Cradd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cradd
Entrez Gene ID	314756
Full Name	CASP2 and RIPK1 domain containing adaptor with death domain
Synonyms	RAIDD
General protein information	Preferred Names CASP2 and RIPK1 domain containing adaptor with death domain Names death domain-containing protein CRADD
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108085.1	NP_001101555.1	death domain-containing protein CRADD

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CRADD	NP_001077242.1
Rattus norvegicus (Norway rat)	Cradd	NP_001101555.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic mapping and exome sequencing identify variants associated with five novel diseases.
Puffenberger EG, Jinks RN, Sougnez C, Cibulskis K, Willert RA, Achilly NP, Cassidy RP, Fiorentini CJ, Heiken KF, Lawrence JJ, Mahoney MH, Miller CJ, Nair DT, Politi KA, Worcester KN, Setton RA, Dipiazza R, Sherman EA, Eastman JT, Francklyn C, Robey-Bond S, Rider NL, Gabriel S, Morton DH, Strauss KA
PloS one7(1)e28936(2012)

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T
Molecular cell43(1)57-71(2011 Jul)

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Smith AJ, Karpova Y, D'Agostino R Jr, Willingham M, Kulik G
PloS one4(7)e6224(2009 Jul)

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Berube C, Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R, Yeh WC, Mak TW, Benchimol S
Proceedings of the National Academy of Sciences of the United States of America102(40)14314-20(2005 Oct)

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons.
Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L
Cell death and differentiation11(6)618-30(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Cradd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cradd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa41499	NM_001108085.1 Latest version!	Rattus norvegicus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cradd ( NM_001108085.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001101555.1 Rattus norvegicus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), mRNA.

Price & Availability↑

CloneID	ORa41499
Clone ID Related Accession (Same CDS sequence)	NM_001108085.1
Accession Version	NM_001108085.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1555516800000
Organism	Rattus norvegicus(Norway rat)
Product	death domain-containing protein CRADD
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473960.2. On or before Oct 4, 2007 this sequence version replaced XM_235061.4, XM_001080418.1.

ATGGATGCCA GAGACAAGCA AGTTCTCCGC TCACTGCGTC TGGAGCTGGG TGCTGAGGTT 
CTGGTAGAAG GACTGGTTCT TCAGTACCTT TACCAGGAAG GAATTTTGAC GGAAAACCAC 
ATTCAAGAAA TCAAAGCTCA AACCACAGGC CTCCGGAAGA CAATGCTTTT GCTGGACATT 
CTGCCTTCCA GGGGCCCCAA AGCCTTTGAC ACCTTCCTAG ATTCCCTCCA GGAATTTCCC 
TGGGTAAGAG AGAAGCTGGA GAAGGCAAGA GAGGAAGCCA CGGCTGAGCT GCCTACAGCT 
CAGCCGAGAA AAGACCATTT GCCTGAGAAG CCTTTTATTA TTAGGCTTAT TACCGCAGCG 
CCAAGGGAGG CAGCACCAGA GTCTCTCAGT CCGGTCGCGG AGACTGCTCA GTCGGGCCAG 
AAGGGGCGTT TGGACCAATC AAACTCTTGC CCCTCCGCAC CTGTCGCAGC CACTGAGGCT 
TGTTTGGACC AATCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001101555.1
CDS	162..659
Translation	MDARDKQVLRSLRLELGAEVLVEGLVLQYLYQEGILTENHIQEIKAQTTGLRKTMLLLDILPSRGPKAFDTFLDSLQEFPWVREKLEKAREEATAELPTAQPRKDHLPEKPFIIRLITAAPREAAPESLSPVAETAQSGQKGRLDQSNSCPSAPVAATEACLDQS

Target ORF information:

RefSeq Version	NM_001108085.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CASP2 and RIPK1 domain containing adaptor with death domain (Cradd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108085.1

ORF Insert Sequence:

ATGGATGCCA GAGACAAGCA AGTTCTCCGC TCACTGCGTC TGGAGCTGGG TGCTGAGGTT 
CTGGTAGAAG GACTGGTTCT TCAGTACCTT TACCAGGAAG GAATTTTGAC GGAAAACCAC 
ATTCAAGAAA TCAAAGCTCA AACCACAGGC CTCCGGAAGA CAATGCTTTT GCTGGACATT 
CTGCCTTCCA GGGGCCCCAA AGCCTTTGAC ACCTTCCTAG ATTCCCTCCA GGAATTTCCC 
TGGGTAAGAG AGAAGCTGGA GAAGGCAAGA GAGGAAGCCA CGGCTGAGCT GCCTACAGCT 
CAGCCGAGAA AAGACCATTT GCCTGAGAAG CCTTTTATTA TTAGGCTTAT TACCGCAGCG 
CCAAGGGAGG CAGCACCAGA GTCTCTCAGT CCGGTCGCGG AGACTGCTCA GTCGGGCCAG 
AAGGGGCGTT TGGACCAATC AAACTCTTGC CCCTCCGCAC CTGTCGCAGC CACTGAGGCT 
TGTTTGGACC AATCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic mapping and exome sequencing identify variants associated with five novel diseases.
PloS one7(1)e28936(2012)
Puffenberger EG,Jinks RN,Sougnez C,Cibulskis K,Willert RA,Achilly NP,Cassidy RP,Fiorentini CJ,Heiken KF,Lawrence JJ,Mahoney MH,Miller CJ,Nair DT,Politi KA,Worcester KN,Setton RA,Dipiazza R,Sherman EA,Eastman JT,Francklyn C,Robey-Bond S,Rider NL,Gabriel S,Morton DH,Strauss KA

Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Molecular cell43(1)57-71(2011 Jul)
Oliver TG,Meylan E,Chang GP,Xue W,Burke JR,Humpton TJ,Hubbard D,Bhutkar A,Jacks T

Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
PloS one4(7)e6224(2009 Jul)
Smith AJ,Karpova Y,D'Agostino R Jr,Willingham M,Kulik G

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.
Proceedings of the National Academy of Sciences of the United States of America102(40)14314-20(2005 Oct)
Berube C,Boucher LM,Ma W,Wakeham A,Salmena L,Hakem R,Yeh WC,Mak TW,Benchimol S

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons.
Cell death and differentiation11(6)618-30(2004 Jun)
Jabado O,Wang Q,Rideout HJ,Yeasmin M,Guo KX,Vekrellis K,Papantonis S,Angelastro JM,Troy CM,Stefanis L

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Cradd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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