo sapiens (human)	FGD1	NP_004454.2
Pan troglodytes (chimpanzee)	FGD1	XP_003317524.1
Canis lupus familiaris (dog)	FGD1	XP_549021.2
Xenopus tropicalis (tropical clawed frog)	fgd1	XP_004914246.1
Danio rerio (zebrafish)	fgd1	XP_688794.3

Gene Ontology
Bibliography

Related articles in PubMed

Novel FGD1 mutation underlying Aarskog-Scott syndrome with myopathy and distal arthropathy.
Al-Semari A, Wakil SM, Al-Muhaizea MA, Dababo M, Al-Amr R, Alkuraya F, Meyer BF
Clinical dysmorphology22(1)13-7(2013 Jan)

Aarskog-Scott syndrome: clinical update and report of nine novel mutations of the FGD1 gene.
Orrico A, Galli L, Faivre L, Clayton-Smith J, Azzarello-Burri SM, Hertz JM, Jacquemont S, Taurisano R, Arroyo Carrera I, Tarantino E, Devriendt K, Melis D, Thelle T, Meinhardt U, Sorrentino V
American journal of medical genetics. Part A152A(2)313-8(2010 Feb)

Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer.
Ayala I, Giacchetti G, Caldieri G, Attanasio F, Mariggiò S, Tetè S, Polishchuk R, Castronovo V, Buccione R
Cancer research69(3)747-52(2009 Feb)

Clinical variation of Aarskog syndrome in a large family with 2189delA in the FGD1 gene.
Shalev SA, Chervinski E, Weiner E, Mazor G, Friez MJ, Schwartz CE
American journal of medical genetics. Part A140(2)162-5(2006 Jan)

Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL
Human molecular genetics12(16)1981-93(2003 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fgd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09431	NM_001037546.1 Latest version!	Rattus norvegicus FYVE, RhoGEF and PH domain containing 1 (Fgd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgd1 ( NM_001037546.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001032635.1 Rattus norvegicus FYVE, RhoGEF and PH domain containing 1 (Fgd1), mRNA.

Price & Availability↑

CloneID	ORa09431
Clone ID Related Accession (Same CDS sequence)	NM_001037546.1
Accession Version	NM_001037546.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2382bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506787200000
Organism	Rattus norvegicus(Norway rat)
Product	FYVE, RhoGEF and PH domain-containing protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC110051.1. On Dec 2, 2005 this sequence version replaced XM_343779.2. ##Evidence-Data-START## Transcript exon combination :: BC110051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04563758, SAMN04563759 [ECO:0000348] ##Evidence-Data-END##

ATGCCCCGGG TGCTTCCTCC TCCTGAGCCC ATTCCTCCGC CACCATCACG CCCTCTGCCT 
GCAGACCCTA GAGTGGCCAA GGGTCTTGCC CCCAGAGCTG AGGCCAGCAC TAGTTCTGCA 
GCAGTATCAT CATTGATCGA GAAGTTTGAA AGAGAGCCTG TGATTGTCGC TTCGGATAGG 
CCAGCCCCTG GCCCCTGCCC AGTTCCCCCA GAGCCAGCCA TGTTGCCACA GCCACCCCCG 
CAGCCAACAG GGTCCCAGCT CCCTGAGGGT GAGGCTTCTC GCTGCCTGTT CCTGCTGGCT 
CCTGGGCCCC GGGATGGTGA GAAGGTGCCT AACCGGGACA GCGGCATTGA CAGCATCAGC 
TCGCCATCCA ACAGTGAAGA GACCTGCTTC GTCAGTGATG ACGGGCCCCC CAGCCACAGC 
CTCTGTCCTG GGCCCCCTGC CCTGGCTAGT ATGCCAGTGG CTTTGGCCGA CCCCCACCGG 
CCTGGCTCCC AGGAGGTTGA CAGTGACCTG GAAGAGGAAG AGGAGGAGGA GGAAGAAGAG 
GAGGAAAAGG AAAGAGAAAT TCCAGTGCCC CCGATGGAGA GACAGGAGTC TGTGGAGCTG 
ACCGTGCAGC AGAAGGTATT CCATATTGCC AATGAACTCC TGCAAACTGA GAAGGCCTAT 
GTTTCCAGGC TTCATCTCCT GGATCAGGTA TTCTGTGCCC GGCTGCTGGA AGAAGCTCGG 
AACCGCAGTT CCTTCCCTGC AGATGTTGTC CATGGCATCT TCTCTAACAT CTGCTCCATC 
TACTGCTTCC ATCAGCAGTT CCTGCTGCCT GAGCTGGAGA AGCGCATGGA GGAATGGGAC 
CGCTACCCAC GCATTGGTGA CATCCTTCAG AAGTTGGCAC CCTTCCTCAA GATGTATGGC 
GAGTATGTGA AAAACTTTGA CCGGGCTGTA GAGCTGGTCA ACACATGGAC AGAGCGTTCT 
ACCCAGTTTA AAGTCATCAT CCATGAAGTA CAGAAGGAGG AAGCCTGTGG CAACCTGACC 
CTGCAGCACC ACATGCTGGA GCCCGTGCAG CGTATCCCCC GCTATGAGCT TCTTCTTAAG 
GACTATCTGT TAAAGCTGCC TCATGGCTCC CCGGACAGCA AGGATGCCCA GAAGTCTTTG 
GAGCTGATAG CCACAGCAGC AGAACACTCT AATGCTGCCA TCCGTAAAAT GGAACGAATG 
CACAAGCTGC TGAAGGTCTA TGAGCTGCTA GGGGGTGAGG AGGACATTGT CAGTCCCACC 
AAAGAGCTCA TAAAAGAAGG TCATATCCTT AAGCTGTCAG CAAAGAATGG GACCACTCAA 
GATCGATACC TCATATTATT CAACGACCGC CTTCTTTACT GCGTGCCCAG GCTGCGGCTC 
CTTGGCCAGA AGTTTAGCGT GCGGGCACGC ATTGATGTAG ATGGCATGGA GCTAAAGGAA 
AGCTCCAACC TCAACATGCC TCGGACCTTC TTGGTGTCAG GAAAACAGCG CTCTCTTGAA 
CTCCAGGCCA GGACTGAGGA GGAGAAGAAA GACTGGGTCC AGGCCATCAA TTCTACCCTC 
CTGAAGCATG AACAGACCCT GGAGACTTTC AAACTGTTGA ACTCAACAAA CAGGGATGAT 
GAAGATACTC CCCCTAACTC TCCAAACGTG GATCTTGGGA AGAGGGCACC TACGCCTATC 
CGGGAAAAGG AAGTCACCAT GTGCATGCGC TGCCAGGAGC CCTTCAATTC CATCACCAAA 
CGCAGGCACC ACTGCAAGGC CTGTGGGCAT GTGGTTTGTG GGAAATGCTC TGAGTTCCGA 
GCACGACTCA TCTATGACAA CAATCGTTCC AACCGTGTGT GCACTGATTG CTATGTGGCC 
TTGCATGGAG CACCCGGGAG CAGTCCAGCC TGTAGCCAAC ATACACCCCA GCGCAGGAGG 
TCCATCCTAG AGAAACAGGC CTCAGTGGCT GCTGAGAACA GCGTCATCTG CAGCTTCCTG 
CACTACATGG AGAAGGGTGG GAAAGGATGG CACAAGGCAT GGTTTGTGGT TCCCGAGAAT 
GAACCCTTGG TGCTGTACAT CTATGGAGCC CCTCAGGATG TGAAAGCCCA ACGCAGCCTG 
CCCCTCATTG GCTTTGAGGT GGGGCCTCCT GAGGCAGGGG AGCGGCCAGA CAGGAGGCAT 
GTCTTCAAGA TCACCCAGAG CCACCTAAGC TGGTACTTCA GCCCAGAGAC AGAAGAACTC 
CAGCGGCGCT GGATGGCTGT GCTTGGCAGG GCGGGCCGTG GGGACACATT CTGCCCAGGG 
CCCACACTGT CTGAGGACAA GGAGATGGAG GAGACAACAG TGGCAGCTTC AGGAGCCACT 
GCTGAACCTC CTGAAGCCTC CCAGACCCGA GACAAGACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001032635.1
CDS	252..2633
Translation	MPRVLPPPEPIPPPPSRPLPADPRVAKGLAPRAEASTSSAAVSSLIEKFEREPVIVASDRPAPGPCPVPPEPAMLPQPPPQPTGSQLPEGEASRCLFLLAPGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASMPVALADPHRPGSQEVDSDLEEEEEEEEEEEEKEREIPVPPMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARIDVDGMELKESSNLNMPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFKLLNSTNRDDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHVVCGKCSEFRARLIYDNNRSNRVCTDCYVALHGAPGSSPACSQHTPQRRRSILEKQASVAAENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPEAGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDKEMEETTVAASGATAEPPEASQTRDKT

Target ORF information:

RefSeq Version	NM_001037546.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus FYVE, RhoGEF and PH domain containing 1 (Fgd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037546.1

ORF Insert Sequence:

ATGCCCCGGG TGCTTCCTCC TCCTGAGCCC ATTCCTCCGC CACCATCACG CCCTCTGCCT 
GCAGACCCTA GAGTGGCCAA GGGTCTTGCC CCCAGAGCTG AGGCCAGCAC TAGTTCTGCA 
GCAGTATCAT CATTGATCGA GAAGTTTGAA AGAGAGCCTG TGATTGTCGC TTCGGATAGG 
CCAGCCCCTG GCCCCTGCCC AGTTCCCCCA GAGCCAGCCA TGTTGCCACA GCCACCCCCG 
CAGCCAACAG GGTCCCAGCT CCCTGAGGGT GAGGCTTCTC GCTGCCTGTT CCTGCTGGCT 
CCTGGGCCCC GGGATGGTGA GAAGGTGCCT AACCGGGACA GCGGCATTGA CAGCATCAGC 
TCGCCATCCA ACAGTGAAGA GACCTGCTTC GTCAGTGATG ACGGGCCCCC CAGCCACAGC 
CTCTGTCCTG GGCCCCCTGC CCTGGCTAGT ATGCCAGTGG CTTTGGCCGA CCCCCACCGG 
CCTGGCTCCC AGGAGGTTGA CAGTGACCTG GAAGAGGAAG AGGAGGAGGA GGAAGAAGAG 
GAGGAAAAGG AAAGAGAAAT TCCAGTGCCC CCGATGGAGA GACAGGAGTC TGTGGAGCTG 
ACCGTGCAGC AGAAGGTATT CCATATTGCC AATGAACTCC TGCAAACTGA GAAGGCCTAT 
GTTTCCAGGC TTCATCTCCT GGATCAGGTA TTCTGTGCCC GGCTGCTGGA AGAAGCTCGG 
AACCGCAGTT CCTTCCCTGC AGATGTTGTC CATGGCATCT TCTCTAACAT CTGCTCCATC 
TACTGCTTCC ATCAGCAGTT CCTGCTGCCT GAGCTGGAGA AGCGCATGGA GGAATGGGAC 
CGCTACCCAC GCATTGGTGA CATCCTTCAG AAGTTGGCAC CCTTCCTCAA GATGTATGGC 
GAGTATGTGA AAAACTTTGA CCGGGCTGTA GAGCTGGTCA ACACATGGAC AGAGCGTTCT 
ACCCAGTTTA AAGTCATCAT CCATGAAGTA CAGAAGGAGG AAGCCTGTGG CAACCTGACC 
CTGCAGCACC ACATGCTGGA GCCCGTGCAG CGTATCCCCC GCTATGAGCT TCTTCTTAAG 
GACTATCTGT TAAAGCTGCC TCATGGCTCC CCGGACAGCA AGGATGCCCA GAAGTCTTTG 
GAGCTGATAG CCACAGCAGC AGAACACTCT AATGCTGCCA TCCGTAAAAT GGAACGAATG 
CACAAGCTGC TGAAGGTCTA TGAGCTGCTA GGGGGTGAGG AGGACATTGT CAGTCCCACC 
AAAGAGCTCA TAAAAGAAGG TCATATCCTT AAGCTGTCAG CAAAGAATGG GACCACTCAA 
GATCGATACC TCATATTATT CAACGACCGC CTTCTTTACT GCGTGCCCAG GCTGCGGCTC 
CTTGGCCAGA AGTTTAGCGT GCGGGCACGC ATTGATGTAG ATGGCATGGA GCTAAAGGAA 
AGCTCCAACC TCAACATGCC TCGGACCTTC TTGGTGTCAG GAAAACAGCG CTCTCTTGAA 
CTCCAGGCCA GGACTGAGGA GGAGAAGAAA GACTGGGTCC AGGCCATCAA TTCTACCCTC 
CTGAAGCATG AACAGACCCT GGAGACTTTC AAACTGTTGA ACTCAACAAA CAGGGATGAT 
GAAGATACTC CCCCTAACTC TCCAAACGTG GATCTTGGGA AGAGGGCACC TACGCCTATC 
CGGGAAAAGG AAGTCACCAT GTGCATGCGC TGCCAGGAGC CCTTCAATTC CATCACCAAA 
CGCAGGCACC ACTGCAAGGC CTGTGGGCAT GTGGTTTGTG GGAAATGCTC TGAGTTCCGA 
GCACGACTCA TCTATGACAA CAATCGTTCC AACCGTGTGT GCACTGATTG CTATGTGGCC 
TTGCATGGAG CACCCGGGAG CAGTCCAGCC TGTAGCCAAC ATACACCCCA GCGCAGGAGG 
TCCATCCTAG AGAAACAGGC CTCAGTGGCT GCTGAGAACA GCGTCATCTG CAGCTTCCTG 
CACTACATGG AGAAGGGTGG GAAAGGATGG CACAAGGCAT GGTTTGTGGT TCCCGAGAAT 
GAACCCTTGG TGCTGTACAT CTATGGAGCC CCTCAGGATG TGAAAGCCCA ACGCAGCCTG 
CCCCTCATTG GCTTTGAGGT GGGGCCTCCT GAGGCAGGGG AGCGGCCAGA CAGGAGGCAT 
GTCTTCAAGA TCACCCAGAG CCACCTAAGC TGGTACTTCA GCCCAGAGAC AGAAGAACTC 
CAGCGGCGCT GGATGGCTGT GCTTGGCAGG GCGGGCCGTG GGGACACATT CTGCCCAGGG 
CCCACACTGT CTGAGGACAA GGAGATGGAG GAGACAACAG TGGCAGCTTC AGGAGCCACT 
GCTGAACCTC CTGAAGCCTC CCAGACCCGA GACAAGACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel FGD1 mutation underlying Aarskog-Scott syndrome with myopathy and distal arthropathy.
Clinical dysmorphology22(1)13-7(2013 Jan)
Al-Semari A,Wakil SM,Al-Muhaizea MA,Dababo M,Al-Amr R,Alkuraya F,Meyer BF

Aarskog-Scott syndrome: clinical update and report of nine novel mutations of the FGD1 gene.
American journal of medical genetics. Part A152A(2)313-8(2010 Feb)
Orrico A,Galli L,Faivre L,Clayton-Smith J,Azzarello-Burri SM,Hertz JM,Jacquemont S,Taurisano R,Arroyo Carrera I,Tarantino E,Devriendt K,Melis D,Thelle T,Meinhardt U,Sorrentino V

Faciogenital dysplasia protein Fgd1 regulates invadopodia biogenesis and extracellular matrix degradation and is up-regulated in prostate and breast cancer.
Cancer research69(3)747-52(2009 Feb)
Ayala I,Giacchetti G,Caldieri G,Attanasio F,Mariggiò S,Tetè S,Polishchuk R,Castronovo V,Buccione R

Clinical variation of Aarskog syndrome in a large family with 2189delA in the FGD1 gene.
American journal of medical genetics. Part A140(2)162-5(2006 Jan)
Shalev SA,Chervinski E,Weiner E,Mazor G,Friez MJ,Schwartz CE

Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.
Human molecular genetics12(16)1981-93(2003 Aug)
Hou P,Estrada L,Kinley AW,Parsons JT,Vojtek AB,Gorski JL

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Fgd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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