Abcb7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb7
Entrez Gene ID	302395
Full Name	ATP binding cassette subfamily B member 7
General protein information	Preferred Names ATP binding cassette subfamily B member 7 Names ATP-binding cassette sub-family B member 7, mitochondrial ABC transporter 7 protein ATP-binding cassette transporter 7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 ATP-binding cassette, sub-family B, member 7, mitochondrial ATP-binding cassette, subfamily B (MDR/TAP), member 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	mouse homolog plays a role in heme biosynthesis in erythroid cells; regulates expression of both the mitochondrial iron-sulfur-containing protein ferrochelatase and the cytosolic iron-sulfur containing protein thioredoxin [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_212518.1	NP_997683.1	ATP-binding cassette sub-family B member 7, mitochondrial

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	atm1	NP_594288.2
Eremothecium gossypii	AGOS_AGL335W	NP_986332.1
Homo sapiens (human)	ABCB7	NP_001258625.1
Macaca mulatta (Rhesus monkey)	ABCB7	XP_001097352.2
Bos taurus (cattle)	ABCB7	NP_001179712.1
Caenorhabditis elegans (roundworm)	abtm-1	NP_001021830.1
Magnaporthe oryzae (rice blast fungus)	MGG_03406	XP_003716534.1
Neurospora crassa	NCU05029	XP_956337.2
Gallus gallus (chicken)	ABCB7	XP_420301.1
Arabidopsis thaliana (thale cress)	ATM2	NP_194591.1
Arabidopsis thaliana (thale cress)	ATM3	NP_200635.1
Canis lupus familiaris (dog)	ABCB7	XP_549087.1
Rattus norvegicus (Norway rat)	Abcb7	NP_997683.1
Pan troglodytes (chimpanzee)	ABCB7	XP_003317575.1
Danio rerio (zebrafish)	abcb7	XP_694879.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006364	XP_001688853.1
Xenopus tropicalis (tropical clawed frog)	abcb7	XP_002931834.1
Kluyveromyces lactis	KLLA0A10131g	XP_451443.1
Drosophila melanogaster (fruit fly)	ABCB7	NP_728642.2
Saccharomyces cerevisiae (baker's yeast)	ATM1	NP_014030.1
Arabidopsis thaliana (thale cress)	ATM1	NP_567813.1
Mus musculus (house mouse)	Abcb7	NP_033722.1

Gene Ontology
Bibliography

Related articles in PubMed

Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
Maio N, Rouault TA
Biochimica et biophysica acta1853(6)1493-512(2015 Jun)

The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts.
Boultwood J, Pellagatti A, Nikpour M, Pushkaran B, Fidler C, Cattan H, Littlewood TJ, Malcovati L, Della Porta MG, Jädersten M, Killick S, Giagounidis A, Bowen D, Hellström-Lindberg E, Cazzola M, Wainscoat JS
PloS one3(4)e1970(2008 Apr)

Identification of a mammalian mitochondrial porphyrin transporter.
Krishnamurthy PC, Du G, Fukuda Y, Sun D, Sampath J, Mercer KE, Wang J, Sosa-Pineda B, Murti KG, Schuetz JD
Nature443(7111)586-9(2006 Oct)

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.
Clarke SL, Vasanthakumar A, Anderson SA, Pondarré C, Koh CM, Deck KM, Pitula JS, Epstein CJ, Fleming MD, Eisenstein RS
The EMBO journal25(3)544-53(2006 Feb)

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell115(5)629-40(2003 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Abcb7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12390	NM_212518.1 Latest version!	Rattus norvegicus ATP binding cassette subfamily B member 7 (Abcb7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb7 ( NM_212518.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_997683.1 Rattus norvegicus ATP binding cassette subfamily B member 7 (Abcb7), mRNA.

Price & Availability↑

CloneID	ORa12390
Clone ID Related Accession (Same CDS sequence)	NM_212518.1
Accession Version	NM_212518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2259bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	ATP-binding cassette sub-family B member 7, mitochondrial
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ621255.1. On Aug 30, 2004 this sequence version replaced XM_217569.2. ##Evidence-Data-START## Transcript exon combination :: AJ621255.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCGCTGC TCGCGATACA TTCTTGGCGC TGGGCAGCCG CGGCGGTCGC TTTCGAAAAG 
CACAAGCATT CGGCAGTTCT GACCCGGTCT CTAGTCTCCA TCTGCGGCTC AGGCCTGCGG 
TGGAGTTCGT ACCAGAGCGG CGCGTCAGGA AGCGCTCGGC TGTCCCAGAC TACAGAATCA 
TTAAGAAATT CTACACAGCA GAGATGGGAA AAAAACAACT CAAGACAGTT ACTAGATGCT 
TCAAAGGTTC TTCAGGCATG GCCATTGATA GAAAAGAGAA CATGTTGGCA TGGGCACGCA 
GGAGGAGGAC TCCACACAGA CCCAAAAGAA GGGTTAAAGG ATGTTGATAC TAGAAAAATC 
ATTAAAGCCA TGCTTTCTTA TGTGTGGCCC AAAGACAGGC CTGATCTGCG AGCCAGAGTT 
GCCATTTCCC TGGGATTTCT GGGTGGTGCA AAGGCCATGA ATATTGTGGT TCCTTTCATG 
TTTAAATATG CTGTAGACAG CCTCAACCAG ATGTCGGGAA ACATGCTGAA CCTGAGTGAT 
GCACCAAATA CAGTTGCAAC CATGGCAACA GCAGTTCTGA TTGGCTATGG TGTATCAAGA 
GCCGGGGCTG CCTTTTTCAA TGAAGTCCGA AATGCAGTAT TTGGCAAAGT AGCACAAAAT 
TCAATCCGAA GAATAGCCAA AAATGTATTT CTCCATCTTC ACAACTTGGA TCTGGGTTTC 
CATCTGAGCA GACAGACAGG AGCCTTATCT AAGGCTATTG ACAGAGGGAC AAGGGGCATT 
AGTTTTGTCC TCAGTGCTTT AGTATTTAAT CTTCTCCCTA TTGTGTTTGA GATGACGCTT 
GTCAGTAGTG TTTTGTATTA CAAATGTGGG GCCCAGTTTG CATTGGTAAC CCTGGGAACA 
CTTGGTGCAT ATACAGCATT CACAGTTGCA GTTACACGGT GGAGAACTAG ATTTAGAATA 
GAAATGAACA AAGCTGATAA CGATGCAGGG AACGCTGCTA TTGACTCACT GCTGAATTAT 
GAAACTGTGA AGTATTTTAA CAATGAAAAA TATGAAGCAC AAAGATATGA TGGATTCTTG 
AAGACATATG AGACTGCTTC ATTGAAAAGT ACCTCTACTC TGGCTATGCT GAATTTTGGC 
CAAAGTGCTA TTTTCAGTGT TGGATTAACA GCTATCATGG TGCTTGCCAG TCAGGGAATT 
GTGGCAGGTG CCCTTACTGT TGGAGATCTA GTAATGGTGA ATGGACTGCT TTTTCAACTT 
TCATTACCCC TTAACTTCTT GGGAACTGTA TATAGAGAGA CACGGCAAGC ACTCATAGAT 
ATGAATACCT TGTTTACTCT GCTCAAGGTA GACACGCGGA TTAAAGACAA AGCGATGGCA 
TCTCCCCTTC AAATAACACC ACAGACAGCC ACGGTGGCCT TTGATAATGT GCATTTTGAG 
TACATTGAAG GACAGAAAGT CCTTAGCGGA GTATCTTTTG AAGTCCCTGC AGGAAAGAAA 
GTGGCCATTG TAGGAGGTAG TGGGTCAGGA AAAAGCACGA TAGTGAGGCT GCTGTTTCGC 
TTCTATGAGC CTCAAAAGGG TAGCATTTAC CTTGCTGGTC AAAATATTCA AGATGTGAGC 
CTGGAAAGTC TTCGGCGTGC AGTGGGAGTA GTACCTCAGG ATGCTGTCCT CTTCCATAAT 
ACTATCTACT ACAACCTCTT ATATGGAAAC ATCAATGCGT CACCAGAGGA AGTATATGCA 
GTCGCAAAAT TGGCTGGTCT TCATGATGCA ATTCTTCGAA TGCCACATGG ATATGACACA 
CAAGTAGGAG AACGAGGACT CAAGTTATCA GGAGGAGAAA AGCAGAGGGT AGCGATTGCA 
AGAGCCATTT TGAAGGATCC CCCAGTTATT CTCTATGATG AAGCTACTTC ATCATTAGAT 
TCGATTACTG AAGAGACTAT TCTTGGTGCC ATGAGGGATG TGGTGAAGCA CAGAACTTCT 
ATTTTCATCG CACATAGATT GTCAACAGTG GTTGATGCAG ATGAAATCAT TGTCCTGAGC 
CAGGGAAAAG TAGCTGAACG TGGTACCCAC TATGGTCTGC TTGCTAACTC TAGCAGTATC 
TATTCAGAGA TGTGGCATAC ACAGAGCACC CGCATACAGA ACCATGATAA CCTTGGATGG 
GATGCAAAGA AAGAGAGTCT CTCTAAAGAG GAGGAGAGAA AGAAGCTCCA AGAAGAGATT 
GTCAACAGCG TGAAAGGCTG TGGAAATTGC TCCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997683.1
CDS	13..2271
Translation	MALLAIHSWRWAAAAVAFEKHKHSAVLTRSLVSICGSGLRWSSYQSGASGSARLSQTTESLRNSTQQRWEKNNSRQLLDASKVLQAWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIVFEMTLVSSVLYYKCGAQFALVTLGTLGAYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNEKYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGALTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTRIKDKAMASPLQITPQTATVAFDNVHFEYIEGQKVLSGVSFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNINASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMRDVVKHRTSIFIAHRLSTVVDADEIIVLSQGKVAERGTHYGLLANSSSIYSEMWHTQSTRIQNHDNLGWDAKKESLSKEEERKKLQEEIVNSVKGCGNCSC

Target ORF information:

RefSeq Version	NM_212518.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily B member 7 (Abcb7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_212518.1

ORF Insert Sequence:

ATGGCGCTGC TCGCGATACA TTCTTGGCGC TGGGCAGCCG CGGCGGTCGC TTTCGAAAAG 
CACAAGCATT CGGCAGTTCT GACCCGGTCT CTAGTCTCCA TCTGCGGCTC AGGCCTGCGG 
TGGAGTTCGT ACCAGAGCGG CGCGTCAGGA AGCGCTCGGC TGTCCCAGAC TACAGAATCA 
TTAAGAAATT CTACACAGCA GAGATGGGAA AAAAACAACT CAAGACAGTT ACTAGATGCT 
TCAAAGGTTC TTCAGGCATG GCCATTGATA GAAAAGAGAA CATGTTGGCA TGGGCACGCA 
GGAGGAGGAC TCCACACAGA CCCAAAAGAA GGGTTAAAGG ATGTTGATAC TAGAAAAATC 
ATTAAAGCCA TGCTTTCTTA TGTGTGGCCC AAAGACAGGC CTGATCTGCG AGCCAGAGTT 
GCCATTTCCC TGGGATTTCT GGGTGGTGCA AAGGCCATGA ATATTGTGGT TCCTTTCATG 
TTTAAATATG CTGTAGACAG CCTCAACCAG ATGTCGGGAA ACATGCTGAA CCTGAGTGAT 
GCACCAAATA CAGTTGCAAC CATGGCAACA GCAGTTCTGA TTGGCTATGG TGTATCAAGA 
GCCGGGGCTG CCTTTTTCAA TGAAGTCCGA AATGCAGTAT TTGGCAAAGT AGCACAAAAT 
TCAATCCGAA GAATAGCCAA AAATGTATTT CTCCATCTTC ACAACTTGGA TCTGGGTTTC 
CATCTGAGCA GACAGACAGG AGCCTTATCT AAGGCTATTG ACAGAGGGAC AAGGGGCATT 
AGTTTTGTCC TCAGTGCTTT AGTATTTAAT CTTCTCCCTA TTGTGTTTGA GATGACGCTT 
GTCAGTAGTG TTTTGTATTA CAAATGTGGG GCCCAGTTTG CATTGGTAAC CCTGGGAACA 
CTTGGTGCAT ATACAGCATT CACAGTTGCA GTTACACGGT GGAGAACTAG ATTTAGAATA 
GAAATGAACA AAGCTGATAA CGATGCAGGG AACGCTGCTA TTGACTCACT GCTGAATTAT 
GAAACTGTGA AGTATTTTAA CAATGAAAAA TATGAAGCAC AAAGATATGA TGGATTCTTG 
AAGACATATG AGACTGCTTC ATTGAAAAGT ACCTCTACTC TGGCTATGCT GAATTTTGGC 
CAAAGTGCTA TTTTCAGTGT TGGATTAACA GCTATCATGG TGCTTGCCAG TCAGGGAATT 
GTGGCAGGTG CCCTTACTGT TGGAGATCTA GTAATGGTGA ATGGACTGCT TTTTCAACTT 
TCATTACCCC TTAACTTCTT GGGAACTGTA TATAGAGAGA CACGGCAAGC ACTCATAGAT 
ATGAATACCT TGTTTACTCT GCTCAAGGTA GACACGCGGA TTAAAGACAA AGCGATGGCA 
TCTCCCCTTC AAATAACACC ACAGACAGCC ACGGTGGCCT TTGATAATGT GCATTTTGAG 
TACATTGAAG GACAGAAAGT CCTTAGCGGA GTATCTTTTG AAGTCCCTGC AGGAAAGAAA 
GTGGCCATTG TAGGAGGTAG TGGGTCAGGA AAAAGCACGA TAGTGAGGCT GCTGTTTCGC 
TTCTATGAGC CTCAAAAGGG TAGCATTTAC CTTGCTGGTC AAAATATTCA AGATGTGAGC 
CTGGAAAGTC TTCGGCGTGC AGTGGGAGTA GTACCTCAGG ATGCTGTCCT CTTCCATAAT 
ACTATCTACT ACAACCTCTT ATATGGAAAC ATCAATGCGT CACCAGAGGA AGTATATGCA 
GTCGCAAAAT TGGCTGGTCT TCATGATGCA ATTCTTCGAA TGCCACATGG ATATGACACA 
CAAGTAGGAG AACGAGGACT CAAGTTATCA GGAGGAGAAA AGCAGAGGGT AGCGATTGCA 
AGAGCCATTT TGAAGGATCC CCCAGTTATT CTCTATGATG AAGCTACTTC ATCATTAGAT 
TCGATTACTG AAGAGACTAT TCTTGGTGCC ATGAGGGATG TGGTGAAGCA CAGAACTTCT 
ATTTTCATCG CACATAGATT GTCAACAGTG GTTGATGCAG ATGAAATCAT TGTCCTGAGC 
CAGGGAAAAG TAGCTGAACG TGGTACCCAC TATGGTCTGC TTGCTAACTC TAGCAGTATC 
TATTCAGAGA TGTGGCATAC ACAGAGCACC CGCATACAGA ACCATGATAA CCTTGGATGG 
GATGCAAAGA AAGAGAGTCT CTCTAAAGAG GAGGAGAGAA AGAAGCTCCA AGAAGAGATT 
GTCAACAGCG TGAAAGGCTG TGGAAATTGC TCCTGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery.
Biochimica et biophysica acta1853(6)1493-512(2015 Jun)
Maio N,Rouault TA

The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts.
PloS one3(4)e1970(2008 Apr)
Boultwood J,Pellagatti A,Nikpour M,Pushkaran B,Fidler C,Cattan H,Littlewood TJ,Malcovati L,Della Porta MG,Jädersten M,Killick S,Giagounidis A,Bowen D,Hellström-Lindberg E,Cazzola M,Wainscoat JS

Identification of a mammalian mitochondrial porphyrin transporter.
Nature443(7111)586-9(2006 Oct)
Krishnamurthy PC,Du G,Fukuda Y,Sun D,Sampath J,Mercer KE,Wang J,Sosa-Pineda B,Murti KG,Schuetz JD

Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.
The EMBO journal25(3)544-53(2006 Feb)
Clarke SL,Vasanthakumar A,Anderson SA,Pondarré C,Koh CM,Deck KM,Pitula JS,Epstein CJ,Fleming MD,Eisenstein RS

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Cell115(5)629-40(2003 Nov)
Mootha VK,Bunkenborg J,Olsen JV,Hjerrild M,Wisniewski JR,Stahl E,Bolouri MS,Ray HN,Sihag S,Kamal M,Patterson N,Lander ES,Mann M

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Abcb7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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