Cav2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cav2
Entrez Gene ID	363425
Full Name	caveolin 2
General protein information	Preferred Names caveolin 2 Names caveolin-2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q21
Summary	a component of caveolae; involved in cholesterol transport, signal transduction, and transcytosis, may also function as a SNARE accessory protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_131914.2	NP_571989.2	caveolin-2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CAV2	NP_001007809.1
Rattus norvegicus (Norway rat)	Cav2	NP_571989.2
Gallus gallus (chicken)	CAV2	NP_001007087.1
Xenopus tropicalis (tropical clawed frog)	cav2	NP_001015763.1
Homo sapiens (human)	CAV2	NP_001224.1
Macaca mulatta (Rhesus monkey)	CAV2	NP_001162090.1
Mus musculus (house mouse)	Cav2	NP_058596.1
Danio rerio (zebrafish)	cav2	NP_001002150.1
Canis lupus familiaris (dog)	CAV2	NP_001010997.2
Pan troglodytes (chimpanzee)	CAV2	NP_001129298.1

Gene Ontology
Bibliography

Related articles in PubMed

Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Kwon H, Lee J, Jeong K, Jang D, Pak Y
Biochimica et biophysica acta1853(5)1022-34(2015 May)

Insulin-response epigenetic activation of Egr-1 and JunB genes at the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in the inner nuclear membrane.
Jeong K, Kwon H, Lee J, Jang D, Pak Y
Nucleic acids research43(6)3114-27(2015 Mar)

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)

Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?
Badaut J, Ajao DO, Sorensen DW, Fukuda AM, Pellerin L
Neuroscience285215-26(2015 Jan)

Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization.
Gargalovic P, Dory L
The Journal of biological chemistry276(28)26164-70(2001 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cav2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cav2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00531	NM_131914.2 Latest version!	Rattus norvegicus caveolin 2 (Cav2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cav2 ( NM_131914.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_571989.2 Rattus norvegicus caveolin 2 (Cav2), mRNA.

Price & Availability↑

CloneID	ORa00531
Clone ID Related Accession (Same CDS sequence)	NM_131914.2
Accession Version	NM_131914.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 489bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	caveolin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062059.1. On Mar 9, 2004 this sequence version replaced NM_131914.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062059.1, FQ209775.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGGGCTGG AGACTGAGAA GGCCGACGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG TCGTCGACTA CACAGATCCT GAGAAGTATG TTGACTCCAG TCAGGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT CGCAGAACCT 
CCGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ACGCGCTCTT TGAAATCAGC 
AAATACGTGA TCTACAAGTT CCTGACGGTG TTTCTAGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGA TCCTAATGCC TTTTGTGAAG 
ACCTGCCTCA TGGTCCTGCC TTCCGTGCAG ACGATATGGA AGAGTGTGAC AGATGTTGTC 
ATTGGCCCAT TGTGTACAAG TGTAGGGCGC ATCTTCTCCT CTGTCAGCAT GCAACTGAGC 
CATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_571989.2
CDS	124..612
Translation	MGLETEKADVQLFMADDAYSHHSVVDYTDPEKYVDSSQDRDPHQLNSHLKLGFEDLIAEPPTTHSFDKVWICSHALFEISKYVIYKFLTVFLAIPLAFIAGILFATLSCLHIWILMPFVKTCLMVLPSVQTIWKSVTDVVIGPLCTSVGRIFSSVSMQLSHD

Target ORF information:

RefSeq Version	NM_131914.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus caveolin 2 (Cav2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_131914.2

ORF Insert Sequence:

ATGGGGCTGG AGACTGAGAA GGCCGACGTG CAGCTCTTCA TGGCCGATGA CGCCTACAGC 
CACCACAGTG TCGTCGACTA CACAGATCCT GAGAAGTATG TTGACTCCAG TCAGGACCGG 
GATCCTCACC AGCTCAACTC TCATCTCAAG CTAGGCTTCG AGGATCTGAT CGCAGAACCT 
CCGACTACAC ACTCCTTTGA CAAAGTGTGG ATCTGCAGCC ACGCGCTCTT TGAAATCAGC 
AAATACGTGA TCTACAAGTT CCTGACGGTG TTTCTAGCCA TCCCCTTGGC CTTCATTGCG 
GGTATCCTGT TTGCTACCCT CAGCTGTCTG CACATCTGGA TCCTAATGCC TTTTGTGAAG 
ACCTGCCTCA TGGTCCTGCC TTCCGTGCAG ACGATATGGA AGAGTGTGAC AGATGTTGTC 
ATTGGCCCAT TGTGTACAAG TGTAGGGCGC ATCTTCTCCT CTGTCAGCAT GCAACTGAGC 
CATGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Biochimica et biophysica acta1853(5)1022-34(2015 May)
Kwon H,Lee J,Jeong K,Jang D,Pak Y

Insulin-response epigenetic activation of Egr-1 and JunB genes at the nuclear periphery by A-type lamin-associated pY19-Caveolin-2 in the inner nuclear membrane.
Nucleic acids research43(6)3114-27(2015 Mar)
Jeong K,Kwon H,Lee J,Jang D,Pak Y

New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Molecular & cellular proteomics : MCP14(3)532-43(2015 Mar)
Kipper S,Hamad S,Caly L,Avrahami D,Bacharach E,Jans DA,Gerber D,Bajorek M

Caveolin expression changes in the neurovascular unit after juvenile traumatic brain injury: signs of blood-brain barrier healing?
Neuroscience285215-26(2015 Jan)
Badaut J,Ajao DO,Sorensen DW,Fukuda AM,Pellerin L

Caveolin-1 and caveolin-2 expression in mouse macrophages. High density lipoprotein 3-stimulated secretion and a lack of significant subcellular co-localization.
The Journal of biological chemistry276(28)26164-70(2001 Jul)
Gargalovic P,Dory L