Hps6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hps6
Entrez Gene ID	309446
Full Name	HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
Synonyms	Hsp6
General protein information	Preferred Names HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Names Hermansky-Pudlak syndrome 6 protein homolog ru ruby-eye protein homolog ruby-eye-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54
Summary	mouse homolog may be involved in synthesis of highly specialized lysosome-related organelles; mutation of human homolog is associated with Hermansky-Pudlak syndrome [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_181432.2	NP_852097.1	Hermansky-Pudlak syndrome 6 protein homolog

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HPS6	XP_851823.2
Pan troglodytes (chimpanzee)	HPS6	XP_001170704.1
Rattus norvegicus (Norway rat)	Hps6	NP_852097.1
Macaca mulatta (Rhesus monkey)	HPS6	XP_001111761.1
Mus musculus (house mouse)	Hps6	NP_789742.2
Gallus gallus (chicken)	HPS6	XP_001233664.1
Danio rerio (zebrafish)	LOC101882947	XP_005156992.1
Xenopus tropicalis (tropical clawed frog)	hps6	XP_002940614.2
Homo sapiens (human)	HPS6	NP_079023.2
Bos taurus (cattle)	HPS6	NP_001075055.1

Gene Ontology
Bibliography

Related articles in PubMed

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
Li K, Yang L, Zhang C, Niu Y, Li W, Liu JJ
Journal of cell science127(Pt 21)4574-88(2014 Nov)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.
Di Pietro SM, Falcón-Pérez JM, Dell'Angelica EC
Traffic (Copenhagen, Denmark)5(4)276-83(2004 Apr)

Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6.
Zhang Q, Zhao B, Li W, Oiso N, Novak EK, Rusiniak ME, Gautam R, Chintala S, O'Brien EP, Zhang Y, Roe BA, Elliott RW, Eicher EM, Liang P, Kratz C, Legius E, Spritz RA, O'Sullivan TN, Copeland NG, Jenkins NA, Swank RT
Nature genetics33(2)145-53(2003 Feb)

The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.
Markert CL, Silvers WK
Genetics41(3)429-50(1956 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Hps6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hps6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42416	NM_181432.2 Latest version!	Rattus norvegicus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hps6 ( NM_181432.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_852097.1 Rattus norvegicus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.

Price & Availability↑

CloneID	ORa42416
Clone ID Related Accession (Same CDS sequence)	NM_181432.2
Accession Version	NM_181432.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2430bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	Hermansky-Pudlak syndrome 6 protein homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086975.1. On Dec 26, 2004 this sequence version replaced NM_181432.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086975.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGCGTG CAGGAACTCT GCGCCTGCTT TCGGATCTGA GCAACTTCAC TGGCGCGGCC 
CGGCTCCGCG AGTTGTTGGC AGGGGACCCA GCTATCCTAG TCCGCTGCAG CCCTGATGGC 
CGTCACCTGC TACTGTTAAG ACCTCCCGGA TCGCCCGCCC CCCAACTTCT AGTGGCTGTG 
CGTGGGCCGG GCCTGCCTCT GGAGCGTGCC TGGTCGGAGG GCGACCCCTC GCCGCTGGAC 
GTCTTTTTCG TTCCATGGCT GGCGCGACCC GCGCTGATAT TGGTATGGGA GAGTGGCCTA 
ACAGAGGTGT GGGGCGTGGG GATGGAGCCT GGATGGAAGC TACTTCAGAG CACTGAGTTG 
TGTCCGGATG GTGGAGCCCG CGTGATGGCT GTGGCAGCAA CCCGAGGCCG CCTAGTTTGG 
TGCGAGGAGC GTCAGCCTGG CGTTGAGGAC CAACCAGGGC AGCTTTCAAT GGCCTTCAAC 
CACTGTGTGT GCGTCAAGAC CCTGGACACC AGCGGGGAGG CTGGCACCAA ACTAGGCTGC 
ACCCACATCC TGCTGCATCA CTGCCCCTCT TTTGGACTGA TAGCCTCCCG CAAGGAACTC 
TTCCTGGTGC CTACTTCCAC CACTTGGCCT GGTGTGGCCC ATGTTCTGCT CATCTGGAGC 
CCAAGCAAGG GGAAGGTAAT AGTTGCTGCC CCATCTCTCG GTCTTTCTCA CAGTAAAAGC 
CTGAATCCCA AACAAGGGGA TACTTGGGAC TTTCGGACCC TGCTGCGAGG CCTTCCTGGA 
TTCCTGTCCC CCAGGGAGCC GCTGGCTGTA CACACTTGGG CCCCATCTTC CCAGGGCTTG 
TTGTTGCTTG ACTTGAAAGG TAAGGTGAGC CTAGTGCAGT GCCATGGTGG TACTCGAACT 
GTGGGACTCC TGCAGGAGGC ACCTGTAGGT CTACAAGGGT CTGCAGCCCT GGGAACATTT 
CATGGCACCT TAGCCTGTGT CTTGGGCTCC ACCTTGGAAC TGCTGGACAT GAGCAGTGGG 
CGGCTGTTGG AAAGGAAGGT ACTAAGTACA GACAGAGTAC ACCTCCTGGA GCCTCCAGCC 
CCTGGCGTGA AGAATGAGGA AGACCTAGAG ACCCGAGGAG CTCTCCGTTT GCTTTCAGCC 
TTGGGTCTCT TTTGTGTGTG TTGGGAAGCT CCCCAAGGCC TTGAGGTGCC CTCGGACAAG 
GATCTGGTGT TTGAGGAGGC CTGTGGGTAC TACCAGCGTC GGAGTCTTCG AGGCACCCAG 
CTTACCCCGG AAGAGCTGAG ACACAACAGC ATGTTTCGGG CACCTCAGGC CTTGGCCTCC 
ATTCTCCAGG GCCACCTGCC CCCATCTGCA CTATTGACCA CCCTGAGGGC TGAACTTCGA 
GATTATCGGA GTATAGAACA GCTCAAGGCC CAGCTGGTGG CTGGGGATGA TGAAGAGACG 
GGCTGGACGG AGTTAGCAGA GCACGAGGTG GCACGCCTGC TGAGAACCCA CTTGACAGGA 
GACCAGCTGG CCCAATTCAA CACCATTTTC CAAGCCCTTC CTACAGCAGC TTGGAGTGCC 
ACCCTCCAAG CCCTACAACT GCAGCCGGAT AGGAGTGGCA GGCTGAGGTC CCAAGCGCCC 
CCGGATGTAT GGAAGAAAGT CCTGAGGGCT CCAACGGCTG GAAAGGAACA TCCCAATGGA 
ATCCTGCCTC CCTTTGAACT CCTGTGTCAG TGCCTAGGCC AGCTAGAGCC TCAGTGGCTT 
CCCCCGTTTG TGGAACTGGC ACAGCAACAG GGTGGTCCAG GCTGGGGCGC CGAAGGTCCC 
AGTCTGCCCC TTTATCGCCG AGCCCTGTCC GTGCTGGGTG AGGAAGGGAA GAGACCTGAG 
GCTCTAGAAC TCGAGCTGCT TCTGGGCAGC GGGCGACCCA AAGCCGTGCT ACAAGCTGTG 
AGGCAGCTAA TAAAGAAAGA ACAGTGGGAA CGGGCTCTGG AGGCCGGCCT GACCCTGGAC 
TCCTCCAGCC CCCTGCTTCG AAGCGAGATC TTCAACCTGC TGCTGGCAGA GTTTGCCCAG 
CACCGCCGCC TTGATACACA CCTCCCTCTC CTCTGTCGCC TGTGCCCACC AGAAGTGGCT 
CCAGATGAGC TCCTGCTTCT ACTGAGGACA CATCTCCCAG ACGATGCGGG AGCCACCCCT 
TTCCCTGAGC CTGGGGCTGA GCCTGGGGCT GAGCCCCCTC TCACAGTGGG CTTGGTCAGA 
GCCCTGCTAG AACAGACTGG GGCTCAGGGA AGGTCCTCTG GCCCAGTTCA AAGCACCTTT 
GAGGACATCC TATGGGATTC AGGCACTCCA CCCCCTACCC CACCTCGCGG ACCTATGACT 
ACTCTCCAGG CATCAGACCA CCCAGGGCAG GAAGCCTGGG GACCATCTGG ACAGGGGCTT 
GGTGCAGCTG ACGTGGGAGT TCATTCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_852097.1
CDS	69..2498
Translation	MKRAGTLRLLSDLSNFTGAARLRELLAGDPAILVRCSPDGRHLLLLRPPGSPAPQLLVAVRGPGLPLERAWSEGDPSPLDVFFVPWLARPALILVWESGLTEVWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVEDQPGQLSMAFNHCVCVKTLDTSGEAGTKLGCTHILLHHCPSFGLIASRKELFLVPTSTTWPGVAHVLLIWSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPSSQGLLLLDLKGKVSLVQCHGGTRTVGLLQEAPVGLQGSAALGTFHGTLACVLGSTLELLDMSSGRLLERKVLSTDRVHLLEPPAPGVKNEEDLETRGALRLLSALGLFCVCWEAPQGLEVPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSALLTTLRAELRDYRSIEQLKAQLVAGDDEETGWTELAEHEVARLLRTHLTGDQLAQFNTIFQALPTAAWSATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFELLCQCLGQLEPQWLPPFVELAQQQGGPGWGAEGPSLPLYRRALSVLGEEGKRPEALELELLLGSGRPKAVLQAVRQLIKKEQWERALEAGLTLDSSSPLLRSEIFNLLLAEFAQHRRLDTHLPLLCRLCPPEVAPDELLLLLRTHLPDDAGATPFPEPGAEPGAEPPLTVGLVRALLEQTGAQGRSSGPVQSTFEDILWDSGTPPPTPPRGPMTTLQASDHPGQEAWGPSGQGLGAADVGVHS

Target ORF information:

RefSeq Version	NM_181432.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 (Hps6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181432.2

ORF Insert Sequence:

ATGAAGCGTG CAGGAACTCT GCGCCTGCTT TCGGATCTGA GCAACTTCAC TGGCGCGGCC 
CGGCTCCGCG AGTTGTTGGC AGGGGACCCA GCTATCCTAG TCCGCTGCAG CCCTGATGGC 
CGTCACCTGC TACTGTTAAG ACCTCCCGGA TCGCCCGCCC CCCAACTTCT AGTGGCTGTG 
CGTGGGCCGG GCCTGCCTCT GGAGCGTGCC TGGTCGGAGG GCGACCCCTC GCCGCTGGAC 
GTCTTTTTCG TTCCATGGCT GGCGCGACCC GCGCTGATAT TGGTATGGGA GAGTGGCCTA 
ACAGAGGTGT GGGGCGTGGG GATGGAGCCT GGATGGAAGC TACTTCAGAG CACTGAGTTG 
TGTCCGGATG GTGGAGCCCG CGTGATGGCT GTGGCAGCAA CCCGAGGCCG CCTAGTTTGG 
TGCGAGGAGC GTCAGCCTGG CGTTGAGGAC CAACCAGGGC AGCTTTCAAT GGCCTTCAAC 
CACTGTGTGT GCGTCAAGAC CCTGGACACC AGCGGGGAGG CTGGCACCAA ACTAGGCTGC 
ACCCACATCC TGCTGCATCA CTGCCCCTCT TTTGGACTGA TAGCCTCCCG CAAGGAACTC 
TTCCTGGTGC CTACTTCCAC CACTTGGCCT GGTGTGGCCC ATGTTCTGCT CATCTGGAGC 
CCAAGCAAGG GGAAGGTAAT AGTTGCTGCC CCATCTCTCG GTCTTTCTCA CAGTAAAAGC 
CTGAATCCCA AACAAGGGGA TACTTGGGAC TTTCGGACCC TGCTGCGAGG CCTTCCTGGA 
TTCCTGTCCC CCAGGGAGCC GCTGGCTGTA CACACTTGGG CCCCATCTTC CCAGGGCTTG 
TTGTTGCTTG ACTTGAAAGG TAAGGTGAGC CTAGTGCAGT GCCATGGTGG TACTCGAACT 
GTGGGACTCC TGCAGGAGGC ACCTGTAGGT CTACAAGGGT CTGCAGCCCT GGGAACATTT 
CATGGCACCT TAGCCTGTGT CTTGGGCTCC ACCTTGGAAC TGCTGGACAT GAGCAGTGGG 
CGGCTGTTGG AAAGGAAGGT ACTAAGTACA GACAGAGTAC ACCTCCTGGA GCCTCCAGCC 
CCTGGCGTGA AGAATGAGGA AGACCTAGAG ACCCGAGGAG CTCTCCGTTT GCTTTCAGCC 
TTGGGTCTCT TTTGTGTGTG TTGGGAAGCT CCCCAAGGCC TTGAGGTGCC CTCGGACAAG 
GATCTGGTGT TTGAGGAGGC CTGTGGGTAC TACCAGCGTC GGAGTCTTCG AGGCACCCAG 
CTTACCCCGG AAGAGCTGAG ACACAACAGC ATGTTTCGGG CACCTCAGGC CTTGGCCTCC 
ATTCTCCAGG GCCACCTGCC CCCATCTGCA CTATTGACCA CCCTGAGGGC TGAACTTCGA 
GATTATCGGA GTATAGAACA GCTCAAGGCC CAGCTGGTGG CTGGGGATGA TGAAGAGACG 
GGCTGGACGG AGTTAGCAGA GCACGAGGTG GCACGCCTGC TGAGAACCCA CTTGACAGGA 
GACCAGCTGG CCCAATTCAA CACCATTTTC CAAGCCCTTC CTACAGCAGC TTGGAGTGCC 
ACCCTCCAAG CCCTACAACT GCAGCCGGAT AGGAGTGGCA GGCTGAGGTC CCAAGCGCCC 
CCGGATGTAT GGAAGAAAGT CCTGAGGGCT CCAACGGCTG GAAAGGAACA TCCCAATGGA 
ATCCTGCCTC CCTTTGAACT CCTGTGTCAG TGCCTAGGCC AGCTAGAGCC TCAGTGGCTT 
CCCCCGTTTG TGGAACTGGC ACAGCAACAG GGTGGTCCAG GCTGGGGCGC CGAAGGTCCC 
AGTCTGCCCC TTTATCGCCG AGCCCTGTCC GTGCTGGGTG AGGAAGGGAA GAGACCTGAG 
GCTCTAGAAC TCGAGCTGCT TCTGGGCAGC GGGCGACCCA AAGCCGTGCT ACAAGCTGTG 
AGGCAGCTAA TAAAGAAAGA ACAGTGGGAA CGGGCTCTGG AGGCCGGCCT GACCCTGGAC 
TCCTCCAGCC CCCTGCTTCG AAGCGAGATC TTCAACCTGC TGCTGGCAGA GTTTGCCCAG 
CACCGCCGCC TTGATACACA CCTCCCTCTC CTCTGTCGCC TGTGCCCACC AGAAGTGGCT 
CCAGATGAGC TCCTGCTTCT ACTGAGGACA CATCTCCCAG ACGATGCGGG AGCCACCCCT 
TTCCCTGAGC CTGGGGCTGA GCCTGGGGCT GAGCCCCCTC TCACAGTGGG CTTGGTCAGA 
GCCCTGCTAG AACAGACTGG GGCTCAGGGA AGGTCCTCTG GCCCAGTTCA AAGCACCTTT 
GAGGACATCC TATGGGATTC AGGCACTCCA CCCCCTACCC CACCTCGCGG ACCTATGACT 
ACTCTCCAGG CATCAGACCA CCCAGGGCAG GAAGCCTGGG GACCATCTGG ACAGGGGCTT 
GGTGCAGCTG ACGTGGGAGT TCATTCGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
Journal of cell science127(Pt 21)4574-88(2014 Nov)
Li K,Yang L,Zhang C,Niu Y,Li W,Liu JJ

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.
Traffic (Copenhagen, Denmark)5(4)276-83(2004 Apr)
Di Pietro SM,Falcón-Pérez JM,Dell'Angelica EC

Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6.
Nature genetics33(2)145-53(2003 Feb)
Zhang Q,Zhao B,Li W,Oiso N,Novak EK,Rusiniak ME,Gautam R,Chintala S,O'Brien EP,Zhang Y,Roe BA,Elliott RW,Eicher EM,Liang P,Kratz C,Legius E,Spritz RA,O'Sullivan TN,Copeland NG,Jenkins NA,Swank RT

The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse.
Genetics41(3)429-50(1956 May)
Markert CL,Silvers WK

REQUEST A QUOTE

EMAIL

gene@genscript.com

PHONE

1-877-436-7274

ONLINE FORM

Online Quote Submission

ONLINE FORM

Online Quote Submission

Hps6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

News & Blogs

REQUEST A QUOTE

EMAIL

PHONE

ONLINE FORM

ONLINE FORM