Ndp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ndp
Entrez Gene ID	363443
Full Name	NDP, norrin cystine knot growth factor
Synonyms	Ndph,RGD1563968
General protein information	Preferred Names NDP, norrin cystine knot growth factor Names NDP, norrin cystine knot growth factor Norrie disease (pseudoglioma) Norrie disease homolog norrin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq11

mRNA and Protein(s)

mRNA	Protein	Name
XM_017602101.1	XP_017457590.1	NDP, norrin cystine knot growth factor isoform X1
NM_001108814.1	NP_001102284.1	norrin cystine knot growth factor NDP precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	LOC100909913	XP_003752046.1
Rattus norvegicus (Norway rat)	Ndp	NP_001102284.1

Gene Ontology
Bibliography

Related articles in PubMed

Dendrobium nobile Lindley and its bibenzyl component moscatilin are able to protect retinal cells from ischemia/hypoxia by dowregulating placental growth factor and upregulating Norrie disease protein.
Chao WH, Lai MY, Pan HT, Shiu HW, Chen MM, Chao HM
BMC complementary and alternative medicine18(1)193(2018 Jun)

Norrin protected blood-brain barrier via frizzled-4/β-catenin pathway after subarachnoid hemorrhage in rats.
Chen Y, Zhang Y, Tang J, Liu F, Hu Q, Luo C, Tang J, Feng H, Zhang JH
Stroke46(2)529-36(2015 Feb)

A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.
Hsu PJ, Wu FJ, Kudo M, Hsiao CL, Hsueh AJ, Luo CW
PloS one9(9)e106804(2014)

Secreted and transmembrane wnt inhibitors and activators.
Cruciat CM, Niehrs C
Cold Spring Harbor perspectives in biology5(3)a015081(2013 Mar)

Norrin immunolocalization and its possible functions in rat endometrium during the estrus cycle and early pregnancy.
Kaloglu C, Cesur I, Bulut HE
Development, growth & differentiation53(7)887-96(2011 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Ndp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ndp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08415	NM_001108814.1 Latest version!	Rattus norvegicus norrin cystine knot growth factor NDP (Ndp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa08415	XM_017602101.1 Latest version!	Rattus norvegicus NDP, norrin cystine knot growth factor (Ndp), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ndp ( NM_001108814.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102284.1 Rattus norvegicus norrin cystine knot growth factor NDP (Ndp), mRNA.

Price & Availability↑

CloneID	ORa08415
Clone ID Related Accession (Same CDS sequence)	XM_017602101.1 , NM_001108814.1
Accession Version	NM_001108814.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1554652800000
Organism	Rattus norvegicus(Norway rat)
Product	norrin cystine knot growth factor NDP precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474009.2. On or before Oct 4, 2007 this sequence version replaced XM_343763.3, XM_001058815.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB577208.1, CB741466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGAAATC ATGTACTAGC TGCATCCATT TCTATGCTCT CCCTGCTGGC CATAATGGGA 
GATACAGACA GCAAAACAGA CAGCTCGTTC CTGATGGACT CTCAACGCTG CATGAGGCAC 
CATTATGTCG ATTCTATCAG TCACCCATTG TACAAATGTA GCTCAAAGAT GGTGCTCCTG 
GCCAGATGTG AGGGGCACTG CAGCCAGGCA TCACGCTCTG AACCCTTGGT GTCCTTCAGC 
ACTGTCCTCA AGCAACCTTT CCGTTCCTCC TGTCACTGCT GCCGACCCCA GACTTCCAAG 
CTGAAGGCTC TGCGTCTGCG TTGCTCAGGG GGCATGCGAC TTACTGCCAC TTACCGGTAC 
ATCCTCTCCT GTCACTGTGA GGAATGCAGC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102284.1
CDS	562..957
Translation	MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

Target ORF information:

RefSeq Version	NM_001108814.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus norrin cystine knot growth factor NDP (Ndp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108814.1

ORF Insert Sequence:

ATGAGAAATC ATGTACTAGC TGCATCCATT TCTATGCTCT CCCTGCTGGC CATAATGGGA 
GATACAGACA GCAAAACAGA CAGCTCGTTC CTGATGGACT CTCAACGCTG CATGAGGCAC 
CATTATGTCG ATTCTATCAG TCACCCATTG TACAAATGTA GCTCAAAGAT GGTGCTCCTG 
GCCAGATGTG AGGGGCACTG CAGCCAGGCA TCACGCTCTG AACCCTTGGT GTCCTTCAGC 
ACTGTCCTCA AGCAACCTTT CCGTTCCTCC TGTCACTGCT GCCGACCCCA GACTTCCAAG 
CTGAAGGCTC TGCGTCTGCG TTGCTCAGGG GGCATGCGAC TTACTGCCAC TTACCGGTAC 
ATCCTCTCCT GTCACTGTGA GGAATGCAGC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ndp ( XM_017602101.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017457590.1 Rattus norvegicus NDP, norrin cystine knot growth factor (Ndp), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa08415
Clone ID Related Accession (Same CDS sequence)	XM_017602101.1 , NM_001108814.1
Accession Version	XM_017602101.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	NDP, norrin cystine knot growth factor isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAATC ATGTACTAGC TGCATCCATT TCTATGCTCT CCCTGCTGGC CATAATGGGA 
GATACAGACA GCAAAACAGA CAGCTCGTTC CTGATGGACT CTCAACGCTG CATGAGGCAC 
CATTATGTCG ATTCTATCAG TCACCCATTG TACAAATGTA GCTCAAAGAT GGTGCTCCTG 
GCCAGATGTG AGGGGCACTG CAGCCAGGCA TCACGCTCTG AACCCTTGGT GTCCTTCAGC 
ACTGTCCTCA AGCAACCTTT CCGTTCCTCC TGTCACTGCT GCCGACCCCA GACTTCCAAG 
CTGAAGGCTC TGCGTCTGCG TTGCTCAGGG GGCATGCGAC TTACTGCCAC TTACCGGTAC 
ATCCTCTCCT GTCACTGTGA GGAATGCAGC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017457590.1
CDS	734..1129
Translation	MRNHVLAASISMLSLLAIMGDTDSKTDSSFLMDSQRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECSS

Target ORF information:

RefSeq Version	XM_017602101.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NDP, norrin cystine knot growth factor (Ndp), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017602101.1

ORF Insert Sequence:

ATGAGAAATC ATGTACTAGC TGCATCCATT TCTATGCTCT CCCTGCTGGC CATAATGGGA 
GATACAGACA GCAAAACAGA CAGCTCGTTC CTGATGGACT CTCAACGCTG CATGAGGCAC 
CATTATGTCG ATTCTATCAG TCACCCATTG TACAAATGTA GCTCAAAGAT GGTGCTCCTG 
GCCAGATGTG AGGGGCACTG CAGCCAGGCA TCACGCTCTG AACCCTTGGT GTCCTTCAGC 
ACTGTCCTCA AGCAACCTTT CCGTTCCTCC TGTCACTGCT GCCGACCCCA GACTTCCAAG 
CTGAAGGCTC TGCGTCTGCG TTGCTCAGGG GGCATGCGAC TTACTGCCAC TTACCGGTAC 
ATCCTCTCCT GTCACTGTGA GGAATGCAGC TCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dendrobium nobile Lindley and its bibenzyl component moscatilin are able to protect retinal cells from ischemia/hypoxia by dowregulating placental growth factor and upregulating Norrie disease protein.
BMC complementary and alternative medicine18(1)193(2018 Jun)
Chao WH,Lai MY,Pan HT,Shiu HW,Chen MM,Chao HM

Norrin protected blood-brain barrier via frizzled-4/β-catenin pathway after subarachnoid hemorrhage in rats.
Stroke46(2)529-36(2015 Feb)
Chen Y,Zhang Y,Tang J,Liu F,Hu Q,Luo C,Tang J,Feng H,Zhang JH

A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.
PloS one9(9)e106804(2014)
Hsu PJ,Wu FJ,Kudo M,Hsiao CL,Hsueh AJ,Luo CW

Secreted and transmembrane wnt inhibitors and activators.
Cold Spring Harbor perspectives in biology5(3)a015081(2013 Mar)
Cruciat CM,Niehrs C

Norrin immunolocalization and its possible functions in rat endometrium during the estrus cycle and early pregnancy.
Development, growth & differentiation53(7)887-96(2011 Sep)
Kaloglu C,Cesur I,Bulut HE