Lrrk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrk1
Entrez Gene ID	308703
Full Name	leucine-rich repeat kinase 1
General protein information	Preferred Names leucine-rich repeat kinase 1 Names leucine-rich repeat serine/threonine-protein kinase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
XM_008759514.2	XP_008757736.1	leucine-rich repeat serine/threonine-protein kinase 1 isoform X1
NM_001191624.1	NP_001178553.1	leucine-rich repeat serine/threonine-protein kinase 1
XM_017589156.1	XP_017444645.1	leucine-rich repeat serine/threonine-protein kinase 1 isoform X2

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	lrrk1	XP_002667476.3
Bos taurus (cattle)	LRRK1	NP_001192703.1
Xenopus tropicalis (tropical clawed frog)	lrrk1	XP_002939309.2
Homo sapiens (human)	LRRK1	NP_078928.3
Pan troglodytes (chimpanzee)	LRRK1	XP_510623.3
Rattus norvegicus (Norway rat)	Lrrk1	NP_001178553.1
Macaca mulatta (Rhesus monkey)	LRRK1	XP_001084079.1
Canis lupus familiaris (dog)	LRRK1	XP_005618338.1
Mus musculus (house mouse)	Lrrk1	NP_666303.3
Gallus gallus (chicken)	LRRK1	XP_003641870.2

Gene Ontology
Bibliography

Related articles in PubMed

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.
Xing W, Liu J, Cheng S, Vogel P, Mohan S, Brommage R
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research28(9)1962-74(2013 Sep)

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Berwick DC, Harvey K
Human molecular genetics21(22)4966-79(2012 Nov)

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
Civiero L, Vancraenenbroeck R, Belluzzi E, Beilina A, Lobbestael E, Reyniers L, Gao F, Micetic I, De Maeyer M, Bubacco L, Baekelandt V, Cookson MR, Greggio E, Taymans JM
PloS one7(8)e43472(2012)

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment.
Klein CL, Rovelli G, Springer W, Schall C, Gasser T, Kahle PJ
Journal of neurochemistry111(3)703-15(2009 Nov)

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.
Westerlund M, Belin AC, Anvret A, Bickford P, Olson L, Galter D
Neuroscience152(2)429-36(2008 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lrrk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa56586	XM_017589156.1 Latest version!	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00
ORa07229	NM_001191624.1 Latest version!	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1091.30 $1559.00
ORa07229	XM_008759514.2 Latest version!	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1091.30 $1559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrk1 ( XM_017589156.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444645.1 Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa56586
Clone ID Related Accession (Same CDS sequence)	XM_017589156.1
Accession Version	XM_017589156.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5934bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCAGCA AACTGTCTTT ACCAGGTGGC AACTCCCCAG TGCAGAGCCC CAACATGGAA 
GAAATCCACA CAGCATACAA GCAGAGAAAC CTCTCCCGAG CCCGGGACCT GCTCAGGGAA 
GTTTGTGAAG AGAGCGAATC CCCACAGGAA AAGGGCCAGT TGCTGAGCAT CTCAGCAGCC 
CACGGGGATC TAGAGACCGT TCGGTTCCTG CTCACTGAGA AGCGCGTGGA GCTGCCGATG 
GAGCCCACCG ATGACAACCC AGCTGTGGTG GCAGCGCATT TTGGACATGC TGAAGTAGTA 
CACGAATTGC TGGAGTCCTT ATCAGGTCCC TGTGCCTCGC AGCGGCTGCT GAACTGGATG 
CTGGCCCTGG CTTGCCAGCG AGGGCACCTG GAGGTTGTGA AGCTGCTGGT CCTGACGCAC 
GGGGCTGACC CGGAGAACTA CGCCGTCAGG AAGAATGAGT TCCCGGTCAT TGTGAGGTTG 
CCCCTCTACG CGGCCATCAA GGCAGGGAAT GAAGACATTG CCATATTCCT GCTTCGGCAC 
GGGGCCTATT TCTGCTCCTA CATCCTATTG GATAGCCCTG ACCCAAGCAA ACATCTGCTC 
AGGAAGTATT TCATCGAGGC CAGCGCCCTG CCCAGCAGCT GTCCCGGGAA AACCGCACTT 
TGTGTGAAAT GGTCCCATCT TAAGTTGCCC TGGGTGGACC TCGACTGGCT CTTAGACATC 
TCCTGTCAGA TCACAGAGCT TGACCTCTCT GCCAACTGCC TGTCTTCTCT CCCCTCCATC 
ATTCCTTGGG GACTGATCAA TCTGAAGAAG CTGAACCTCT CAAACAACCA CCTGGGGGAG 
CTGCCCTGTG TGCAATCATC GGACGAAATC ATCTGCTCCA GGTTAGTTGA AATCGACATC 
TCCAGTAACA AACTGTCCCA CCTCCCGCCT GGATTCTTGC ACCTCTCAAA ACTTGAAAGG 
CTGACTGCTT CCAAAAACTA TCTGGAGCGG TTGTTTGAAG AAGAAAATGC CACAAACTGG 
ATCGGCCTGC GGAAGCTGGA GGAACTCGAC CTAGCTGACA ACAGACTGAC GGAGCTCCCT 
GTCCAATTTA TGCACTCCTT CAAGTCTCTC ACCAATCTGA ATGTCTCCAG GAACAGCCTC 
AAGAGCTTTC CAGACCCCTG GTCCTGCCCT CTGAAATGTT GTAAAGCCTC CAAAAATGCT 
CTGGAATCGC TGCCAGACAA AATGGCCGTC TTCTGGAAAA ACCACCTCAG GGACGTGGAT 
TTCTCCGAGA ACTCTCTGAA AGCGGTGCCC CTGGGGGTTT TCCAACTTGA TGCCCTCATG 
TTCTTGAGGT TACAGGGAAA CCTGCTGTTG TCACTGCCAC ATCATGAGAA GTGGACCTGC 
AGACAACTCA AGACCCTGGA CCTCTCCAGA AACCAACTTG GCAAAAATGA AGATGGGCTT 
AAAACAAAGC GGATCTCCCT TTTTACCACC AGAGGGCGCC AGCGTTCTGG AACTGAGACA 
GCGTCCGTGC TAGAATTCCC AGCTTTTCTA AGCGAGTCTT TGGAGGTCCT TTGTCTGAAT 
GACAACCATC TTGATGCAGT TCCTCCGTCA GTCTGCCTGC TGAAGAACCT CTCAGAGCTC 
TACTTGGGCA ATAACCCTGG TCTCCGAGAG CTCCCTCCGG AGCTAGGCCA GCTGGGAAAC 
CTCTGGCAAC TGGACATTGA AGATCTGAAC ATTGGCAACG TGCCTGCAGA GGTCAGGAAA 
GAAGGCCCAA AAGCAACGCT GTCTTTCCTG CGTGCTCAGC TGCGCAAAGC AGAGAAGTGT 
AAACTGATGA AGATGATCCT CGTGGGCCCC CCACGCCAGG GCAAGTCCAC ACTCCTGGAG 
ATCTTACAGA CAGGGAAGGC CCCGCAGCCA GCACACAGCG AAGCCACTGT CAGGACCACC 
AAGTGGGAGC TCCAGAGACC AGCAGGCTCC AAAGCCAAGG TTGAGTCTGT GGAGTTCAAC 
GTCTGGGACA TCGGGGGCCC TGCCAGCATG GCCACAGTCA ATCAGTGCTT CTTCACAGAT 
AAGGCCCTAT ATGTGGTGGT CTGGAACCTG GCCCTGGGGG AAGAAGCTGT GGCCAACCTC 
CAGTTCTGGC TTCTCAACAT TGAGGCCAAG GCCCCAAACG CCGTTGTGCT GGTGGTTGGG 
ACACATCTGG ACCTTATCGA AGCTAAATTC CGAGTAGAGA GGATCGCAAC ACTGCGTGCC 
TACGTGCTGG CCCTCTGCCG CTCACCATCG GGGTCCAGAG CTACAGGATT CCCAGACATC 
ACTTTCAAAC ACTTGCACGA GATCTCCTGC AAGAATCTGG AAGGGCAGGA GGGGCTGAGG 
CAACTGATCT TCCATGTCAC GTGCAACATG AAGGACGTGG GCAGCACTAT CGGCTGTCAA 
AAACTCGCTG GCAGGCTGAT CCCCAGGAGC TACATAAGCC TACAGGAGGC TGTGCTGGCT 
GAACAACAGC GCCGCAGCCT GGAAGATCAA GTACAGTACC TGACGGACAG GCAGCTGGAG 
CAGCTGGTGG AGCAGACGCC TGGCAATGAC ATCAAAGACT ATGAGGACCT GCAGTCTGCC 
ATCAGCTTCC TCATAGAAAC CGGAACCCTG CTGCACTTCC CAGACACGAG CCATGGCCTA 
AGGAATCTCT ACTTCCTGGA TCCCATCTGG CTCTCTGAAT GCCTACAGAG GATCTTTAAT 
ATCAAGGGCT CGCGGTCGGT GGCGAAGAAT GGGGTGATCC GAGCAGAGGA CCTCAGGATG 
CTGCTGGTGG GGACAGGCTT CACGCAGCAG ACGGAGGAGC AATACTTCCA GTTCCTTGCC 
AAGTTCGAGA TTGCCCTTCC GGTTGCCAAT GACAGTTACC TCCTACCACA CCTCCTCCCA 
TCCAAACCTG GGCTGGACAC CCACAGCATG CGGCACCCAA TGGCTAACAC CATCCAGCGG 
GTGTTTAAGA TGAGCTTCGT GCCTGTTGGC TTCTGGCAAA GGTTCATAGC ACGGATGCTG 
ATCAGCTTGG CTGAGATGGA CCTGCAGCTT TTTGAAAACA AGAAGAATAC GAAAAGCAGG 
AACCGGAAAG TCACCATTTA CAGCTTTACA GGGAACCAGA GAAACCGCTG CAGCACATTC 
AGAGTCCGAA GGAATCAGAC CATCTACTGG CAGGAAGGGC TGCTGGTCAC TTTCGATGGG 
GGCTACCTCA GTGTGGAATC CTCAGACGTG AACTGGAAAA AGAAAAAAAG CGGAGGGATT 
AAAATCGTCT GCCAGTCAGA AATGAGGGAC TTCTCAGCAA TGGCTTTTAT CACAGACCAC 
GTCAACTCCC TGATCGACCA GTGGTTCCCC GCCCTGACAG CCACAGAAAG TGACGGGACC 
CCACTTATGG AGCAGTATGT GCCCTGCCCC GTCTGTGAAG CATCCTGGGC CCAGCATGCA 
GATCCAAACG AGAGGTCGGA GAGCGTGCAG TACTTCGATA TGGAAGATTG TGTGCTCACA 
GCCATTGAAG GGAACTTCAT CTCCTGCCCC AGACACCCAG ACCTCCCAGT GCCACTTCAG 
GAGCTTGTAC CAGAGCTGTT TATGACTGAC TTCCCAGCCA GGCTTTTCCT GGAGAACAGC 
AAGCTGGAGC ACACAGAGGG TGAGAACAGC ATCCTGGGCC AAGGTGGCAG TGGCACAGTC 
ATCTACCAGG CCCAGTACCA GGGCCAGCCT GTGGCTGTGA AGAGATTCCA CATCAAGAAG 
TTCAAGAATT CTGCTAATGC CCCGGCAGAC ACCATGCTGA GGCACCTGAG AGCCATGGAT 
GCCATGAAGA ACTTCTCGGA TTTCCGTCAG GAGGCCAGCA TGCTGCATGC CTTGCAGCAC 
CCCTGCATTG TGTCACTCAT CGGCATCAGC ATCCACCCCC TCTGCTTCGC CCTGGAGCTC 
GCCCCGCTGG GCAGCCTCAA CACTGTGCTG TCTGAGAATG CCAAAGATTC TTCCTTTATG 
CCCCTGGGAC ACATGCTCAC CCAAAAAATA GCCTACCAGA TTGCCTCGGG CCTGGCCTAC 
CTGCACAAGA AGAACATCAT CTTCTGTGAC CTCAAGTCAG ACAACATCCT GGTGTGGTCA 
CTGAGCGTCA AGGAGCTCAT CAACATCAAA CTGTCAGACT ACGGCATCTC GAGGCAGTCC 
TTTCACGAGG GGGCCCTGGG TGTGGAGGGC ACCCCAGGCT ACCAGGCTCC AGAGATCAGG 
CCTCGCATTG TGTATGACGA GAAGGTAGAC ATGTTCTCCT ATGGCATGGT GCTGTATGAG 
CTGCTCTCAG GACAGCGTCC TGCGCTGGGC CACCACCAAC TTCAGATTGT CAAGAAGTTG 
TCCAAGGGCA TCCGCCCAGT GCTGGGGCAG CCAGAGGAAG TGCAATTCTA TCGACTGCAG 
GCGCTCATGA TGGAGTGCTG GGACACGAAG CCGGAGAAGC GTCCCCTGGC CCTGTCTGTG 
GTGAGCCAGA TGAAAGACCC AACCTTCGCC ACCTTCATGT ACATGCTGCC CTGTGGGAAG 
CAGTCGTCCT TCTTCTCATC CCAGAGCCAG GAGTACACTG TGGTGTTCTG GGATGGGAAG 
GAGGAGTCAA GGAATTACAC GGTGGTCAAC ACCGAGAAGG GCCTTCTGGA AGTACAGAGG 
ATGACCTGTC CTGGGATGAA GCTGAGCTGT CAGCTCAAGG TCCAGAGCTC AGTGTGGCTA 
GCCACCGAGG ACCAGAAAAT CTATATCTAC AGCCTTAAGG GTATGTGCCC ATTAAGCATG 
CCCCAGCAGG CCCTGGACAC GCCGGCTGTT GTCACCTGTT TCTTGGCAGT ACCTGTTATT 
AAAAAGAACT CCTTTCTGGT GCTGGCTGGC CTGGCTGATG GACTCGTGGC TGTGTTTTCT 
ATGGCACGGG GCACCCCAAA AGAAAGCTGC TCCTACCTGT GCTCGCACAC AGCCAACAGG 
TCCAAGTTCT GCATCCCAGA CGAAGACTCA CGGCAGAACC CCTACCCAGT GAGGGCAATG 
GAAGTGGTCA ACAGCGGGTC TGAGGTCTGG TACAGCAATG GGCCAGGCCT CCTCATCATC 
GACTGTGCCA TCCTGGACAT CAGCAGGCGG CTGGAGCCCT ATGCAGCCCC ATCTGTGGTC 
ACATCACTTG TGTGCAGCTC AGACTGCAGA GGAGAGGAGA CAGTCTGGTG CCTGGACGAC 
AAGGGCAATT CCTTAGTGAT GTACCATTCA GCCACCTACC AGCTGTGTGC CCGGTACTTC 
TGCGGGGACC CCAGTCCTCT CAGGGACACG TTTTCTGTAC AGCCCTCAGT CCCAGAAAGC 
CCAATCCGTC ACATAACCAC CTCAAAGGAG CCTGAGGAAG AGTGCATCGC CGACGTGAGC 
ATCATGTACA GCGAGGAGCT GGGCATGCAG ATCCTCACCC ACCAGGACTC GCTCACTGAC 
TACTGCTCCG TATCCTCGTA CTCATCCACA CCCCACCCAG ACCCCAAGTC CCCCACCAGC 
CTGCCCAGCT CCCTCACCAG CTATTCCAGT GTGCCTTTCT CCGCCAATTA TGAAGACCCA 
GACAGGCTGC AGGAGCCCAG CGTCACCCCT GACAGAACTG AGCATGATCT GAGCCCCATG 
GATGGGGAGA CGTTCAGCCA ACACCTGCAG GCTGTGAAGG TGCTTGCTGT CCAAGACCTC 
ATTTGGGTCC CTAGACATGG TGGAGATATC ATTGTCATCG GCCTGGAGAA GGATTCGGGT 
GCCCAGCGGG GCAGGGTCAT CGCTGTTTTA AAAGCCAGAG AGCTCAATCC GCATGGGGTC 
CTGGTGGATG CGGCAGTGGT GGCAAAGGAC ACCGTAGTGT GCGGCTTTGC AAACGAAAAC 
ACAGAGTGGT GCCTGGCTGT CTGGAGGGGC TGGGGCGCCA GGGAGTTTGA CATCTTCTAC 
CAGTCCTATG AGGAGCTGGG CCGGCTGGAG GCGTGTCCTC GCAAGAGAAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444645.1
CDS	2157..8090
Translation	MGSKLSLPGGNSPVQSPNMEEIHTAYKQRNLSRARDLLREVCEESESPQEKGQLLSISAAHGDLETVRFLLTEKRVELPMEPTDDNPAVVAAHFGHAEVVHELLESLSGPCASQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASALPSSCPGKTALCVKWSHLKLPWVDLDWLLDISCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCVQSSDEIICSRLVEIDISSNKLSHLPPGFLHLSKLERLTASKNYLERLFEEENATNWIGLRKLEELDLADNRLTELPVQFMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKNHLRDVDFSENSLKAVPLGVFQLDALMFLRLQGNLLLSLPHHEKWTCRQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASVLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQPAHSEATVRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLEDQVQYLTDRQLEQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIVCQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIEGNFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFYRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSSFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATEDQKIYIYSLKGMCPLSMPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKESCSYLCSHTANRSKFCIPDEDSRQNPYPVRAMEVVNSGSEVWYSNGPGLLIIDCAILDISRRLEPYAAPSVVTSLVCSSDCRGEETVWCLDDKGNSLVMYHSATYQLCARYFCGDPSPLRDTFSVQPSVPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSSYSSTPHPDPKSPTSLPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGETFSQHLQAVKVLAVQDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNPHGVLVDAAVVAKDTVVCGFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACPRKRR

Target ORF information:

RefSeq Version	XM_017589156.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589156.1

ORF Insert Sequence:

ATGGGCAGCA AACTGTCTTT ACCAGGTGGC AACTCCCCAG TGCAGAGCCC CAACATGGAA 
GAAATCCACA CAGCATACAA GCAGAGAAAC CTCTCCCGAG CCCGGGACCT GCTCAGGGAA 
GTTTGTGAAG AGAGCGAATC CCCACAGGAA AAGGGCCAGT TGCTGAGCAT CTCAGCAGCC 
CACGGGGATC TAGAGACCGT TCGGTTCCTG CTCACTGAGA AGCGCGTGGA GCTGCCGATG 
GAGCCCACCG ATGACAACCC AGCTGTGGTG GCAGCGCATT TTGGACATGC TGAAGTAGTA 
CACGAATTGC TGGAGTCCTT ATCAGGTCCC TGTGCCTCGC AGCGGCTGCT GAACTGGATG 
CTGGCCCTGG CTTGCCAGCG AGGGCACCTG GAGGTTGTGA AGCTGCTGGT CCTGACGCAC 
GGGGCTGACC CGGAGAACTA CGCCGTCAGG AAGAATGAGT TCCCGGTCAT TGTGAGGTTG 
CCCCTCTACG CGGCCATCAA GGCAGGGAAT GAAGACATTG CCATATTCCT GCTTCGGCAC 
GGGGCCTATT TCTGCTCCTA CATCCTATTG GATAGCCCTG ACCCAAGCAA ACATCTGCTC 
AGGAAGTATT TCATCGAGGC CAGCGCCCTG CCCAGCAGCT GTCCCGGGAA AACCGCACTT 
TGTGTGAAAT GGTCCCATCT TAAGTTGCCC TGGGTGGACC TCGACTGGCT CTTAGACATC 
TCCTGTCAGA TCACAGAGCT TGACCTCTCT GCCAACTGCC TGTCTTCTCT CCCCTCCATC 
ATTCCTTGGG GACTGATCAA TCTGAAGAAG CTGAACCTCT CAAACAACCA CCTGGGGGAG 
CTGCCCTGTG TGCAATCATC GGACGAAATC ATCTGCTCCA GGTTAGTTGA AATCGACATC 
TCCAGTAACA AACTGTCCCA CCTCCCGCCT GGATTCTTGC ACCTCTCAAA ACTTGAAAGG 
CTGACTGCTT CCAAAAACTA TCTGGAGCGG TTGTTTGAAG AAGAAAATGC CACAAACTGG 
ATCGGCCTGC GGAAGCTGGA GGAACTCGAC CTAGCTGACA ACAGACTGAC GGAGCTCCCT 
GTCCAATTTA TGCACTCCTT CAAGTCTCTC ACCAATCTGA ATGTCTCCAG GAACAGCCTC 
AAGAGCTTTC CAGACCCCTG GTCCTGCCCT CTGAAATGTT GTAAAGCCTC CAAAAATGCT 
CTGGAATCGC TGCCAGACAA AATGGCCGTC TTCTGGAAAA ACCACCTCAG GGACGTGGAT 
TTCTCCGAGA ACTCTCTGAA AGCGGTGCCC CTGGGGGTTT TCCAACTTGA TGCCCTCATG 
TTCTTGAGGT TACAGGGAAA CCTGCTGTTG TCACTGCCAC ATCATGAGAA GTGGACCTGC 
AGACAACTCA AGACCCTGGA CCTCTCCAGA AACCAACTTG GCAAAAATGA AGATGGGCTT 
AAAACAAAGC GGATCTCCCT TTTTACCACC AGAGGGCGCC AGCGTTCTGG AACTGAGACA 
GCGTCCGTGC TAGAATTCCC AGCTTTTCTA AGCGAGTCTT TGGAGGTCCT TTGTCTGAAT 
GACAACCATC TTGATGCAGT TCCTCCGTCA GTCTGCCTGC TGAAGAACCT CTCAGAGCTC 
TACTTGGGCA ATAACCCTGG TCTCCGAGAG CTCCCTCCGG AGCTAGGCCA GCTGGGAAAC 
CTCTGGCAAC TGGACATTGA AGATCTGAAC ATTGGCAACG TGCCTGCAGA GGTCAGGAAA 
GAAGGCCCAA AAGCAACGCT GTCTTTCCTG CGTGCTCAGC TGCGCAAAGC AGAGAAGTGT 
AAACTGATGA AGATGATCCT CGTGGGCCCC CCACGCCAGG GCAAGTCCAC ACTCCTGGAG 
ATCTTACAGA CAGGGAAGGC CCCGCAGCCA GCACACAGCG AAGCCACTGT CAGGACCACC 
AAGTGGGAGC TCCAGAGACC AGCAGGCTCC AAAGCCAAGG TTGAGTCTGT GGAGTTCAAC 
GTCTGGGACA TCGGGGGCCC TGCCAGCATG GCCACAGTCA ATCAGTGCTT CTTCACAGAT 
AAGGCCCTAT ATGTGGTGGT CTGGAACCTG GCCCTGGGGG AAGAAGCTGT GGCCAACCTC 
CAGTTCTGGC TTCTCAACAT TGAGGCCAAG GCCCCAAACG CCGTTGTGCT GGTGGTTGGG 
ACACATCTGG ACCTTATCGA AGCTAAATTC CGAGTAGAGA GGATCGCAAC ACTGCGTGCC 
TACGTGCTGG CCCTCTGCCG CTCACCATCG GGGTCCAGAG CTACAGGATT CCCAGACATC 
ACTTTCAAAC ACTTGCACGA GATCTCCTGC AAGAATCTGG AAGGGCAGGA GGGGCTGAGG 
CAACTGATCT TCCATGTCAC GTGCAACATG AAGGACGTGG GCAGCACTAT CGGCTGTCAA 
AAACTCGCTG GCAGGCTGAT CCCCAGGAGC TACATAAGCC TACAGGAGGC TGTGCTGGCT 
GAACAACAGC GCCGCAGCCT GGAAGATCAA GTACAGTACC TGACGGACAG GCAGCTGGAG 
CAGCTGGTGG AGCAGACGCC TGGCAATGAC ATCAAAGACT ATGAGGACCT GCAGTCTGCC 
ATCAGCTTCC TCATAGAAAC CGGAACCCTG CTGCACTTCC CAGACACGAG CCATGGCCTA 
AGGAATCTCT ACTTCCTGGA TCCCATCTGG CTCTCTGAAT GCCTACAGAG GATCTTTAAT 
ATCAAGGGCT CGCGGTCGGT GGCGAAGAAT GGGGTGATCC GAGCAGAGGA CCTCAGGATG 
CTGCTGGTGG GGACAGGCTT CACGCAGCAG ACGGAGGAGC AATACTTCCA GTTCCTTGCC 
AAGTTCGAGA TTGCCCTTCC GGTTGCCAAT GACAGTTACC TCCTACCACA CCTCCTCCCA 
TCCAAACCTG GGCTGGACAC CCACAGCATG CGGCACCCAA TGGCTAACAC CATCCAGCGG 
GTGTTTAAGA TGAGCTTCGT GCCTGTTGGC TTCTGGCAAA GGTTCATAGC ACGGATGCTG 
ATCAGCTTGG CTGAGATGGA CCTGCAGCTT TTTGAAAACA AGAAGAATAC GAAAAGCAGG 
AACCGGAAAG TCACCATTTA CAGCTTTACA GGGAACCAGA GAAACCGCTG CAGCACATTC 
AGAGTCCGAA GGAATCAGAC CATCTACTGG CAGGAAGGGC TGCTGGTCAC TTTCGATGGG 
GGCTACCTCA GTGTGGAATC CTCAGACGTG AACTGGAAAA AGAAAAAAAG CGGAGGGATT 
AAAATCGTCT GCCAGTCAGA AATGAGGGAC TTCTCAGCAA TGGCTTTTAT CACAGACCAC 
GTCAACTCCC TGATCGACCA GTGGTTCCCC GCCCTGACAG CCACAGAAAG TGACGGGACC 
CCACTTATGG AGCAGTATGT GCCCTGCCCC GTCTGTGAAG CATCCTGGGC CCAGCATGCA 
GATCCAAACG AGAGGTCGGA GAGCGTGCAG TACTTCGATA TGGAAGATTG TGTGCTCACA 
GCCATTGAAG GGAACTTCAT CTCCTGCCCC AGACACCCAG ACCTCCCAGT GCCACTTCAG 
GAGCTTGTAC CAGAGCTGTT TATGACTGAC TTCCCAGCCA GGCTTTTCCT GGAGAACAGC 
AAGCTGGAGC ACACAGAGGG TGAGAACAGC ATCCTGGGCC AAGGTGGCAG TGGCACAGTC 
ATCTACCAGG CCCAGTACCA GGGCCAGCCT GTGGCTGTGA AGAGATTCCA CATCAAGAAG 
TTCAAGAATT CTGCTAATGC CCCGGCAGAC ACCATGCTGA GGCACCTGAG AGCCATGGAT 
GCCATGAAGA ACTTCTCGGA TTTCCGTCAG GAGGCCAGCA TGCTGCATGC CTTGCAGCAC 
CCCTGCATTG TGTCACTCAT CGGCATCAGC ATCCACCCCC TCTGCTTCGC CCTGGAGCTC 
GCCCCGCTGG GCAGCCTCAA CACTGTGCTG TCTGAGAATG CCAAAGATTC TTCCTTTATG 
CCCCTGGGAC ACATGCTCAC CCAAAAAATA GCCTACCAGA TTGCCTCGGG CCTGGCCTAC 
CTGCACAAGA AGAACATCAT CTTCTGTGAC CTCAAGTCAG ACAACATCCT GGTGTGGTCA 
CTGAGCGTCA AGGAGCTCAT CAACATCAAA CTGTCAGACT ACGGCATCTC GAGGCAGTCC 
TTTCACGAGG GGGCCCTGGG TGTGGAGGGC ACCCCAGGCT ACCAGGCTCC AGAGATCAGG 
CCTCGCATTG TGTATGACGA GAAGGTAGAC ATGTTCTCCT ATGGCATGGT GCTGTATGAG 
CTGCTCTCAG GACAGCGTCC TGCGCTGGGC CACCACCAAC TTCAGATTGT CAAGAAGTTG 
TCCAAGGGCA TCCGCCCAGT GCTGGGGCAG CCAGAGGAAG TGCAATTCTA TCGACTGCAG 
GCGCTCATGA TGGAGTGCTG GGACACGAAG CCGGAGAAGC GTCCCCTGGC CCTGTCTGTG 
GTGAGCCAGA TGAAAGACCC AACCTTCGCC ACCTTCATGT ACATGCTGCC CTGTGGGAAG 
CAGTCGTCCT TCTTCTCATC CCAGAGCCAG GAGTACACTG TGGTGTTCTG GGATGGGAAG 
GAGGAGTCAA GGAATTACAC GGTGGTCAAC ACCGAGAAGG GCCTTCTGGA AGTACAGAGG 
ATGACCTGTC CTGGGATGAA GCTGAGCTGT CAGCTCAAGG TCCAGAGCTC AGTGTGGCTA 
GCCACCGAGG ACCAGAAAAT CTATATCTAC AGCCTTAAGG GTATGTGCCC ATTAAGCATG 
CCCCAGCAGG CCCTGGACAC GCCGGCTGTT GTCACCTGTT TCTTGGCAGT ACCTGTTATT 
AAAAAGAACT CCTTTCTGGT GCTGGCTGGC CTGGCTGATG GACTCGTGGC TGTGTTTTCT 
ATGGCACGGG GCACCCCAAA AGAAAGCTGC TCCTACCTGT GCTCGCACAC AGCCAACAGG 
TCCAAGTTCT GCATCCCAGA CGAAGACTCA CGGCAGAACC CCTACCCAGT GAGGGCAATG 
GAAGTGGTCA ACAGCGGGTC TGAGGTCTGG TACAGCAATG GGCCAGGCCT CCTCATCATC 
GACTGTGCCA TCCTGGACAT CAGCAGGCGG CTGGAGCCCT ATGCAGCCCC ATCTGTGGTC 
ACATCACTTG TGTGCAGCTC AGACTGCAGA GGAGAGGAGA CAGTCTGGTG CCTGGACGAC 
AAGGGCAATT CCTTAGTGAT GTACCATTCA GCCACCTACC AGCTGTGTGC CCGGTACTTC 
TGCGGGGACC CCAGTCCTCT CAGGGACACG TTTTCTGTAC AGCCCTCAGT CCCAGAAAGC 
CCAATCCGTC ACATAACCAC CTCAAAGGAG CCTGAGGAAG AGTGCATCGC CGACGTGAGC 
ATCATGTACA GCGAGGAGCT GGGCATGCAG ATCCTCACCC ACCAGGACTC GCTCACTGAC 
TACTGCTCCG TATCCTCGTA CTCATCCACA CCCCACCCAG ACCCCAAGTC CCCCACCAGC 
CTGCCCAGCT CCCTCACCAG CTATTCCAGT GTGCCTTTCT CCGCCAATTA TGAAGACCCA 
GACAGGCTGC AGGAGCCCAG CGTCACCCCT GACAGAACTG AGCATGATCT GAGCCCCATG 
GATGGGGAGA CGTTCAGCCA ACACCTGCAG GCTGTGAAGG TGCTTGCTGT CCAAGACCTC 
ATTTGGGTCC CTAGACATGG TGGAGATATC ATTGTCATCG GCCTGGAGAA GGATTCGGGT 
GCCCAGCGGG GCAGGGTCAT CGCTGTTTTA AAAGCCAGAG AGCTCAATCC GCATGGGGTC 
CTGGTGGATG CGGCAGTGGT GGCAAAGGAC ACCGTAGTGT GCGGCTTTGC AAACGAAAAC 
ACAGAGTGGT GCCTGGCTGT CTGGAGGGGC TGGGGCGCCA GGGAGTTTGA CATCTTCTAC 
CAGTCCTATG AGGAGCTGGG CCGGCTGGAG GCGTGTCCTC GCAAGAGAAG GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrrk1 ( NM_001191624.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178553.1 Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), mRNA.

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CloneID	ORa07229
Clone ID Related Accession (Same CDS sequence)	XM_008759514.2 , NM_001191624.1
Accession Version	NM_001191624.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6042bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527696000000
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07004146.1, AABR07004145.1 and AABR07004144.1. On Jul 17, 2010 this sequence version replaced XM_218760.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCTGCCG TGTCACAGCG ACCACCCAGT ATGTACTGGT GTGTGGGGAC AGAAGGATCA 
GTTGTGTGTC CAGGGCCTGC CATGGAGACC CATAATGGTG CCGAAGACAT GGGCAGCAAA 
CTGTCTTTAC CAGGTGGCAA CTCCCCAGTG CAGAGCCCCA ACATGGAAGA AATCCACACA 
GCATACAAGC AGAGAAACCT CTCCCGAGCC CGGGACCTGC TCAGGGAAGT TTGTGAAGAG 
AGCGAATCCC CACAGGAAAA GGGCCAGTTG CTGAGCATCT CAGCAGCCCA CGGGGATCTA 
GAGACCGTTC GGTTCCTGCT CACTGAGAAG CGCGTGGAGC TGCCGATGGA GCCCACCGAT 
GACAACCCAG CTGTGGTGGC AGCGCATTTT GGACATGCTG AAGTAGTACA CGAATTGCTG 
GAGTCCTTAT CAGGTCCCTG TGCCTCGCAG CGGCTGCTGA ACTGGATGCT GGCCCTGGCT 
TGCCAGCGAG GGCACCTGGA GGTTGTGAAG CTGCTGGTCC TGACGCACGG GGCTGACCCG 
GAGAACTACG CCGTCAGGAA GAATGAGTTC CCGGTCATTG TGAGGTTGCC CCTCTACGCG 
GCCATCAAGG CAGGGAATGA AGACATTGCC ATATTCCTGC TTCGGCACGG GGCCTATTTC 
TGCTCCTACA TCCTATTGGA TAGCCCTGAC CCAAGCAAAC ATCTGCTCAG GAAGTATTTC 
ATCGAGGCCA GCGCCCTGCC CAGCAGCTGT CCCGGGAAAA CCGCACTTTG TGTGAAATGG 
TCCCATCTTA AGTTGCCCTG GGTGGACCTC GACTGGCTCT TAGACATCTC CTGTCAGATC 
ACAGAGCTTG ACCTCTCTGC CAACTGCCTG TCTTCTCTCC CCTCCATCAT TCCTTGGGGA 
CTGATCAATC TGAAGAAGCT GAACCTCTCA AACAACCACC TGGGGGAGCT GCCCTGTGTG 
CAATCATCGG ACGAAATCAT CTGCTCCAGG TTAGTTGAAA TCGACATCTC CAGTAACAAA 
CTGTCCCACC TCCCGCCTGG ATTCTTGCAC CTCTCAAAAC TTGAAAGGCT GACTGCTTCC 
AAAAACTATC TGGAGCGGTT GTTTGAAGAA GAAAATGCCA CAAACTGGAT CGGCCTGCGG 
AAGCTGGAGG AACTCGACCT AGCTGACAAC AGACTGACGG AGCTCCCTGT CCAATTTATG 
CACTCCTTCA AGTCTCTCAC CAATCTGAAT GTCTCCAGGA ACAGCCTCAA GAGCTTTCCA 
GACCCCTGGT CCTGCCCTCT GAAATGTTGT AAAGCCTCCA AAAATGCTCT GGAATCGCTG 
CCAGACAAAA TGGCCGTCTT CTGGAAAAAC CACCTCAGGG ACGTGGATTT CTCCGAGAAC 
TCTCTGAAAG CGGTGCCCCT GGGGGTTTTC CAACTTGATG CCCTCATGTT CTTGAGGTTA 
CAGGGAAACC TGCTGTTGTC ACTGCCACAT CATGAGAAGT GGACCTGCAG ACAACTCAAG 
ACCCTGGACC TCTCCAGAAA CCAACTTGGC AAAAATGAAG ATGGGCTTAA AACAAAGCGG 
ATCTCCCTTT TTACCACCAG AGGGCGCCAG CGTTCTGGAA CTGAGACAGC GTCCGTGCTA 
GAATTCCCAG CTTTTCTAAG CGAGTCTTTG GAGGTCCTTT GTCTGAATGA CAACCATCTT 
GATGCAGTTC CTCCGTCAGT CTGCCTGCTG AAGAACCTCT CAGAGCTCTA CTTGGGCAAT 
AACCCTGGTC TCCGAGAGCT CCCTCCGGAG CTAGGCCAGC TGGGAAACCT CTGGCAACTG 
GACATTGAAG ATCTGAACAT TGGCAACGTG CCTGCAGAGG TCAGGAAAGA AGGCCCAAAA 
GCAACGCTGT CTTTCCTGCG TGCTCAGCTG CGCAAAGCAG AGAAGTGTAA ACTGATGAAG 
ATGATCCTCG TGGGCCCCCC ACGCCAGGGC AAGTCCACAC TCCTGGAGAT CTTACAGACA 
GGGAAGGCCC CGCAGCCAGC ACACAGCGAA GCCACTGTCA GGACCACCAA GTGGGAGCTC 
CAGAGACCAG CAGGCTCCAA AGCCAAGGTT GAGTCTGTGG AGTTCAACGT CTGGGACATC 
GGGGGCCCTG CCAGCATGGC CACAGTCAAT CAGTGCTTCT TCACAGATAA GGCCCTATAT 
GTGGTGGTCT GGAACCTGGC CCTGGGGGAA GAAGCTGTGG CCAACCTCCA GTTCTGGCTT 
CTCAACATTG AGGCCAAGGC CCCAAACGCC GTTGTGCTGG TGGTTGGGAC ACATCTGGAC 
CTTATCGAAG CTAAATTCCG AGTAGAGAGG ATCGCAACAC TGCGTGCCTA CGTGCTGGCC 
CTCTGCCGCT CACCATCGGG GTCCAGAGCT ACAGGATTCC CAGACATCAC TTTCAAACAC 
TTGCACGAGA TCTCCTGCAA GAATCTGGAA GGGCAGGAGG GGCTGAGGCA ACTGATCTTC 
CATGTCACGT GCAACATGAA GGACGTGGGC AGCACTATCG GCTGTCAAAA ACTCGCTGGC 
AGGCTGATCC CCAGGAGCTA CATAAGCCTA CAGGAGGCTG TGCTGGCTGA ACAACAGCGC 
CGCAGCCTGG AAGATCAAGT ACAGTACCTG ACGGACAGGC AGCTGGAGCA GCTGGTGGAG 
CAGACGCCTG GCAATGACAT CAAAGACTAT GAGGACCTGC AGTCTGCCAT CAGCTTCCTC 
ATAGAAACCG GAACCCTGCT GCACTTCCCA GACACGAGCC ATGGCCTAAG GAATCTCTAC 
TTCCTGGATC CCATCTGGCT CTCTGAATGC CTACAGAGGA TCTTTAATAT CAAGGGCTCG 
CGGTCGGTGG CGAAGAATGG GGTGATCCGA GCAGAGGACC TCAGGATGCT GCTGGTGGGG 
ACAGGCTTCA CGCAGCAGAC GGAGGAGCAA TACTTCCAGT TCCTTGCCAA GTTCGAGATT 
GCCCTTCCGG TTGCCAATGA CAGTTACCTC CTACCACACC TCCTCCCATC CAAACCTGGG 
CTGGACACCC ACAGCATGCG GCACCCAATG GCTAACACCA TCCAGCGGGT GTTTAAGATG 
AGCTTCGTGC CTGTTGGCTT CTGGCAAAGG TTCATAGCAC GGATGCTGAT CAGCTTGGCT 
GAGATGGACC TGCAGCTTTT TGAAAACAAG AAGAATACGA AAAGCAGGAA CCGGAAAGTC 
ACCATTTACA GCTTTACAGG GAACCAGAGA AACCGCTGCA GCACATTCAG AGTCCGAAGG 
AATCAGACCA TCTACTGGCA GGAAGGGCTG CTGGTCACTT TCGATGGGGG CTACCTCAGT 
GTGGAATCCT CAGACGTGAA CTGGAAAAAG AAAAAAAGCG GAGGGATTAA AATCGTCTGC 
CAGTCAGAAA TGAGGGACTT CTCAGCAATG GCTTTTATCA CAGACCACGT CAACTCCCTG 
ATCGACCAGT GGTTCCCCGC CCTGACAGCC ACAGAAAGTG ACGGGACCCC ACTTATGGAG 
CAGTATGTGC CCTGCCCCGT CTGTGAAGCA TCCTGGGCCC AGCATGCAGA TCCAAACGAG 
AGGTCGGAGA GCGTGCAGTA CTTCGATATG GAAGATTGTG TGCTCACAGC CATTGAAGGG 
AACTTCATCT CCTGCCCCAG ACACCCAGAC CTCCCAGTGC CACTTCAGGA GCTTGTACCA 
GAGCTGTTTA TGACTGACTT CCCAGCCAGG CTTTTCCTGG AGAACAGCAA GCTGGAGCAC 
ACAGAGGGTG AGAACAGCAT CCTGGGCCAA GGTGGCAGTG GCACAGTCAT CTACCAGGCC 
CAGTACCAGG GCCAGCCTGT GGCTGTGAAG AGATTCCACA TCAAGAAGTT CAAGAATTCT 
GCTAATGCCC CGGCAGACAC CATGCTGAGG CACCTGAGAG CCATGGATGC CATGAAGAAC 
TTCTCGGATT TCCGTCAGGA GGCCAGCATG CTGCATGCCT TGCAGCACCC CTGCATTGTG 
TCACTCATCG GCATCAGCAT CCACCCCCTC TGCTTCGCCC TGGAGCTCGC CCCGCTGGGC 
AGCCTCAACA CTGTGCTGTC TGAGAATGCC AAAGATTCTT CCTTTATGCC CCTGGGACAC 
ATGCTCACCC AAAAAATAGC CTACCAGATT GCCTCGGGCC TGGCCTACCT GCACAAGAAG 
AACATCATCT TCTGTGACCT CAAGTCAGAC AACATCCTGG TGTGGTCACT GAGCGTCAAG 
GAGCTCATCA ACATCAAACT GTCAGACTAC GGCATCTCGA GGCAGTCCTT TCACGAGGGG 
GCCCTGGGTG TGGAGGGCAC CCCAGGCTAC CAGGCTCCAG AGATCAGGCC TCGCATTGTG 
TATGACGAGA AGGTAGACAT GTTCTCCTAT GGCATGGTGC TGTATGAGCT GCTCTCAGGA 
CAGCGTCCTG CGCTGGGCCA CCACCAACTT CAGATTGTCA AGAAGTTGTC CAAGGGCATC 
CGCCCAGTGC TGGGGCAGCC AGAGGAAGTG CAATTCTATC GACTGCAGGC GCTCATGATG 
GAGTGCTGGG ACACGAAGCC GGAGAAGCGT CCCCTGGCCC TGTCTGTGGT GAGCCAGATG 
AAAGACCCAA CCTTCGCCAC CTTCATGTAC ATGCTGCCCT GTGGGAAGCA GTCGTCCTTC 
TTCTCATCCC AGAGCCAGGA GTACACTGTG GTGTTCTGGG ATGGGAAGGA GGAGTCAAGG 
AATTACACGG TGGTCAACAC CGAGAAGGGC CTTCTGGAAG TACAGAGGAT GACCTGTCCT 
GGGATGAAGC TGAGCTGTCA GCTCAAGGTC CAGAGCTCAG TGTGGCTAGC CACCGAGGAC 
CAGAAAATCT ATATCTACAG CCTTAAGGGT ATGTGCCCAT TAAGCATGCC CCAGCAGGCC 
CTGGACACGC CGGCTGTTGT CACCTGTTTC TTGGCAGTAC CTGTTATTAA AAAGAACTCC 
TTTCTGGTGC TGGCTGGCCT GGCTGATGGA CTCGTGGCTG TGTTTTCTAT GGCACGGGGC 
ACCCCAAAAG AAAGCTGCTC CTACCTGTGC TCGCACACAG CCAACAGGTC CAAGTTCTGC 
ATCCCAGACG AAGACTCACG GCAGAACCCC TACCCAGTGA GGGCAATGGA AGTGGTCAAC 
AGCGGGTCTG AGGTCTGGTA CAGCAATGGG CCAGGCCTCC TCATCATCGA CTGTGCCATC 
CTGGACATCA GCAGGCGGCT GGAGCCCTAT GCAGCCCCAT CTGTGGTCAC ATCACTTGTG 
TGCAGCTCAG ACTGCAGAGG AGAGGAGACA GTCTGGTGCC TGGACGACAA GGGCAATTCC 
TTAGTGATGT ACCATTCAGC CACCTACCAG CTGTGTGCCC GGTACTTCTG CGGGGACCCC 
AGTCCTCTCA GGGACACGTT TTCTGTACAG CCCTCAGTCC CAGAAAGCCC AATCCGTCAC 
ATAACCACCT CAAAGGAGCC TGAGGAAGAG TGCATCGCCG ACGTGAGCAT CATGTACAGC 
GAGGAGCTGG GCATGCAGAT CCTCACCCAC CAGGACTCGC TCACTGACTA CTGCTCCGTA 
TCCTCGTACT CATCCACACC CCACCCAGAC CCCAAGTCCC CCACCAGCCT GCCCAGCTCC 
CTCACCAGCT ATTCCAGTGT GCCTTTCTCC GCCAATTATG AAGACCCAGA CAGGCTGCAG 
GAGCCCAGCG TCACCCCTGA CAGAACTGAG CATGATCTGA GCCCCATGGA TGGGGAGACG 
TTCAGCCAAC ACCTGCAGGC TGTGAAGGTG CTTGCTGTCC AAGACCTCAT TTGGGTCCCT 
AGACATGGTG GAGATATCAT TGTCATCGGC CTGGAGAAGG ATTCGGGTGC CCAGCGGGGC 
AGGGTCATCG CTGTTTTAAA AGCCAGAGAG CTCAATCCGC ATGGGGTCCT GGTGGATGCG 
GCAGTGGTGG CAAAGGACAC CGTAGTGTGC GGCTTTGCAA ACGAAAACAC AGAGTGGTGC 
CTGGCTGTCT GGAGGGGCTG GGGCGCCAGG GAGTTTGACA TCTTCTACCA GTCCTATGAG 
GAGCTGGGCC GGCTGGAGGC GTGTCCTCGC AAGAGAAGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178553.1
CDS	1..6042
Translation	MAAVSQRPPSMYWCVGTEGSVVCPGPAMETHNGAEDMGSKLSLPGGNSPVQSPNMEEIHTAYKQRNLSRARDLLREVCEESESPQEKGQLLSISAAHGDLETVRFLLTEKRVELPMEPTDDNPAVVAAHFGHAEVVHELLESLSGPCASQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASALPSSCPGKTALCVKWSHLKLPWVDLDWLLDISCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCVQSSDEIICSRLVEIDISSNKLSHLPPGFLHLSKLERLTASKNYLERLFEEENATNWIGLRKLEELDLADNRLTELPVQFMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKNHLRDVDFSENSLKAVPLGVFQLDALMFLRLQGNLLLSLPHHEKWTCRQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASVLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQPAHSEATVRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLEDQVQYLTDRQLEQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIVCQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIEGNFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFYRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSSFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATEDQKIYIYSLKGMCPLSMPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKESCSYLCSHTANRSKFCIPDEDSRQNPYPVRAMEVVNSGSEVWYSNGPGLLIIDCAILDISRRLEPYAAPSVVTSLVCSSDCRGEETVWCLDDKGNSLVMYHSATYQLCARYFCGDPSPLRDTFSVQPSVPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSSYSSTPHPDPKSPTSLPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGETFSQHLQAVKVLAVQDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNPHGVLVDAAVVAKDTVVCGFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACPRKRR

Target ORF information:

RefSeq Version	NM_001191624.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191624.1

ORF Insert Sequence:

ATGGCTGCCG TGTCACAGCG ACCACCCAGT ATGTACTGGT GTGTGGGGAC AGAAGGATCA 
GTTGTGTGTC CAGGGCCTGC CATGGAGACC CATAATGGTG CCGAAGACAT GGGCAGCAAA 
CTGTCTTTAC CAGGTGGCAA CTCCCCAGTG CAGAGCCCCA ACATGGAAGA AATCCACACA 
GCATACAAGC AGAGAAACCT CTCCCGAGCC CGGGACCTGC TCAGGGAAGT TTGTGAAGAG 
AGCGAATCCC CACAGGAAAA GGGCCAGTTG CTGAGCATCT CAGCAGCCCA CGGGGATCTA 
GAGACCGTTC GGTTCCTGCT CACTGAGAAG CGCGTGGAGC TGCCGATGGA GCCCACCGAT 
GACAACCCAG CTGTGGTGGC AGCGCATTTT GGACATGCTG AAGTAGTACA CGAATTGCTG 
GAGTCCTTAT CAGGTCCCTG TGCCTCGCAG CGGCTGCTGA ACTGGATGCT GGCCCTGGCT 
TGCCAGCGAG GGCACCTGGA GGTTGTGAAG CTGCTGGTCC TGACGCACGG GGCTGACCCG 
GAGAACTACG CCGTCAGGAA GAATGAGTTC CCGGTCATTG TGAGGTTGCC CCTCTACGCG 
GCCATCAAGG CAGGGAATGA AGACATTGCC ATATTCCTGC TTCGGCACGG GGCCTATTTC 
TGCTCCTACA TCCTATTGGA TAGCCCTGAC CCAAGCAAAC ATCTGCTCAG GAAGTATTTC 
ATCGAGGCCA GCGCCCTGCC CAGCAGCTGT CCCGGGAAAA CCGCACTTTG TGTGAAATGG 
TCCCATCTTA AGTTGCCCTG GGTGGACCTC GACTGGCTCT TAGACATCTC CTGTCAGATC 
ACAGAGCTTG ACCTCTCTGC CAACTGCCTG TCTTCTCTCC CCTCCATCAT TCCTTGGGGA 
CTGATCAATC TGAAGAAGCT GAACCTCTCA AACAACCACC TGGGGGAGCT GCCCTGTGTG 
CAATCATCGG ACGAAATCAT CTGCTCCAGG TTAGTTGAAA TCGACATCTC CAGTAACAAA 
CTGTCCCACC TCCCGCCTGG ATTCTTGCAC CTCTCAAAAC TTGAAAGGCT GACTGCTTCC 
AAAAACTATC TGGAGCGGTT GTTTGAAGAA GAAAATGCCA CAAACTGGAT CGGCCTGCGG 
AAGCTGGAGG AACTCGACCT AGCTGACAAC AGACTGACGG AGCTCCCTGT CCAATTTATG 
CACTCCTTCA AGTCTCTCAC CAATCTGAAT GTCTCCAGGA ACAGCCTCAA GAGCTTTCCA 
GACCCCTGGT CCTGCCCTCT GAAATGTTGT AAAGCCTCCA AAAATGCTCT GGAATCGCTG 
CCAGACAAAA TGGCCGTCTT CTGGAAAAAC CACCTCAGGG ACGTGGATTT CTCCGAGAAC 
TCTCTGAAAG CGGTGCCCCT GGGGGTTTTC CAACTTGATG CCCTCATGTT CTTGAGGTTA 
CAGGGAAACC TGCTGTTGTC ACTGCCACAT CATGAGAAGT GGACCTGCAG ACAACTCAAG 
ACCCTGGACC TCTCCAGAAA CCAACTTGGC AAAAATGAAG ATGGGCTTAA AACAAAGCGG 
ATCTCCCTTT TTACCACCAG AGGGCGCCAG CGTTCTGGAA CTGAGACAGC GTCCGTGCTA 
GAATTCCCAG CTTTTCTAAG CGAGTCTTTG GAGGTCCTTT GTCTGAATGA CAACCATCTT 
GATGCAGTTC CTCCGTCAGT CTGCCTGCTG AAGAACCTCT CAGAGCTCTA CTTGGGCAAT 
AACCCTGGTC TCCGAGAGCT CCCTCCGGAG CTAGGCCAGC TGGGAAACCT CTGGCAACTG 
GACATTGAAG ATCTGAACAT TGGCAACGTG CCTGCAGAGG TCAGGAAAGA AGGCCCAAAA 
GCAACGCTGT CTTTCCTGCG TGCTCAGCTG CGCAAAGCAG AGAAGTGTAA ACTGATGAAG 
ATGATCCTCG TGGGCCCCCC ACGCCAGGGC AAGTCCACAC TCCTGGAGAT CTTACAGACA 
GGGAAGGCCC CGCAGCCAGC ACACAGCGAA GCCACTGTCA GGACCACCAA GTGGGAGCTC 
CAGAGACCAG CAGGCTCCAA AGCCAAGGTT GAGTCTGTGG AGTTCAACGT CTGGGACATC 
GGGGGCCCTG CCAGCATGGC CACAGTCAAT CAGTGCTTCT TCACAGATAA GGCCCTATAT 
GTGGTGGTCT GGAACCTGGC CCTGGGGGAA GAAGCTGTGG CCAACCTCCA GTTCTGGCTT 
CTCAACATTG AGGCCAAGGC CCCAAACGCC GTTGTGCTGG TGGTTGGGAC ACATCTGGAC 
CTTATCGAAG CTAAATTCCG AGTAGAGAGG ATCGCAACAC TGCGTGCCTA CGTGCTGGCC 
CTCTGCCGCT CACCATCGGG GTCCAGAGCT ACAGGATTCC CAGACATCAC TTTCAAACAC 
TTGCACGAGA TCTCCTGCAA GAATCTGGAA GGGCAGGAGG GGCTGAGGCA ACTGATCTTC 
CATGTCACGT GCAACATGAA GGACGTGGGC AGCACTATCG GCTGTCAAAA ACTCGCTGGC 
AGGCTGATCC CCAGGAGCTA CATAAGCCTA CAGGAGGCTG TGCTGGCTGA ACAACAGCGC 
CGCAGCCTGG AAGATCAAGT ACAGTACCTG ACGGACAGGC AGCTGGAGCA GCTGGTGGAG 
CAGACGCCTG GCAATGACAT CAAAGACTAT GAGGACCTGC AGTCTGCCAT CAGCTTCCTC 
ATAGAAACCG GAACCCTGCT GCACTTCCCA GACACGAGCC ATGGCCTAAG GAATCTCTAC 
TTCCTGGATC CCATCTGGCT CTCTGAATGC CTACAGAGGA TCTTTAATAT CAAGGGCTCG 
CGGTCGGTGG CGAAGAATGG GGTGATCCGA GCAGAGGACC TCAGGATGCT GCTGGTGGGG 
ACAGGCTTCA CGCAGCAGAC GGAGGAGCAA TACTTCCAGT TCCTTGCCAA GTTCGAGATT 
GCCCTTCCGG TTGCCAATGA CAGTTACCTC CTACCACACC TCCTCCCATC CAAACCTGGG 
CTGGACACCC ACAGCATGCG GCACCCAATG GCTAACACCA TCCAGCGGGT GTTTAAGATG 
AGCTTCGTGC CTGTTGGCTT CTGGCAAAGG TTCATAGCAC GGATGCTGAT CAGCTTGGCT 
GAGATGGACC TGCAGCTTTT TGAAAACAAG AAGAATACGA AAAGCAGGAA CCGGAAAGTC 
ACCATTTACA GCTTTACAGG GAACCAGAGA AACCGCTGCA GCACATTCAG AGTCCGAAGG 
AATCAGACCA TCTACTGGCA GGAAGGGCTG CTGGTCACTT TCGATGGGGG CTACCTCAGT 
GTGGAATCCT CAGACGTGAA CTGGAAAAAG AAAAAAAGCG GAGGGATTAA AATCGTCTGC 
CAGTCAGAAA TGAGGGACTT CTCAGCAATG GCTTTTATCA CAGACCACGT CAACTCCCTG 
ATCGACCAGT GGTTCCCCGC CCTGACAGCC ACAGAAAGTG ACGGGACCCC ACTTATGGAG 
CAGTATGTGC CCTGCCCCGT CTGTGAAGCA TCCTGGGCCC AGCATGCAGA TCCAAACGAG 
AGGTCGGAGA GCGTGCAGTA CTTCGATATG GAAGATTGTG TGCTCACAGC CATTGAAGGG 
AACTTCATCT CCTGCCCCAG ACACCCAGAC CTCCCAGTGC CACTTCAGGA GCTTGTACCA 
GAGCTGTTTA TGACTGACTT CCCAGCCAGG CTTTTCCTGG AGAACAGCAA GCTGGAGCAC 
ACAGAGGGTG AGAACAGCAT CCTGGGCCAA GGTGGCAGTG GCACAGTCAT CTACCAGGCC 
CAGTACCAGG GCCAGCCTGT GGCTGTGAAG AGATTCCACA TCAAGAAGTT CAAGAATTCT 
GCTAATGCCC CGGCAGACAC CATGCTGAGG CACCTGAGAG CCATGGATGC CATGAAGAAC 
TTCTCGGATT TCCGTCAGGA GGCCAGCATG CTGCATGCCT TGCAGCACCC CTGCATTGTG 
TCACTCATCG GCATCAGCAT CCACCCCCTC TGCTTCGCCC TGGAGCTCGC CCCGCTGGGC 
AGCCTCAACA CTGTGCTGTC TGAGAATGCC AAAGATTCTT CCTTTATGCC CCTGGGACAC 
ATGCTCACCC AAAAAATAGC CTACCAGATT GCCTCGGGCC TGGCCTACCT GCACAAGAAG 
AACATCATCT TCTGTGACCT CAAGTCAGAC AACATCCTGG TGTGGTCACT GAGCGTCAAG 
GAGCTCATCA ACATCAAACT GTCAGACTAC GGCATCTCGA GGCAGTCCTT TCACGAGGGG 
GCCCTGGGTG TGGAGGGCAC CCCAGGCTAC CAGGCTCCAG AGATCAGGCC TCGCATTGTG 
TATGACGAGA AGGTAGACAT GTTCTCCTAT GGCATGGTGC TGTATGAGCT GCTCTCAGGA 
CAGCGTCCTG CGCTGGGCCA CCACCAACTT CAGATTGTCA AGAAGTTGTC CAAGGGCATC 
CGCCCAGTGC TGGGGCAGCC AGAGGAAGTG CAATTCTATC GACTGCAGGC GCTCATGATG 
GAGTGCTGGG ACACGAAGCC GGAGAAGCGT CCCCTGGCCC TGTCTGTGGT GAGCCAGATG 
AAAGACCCAA CCTTCGCCAC CTTCATGTAC ATGCTGCCCT GTGGGAAGCA GTCGTCCTTC 
TTCTCATCCC AGAGCCAGGA GTACACTGTG GTGTTCTGGG ATGGGAAGGA GGAGTCAAGG 
AATTACACGG TGGTCAACAC CGAGAAGGGC CTTCTGGAAG TACAGAGGAT GACCTGTCCT 
GGGATGAAGC TGAGCTGTCA GCTCAAGGTC CAGAGCTCAG TGTGGCTAGC CACCGAGGAC 
CAGAAAATCT ATATCTACAG CCTTAAGGGT ATGTGCCCAT TAAGCATGCC CCAGCAGGCC 
CTGGACACGC CGGCTGTTGT CACCTGTTTC TTGGCAGTAC CTGTTATTAA AAAGAACTCC 
TTTCTGGTGC TGGCTGGCCT GGCTGATGGA CTCGTGGCTG TGTTTTCTAT GGCACGGGGC 
ACCCCAAAAG AAAGCTGCTC CTACCTGTGC TCGCACACAG CCAACAGGTC CAAGTTCTGC 
ATCCCAGACG AAGACTCACG GCAGAACCCC TACCCAGTGA GGGCAATGGA AGTGGTCAAC 
AGCGGGTCTG AGGTCTGGTA CAGCAATGGG CCAGGCCTCC TCATCATCGA CTGTGCCATC 
CTGGACATCA GCAGGCGGCT GGAGCCCTAT GCAGCCCCAT CTGTGGTCAC ATCACTTGTG 
TGCAGCTCAG ACTGCAGAGG AGAGGAGACA GTCTGGTGCC TGGACGACAA GGGCAATTCC 
TTAGTGATGT ACCATTCAGC CACCTACCAG CTGTGTGCCC GGTACTTCTG CGGGGACCCC 
AGTCCTCTCA GGGACACGTT TTCTGTACAG CCCTCAGTCC CAGAAAGCCC AATCCGTCAC 
ATAACCACCT CAAAGGAGCC TGAGGAAGAG TGCATCGCCG ACGTGAGCAT CATGTACAGC 
GAGGAGCTGG GCATGCAGAT CCTCACCCAC CAGGACTCGC TCACTGACTA CTGCTCCGTA 
TCCTCGTACT CATCCACACC CCACCCAGAC CCCAAGTCCC CCACCAGCCT GCCCAGCTCC 
CTCACCAGCT ATTCCAGTGT GCCTTTCTCC GCCAATTATG AAGACCCAGA CAGGCTGCAG 
GAGCCCAGCG TCACCCCTGA CAGAACTGAG CATGATCTGA GCCCCATGGA TGGGGAGACG 
TTCAGCCAAC ACCTGCAGGC TGTGAAGGTG CTTGCTGTCC AAGACCTCAT TTGGGTCCCT 
AGACATGGTG GAGATATCAT TGTCATCGGC CTGGAGAAGG ATTCGGGTGC CCAGCGGGGC 
AGGGTCATCG CTGTTTTAAA AGCCAGAGAG CTCAATCCGC ATGGGGTCCT GGTGGATGCG 
GCAGTGGTGG CAAAGGACAC CGTAGTGTGC GGCTTTGCAA ACGAAAACAC AGAGTGGTGC 
CTGGCTGTCT GGAGGGGCTG GGGCGCCAGG GAGTTTGACA TCTTCTACCA GTCCTATGAG 
GAGCTGGGCC GGCTGGAGGC GTGTCCTCGC AAGAGAAGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrrk1 ( XM_008759514.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757736.1 Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X1, mRNA.

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CloneID	ORa07229
Clone ID Related Accession (Same CDS sequence)	XM_008759514.2 , NM_001191624.1
Accession Version	XM_008759514.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6042bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759514.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTGCCG TGTCACAGCG ACCACCCAGT ATGTACTGGT GTGTGGGGAC AGAAGGATCA 
GTTGTGTGTC CAGGGCCTGC CATGGAGACC CATAATGGTG CCGAAGACAT GGGCAGCAAA 
CTGTCTTTAC CAGGTGGCAA CTCCCCAGTG CAGAGCCCCA ACATGGAAGA AATCCACACA 
GCATACAAGC AGAGAAACCT CTCCCGAGCC CGGGACCTGC TCAGGGAAGT TTGTGAAGAG 
AGCGAATCCC CACAGGAAAA GGGCCAGTTG CTGAGCATCT CAGCAGCCCA CGGGGATCTA 
GAGACCGTTC GGTTCCTGCT CACTGAGAAG CGCGTGGAGC TGCCGATGGA GCCCACCGAT 
GACAACCCAG CTGTGGTGGC AGCGCATTTT GGACATGCTG AAGTAGTACA CGAATTGCTG 
GAGTCCTTAT CAGGTCCCTG TGCCTCGCAG CGGCTGCTGA ACTGGATGCT GGCCCTGGCT 
TGCCAGCGAG GGCACCTGGA GGTTGTGAAG CTGCTGGTCC TGACGCACGG GGCTGACCCG 
GAGAACTACG CCGTCAGGAA GAATGAGTTC CCGGTCATTG TGAGGTTGCC CCTCTACGCG 
GCCATCAAGG CAGGGAATGA AGACATTGCC ATATTCCTGC TTCGGCACGG GGCCTATTTC 
TGCTCCTACA TCCTATTGGA TAGCCCTGAC CCAAGCAAAC ATCTGCTCAG GAAGTATTTC 
ATCGAGGCCA GCGCCCTGCC CAGCAGCTGT CCCGGGAAAA CCGCACTTTG TGTGAAATGG 
TCCCATCTTA AGTTGCCCTG GGTGGACCTC GACTGGCTCT TAGACATCTC CTGTCAGATC 
ACAGAGCTTG ACCTCTCTGC CAACTGCCTG TCTTCTCTCC CCTCCATCAT TCCTTGGGGA 
CTGATCAATC TGAAGAAGCT GAACCTCTCA AACAACCACC TGGGGGAGCT GCCCTGTGTG 
CAATCATCGG ACGAAATCAT CTGCTCCAGG TTAGTTGAAA TCGACATCTC CAGTAACAAA 
CTGTCCCACC TCCCGCCTGG ATTCTTGCAC CTCTCAAAAC TTGAAAGGCT GACTGCTTCC 
AAAAACTATC TGGAGCGGTT GTTTGAAGAA GAAAATGCCA CAAACTGGAT CGGCCTGCGG 
AAGCTGGAGG AACTCGACCT AGCTGACAAC AGACTGACGG AGCTCCCTGT CCAATTTATG 
CACTCCTTCA AGTCTCTCAC CAATCTGAAT GTCTCCAGGA ACAGCCTCAA GAGCTTTCCA 
GACCCCTGGT CCTGCCCTCT GAAATGTTGT AAAGCCTCCA AAAATGCTCT GGAATCGCTG 
CCAGACAAAA TGGCCGTCTT CTGGAAAAAC CACCTCAGGG ACGTGGATTT CTCCGAGAAC 
TCTCTGAAAG CGGTGCCCCT GGGGGTTTTC CAACTTGATG CCCTCATGTT CTTGAGGTTA 
CAGGGAAACC TGCTGTTGTC ACTGCCACAT CATGAGAAGT GGACCTGCAG ACAACTCAAG 
ACCCTGGACC TCTCCAGAAA CCAACTTGGC AAAAATGAAG ATGGGCTTAA AACAAAGCGG 
ATCTCCCTTT TTACCACCAG AGGGCGCCAG CGTTCTGGAA CTGAGACAGC GTCCGTGCTA 
GAATTCCCAG CTTTTCTAAG CGAGTCTTTG GAGGTCCTTT GTCTGAATGA CAACCATCTT 
GATGCAGTTC CTCCGTCAGT CTGCCTGCTG AAGAACCTCT CAGAGCTCTA CTTGGGCAAT 
AACCCTGGTC TCCGAGAGCT CCCTCCGGAG CTAGGCCAGC TGGGAAACCT CTGGCAACTG 
GACATTGAAG ATCTGAACAT TGGCAACGTG CCTGCAGAGG TCAGGAAAGA AGGCCCAAAA 
GCAACGCTGT CTTTCCTGCG TGCTCAGCTG CGCAAAGCAG AGAAGTGTAA ACTGATGAAG 
ATGATCCTCG TGGGCCCCCC ACGCCAGGGC AAGTCCACAC TCCTGGAGAT CTTACAGACA 
GGGAAGGCCC CGCAGCCAGC ACACAGCGAA GCCACTGTCA GGACCACCAA GTGGGAGCTC 
CAGAGACCAG CAGGCTCCAA AGCCAAGGTT GAGTCTGTGG AGTTCAACGT CTGGGACATC 
GGGGGCCCTG CCAGCATGGC CACAGTCAAT CAGTGCTTCT TCACAGATAA GGCCCTATAT 
GTGGTGGTCT GGAACCTGGC CCTGGGGGAA GAAGCTGTGG CCAACCTCCA GTTCTGGCTT 
CTCAACATTG AGGCCAAGGC CCCAAACGCC GTTGTGCTGG TGGTTGGGAC ACATCTGGAC 
CTTATCGAAG CTAAATTCCG AGTAGAGAGG ATCGCAACAC TGCGTGCCTA CGTGCTGGCC 
CTCTGCCGCT CACCATCGGG GTCCAGAGCT ACAGGATTCC CAGACATCAC TTTCAAACAC 
TTGCACGAGA TCTCCTGCAA GAATCTGGAA GGGCAGGAGG GGCTGAGGCA ACTGATCTTC 
CATGTCACGT GCAACATGAA GGACGTGGGC AGCACTATCG GCTGTCAAAA ACTCGCTGGC 
AGGCTGATCC CCAGGAGCTA CATAAGCCTA CAGGAGGCTG TGCTGGCTGA ACAACAGCGC 
CGCAGCCTGG AAGATCAAGT ACAGTACCTG ACGGACAGGC AGCTGGAGCA GCTGGTGGAG 
CAGACGCCTG GCAATGACAT CAAAGACTAT GAGGACCTGC AGTCTGCCAT CAGCTTCCTC 
ATAGAAACCG GAACCCTGCT GCACTTCCCA GACACGAGCC ATGGCCTAAG GAATCTCTAC 
TTCCTGGATC CCATCTGGCT CTCTGAATGC CTACAGAGGA TCTTTAATAT CAAGGGCTCG 
CGGTCGGTGG CGAAGAATGG GGTGATCCGA GCAGAGGACC TCAGGATGCT GCTGGTGGGG 
ACAGGCTTCA CGCAGCAGAC GGAGGAGCAA TACTTCCAGT TCCTTGCCAA GTTCGAGATT 
GCCCTTCCGG TTGCCAATGA CAGTTACCTC CTACCACACC TCCTCCCATC CAAACCTGGG 
CTGGACACCC ACAGCATGCG GCACCCAATG GCTAACACCA TCCAGCGGGT GTTTAAGATG 
AGCTTCGTGC CTGTTGGCTT CTGGCAAAGG TTCATAGCAC GGATGCTGAT CAGCTTGGCT 
GAGATGGACC TGCAGCTTTT TGAAAACAAG AAGAATACGA AAAGCAGGAA CCGGAAAGTC 
ACCATTTACA GCTTTACAGG GAACCAGAGA AACCGCTGCA GCACATTCAG AGTCCGAAGG 
AATCAGACCA TCTACTGGCA GGAAGGGCTG CTGGTCACTT TCGATGGGGG CTACCTCAGT 
GTGGAATCCT CAGACGTGAA CTGGAAAAAG AAAAAAAGCG GAGGGATTAA AATCGTCTGC 
CAGTCAGAAA TGAGGGACTT CTCAGCAATG GCTTTTATCA CAGACCACGT CAACTCCCTG 
ATCGACCAGT GGTTCCCCGC CCTGACAGCC ACAGAAAGTG ACGGGACCCC ACTTATGGAG 
CAGTATGTGC CCTGCCCCGT CTGTGAAGCA TCCTGGGCCC AGCATGCAGA TCCAAACGAG 
AGGTCGGAGA GCGTGCAGTA CTTCGATATG GAAGATTGTG TGCTCACAGC CATTGAAGGG 
AACTTCATCT CCTGCCCCAG ACACCCAGAC CTCCCAGTGC CACTTCAGGA GCTTGTACCA 
GAGCTGTTTA TGACTGACTT CCCAGCCAGG CTTTTCCTGG AGAACAGCAA GCTGGAGCAC 
ACAGAGGGTG AGAACAGCAT CCTGGGCCAA GGTGGCAGTG GCACAGTCAT CTACCAGGCC 
CAGTACCAGG GCCAGCCTGT GGCTGTGAAG AGATTCCACA TCAAGAAGTT CAAGAATTCT 
GCTAATGCCC CGGCAGACAC CATGCTGAGG CACCTGAGAG CCATGGATGC CATGAAGAAC 
TTCTCGGATT TCCGTCAGGA GGCCAGCATG CTGCATGCCT TGCAGCACCC CTGCATTGTG 
TCACTCATCG GCATCAGCAT CCACCCCCTC TGCTTCGCCC TGGAGCTCGC CCCGCTGGGC 
AGCCTCAACA CTGTGCTGTC TGAGAATGCC AAAGATTCTT CCTTTATGCC CCTGGGACAC 
ATGCTCACCC AAAAAATAGC CTACCAGATT GCCTCGGGCC TGGCCTACCT GCACAAGAAG 
AACATCATCT TCTGTGACCT CAAGTCAGAC AACATCCTGG TGTGGTCACT GAGCGTCAAG 
GAGCTCATCA ACATCAAACT GTCAGACTAC GGCATCTCGA GGCAGTCCTT TCACGAGGGG 
GCCCTGGGTG TGGAGGGCAC CCCAGGCTAC CAGGCTCCAG AGATCAGGCC TCGCATTGTG 
TATGACGAGA AGGTAGACAT GTTCTCCTAT GGCATGGTGC TGTATGAGCT GCTCTCAGGA 
CAGCGTCCTG CGCTGGGCCA CCACCAACTT CAGATTGTCA AGAAGTTGTC CAAGGGCATC 
CGCCCAGTGC TGGGGCAGCC AGAGGAAGTG CAATTCTATC GACTGCAGGC GCTCATGATG 
GAGTGCTGGG ACACGAAGCC GGAGAAGCGT CCCCTGGCCC TGTCTGTGGT GAGCCAGATG 
AAAGACCCAA CCTTCGCCAC CTTCATGTAC ATGCTGCCCT GTGGGAAGCA GTCGTCCTTC 
TTCTCATCCC AGAGCCAGGA GTACACTGTG GTGTTCTGGG ATGGGAAGGA GGAGTCAAGG 
AATTACACGG TGGTCAACAC CGAGAAGGGC CTTCTGGAAG TACAGAGGAT GACCTGTCCT 
GGGATGAAGC TGAGCTGTCA GCTCAAGGTC CAGAGCTCAG TGTGGCTAGC CACCGAGGAC 
CAGAAAATCT ATATCTACAG CCTTAAGGGT ATGTGCCCAT TAAGCATGCC CCAGCAGGCC 
CTGGACACGC CGGCTGTTGT CACCTGTTTC TTGGCAGTAC CTGTTATTAA AAAGAACTCC 
TTTCTGGTGC TGGCTGGCCT GGCTGATGGA CTCGTGGCTG TGTTTTCTAT GGCACGGGGC 
ACCCCAAAAG AAAGCTGCTC CTACCTGTGC TCGCACACAG CCAACAGGTC CAAGTTCTGC 
ATCCCAGACG AAGACTCACG GCAGAACCCC TACCCAGTGA GGGCAATGGA AGTGGTCAAC 
AGCGGGTCTG AGGTCTGGTA CAGCAATGGG CCAGGCCTCC TCATCATCGA CTGTGCCATC 
CTGGACATCA GCAGGCGGCT GGAGCCCTAT GCAGCCCCAT CTGTGGTCAC ATCACTTGTG 
TGCAGCTCAG ACTGCAGAGG AGAGGAGACA GTCTGGTGCC TGGACGACAA GGGCAATTCC 
TTAGTGATGT ACCATTCAGC CACCTACCAG CTGTGTGCCC GGTACTTCTG CGGGGACCCC 
AGTCCTCTCA GGGACACGTT TTCTGTACAG CCCTCAGTCC CAGAAAGCCC AATCCGTCAC 
ATAACCACCT CAAAGGAGCC TGAGGAAGAG TGCATCGCCG ACGTGAGCAT CATGTACAGC 
GAGGAGCTGG GCATGCAGAT CCTCACCCAC CAGGACTCGC TCACTGACTA CTGCTCCGTA 
TCCTCGTACT CATCCACACC CCACCCAGAC CCCAAGTCCC CCACCAGCCT GCCCAGCTCC 
CTCACCAGCT ATTCCAGTGT GCCTTTCTCC GCCAATTATG AAGACCCAGA CAGGCTGCAG 
GAGCCCAGCG TCACCCCTGA CAGAACTGAG CATGATCTGA GCCCCATGGA TGGGGAGACG 
TTCAGCCAAC ACCTGCAGGC TGTGAAGGTG CTTGCTGTCC AAGACCTCAT TTGGGTCCCT 
AGACATGGTG GAGATATCAT TGTCATCGGC CTGGAGAAGG ATTCGGGTGC CCAGCGGGGC 
AGGGTCATCG CTGTTTTAAA AGCCAGAGAG CTCAATCCGC ATGGGGTCCT GGTGGATGCG 
GCAGTGGTGG CAAAGGACAC CGTAGTGTGC GGCTTTGCAA ACGAAAACAC AGAGTGGTGC 
CTGGCTGTCT GGAGGGGCTG GGGCGCCAGG GAGTTTGACA TCTTCTACCA GTCCTATGAG 
GAGCTGGGCC GGCTGGAGGC GTGTCCTCGC AAGAGAAGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757736.1
CDS	2693..8734
Translation	MAAVSQRPPSMYWCVGTEGSVVCPGPAMETHNGAEDMGSKLSLPGGNSPVQSPNMEEIHTAYKQRNLSRARDLLREVCEESESPQEKGQLLSISAAHGDLETVRFLLTEKRVELPMEPTDDNPAVVAAHFGHAEVVHELLESLSGPCASQRLLNWMLALACQRGHLEVVKLLVLTHGADPENYAVRKNEFPVIVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASALPSSCPGKTALCVKWSHLKLPWVDLDWLLDISCQITELDLSANCLSSLPSIIPWGLINLKKLNLSNNHLGELPCVQSSDEIICSRLVEIDISSNKLSHLPPGFLHLSKLERLTASKNYLERLFEEENATNWIGLRKLEELDLADNRLTELPVQFMHSFKSLTNLNVSRNSLKSFPDPWSCPLKCCKASKNALESLPDKMAVFWKNHLRDVDFSENSLKAVPLGVFQLDALMFLRLQGNLLLSLPHHEKWTCRQLKTLDLSRNQLGKNEDGLKTKRISLFTTRGRQRSGTETASVLEFPAFLSESLEVLCLNDNHLDAVPPSVCLLKNLSELYLGNNPGLRELPPELGQLGNLWQLDIEDLNIGNVPAEVRKEGPKATLSFLRAQLRKAEKCKLMKMILVGPPRQGKSTLLEILQTGKAPQPAHSEATVRTTKWELQRPAGSKAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITFKHLHEISCKNLEGQEGLRQLIFHVTCNMKDVGSTIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLEDQVQYLTDRQLEQLVEQTPGNDIKDYEDLQSAISFLIETGTLLHFPDTSHGLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYFQFLAKFEIALPVANDSYLLPHLLPSKPGLDTHSMRHPMANTIQRVFKMSFVPVGFWQRFIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVRRNQTIYWQEGLLVTFDGGYLSVESSDVNWKKKKSGGIKIVCQSEMRDFSAMAFITDHVNSLIDQWFPALTATESDGTPLMEQYVPCPVCEASWAQHADPNERSESVQYFDMEDCVLTAIEGNFISCPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHTEGENSILGQGGSGTVIYQAQYQGQPVAVKRFHIKKFKNSANAPADTMLRHLRAMDAMKNFSDFRQEASMLHALQHPCIVSLIGISIHPLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSLSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIVKKLSKGIRPVLGQPEEVQFYRLQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYMLPCGKQSSFFSSQSQEYTVVFWDGKEESRNYTVVNTEKGLLEVQRMTCPGMKLSCQLKVQSSVWLATEDQKIYIYSLKGMCPLSMPQQALDTPAVVTCFLAVPVIKKNSFLVLAGLADGLVAVFSMARGTPKESCSYLCSHTANRSKFCIPDEDSRQNPYPVRAMEVVNSGSEVWYSNGPGLLIIDCAILDISRRLEPYAAPSVVTSLVCSSDCRGEETVWCLDDKGNSLVMYHSATYQLCARYFCGDPSPLRDTFSVQPSVPESPIRHITTSKEPEEECIADVSIMYSEELGMQILTHQDSLTDYCSVSSYSSTPHPDPKSPTSLPSSLTSYSSVPFSANYEDPDRLQEPSVTPDRTEHDLSPMDGETFSQHLQAVKVLAVQDLIWVPRHGGDIIVIGLEKDSGAQRGRVIAVLKARELNPHGVLVDAAVVAKDTVVCGFANENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACPRKRR

Target ORF information:

RefSeq Version	XM_008759514.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 1 (Lrrk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759514.2

ORF Insert Sequence:

ATGGCTGCCG TGTCACAGCG ACCACCCAGT ATGTACTGGT GTGTGGGGAC AGAAGGATCA 
GTTGTGTGTC CAGGGCCTGC CATGGAGACC CATAATGGTG CCGAAGACAT GGGCAGCAAA 
CTGTCTTTAC CAGGTGGCAA CTCCCCAGTG CAGAGCCCCA ACATGGAAGA AATCCACACA 
GCATACAAGC AGAGAAACCT CTCCCGAGCC CGGGACCTGC TCAGGGAAGT TTGTGAAGAG 
AGCGAATCCC CACAGGAAAA GGGCCAGTTG CTGAGCATCT CAGCAGCCCA CGGGGATCTA 
GAGACCGTTC GGTTCCTGCT CACTGAGAAG CGCGTGGAGC TGCCGATGGA GCCCACCGAT 
GACAACCCAG CTGTGGTGGC AGCGCATTTT GGACATGCTG AAGTAGTACA CGAATTGCTG 
GAGTCCTTAT CAGGTCCCTG TGCCTCGCAG CGGCTGCTGA ACTGGATGCT GGCCCTGGCT 
TGCCAGCGAG GGCACCTGGA GGTTGTGAAG CTGCTGGTCC TGACGCACGG GGCTGACCCG 
GAGAACTACG CCGTCAGGAA GAATGAGTTC CCGGTCATTG TGAGGTTGCC CCTCTACGCG 
GCCATCAAGG CAGGGAATGA AGACATTGCC ATATTCCTGC TTCGGCACGG GGCCTATTTC 
TGCTCCTACA TCCTATTGGA TAGCCCTGAC CCAAGCAAAC ATCTGCTCAG GAAGTATTTC 
ATCGAGGCCA GCGCCCTGCC CAGCAGCTGT CCCGGGAAAA CCGCACTTTG TGTGAAATGG 
TCCCATCTTA AGTTGCCCTG GGTGGACCTC GACTGGCTCT TAGACATCTC CTGTCAGATC 
ACAGAGCTTG ACCTCTCTGC CAACTGCCTG TCTTCTCTCC CCTCCATCAT TCCTTGGGGA 
CTGATCAATC TGAAGAAGCT GAACCTCTCA AACAACCACC TGGGGGAGCT GCCCTGTGTG 
CAATCATCGG ACGAAATCAT CTGCTCCAGG TTAGTTGAAA TCGACATCTC CAGTAACAAA 
CTGTCCCACC TCCCGCCTGG ATTCTTGCAC CTCTCAAAAC TTGAAAGGCT GACTGCTTCC 
AAAAACTATC TGGAGCGGTT GTTTGAAGAA GAAAATGCCA CAAACTGGAT CGGCCTGCGG 
AAGCTGGAGG AACTCGACCT AGCTGACAAC AGACTGACGG AGCTCCCTGT CCAATTTATG 
CACTCCTTCA AGTCTCTCAC CAATCTGAAT GTCTCCAGGA ACAGCCTCAA GAGCTTTCCA 
GACCCCTGGT CCTGCCCTCT GAAATGTTGT AAAGCCTCCA AAAATGCTCT GGAATCGCTG 
CCAGACAAAA TGGCCGTCTT CTGGAAAAAC CACCTCAGGG ACGTGGATTT CTCCGAGAAC 
TCTCTGAAAG CGGTGCCCCT GGGGGTTTTC CAACTTGATG CCCTCATGTT CTTGAGGTTA 
CAGGGAAACC TGCTGTTGTC ACTGCCACAT CATGAGAAGT GGACCTGCAG ACAACTCAAG 
ACCCTGGACC TCTCCAGAAA CCAACTTGGC AAAAATGAAG ATGGGCTTAA AACAAAGCGG 
ATCTCCCTTT TTACCACCAG AGGGCGCCAG CGTTCTGGAA CTGAGACAGC GTCCGTGCTA 
GAATTCCCAG CTTTTCTAAG CGAGTCTTTG GAGGTCCTTT GTCTGAATGA CAACCATCTT 
GATGCAGTTC CTCCGTCAGT CTGCCTGCTG AAGAACCTCT CAGAGCTCTA CTTGGGCAAT 
AACCCTGGTC TCCGAGAGCT CCCTCCGGAG CTAGGCCAGC TGGGAAACCT CTGGCAACTG 
GACATTGAAG ATCTGAACAT TGGCAACGTG CCTGCAGAGG TCAGGAAAGA AGGCCCAAAA 
GCAACGCTGT CTTTCCTGCG TGCTCAGCTG CGCAAAGCAG AGAAGTGTAA ACTGATGAAG 
ATGATCCTCG TGGGCCCCCC ACGCCAGGGC AAGTCCACAC TCCTGGAGAT CTTACAGACA 
GGGAAGGCCC CGCAGCCAGC ACACAGCGAA GCCACTGTCA GGACCACCAA GTGGGAGCTC 
CAGAGACCAG CAGGCTCCAA AGCCAAGGTT GAGTCTGTGG AGTTCAACGT CTGGGACATC 
GGGGGCCCTG CCAGCATGGC CACAGTCAAT CAGTGCTTCT TCACAGATAA GGCCCTATAT 
GTGGTGGTCT GGAACCTGGC CCTGGGGGAA GAAGCTGTGG CCAACCTCCA GTTCTGGCTT 
CTCAACATTG AGGCCAAGGC CCCAAACGCC GTTGTGCTGG TGGTTGGGAC ACATCTGGAC 
CTTATCGAAG CTAAATTCCG AGTAGAGAGG ATCGCAACAC TGCGTGCCTA CGTGCTGGCC 
CTCTGCCGCT CACCATCGGG GTCCAGAGCT ACAGGATTCC CAGACATCAC TTTCAAACAC 
TTGCACGAGA TCTCCTGCAA GAATCTGGAA GGGCAGGAGG GGCTGAGGCA ACTGATCTTC 
CATGTCACGT GCAACATGAA GGACGTGGGC AGCACTATCG GCTGTCAAAA ACTCGCTGGC 
AGGCTGATCC CCAGGAGCTA CATAAGCCTA CAGGAGGCTG TGCTGGCTGA ACAACAGCGC 
CGCAGCCTGG AAGATCAAGT ACAGTACCTG ACGGACAGGC AGCTGGAGCA GCTGGTGGAG 
CAGACGCCTG GCAATGACAT CAAAGACTAT GAGGACCTGC AGTCTGCCAT CAGCTTCCTC 
ATAGAAACCG GAACCCTGCT GCACTTCCCA GACACGAGCC ATGGCCTAAG GAATCTCTAC 
TTCCTGGATC CCATCTGGCT CTCTGAATGC CTACAGAGGA TCTTTAATAT CAAGGGCTCG 
CGGTCGGTGG CGAAGAATGG GGTGATCCGA GCAGAGGACC TCAGGATGCT GCTGGTGGGG 
ACAGGCTTCA CGCAGCAGAC GGAGGAGCAA TACTTCCAGT TCCTTGCCAA GTTCGAGATT 
GCCCTTCCGG TTGCCAATGA CAGTTACCTC CTACCACACC TCCTCCCATC CAAACCTGGG 
CTGGACACCC ACAGCATGCG GCACCCAATG GCTAACACCA TCCAGCGGGT GTTTAAGATG 
AGCTTCGTGC CTGTTGGCTT CTGGCAAAGG TTCATAGCAC GGATGCTGAT CAGCTTGGCT 
GAGATGGACC TGCAGCTTTT TGAAAACAAG AAGAATACGA AAAGCAGGAA CCGGAAAGTC 
ACCATTTACA GCTTTACAGG GAACCAGAGA AACCGCTGCA GCACATTCAG AGTCCGAAGG 
AATCAGACCA TCTACTGGCA GGAAGGGCTG CTGGTCACTT TCGATGGGGG CTACCTCAGT 
GTGGAATCCT CAGACGTGAA CTGGAAAAAG AAAAAAAGCG GAGGGATTAA AATCGTCTGC 
CAGTCAGAAA TGAGGGACTT CTCAGCAATG GCTTTTATCA CAGACCACGT CAACTCCCTG 
ATCGACCAGT GGTTCCCCGC CCTGACAGCC ACAGAAAGTG ACGGGACCCC ACTTATGGAG 
CAGTATGTGC CCTGCCCCGT CTGTGAAGCA TCCTGGGCCC AGCATGCAGA TCCAAACGAG 
AGGTCGGAGA GCGTGCAGTA CTTCGATATG GAAGATTGTG TGCTCACAGC CATTGAAGGG 
AACTTCATCT CCTGCCCCAG ACACCCAGAC CTCCCAGTGC CACTTCAGGA GCTTGTACCA 
GAGCTGTTTA TGACTGACTT CCCAGCCAGG CTTTTCCTGG AGAACAGCAA GCTGGAGCAC 
ACAGAGGGTG AGAACAGCAT CCTGGGCCAA GGTGGCAGTG GCACAGTCAT CTACCAGGCC 
CAGTACCAGG GCCAGCCTGT GGCTGTGAAG AGATTCCACA TCAAGAAGTT CAAGAATTCT 
GCTAATGCCC CGGCAGACAC CATGCTGAGG CACCTGAGAG CCATGGATGC CATGAAGAAC 
TTCTCGGATT TCCGTCAGGA GGCCAGCATG CTGCATGCCT TGCAGCACCC CTGCATTGTG 
TCACTCATCG GCATCAGCAT CCACCCCCTC TGCTTCGCCC TGGAGCTCGC CCCGCTGGGC 
AGCCTCAACA CTGTGCTGTC TGAGAATGCC AAAGATTCTT CCTTTATGCC CCTGGGACAC 
ATGCTCACCC AAAAAATAGC CTACCAGATT GCCTCGGGCC TGGCCTACCT GCACAAGAAG 
AACATCATCT TCTGTGACCT CAAGTCAGAC AACATCCTGG TGTGGTCACT GAGCGTCAAG 
GAGCTCATCA ACATCAAACT GTCAGACTAC GGCATCTCGA GGCAGTCCTT TCACGAGGGG 
GCCCTGGGTG TGGAGGGCAC CCCAGGCTAC CAGGCTCCAG AGATCAGGCC TCGCATTGTG 
TATGACGAGA AGGTAGACAT GTTCTCCTAT GGCATGGTGC TGTATGAGCT GCTCTCAGGA 
CAGCGTCCTG CGCTGGGCCA CCACCAACTT CAGATTGTCA AGAAGTTGTC CAAGGGCATC 
CGCCCAGTGC TGGGGCAGCC AGAGGAAGTG CAATTCTATC GACTGCAGGC GCTCATGATG 
GAGTGCTGGG ACACGAAGCC GGAGAAGCGT CCCCTGGCCC TGTCTGTGGT GAGCCAGATG 
AAAGACCCAA CCTTCGCCAC CTTCATGTAC ATGCTGCCCT GTGGGAAGCA GTCGTCCTTC 
TTCTCATCCC AGAGCCAGGA GTACACTGTG GTGTTCTGGG ATGGGAAGGA GGAGTCAAGG 
AATTACACGG TGGTCAACAC CGAGAAGGGC CTTCTGGAAG TACAGAGGAT GACCTGTCCT 
GGGATGAAGC TGAGCTGTCA GCTCAAGGTC CAGAGCTCAG TGTGGCTAGC CACCGAGGAC 
CAGAAAATCT ATATCTACAG CCTTAAGGGT ATGTGCCCAT TAAGCATGCC CCAGCAGGCC 
CTGGACACGC CGGCTGTTGT CACCTGTTTC TTGGCAGTAC CTGTTATTAA AAAGAACTCC 
TTTCTGGTGC TGGCTGGCCT GGCTGATGGA CTCGTGGCTG TGTTTTCTAT GGCACGGGGC 
ACCCCAAAAG AAAGCTGCTC CTACCTGTGC TCGCACACAG CCAACAGGTC CAAGTTCTGC 
ATCCCAGACG AAGACTCACG GCAGAACCCC TACCCAGTGA GGGCAATGGA AGTGGTCAAC 
AGCGGGTCTG AGGTCTGGTA CAGCAATGGG CCAGGCCTCC TCATCATCGA CTGTGCCATC 
CTGGACATCA GCAGGCGGCT GGAGCCCTAT GCAGCCCCAT CTGTGGTCAC ATCACTTGTG 
TGCAGCTCAG ACTGCAGAGG AGAGGAGACA GTCTGGTGCC TGGACGACAA GGGCAATTCC 
TTAGTGATGT ACCATTCAGC CACCTACCAG CTGTGTGCCC GGTACTTCTG CGGGGACCCC 
AGTCCTCTCA GGGACACGTT TTCTGTACAG CCCTCAGTCC CAGAAAGCCC AATCCGTCAC 
ATAACCACCT CAAAGGAGCC TGAGGAAGAG TGCATCGCCG ACGTGAGCAT CATGTACAGC 
GAGGAGCTGG GCATGCAGAT CCTCACCCAC CAGGACTCGC TCACTGACTA CTGCTCCGTA 
TCCTCGTACT CATCCACACC CCACCCAGAC CCCAAGTCCC CCACCAGCCT GCCCAGCTCC 
CTCACCAGCT ATTCCAGTGT GCCTTTCTCC GCCAATTATG AAGACCCAGA CAGGCTGCAG 
GAGCCCAGCG TCACCCCTGA CAGAACTGAG CATGATCTGA GCCCCATGGA TGGGGAGACG 
TTCAGCCAAC ACCTGCAGGC TGTGAAGGTG CTTGCTGTCC AAGACCTCAT TTGGGTCCCT 
AGACATGGTG GAGATATCAT TGTCATCGGC CTGGAGAAGG ATTCGGGTGC CCAGCGGGGC 
AGGGTCATCG CTGTTTTAAA AGCCAGAGAG CTCAATCCGC ATGGGGTCCT GGTGGATGCG 
GCAGTGGTGG CAAAGGACAC CGTAGTGTGC GGCTTTGCAA ACGAAAACAC AGAGTGGTGC 
CTGGCTGTCT GGAGGGGCTG GGGCGCCAGG GAGTTTGACA TCTTCTACCA GTCCTATGAG 
GAGCTGGGCC GGCTGGAGGC GTGTCCTCGC AAGAGAAGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research28(9)1962-74(2013 Sep)
Xing W,Liu J,Cheng S,Vogel P,Mohan S,Brommage R

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
Human molecular genetics21(22)4966-79(2012 Nov)
Berwick DC,Harvey K

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers.
PloS one7(8)e43472(2012)
Civiero L,Vancraenenbroeck R,Belluzzi E,Beilina A,Lobbestael E,Reyniers L,Gao F,Micetic I,De Maeyer M,Bubacco L,Baekelandt V,Cookson MR,Greggio E,Taymans JM

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment.
Journal of neurochemistry111(3)703-15(2009 Nov)
Klein CL,Rovelli G,Springer W,Schall C,Gasser T,Kahle PJ

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.
Neuroscience152(2)429-36(2008 Mar)
Westerlund M,Belin AC,Anvret A,Bickford P,Olson L,Galter D

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Lrrk1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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