Exd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Exd2
Entrez Gene ID	362759
Full Name	exonuclease 3'-5' domain containing 2
Synonyms	Exdl2,RGD1311087
General protein information	Preferred Names exonuclease 3'-5' domain containing 2 Names exonuclease 3'-5' domain-containing protein 2 exonuclease 3''-5'' domain-like 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24

mRNA and Protein(s)

mRNA	Protein	Name
XM_006240286.2	XP_006240348.1	exonuclease 3'-5' domain-containing protein 2 isoform X1
NM_001108715.1	NP_001102185.1	exonuclease 3'-5' domain-containing protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	EXD2	NP_001180292.1
Canis lupus familiaris (dog)	EXD2	XP_547872.3
Xenopus tropicalis (tropical clawed frog)	exd2	NP_001016454.2
Pan troglodytes (chimpanzee)	EXD2	XP_510030.2
Macaca mulatta (Rhesus monkey)	EXD2	XP_001108864.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001549	XP_321572.5
Bos taurus (cattle)	EXD2	XP_005212140.1
Gallus gallus (chicken)	EXD2	NP_001186629.1
Mus musculus (house mouse)	Exd2	NP_598559.2
Rattus norvegicus (Norway rat)	Exd2	NP_001102185.1
Danio rerio (zebrafish)	exd2	NP_001107878.1
Drosophila melanogaster (fruit fly)	CG6744	NP_001247048.1

Gene Ontology
Bibliography

Related articles in PubMed

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.
Nieminuszczy J, Broderick R, Bellani MA, Smethurst E, Schwab RA, Cherdyntseva V, Evmorfopoulou T, Lin YL, Minczuk M, Pasero P, Gagos S, Seidman MM, Niedzwiedz W
Molecular cell75(3)605-619.e6(2019 08)

The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Park J, Lee SY, Jeong H, Kang MG, Van Haute L, Minczuk M, Seo JK, Jun Y, Myung K, Rhee HW, Lee C
Nucleic acids research47(13)7078-7093(2019 07)

The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.
Hensen F, Moretton A, van Esveld S, Farge G, Spelbrink JN
Scientific reports8(1)5368(2018 03)

EXD2 promotes homologous recombination by facilitating DNA end resection.
Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W
Nature cell biology18(3)271-280(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Exd2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Exd2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa29452	NM_001108715.1 Latest version!	Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa29452	XM_006240286.2 Latest version!	Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Exd2 ( NM_001108715.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102185.1 Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), mRNA.

Price & Availability↑

CloneID	ORa29452
Clone ID Related Accession (Same CDS sequence)	XM_006240286.2 , NM_001108715.1
Accession Version	NM_001108715.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1570636800000
Organism	Rattus norvegicus(Norway rat)
Product	exonuclease 3'-5' domain-containing protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473982.1. On or before Oct 4, 2007 this sequence version replaced XM_343086.3, XM_001053206.1. ##Evidence-Data-START## CDS exon combination :: BC166432.1 [ECO:0000331] ##Evidence-Data-END##

ATGTCTAGAC AGAATTTACT GGCTTTGACA GTGACCACCC TTTTGGGTGT GGCCATGGGG 
GGATTTGTCC TGTGGAAAGG CATCCAGCGT AAATGGAGTA AGACAAGCAG AGTGATGCAG 
CCACAGCTGC AGCCACAACC ACAGCAGCAG CAGCAGCCGC AGCCACAGCA GCAACAGCAG 
CCGCCACAGC AGGAGCAGCA GAAGCAGCAA GTGCCCGGTG CGAGGGAGTG GCCCCCTCCA 
GAAGATGACC AGTTACCCTT TGGTGCCCTG AGAACACCCA GAGCTTCATG GGAGGAGAGG 
ATACTCCAGG CAGAGGTGGT GACAGTTTCT CAGGAGGCAG AGTGGAATCA AATCCAGCCC 
TTTCTTAAAA GAGAGTTGGA AGATTTTCCA GTACTTGGAA TTGACTGTGA ATGGGTGAAT 
TTGGAAGGCA AAGCCAGTCC TTTGTCACTC CTACAGATGG CTTCCCCAAG TGGCTTCTGT 
GCATTGGTTC GCTTGCCCAG GCTGATATAT GGAGGCAAAA CACTACCCAG AACACTTTTG 
GACATATTGG CAGATGGCAC TATCTTGAAA GTAGGAGTGG GATGCTCAGA AGATGCCAAC 
AAACTTCTAC AGGATTATGG CCTCATTGTT AGGGGATGTC TGGACCTCCG CTACCTAGCC 
ATGAAGCAGG GAAACAGTGT ACTCTGTAAT GGGCTTAGCC TGAAATCACT TGCTGAGACT 
CTTTTGAACT TCCCACTTGA CAAGTCCCTT CTACTTCGTT GCAGCAACTG GGATGCTGAG 
AATCTTACTG AAGACCAGGT AACTTATGCT GCCAGGGATG CACAGATTTC AGTGGCTCTC 
TTTCTCCATC TTCTTGGATA CCCTTTCTCT AGAAATTCCT ATGAAGAGGA AAACAATGGC 
CAAATCAACT GGCAAAAAGT CTTGGAGAAA TGCAGGGATA TGGTAGACAT CCCATTCCGA 
AGCAAAGGAC TTGCCCGGCT GGGTGAAGAG ATTAATGGGG AAGCACTGGA ATCGCAGCAG 
AAGCCAAGAA ATAGGAAGGC TAGGACTGAT GGAATGGTGC CAGGCAGCAA CCAAGGGAGA 
GACCCCAGGA AGCATAAGAG GAAGCCCCTG GGGGTGGGCT ATTCTGCCAG AAAGTCACCT 
CTCTATGATA ACTGCTTTCT CCAAGCTCCT GATGGACAGC CCTTGTGCAC CTGTGACCGG 
AGGAAAGCTC AGTGGTACCT GGACAAAGGC ATTGGAGAGC TGGTGAGTAA AGAACCCTTT 
GTGGTCAGGC TACAGTTTGA ACCTGCAGGA AGACCTGAAT CCCCGGGAGA TTATTACTTG 
ATGGTTAAAG AGAACCTGTG TGTTGTCTGT GGCAAGACAG ATACCTACAT CCGGAAAAAC 
ATAATTCCAC ATGAGTACCG CAAGCACTTC CCCATTGAGA TGAAGGACCA CAACTCCCAT 
GATGTGCTGC TGCTCTGCAC CTCCTGCCAT GCCATCTCTA ACTACTATGA CAACCATCTG 
AAGCAGCAGC TGGCCAAGGA GTTCCAGGCC CCCATTGGCT CAGAGGAGGG CCTGCGCCTG 
CTGGAAGACC TAGAGCGTAG GCAGGTGCGT TCCGGAGCCA GAGCCCTGCT CAATGCGGAG 
AGCCTACCTG CCCATCGGAA AGAAGAGTTG CTGCATGCAC TCAGGGAGTT TTACAACACA 
GACATTGTTA CAGAGGAGAT GCTCCAAGAG GCGGCCAGCC TGGAGACCAG GATATACAAT 
GAAAGTTATA TTCCTCATGG GCTAAAGGTG GTACAGCGGC ACACGGAGGG TGGGCTGCGC 
TCCCTCATGC AGCTGGAGAG CCGCTGGCGT CAGCACTTCC TGGACTCCAT GCAGCCTAAG 
CACCTGCCCC AGCAGTGGTC AGTGGACCAT AACCATCAGA AGCTGCTCCG AAAGTATGGG 
GACGACCTTC CCATCAAGCT GTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102185.1
CDS	139..2085
Translation	MSRQNLLALTVTTLLGVAMGGFVLWKGIQRKWSKTSRVMQPQLQPQPQQQQQPQPQQQQQPPQQEQQKQQVPGAREWPPPEDDQLPFGALRTPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGKTLPRTLLDILADGTILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNSVLCNGLSLKSLAETLLNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRNSYEEENNGQINWQKVLEKCRDMVDIPFRSKGLARLGEEINGEALESQQKPRNRKARTDGMVPGSNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIVTEEMLQEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS

Target ORF information:

RefSeq Version	NM_001108715.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108715.1

ORF Insert Sequence:

ATGTCTAGAC AGAATTTACT GGCTTTGACA GTGACCACCC TTTTGGGTGT GGCCATGGGG 
GGATTTGTCC TGTGGAAAGG CATCCAGCGT AAATGGAGTA AGACAAGCAG AGTGATGCAG 
CCACAGCTGC AGCCACAACC ACAGCAGCAG CAGCAGCCGC AGCCACAGCA GCAACAGCAG 
CCGCCACAGC AGGAGCAGCA GAAGCAGCAA GTGCCCGGTG CGAGGGAGTG GCCCCCTCCA 
GAAGATGACC AGTTACCCTT TGGTGCCCTG AGAACACCCA GAGCTTCATG GGAGGAGAGG 
ATACTCCAGG CAGAGGTGGT GACAGTTTCT CAGGAGGCAG AGTGGAATCA AATCCAGCCC 
TTTCTTAAAA GAGAGTTGGA AGATTTTCCA GTACTTGGAA TTGACTGTGA ATGGGTGAAT 
TTGGAAGGCA AAGCCAGTCC TTTGTCACTC CTACAGATGG CTTCCCCAAG TGGCTTCTGT 
GCATTGGTTC GCTTGCCCAG GCTGATATAT GGAGGCAAAA CACTACCCAG AACACTTTTG 
GACATATTGG CAGATGGCAC TATCTTGAAA GTAGGAGTGG GATGCTCAGA AGATGCCAAC 
AAACTTCTAC AGGATTATGG CCTCATTGTT AGGGGATGTC TGGACCTCCG CTACCTAGCC 
ATGAAGCAGG GAAACAGTGT ACTCTGTAAT GGGCTTAGCC TGAAATCACT TGCTGAGACT 
CTTTTGAACT TCCCACTTGA CAAGTCCCTT CTACTTCGTT GCAGCAACTG GGATGCTGAG 
AATCTTACTG AAGACCAGGT AACTTATGCT GCCAGGGATG CACAGATTTC AGTGGCTCTC 
TTTCTCCATC TTCTTGGATA CCCTTTCTCT AGAAATTCCT ATGAAGAGGA AAACAATGGC 
CAAATCAACT GGCAAAAAGT CTTGGAGAAA TGCAGGGATA TGGTAGACAT CCCATTCCGA 
AGCAAAGGAC TTGCCCGGCT GGGTGAAGAG ATTAATGGGG AAGCACTGGA ATCGCAGCAG 
AAGCCAAGAA ATAGGAAGGC TAGGACTGAT GGAATGGTGC CAGGCAGCAA CCAAGGGAGA 
GACCCCAGGA AGCATAAGAG GAAGCCCCTG GGGGTGGGCT ATTCTGCCAG AAAGTCACCT 
CTCTATGATA ACTGCTTTCT CCAAGCTCCT GATGGACAGC CCTTGTGCAC CTGTGACCGG 
AGGAAAGCTC AGTGGTACCT GGACAAAGGC ATTGGAGAGC TGGTGAGTAA AGAACCCTTT 
GTGGTCAGGC TACAGTTTGA ACCTGCAGGA AGACCTGAAT CCCCGGGAGA TTATTACTTG 
ATGGTTAAAG AGAACCTGTG TGTTGTCTGT GGCAAGACAG ATACCTACAT CCGGAAAAAC 
ATAATTCCAC ATGAGTACCG CAAGCACTTC CCCATTGAGA TGAAGGACCA CAACTCCCAT 
GATGTGCTGC TGCTCTGCAC CTCCTGCCAT GCCATCTCTA ACTACTATGA CAACCATCTG 
AAGCAGCAGC TGGCCAAGGA GTTCCAGGCC CCCATTGGCT CAGAGGAGGG CCTGCGCCTG 
CTGGAAGACC TAGAGCGTAG GCAGGTGCGT TCCGGAGCCA GAGCCCTGCT CAATGCGGAG 
AGCCTACCTG CCCATCGGAA AGAAGAGTTG CTGCATGCAC TCAGGGAGTT TTACAACACA 
GACATTGTTA CAGAGGAGAT GCTCCAAGAG GCGGCCAGCC TGGAGACCAG GATATACAAT 
GAAAGTTATA TTCCTCATGG GCTAAAGGTG GTACAGCGGC ACACGGAGGG TGGGCTGCGC 
TCCCTCATGC AGCTGGAGAG CCGCTGGCGT CAGCACTTCC TGGACTCCAT GCAGCCTAAG 
CACCTGCCCC AGCAGTGGTC AGTGGACCAT AACCATCAGA AGCTGCTCCG AAAGTATGGG 
GACGACCTTC CCATCAAGCT GTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Exd2 ( XM_006240286.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006240348.1 Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa29452
Clone ID Related Accession (Same CDS sequence)	XM_006240286.2 , NM_001108715.1
Accession Version	XM_006240286.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	exonuclease 3'-5' domain-containing protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006240286.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTAGAC AGAATTTACT GGCTTTGACA GTGACCACCC TTTTGGGTGT GGCCATGGGG 
GGATTTGTCC TGTGGAAAGG CATCCAGCGT AAATGGAGTA AGACAAGCAG AGTGATGCAG 
CCACAGCTGC AGCCACAACC ACAGCAGCAG CAGCAGCCGC AGCCACAGCA GCAACAGCAG 
CCGCCACAGC AGGAGCAGCA GAAGCAGCAA GTGCCCGGTG CGAGGGAGTG GCCCCCTCCA 
GAAGATGACC AGTTACCCTT TGGTGCCCTG AGAACACCCA GAGCTTCATG GGAGGAGAGG 
ATACTCCAGG CAGAGGTGGT GACAGTTTCT CAGGAGGCAG AGTGGAATCA AATCCAGCCC 
TTTCTTAAAA GAGAGTTGGA AGATTTTCCA GTACTTGGAA TTGACTGTGA ATGGGTGAAT 
TTGGAAGGCA AAGCCAGTCC TTTGTCACTC CTACAGATGG CTTCCCCAAG TGGCTTCTGT 
GCATTGGTTC GCTTGCCCAG GCTGATATAT GGAGGCAAAA CACTACCCAG AACACTTTTG 
GACATATTGG CAGATGGCAC TATCTTGAAA GTAGGAGTGG GATGCTCAGA AGATGCCAAC 
AAACTTCTAC AGGATTATGG CCTCATTGTT AGGGGATGTC TGGACCTCCG CTACCTAGCC 
ATGAAGCAGG GAAACAGTGT ACTCTGTAAT GGGCTTAGCC TGAAATCACT TGCTGAGACT 
CTTTTGAACT TCCCACTTGA CAAGTCCCTT CTACTTCGTT GCAGCAACTG GGATGCTGAG 
AATCTTACTG AAGACCAGGT AACTTATGCT GCCAGGGATG CACAGATTTC AGTGGCTCTC 
TTTCTCCATC TTCTTGGATA CCCTTTCTCT AGAAATTCCT ATGAAGAGGA AAACAATGGC 
CAAATCAACT GGCAAAAAGT CTTGGAGAAA TGCAGGGATA TGGTAGACAT CCCATTCCGA 
AGCAAAGGAC TTGCCCGGCT GGGTGAAGAG ATTAATGGGG AAGCACTGGA ATCGCAGCAG 
AAGCCAAGAA ATAGGAAGGC TAGGACTGAT GGAATGGTGC CAGGCAGCAA CCAAGGGAGA 
GACCCCAGGA AGCATAAGAG GAAGCCCCTG GGGGTGGGCT ATTCTGCCAG AAAGTCACCT 
CTCTATGATA ACTGCTTTCT CCAAGCTCCT GATGGACAGC CCTTGTGCAC CTGTGACCGG 
AGGAAAGCTC AGTGGTACCT GGACAAAGGC ATTGGAGAGC TGGTGAGTAA AGAACCCTTT 
GTGGTCAGGC TACAGTTTGA ACCTGCAGGA AGACCTGAAT CCCCGGGAGA TTATTACTTG 
ATGGTTAAAG AGAACCTGTG TGTTGTCTGT GGCAAGACAG ATACCTACAT CCGGAAAAAC 
ATAATTCCAC ATGAGTACCG CAAGCACTTC CCCATTGAGA TGAAGGACCA CAACTCCCAT 
GATGTGCTGC TGCTCTGCAC CTCCTGCCAT GCCATCTCTA ACTACTATGA CAACCATCTG 
AAGCAGCAGC TGGCCAAGGA GTTCCAGGCC CCCATTGGCT CAGAGGAGGG CCTGCGCCTG 
CTGGAAGACC TAGAGCGTAG GCAGGTGCGT TCCGGAGCCA GAGCCCTGCT CAATGCGGAG 
AGCCTACCTG CCCATCGGAA AGAAGAGTTG CTGCATGCAC TCAGGGAGTT TTACAACACA 
GACATTGTTA CAGAGGAGAT GCTCCAAGAG GCGGCCAGCC TGGAGACCAG GATATACAAT 
GAAAGTTATA TTCCTCATGG GCTAAAGGTG GTACAGCGGC ACACGGAGGG TGGGCTGCGC 
TCCCTCATGC AGCTGGAGAG CCGCTGGCGT CAGCACTTCC TGGACTCCAT GCAGCCTAAG 
CACCTGCCCC AGCAGTGGTC AGTGGACCAT AACCATCAGA AGCTGCTCCG AAAGTATGGG 
GACGACCTTC CCATCAAGCT GTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006240348.1
CDS	487..2433
Translation	MSRQNLLALTVTTLLGVAMGGFVLWKGIQRKWSKTSRVMQPQLQPQPQQQQQPQPQQQQQPPQQEQQKQQVPGAREWPPPEDDQLPFGALRTPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGKTLPRTLLDILADGTILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNSVLCNGLSLKSLAETLLNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRNSYEEENNGQINWQKVLEKCRDMVDIPFRSKGLARLGEEINGEALESQQKPRNRKARTDGMVPGSNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIVTEEMLQEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS

Target ORF information:

RefSeq Version	XM_006240286.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus exonuclease 3'-5' domain containing 2 (Exd2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006240286.2

ORF Insert Sequence:

ATGTCTAGAC AGAATTTACT GGCTTTGACA GTGACCACCC TTTTGGGTGT GGCCATGGGG 
GGATTTGTCC TGTGGAAAGG CATCCAGCGT AAATGGAGTA AGACAAGCAG AGTGATGCAG 
CCACAGCTGC AGCCACAACC ACAGCAGCAG CAGCAGCCGC AGCCACAGCA GCAACAGCAG 
CCGCCACAGC AGGAGCAGCA GAAGCAGCAA GTGCCCGGTG CGAGGGAGTG GCCCCCTCCA 
GAAGATGACC AGTTACCCTT TGGTGCCCTG AGAACACCCA GAGCTTCATG GGAGGAGAGG 
ATACTCCAGG CAGAGGTGGT GACAGTTTCT CAGGAGGCAG AGTGGAATCA AATCCAGCCC 
TTTCTTAAAA GAGAGTTGGA AGATTTTCCA GTACTTGGAA TTGACTGTGA ATGGGTGAAT 
TTGGAAGGCA AAGCCAGTCC TTTGTCACTC CTACAGATGG CTTCCCCAAG TGGCTTCTGT 
GCATTGGTTC GCTTGCCCAG GCTGATATAT GGAGGCAAAA CACTACCCAG AACACTTTTG 
GACATATTGG CAGATGGCAC TATCTTGAAA GTAGGAGTGG GATGCTCAGA AGATGCCAAC 
AAACTTCTAC AGGATTATGG CCTCATTGTT AGGGGATGTC TGGACCTCCG CTACCTAGCC 
ATGAAGCAGG GAAACAGTGT ACTCTGTAAT GGGCTTAGCC TGAAATCACT TGCTGAGACT 
CTTTTGAACT TCCCACTTGA CAAGTCCCTT CTACTTCGTT GCAGCAACTG GGATGCTGAG 
AATCTTACTG AAGACCAGGT AACTTATGCT GCCAGGGATG CACAGATTTC AGTGGCTCTC 
TTTCTCCATC TTCTTGGATA CCCTTTCTCT AGAAATTCCT ATGAAGAGGA AAACAATGGC 
CAAATCAACT GGCAAAAAGT CTTGGAGAAA TGCAGGGATA TGGTAGACAT CCCATTCCGA 
AGCAAAGGAC TTGCCCGGCT GGGTGAAGAG ATTAATGGGG AAGCACTGGA ATCGCAGCAG 
AAGCCAAGAA ATAGGAAGGC TAGGACTGAT GGAATGGTGC CAGGCAGCAA CCAAGGGAGA 
GACCCCAGGA AGCATAAGAG GAAGCCCCTG GGGGTGGGCT ATTCTGCCAG AAAGTCACCT 
CTCTATGATA ACTGCTTTCT CCAAGCTCCT GATGGACAGC CCTTGTGCAC CTGTGACCGG 
AGGAAAGCTC AGTGGTACCT GGACAAAGGC ATTGGAGAGC TGGTGAGTAA AGAACCCTTT 
GTGGTCAGGC TACAGTTTGA ACCTGCAGGA AGACCTGAAT CCCCGGGAGA TTATTACTTG 
ATGGTTAAAG AGAACCTGTG TGTTGTCTGT GGCAAGACAG ATACCTACAT CCGGAAAAAC 
ATAATTCCAC ATGAGTACCG CAAGCACTTC CCCATTGAGA TGAAGGACCA CAACTCCCAT 
GATGTGCTGC TGCTCTGCAC CTCCTGCCAT GCCATCTCTA ACTACTATGA CAACCATCTG 
AAGCAGCAGC TGGCCAAGGA GTTCCAGGCC CCCATTGGCT CAGAGGAGGG CCTGCGCCTG 
CTGGAAGACC TAGAGCGTAG GCAGGTGCGT TCCGGAGCCA GAGCCCTGCT CAATGCGGAG 
AGCCTACCTG CCCATCGGAA AGAAGAGTTG CTGCATGCAC TCAGGGAGTT TTACAACACA 
GACATTGTTA CAGAGGAGAT GCTCCAAGAG GCGGCCAGCC TGGAGACCAG GATATACAAT 
GAAAGTTATA TTCCTCATGG GCTAAAGGTG GTACAGCGGC ACACGGAGGG TGGGCTGCGC 
TCCCTCATGC AGCTGGAGAG CCGCTGGCGT CAGCACTTCC TGGACTCCAT GCAGCCTAAG 
CACCTGCCCC AGCAGTGGTC AGTGGACCAT AACCATCAGA AGCTGCTCCG AAAGTATGGG 
GACGACCTTC CCATCAAGCT GTCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.
Molecular cell75(3)605-619.e6(2019 08)
Nieminuszczy J,Broderick R,Bellani MA,Smethurst E,Schwab RA,Cherdyntseva V,Evmorfopoulou T,Lin YL,Minczuk M,Pasero P,Gagos S,Seidman MM,Niedzwiedz W

The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Nucleic acids research47(13)7078-7093(2019 07)
Park J,Lee SY,Jeong H,Kang MG,Van Haute L,Minczuk M,Seo JK,Jun Y,Myung K,Rhee HW,Lee C

The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair.
Scientific reports8(1)5368(2018 03)
Hensen F,Moretton A,van Esveld S,Farge G,Spelbrink JN

EXD2 promotes homologous recombination by facilitating DNA end resection.
Nature cell biology18(3)271-280(2016 Mar)
Broderick R,Nieminuszczy J,Baddock HT,Deshpande R,Gileadi O,Paull TT,McHugh PJ,Niedzwiedz W

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Exd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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