Dram2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dram2
Entrez Gene ID	362011
Full Name	DNA-damage regulated autophagy modulator 2
Synonyms	Tmem77
General protein information	Preferred Names DNA-damage regulated autophagy modulator 2 Names DNA damage-regulated autophagy modulator protein 2 transmembrane protein 77
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
XM_006233120.3	XP_006233182.1	DNA damage-regulated autophagy modulator protein 2 isoform X1
XM_006233121.2	XP_006233183.1	DNA damage-regulated autophagy modulator protein 2 isoform X1
XM_006233123.3	XP_006233185.1	DNA damage-regulated autophagy modulator protein 2 isoform X2
XM_006233122.3	XP_006233184.1	DNA damage-regulated autophagy modulator protein 2 isoform X1
NM_001025018.1	NP_001020189.1	DNA damage-regulated autophagy modulator protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	DRAM2	NP_848549.3
Rattus norvegicus (Norway rat)	Dram2	NP_001020189.1
Canis lupus familiaris (dog)	DRAM2	XP_005621845.1
Danio rerio (zebrafish)	dram2b	NP_001002135.1
Macaca mulatta (Rhesus monkey)	DRAM2	XP_001104325.2
Bos taurus (cattle)	DRAM2	NP_001070464.1
Pan troglodytes (chimpanzee)	DRAM2	XP_001162049.1
Mus musculus (house mouse)	Dram2	NP_080289.1
Caenorhabditis elegans (roundworm)	C33A11.2	NP_510541.1
Gallus gallus (chicken)	DRAM2	XP_003642762.1

Gene Ontology
Bibliography

Related articles in PubMed

Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.
El-Asrag ME, Sergouniotis PI, McKibbin M, Plagnol V, Sheridan E, Waseem N, Abdelhamed Z, McKeefry D, Van Schil K, Poulter JA, , Johnson CA, Carr IM, Leroy BP, De Baere E, Inglehearn CF, Webster AR, Toomes C, Ali M
American journal of human genetics96(6)948-54(2015 Jun)

Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death.
Park SM, Kim K, Lee EJ, Kim BK, Lee TJ, Seo T, Jang IS, Lee SH, Kim S, Lee JH, Park J
Biochemical and biophysical research communications390(4)1340-4(2009 Dec)

Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy.
O'Prey J, Skommer J, Wilkinson S, Ryan KM
Cell cycle (Georgetown, Tex.)8(14)2260-5(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dram2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dram2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa07037	NM_001025018.1 Latest version!	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa07037	XM_006233122.3 Latest version!	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa07037	XM_006233120.3 Latest version!	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa07037	XM_006233121.2 Latest version!	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa25157	XM_006233123.3 Latest version!	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dram2 ( NM_001025018.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020189.1 Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), mRNA.

Price & Availability↑

CloneID	ORa07037
Clone ID Related Accession (Same CDS sequence)	XM_006233120.3 , XM_006233121.2 , XM_006233122.3 , NM_001025018.1
Accession Version	NM_001025018.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	DNA damage-regulated autophagy modulator protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091251.1. On Jun 25, 2005 this sequence version replaced XM_342310.2. ##Evidence-Data-START## Transcript exon combination :: BC091251.1, FQ218349.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020189.1
CDS	349..1152
Translation	MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ

Target ORF information:

RefSeq Version	NM_001025018.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025018.1

ORF Insert Sequence:

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram2 ( XM_006233120.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233182.1 Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa07037
Clone ID Related Accession (Same CDS sequence)	XM_006233120.3 , XM_006233121.2 , XM_006233122.3 , NM_001025018.1
Accession Version	XM_006233120.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	DNA damage-regulated autophagy modulator protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233120.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233182.1
CDS	296..1099
Translation	MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ

Target ORF information:

RefSeq Version	XM_006233120.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233120.3

ORF Insert Sequence:

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram2 ( XM_006233121.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233183.1 Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa07037
Clone ID Related Accession (Same CDS sequence)	XM_006233120.3 , XM_006233121.2 , XM_006233122.3 , NM_001025018.1
Accession Version	XM_006233121.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	DNA damage-regulated autophagy modulator protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006233121.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233183.1
CDS	233..1036
Translation	MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ

Target ORF information:

RefSeq Version	XM_006233121.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233121.2

ORF Insert Sequence:

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram2 ( XM_006233122.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233184.1 Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	ORa07037
Clone ID Related Accession (Same CDS sequence)	XM_006233120.3 , XM_006233121.2 , XM_006233122.3 , NM_001025018.1
Accession Version	XM_006233122.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	DNA damage-regulated autophagy modulator protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233122.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233184.1
CDS	335..1138
Translation	MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ

Target ORF information:

RefSeq Version	XM_006233122.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233122.3

ORF Insert Sequence:

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGTAAGTGCA CTTAGCATGA TGACTTGCTC ATCAATTTTG 
TACAGTAGTG ACTTTGGTGC TGATATAGTA CAGAAACTAC ACTGGAACCC AGAGGACAAA 
GGTTATGTGC TTCACATAGT TACTACTGCA GCAGAATGGT CTATGTCATT TTCCTTCTTT 
GGATTTTTCC TGACTTATAT TCGTGATTTT CAGAAAATTA CTTTACGGGT GGAAGCCAAT 
TTACATGGAT TAACCCTCTA TGACACTGTT CCTTGCCCTG TTACCAATGA AAGAACACCA 
TTGCTTTCCA GAGATTTTCA ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dram2 ( XM_006233123.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006233185.1 Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X4, mRNA.

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CloneID	ORa25157
Clone ID Related Accession (Same CDS sequence)	XM_006233123.3
Accession Version	XM_006233123.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 705bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	DNA damage-regulated autophagy modulator protein 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006233123.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGGTTATGTG CTTCACATAG TTACTACTGC AGCAGAATGG 
TCTATGTCAT TTTCCTTCTT TGGATTTTTC CTGACTTATA TTCGTGATTT TCAGAAAATT 
ACTTTACGGG TGGAAGCCAA TTTACATGGA TTAACCCTCT ATGACACTGT TCCTTGCCCT 
GTTACCAATG AAAGAACACC ATTGCTTTCC AGAGATTTTC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006233185.1
CDS	298..1002
Translation	MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ

Target ORF information:

RefSeq Version	XM_006233123.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA-damage regulated autophagy modulator 2 (Dram2), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006233123.3

ORF Insert Sequence:

ATGTGGTGGT TTCAGCAAGG CCTTAGCTTC CTTCCGTCGG CCCTTGTAAT TTGGACATTT 
GCTACCTTTA TATTCTCATA TATCACTGCA ATAACACTCC ACCATGTTGA CCCTGCATTG 
CCTTACATCA GCGACACTGG GACAATGCCT CCTGAAAGGT GCCTCTTTGG AGTAATGCTG 
AATATCGCTG CCGTTTTAGG CATTGCTACT ATCTATGTTC GTTACAAGCA AGTTCATGCA 
CTGAACCCTG AAGAGAACCT TATCATCAAA TTAAACAAGG CTGGCCTTGT ACTTGGGATA 
CTGAGTTGTT TAGGACTTTC TCTTGTGGCA AATTTCCAGA AATCAGCACT ATTTATTGTT 
CATGTATGTG GAGCTGTCCT TGCCTTTAGT ATGGGCTCAT TTTACATGTT TGTTCAGACC 
ATCCTTTCCT ACCAAATGCA GCCCAAAATT CACAGCAAAC AAGTCTTCTG GGTCCGACTA 
CTATTGGTTA TCTGGTGTGG AGGTTATGTG CTTCACATAG TTACTACTGC AGCAGAATGG 
TCTATGTCAT TTTCCTTCTT TGGATTTTTC CTGACTTATA TTCGTGATTT TCAGAAAATT 
ACTTTACGGG TGGAAGCCAA TTTACATGGA TTAACCCTCT ATGACACTGT TCCTTGCCCT 
GTTACCAATG AAAGAACACC ATTGCTTTCC AGAGATTTTC AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.
American journal of human genetics96(6)948-54(2015 Jun)
El-Asrag ME,Sergouniotis PI,McKibbin M,Plagnol V,Sheridan E,Waseem N,Abdelhamed Z,McKeefry D,Van Schil K,Poulter JA,,Johnson CA,Carr IM,Leroy BP,De Baere E,Inglehearn CF,Webster AR,Toomes C,Ali M

Reduced expression of DRAM2/TMEM77 in tumor cells interferes with cell death.
Biochemical and biophysical research communications390(4)1340-4(2009 Dec)
Park SM,Kim K,Lee EJ,Kim BK,Lee TJ,Seo T,Jang IS,Lee SH,Kim S,Lee JH,Park J

Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy.
Cell cycle (Georgetown, Tex.)8(14)2260-5(2009 Jul)
O'Prey J,Skommer J,Wilkinson S,Ryan KM

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Dram2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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