Sim2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sim2
Entrez Gene ID	304071
Full Name	single-minded family bHLH transcription factor 2
General protein information	Preferred Names single-minded family bHLH transcription factor 2 Names single-minded homolog 2 single-minded 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001107108.3	NP_001100578.1	single-minded homolog 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	SIM2	XP_004934598.1
Bos taurus (cattle)	SIM2	XP_002685213.2
Xenopus tropicalis (tropical clawed frog)	sim2	XP_002941575.2
Macaca mulatta (Rhesus monkey)	SIM2	XP_001085660.1
Canis lupus familiaris (dog)	SIM2	XP_005639049.1
Homo sapiens (human)	SIM2	NP_005060.1
Rattus norvegicus (Norway rat)	Sim2	NP_001100578.1
Danio rerio (zebrafish)	sim2	NP_571911.1
Pan troglodytes (chimpanzee)	SIM2	XP_001169453.1
Mus musculus (house mouse)	Sim2	NP_035507.2

Gene Ontology
Bibliography

Related articles in PubMed

Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells.
Wang X, Yang Z, Sun Y, Zhou H, Chu G, Zhang J, Meng X
Molecular neurobiology52(3)1234-1244(2015 Dec)

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.
Wang X, Song Y, Chen L, Zhuang G, Zhang J, Li M, Meng XF
Neurotoxicology35106-12(2013 Mar)

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.
Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H
Molecular and cellular biology24(2)608-16(2004 Jan)

Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.
Goshu E, Jin H, Fasnacht R, Sepenski M, Michaud JL, Fan CM
Molecular and cellular biology22(12)4147-57(2002 Jun)

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.
Woods SL, Whitelaw ML
The Journal of biological chemistry277(12)10236-43(2002 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sim2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sim2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02893	NM_001107108.3 Latest version!	Rattus norvegicus SIM bHLH transcription factor 2 (Sim2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sim2 ( NM_001107108.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100578.1 Rattus norvegicus SIM bHLH transcription factor 2 (Sim2), mRNA.

Price & Availability↑

CloneID	ORa02893
Clone ID Related Accession (Same CDS sequence)	NM_001107108.3
Accession Version	NM_001107108.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1971bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527696000000
Organism	Rattus norvegicus(Norway rat)
Product	single-minded homolog 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07033666.1. On Sep 11, 2014 this sequence version replaced NM_001107108.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689597, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGAGA AGTCCAAAAA TGCGGCCAAA ACCAGGAGGG AGAAGGAAAA TGGCGAGTTT 
TACGAGCTGG CCAAGCTGCT CCCGCTGCCT TCGGCCATCA CCTCGCAGCT GGACAAAGCT 
TCCATCATCC GGCTCACCAC CAGCTACCTG AAGATGCGCG CAGTCTTCCC GGAAGGTCTA 
GGAGATGCGT GGGGACAGCC GAGCAGAACA GGGCCTCTGG ACAGCGTGGC CAAAGAACTA 
GGATCCCATT TGCTGCAGAC TCTAGATGGA TTTGTGTTTG TGGTGGCCTC TGATGGCAAA 
ATCATGTATA TATCGGAGAC CGCTTCTGTC CATTTAGGCT TGTCCCAGGT GGAGCTCACA 
GGCAACAGTA TTTACGAATA CATCCATCCT TCTGACCACG ACGAGATGAC AGCAGTACTG 
ACGGCCCACC CACCGCTCCA CCATCACCTG CTCCAAGAGT ACGAGATAGA GCGGTCTTTC 
TTTCTCCGAA TGAAGTGCGT CTTGGCAAAA AGAAATGCAG GCCTGACGTG CAGTGGATAC 
AAGGTCATTC ACTGCAGTGG CTACTTAAAG ATCAGGCAGT ACATGCTGGA CATGTCCCTG 
TATGACTCCT GTTACCAGAT TGTGGGGCTG GTGGCCGTGG GCCAGTCGCT GCCACCCAGC 
GCCATCACGG AGATCAAACT CCACAACAAT ATGTTCATGT TCAGAGCCAG CCTCGACCTG 
AAGCTCATCT TCCTGGATTC CAGGGTGACA GAGCTTACCG GCTATGAGCC ACAGGACCTG 
ATTGAAAAAA CACTCTACCA TCATGTGCAC GGCTGTGACA CCTTCCACCT CCGCTATGCA 
CACCACCTCT TGCTTGTGAA GGGCCAGGTC ACCACCAAAT ACTACCGGCT GCTTTCAAAG 
CTGGGCGGCT GGGTCTGGGT GCAGAGCTAC GCCACCGTGG TGCACAACAG CCGTTCCTCC 
CGGCCTCACT GCATCGTGAG TGTCAATTAT GTTCTCACGG AGGTCGAATA CAAGGAACTT 
CAGCTCTCTC TGGACCAGGT ATCCACCTCT AAGTCCCAGG AGTCCTGGAG AACCACCTTG 
TCTACCTCAC AAGAAACTAG GAAATCAGCT AAACCCAAAA CCACGAAGAT GAGGACAAAG 
CTGAGAACCA ACCCATATCC CTCACAGCAA TACAGCTCGT TCCAAATGGA CAAACTGGAG 
TGCAGCCAGG CGGGAAACTG GAGAACGAGT CCCCCCACAA GTGCTGTGGC TCCCCCGGAA 
CAGCAGCTCC ATTCAGAAGC CAGCGACCTT TTATATGGGC CGCCCTACAG CCTCCCCTTC 
TCCTACCGTT ACGGACACTT CCCCCTGGAC TCTCATGTCT TCAGCAGCAA GAAGCCAGGA 
CTGCCCGCCA AGTTCGGGCA GCCCCAAGGA TCCCCGTGTG AGGTGGCACG CTTTTTCCTG 
AGCACACTGC CAGCCAGCAG CGAGTGCCAG TGGCATTATG CCAACTCCCT CATGCCCAGC 
AGCCCTTCAC CAGCTAAAAA CCTTTCTGAG TCTCCTGTGA ATGCTGCCCG GCATGGACTT 
GTGCCAAACT ATGAAGCGCC CGCCGCCACC GCGCGCAGGT TCGGCGAGGA CCCCGCACCC 
TCAAGCTTCC CGAGCTGCGG CCACTACCGC GAGGAGCCGA CGCTGGGCTC CGCCAAGGCA 
GCTCGCCAGG CGTCCCGGGA CACAGCCCGA CTGGCGCTGG CCCGAGCGAC CCCCGAGTGC 
TGCGCGCCGC CGGCCCCCGA GCCACAGGCG CCGGCGCAGC TGCCCTTCGT GCTGCTCAAC 
TACCACCGCG TGCTGGCGCG CCGCGGGCCG CTGGGGAGCG CTGCGCCCGG AGCTCCGGAG 
GCGGCCGGCT CGCTGCGGCC CCGACACCCG GGCCCGGTCG CAGCCTCTGC ACCCGGCGCG 
CCCCGGCCAC ACTACCTGGG CGCCTCGGTC ATCATCACCA ACGGCAGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100578.1
CDS	557..2527
Translation	MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHNNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEVEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKTTKMRTKLRTNPYPSQQYSSFQMDKLECSQAGNWRTSPPTSAVAPPEQQLHSEASDLLYGPPYSLPFSYRYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHYANSLMPSSPSPAKNLSESPVNAARHGLVPNYEAPAATARRFGEDPAPSSFPSCGHYREEPTLGSAKAARQASRDTARLALARATPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGSLRPRHPGPVAASAPGAPRPHYLGASVIITNGR

Target ORF information:

RefSeq Version	NM_001107108.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SIM bHLH transcription factor 2 (Sim2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001107108.3

ORF Insert Sequence:

ATGAAGGAGA AGTCCAAAAA TGCGGCCAAA ACCAGGAGGG AGAAGGAAAA TGGCGAGTTT 
TACGAGCTGG CCAAGCTGCT CCCGCTGCCT TCGGCCATCA CCTCGCAGCT GGACAAAGCT 
TCCATCATCC GGCTCACCAC CAGCTACCTG AAGATGCGCG CAGTCTTCCC GGAAGGTCTA 
GGAGATGCGT GGGGACAGCC GAGCAGAACA GGGCCTCTGG ACAGCGTGGC CAAAGAACTA 
GGATCCCATT TGCTGCAGAC TCTAGATGGA TTTGTGTTTG TGGTGGCCTC TGATGGCAAA 
ATCATGTATA TATCGGAGAC CGCTTCTGTC CATTTAGGCT TGTCCCAGGT GGAGCTCACA 
GGCAACAGTA TTTACGAATA CATCCATCCT TCTGACCACG ACGAGATGAC AGCAGTACTG 
ACGGCCCACC CACCGCTCCA CCATCACCTG CTCCAAGAGT ACGAGATAGA GCGGTCTTTC 
TTTCTCCGAA TGAAGTGCGT CTTGGCAAAA AGAAATGCAG GCCTGACGTG CAGTGGATAC 
AAGGTCATTC ACTGCAGTGG CTACTTAAAG ATCAGGCAGT ACATGCTGGA CATGTCCCTG 
TATGACTCCT GTTACCAGAT TGTGGGGCTG GTGGCCGTGG GCCAGTCGCT GCCACCCAGC 
GCCATCACGG AGATCAAACT CCACAACAAT ATGTTCATGT TCAGAGCCAG CCTCGACCTG 
AAGCTCATCT TCCTGGATTC CAGGGTGACA GAGCTTACCG GCTATGAGCC ACAGGACCTG 
ATTGAAAAAA CACTCTACCA TCATGTGCAC GGCTGTGACA CCTTCCACCT CCGCTATGCA 
CACCACCTCT TGCTTGTGAA GGGCCAGGTC ACCACCAAAT ACTACCGGCT GCTTTCAAAG 
CTGGGCGGCT GGGTCTGGGT GCAGAGCTAC GCCACCGTGG TGCACAACAG CCGTTCCTCC 
CGGCCTCACT GCATCGTGAG TGTCAATTAT GTTCTCACGG AGGTCGAATA CAAGGAACTT 
CAGCTCTCTC TGGACCAGGT ATCCACCTCT AAGTCCCAGG AGTCCTGGAG AACCACCTTG 
TCTACCTCAC AAGAAACTAG GAAATCAGCT AAACCCAAAA CCACGAAGAT GAGGACAAAG 
CTGAGAACCA ACCCATATCC CTCACAGCAA TACAGCTCGT TCCAAATGGA CAAACTGGAG 
TGCAGCCAGG CGGGAAACTG GAGAACGAGT CCCCCCACAA GTGCTGTGGC TCCCCCGGAA 
CAGCAGCTCC ATTCAGAAGC CAGCGACCTT TTATATGGGC CGCCCTACAG CCTCCCCTTC 
TCCTACCGTT ACGGACACTT CCCCCTGGAC TCTCATGTCT TCAGCAGCAA GAAGCCAGGA 
CTGCCCGCCA AGTTCGGGCA GCCCCAAGGA TCCCCGTGTG AGGTGGCACG CTTTTTCCTG 
AGCACACTGC CAGCCAGCAG CGAGTGCCAG TGGCATTATG CCAACTCCCT CATGCCCAGC 
AGCCCTTCAC CAGCTAAAAA CCTTTCTGAG TCTCCTGTGA ATGCTGCCCG GCATGGACTT 
GTGCCAAACT ATGAAGCGCC CGCCGCCACC GCGCGCAGGT TCGGCGAGGA CCCCGCACCC 
TCAAGCTTCC CGAGCTGCGG CCACTACCGC GAGGAGCCGA CGCTGGGCTC CGCCAAGGCA 
GCTCGCCAGG CGTCCCGGGA CACAGCCCGA CTGGCGCTGG CCCGAGCGAC CCCCGAGTGC 
TGCGCGCCGC CGGCCCCCGA GCCACAGGCG CCGGCGCAGC TGCCCTTCGT GCTGCTCAAC 
TACCACCGCG TGCTGGCGCG CCGCGGGCCG CTGGGGAGCG CTGCGCCCGG AGCTCCGGAG 
GCGGCCGGCT CGCTGCGGCC CCGACACCCG GGCCCGGTCG CAGCCTCTGC ACCCGGCGCG 
CCCCGGCCAC ACTACCTGGG CGCCTCGGTC ATCATCACCA ACGGCAGGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells.
Molecular neurobiology52(3)1234-1244(2015 Dec)
Wang X,Yang Z,Sun Y,Zhou H,Chu G,Zhang J,Meng X

Contribution of single-minded 2 to hyperglycaemia-induced neurotoxicity.
Neurotoxicology35106-12(2013 Mar)
Wang X,Song Y,Chen L,Zhuang G,Zhang J,Li M,Meng XF

Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.
Molecular and cellular biology24(2)608-16(2004 Jan)
Ooe N,Saito K,Mikami N,Nakatuka I,Kaneko H

Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants.
Molecular and cellular biology22(12)4147-57(2002 Jun)
Goshu E,Jin H,Fasnacht R,Sepenski M,Michaud JL,Fan CM

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors.
The Journal of biological chemistry277(12)10236-43(2002 Mar)
Woods SL,Whitelaw ML

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Sim2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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