| Gene Symbol | Rhoh |
| Entrez Gene ID | 305341 |
| Full Name | ras homolog family member H |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
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Rhoh cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Rhoh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rhoh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa03962 Clone ID Related Accession (Same CDS sequence) NM_001013430.1 Accession Version NM_001013430.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1570550400000 Organism Rattus norvegicus(Norway rat) Product rho-related GTP-binding protein RhoH Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC091269.1. On Apr 20, 2005 this sequence version replaced XM_223404.2. ##Evidence-Data-START## Transcript exon combination :: BC091269.1, FQ232983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541ATGCTGAGCT CTATCAAGTG TGTGCTGGTC GGCGACAGTG CTGTGGGAAA AACCTCACTG
TTGGTGCGCT TCACCTCTGA GACCTTCCCC GAGGCCTACA AACCCACTGT GTATGAGAAT
ACAGGTGTAG ACGTCTTCAT GGATGGCATC CAGATCAGCC TGGGTCTCTG GGACACTGCA
GGCAATGATG CCTTCAGAAG CATCCGCCCC CTGTCCTACC AGCAGGCAGA TGTGGTACTA
ATGTGTTACT CGGTGGCCAA CCATAGCTCG TTCCTGAACT TGAAGAACAA ATGGATTAGT
GAGGTCAGGA GCAACCTACC CTGTACCCCG GTGCTGGTGG TGGCCACTCA GACTGACCAG
AGAGAGATGG GACCTCACAG GGCTTCCTGC ATCAATGCCA TAGAAGGGAA GAGACTTGCC
CAGGATGTGC GAGCCAAGGG CTACCTGGAG TGCTCAGCCC TTAGCAACCG GGGAGTCCAG
CAGGTATTTG AATGTGCTGT CCGAACAGCT GTCAACCAGG CCAGGAGACG AAATAGAAGG
AAGCTGTTTT CCATCAACGA ATGCAAGATC TTCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_001013448.1 CDS 568..1143 Translation 
Target ORF information:
RefSeq Version NM_001013430.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus ras homolog family member H (Rhoh), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_001013430.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGCTGAGCT CTATCAAGTG TGTGCTGGTC GGCGACAGTG CTGTGGGAAA AACCTCACTG
TTGGTGCGCT TCACCTCTGA GACCTTCCCC GAGGCCTACA AACCCACTGT GTATGAGAAT
ACAGGTGTAG ACGTCTTCAT GGATGGCATC CAGATCAGCC TGGGTCTCTG GGACACTGCA
GGCAATGATG CCTTCAGAAG CATCCGCCCC CTGTCCTACC AGCAGGCAGA TGTGGTACTA
ATGTGTTACT CGGTGGCCAA CCATAGCTCG TTCCTGAACT TGAAGAACAA ATGGATTAGT
GAGGTCAGGA GCAACCTACC CTGTACCCCG GTGCTGGTGG TGGCCACTCA GACTGACCAG
AGAGAGATGG GACCTCACAG GGCTTCCTGC ATCAATGCCA TAGAAGGGAA GAGACTTGCC
CAGGATGTGC GAGCCAAGGG CTACCTGGAG TGCTCAGCCC TTAGCAACCG GGGAGTCCAG
CAGGTATTTG AATGTGCTGT CCGAACAGCT GTCAACCAGG CCAGGAGACG AAATAGAAGG
AAGCTGTTTT CCATCAACGA ATGCAAGATC TTCTAAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
The Journal of clinical investigation122(9)3239-47(2012 Sep)
Crequer A,Troeger A,Patin E,Ma CS,Picard C,Pedergnana V,Fieschi C,Lim A,Abhyankar A,Gineau L,Mueller-Fleckenstein I,Schmidt M,Taieb A,Krueger J,Abel L,Tangye SG,Orth G,Williams DA,Casanova JL,Jouanguy E
RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Journal of immunology (Baltimore, Md. : 1950)182(2)957-62(2009 Jan)
Oda H,Fujimoto M,Patrick MS,Chida D,Sato Y,Azuma Y,Aoki H,Abe T,Suzuki H,Shirai M
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood109(6)2346-55(2007 Mar)
Dorn T,Kuhn U,Bungartz G,Stiller S,Bauer M,Ellwart J,Peters T,Scharffetter-Kochanek K,Semmrich M,Laschinger M,Holzmann B,Klinkert WE,Straten PT,Køllgaard T,Sixt M,Brakebusch C
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Nature immunology7(11)1182-90(2006 Nov)
Gu Y,Chae HD,Siefring JE,Jasti AC,Hildeman DA,Williams DA
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Molecular and cellular biology22(4)1158-71(2002 Feb)
Li X,Bu X,Lu B,Avraham H,Flavell RA,Lim B
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