Bcs1l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bcs1l
Entrez Gene ID	301514
Full Name	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
General protein information	Preferred Names BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Names mitochondrial chaperone BCS1 BC1 (ubiquinol-cytochrome c reductase) synthesis-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q33

mRNA and Protein(s)

mRNA	Protein	Name
XM_017596370.1	XP_017451859.1	mitochondrial chaperone BCS1 isoform X1
XM_017596371.1	XP_017451860.1	mitochondrial chaperone BCS1 isoform X1
NM_001007666.1	NP_001007667.1	mitochondrial chaperone BCS1

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	SPAC644.07	NP_593875.1
Homo sapiens (human)	BCS1L	NP_004319.1
Pan troglodytes (chimpanzee)	BCS1L	XP_516092.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004266	XP_313188.3
Xenopus tropicalis (tropical clawed frog)	bcs1l	NP_001016865.1
Canis lupus familiaris (dog)	BCS1L	XP_536070.1
Gallus gallus (chicken)	BCS1L	NP_001006520.1
Danio rerio (zebrafish)	bcs1l	NP_957476.2
Drosophila melanogaster (fruit fly)	CG4908	NP_609358.1
Kluyveromyces lactis	KLLA0E02487g	XP_454059.1
Macaca mulatta (Rhesus monkey)	BCS1L	XP_001092421.1
Bos taurus (cattle)	BCS1L	NP_001015671.1
Mus musculus (house mouse)	Bcs1l	NP_080060.1
Rattus norvegicus (Norway rat)	Bcs1l	NP_001007667.1
Caenorhabditis elegans (roundworm)	bcs-1	NP_001022191.1
Saccharomyces cerevisiae (baker's yeast)	BCS1	NP_010663.1
Eremothecium gossypii	AGOS_ACR200C	NP_983602.1

Gene Ontology
Bibliography

Related articles in PubMed

The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy.
Levéen P, Kotarsky H, Mörgelin M, Karikoski R, Elmér E, Fellman V
Hepatology (Baltimore, Md.)53(2)437-47(2011 Feb)

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.
Tamai S, Iida H, Yokota S, Sayano T, Kiguchiya S, Ishihara N, Hayashi J, Mihara K, Oka T
Journal of cell science121(Pt 15)2588-600(2008 Aug)

GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L.
Visapää I, Fellman V, Vesa J, Dasvarma A, Hutton JL, Kumar V, Payne GS, Makarow M, Van Coster R, Taylor RW, Turnbull DM, Suomalainen A, Peltonen L
American journal of human genetics71(4)863-76(2002 Oct)

A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.
de Lonlay P, Valnot I, Barrientos A, Gorbatyuk M, Tzagoloff A, Taanman JW, Benayoun E, Chrétien D, Kadhom N, Lombès A, de Baulny HO, Niaudet P, Munnich A, Rustin P, Rötig A
Nature genetics29(1)57-60(2001 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Bcs1l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bcs1l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa11486	NM_001007666.1 Latest version!	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa11486	XM_017596371.1 Latest version!	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa11486	XM_017596370.1 Latest version!	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bcs1l ( NM_001007666.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001007667.1 Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), mRNA.

Price & Availability↑

CloneID	ORa11486
Clone ID Related Accession (Same CDS sequence)	XM_017596370.1 , XM_017596371.1 , NM_001007666.1
Accession Version	NM_001007666.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial chaperone BCS1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083660.1. On Nov 29, 2004 this sequence version replaced XM_217434.2. ##Evidence-Data-START## Transcript exon combination :: BC083660.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001007667.1
CDS	305..1561
Translation	MPFTDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSQISPAQVQGYFMLYKNDPMGAIHNVESLR

Target ORF information:

RefSeq Version	NM_001007666.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001007666.1

ORF Insert Sequence:

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcs1l ( XM_017596370.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451859.1 Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa11486
Clone ID Related Accession (Same CDS sequence)	XM_017596370.1 , XM_017596371.1 , NM_001007666.1
Accession Version	XM_017596370.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial chaperone BCS1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451859.1
CDS	573..1829
Translation	MPFTDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSQISPAQVQGYFMLYKNDPMGAIHNVESLR

Target ORF information:

RefSeq Version	XM_017596370.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596370.1

ORF Insert Sequence:

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bcs1l ( XM_017596371.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451860.1 Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa11486
Clone ID Related Accession (Same CDS sequence)	XM_017596370.1 , XM_017596371.1 , NM_001007666.1
Accession Version	XM_017596371.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	mitochondrial chaperone BCS1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005108.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451860.1
CDS	146..1402
Translation	MPFTDFVLALKDNPYFGAGFGLVGVGTALAMARKGAQLGLVAFRRHYMITLEVPARDRSYAWLLSWLTRHSTRTQHLSVETSYLQHESGRISTKFEFIPSPGNHFIWYQGKWIRVERNREMQMVDLQTGTPWESVTFTALGTDRKVFFNILEEARALALQQEEGKTVMYTAVGSEWRTFGYPRRRRPLDSVVLQQGLADRIVKDIREFIDNPKWYIDRGIPYRRGYLLYGPPGCGKSSFITALAGELEHSICLLSLTDSSLSDDRLNHLLSVAPQQSLVLLEDVDAAFLSRDLAVENPVKYQGLGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDLKEYVGYCSHWQLTQMFQRFYPGQAPSLAENFAEHVLKATSQISPAQVQGYFMLYKNDPMGAIHNVESLR

Target ORF information:

RefSeq Version	XM_017596371.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone (Bcs1l), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017596371.1

ORF Insert Sequence:

ATGCCATTTA CAGACTTTGT TCTGGCCCTC AAAGACAATC CCTACTTTGG GGCTGGATTT 
GGGCTGGTAG GTGTGGGTAC AGCTCTGGCT ATGGCCCGGA AAGGAGCCCA GTTGGGTCTA 
GTGGCATTCC GTCGCCATTA CATGATCACA CTGGAAGTCC CTGCTAGAGA CAGAAGCTAT 
GCCTGGTTGC TTAGCTGGCT GACCCGGCAC AGCACCCGCA CTCAGCACCT CAGTGTTGAG 
ACCTCATACC TTCAGCATGA AAGTGGCCGA ATCTCCACCA AGTTTGAATT CATCCCCAGC 
CCTGGAAACC ACTTCATTTG GTATCAGGGA AAATGGATCC GGGTAGAGCG AAATCGAGAA 
ATGCAGATGG TGGACTTGCA AACGGGGACT CCTTGGGAAT CTGTCACCTT CACGGCCCTG 
GGCACTGATC GAAAGGTTTT CTTCAACATC CTGGAGGAAG CGAGAGCCCT GGCTCTGCAG 
CAGGAGGAAG GGAAGACTGT GATGTACACA GCTGTGGGTT CTGAATGGCG AACCTTCGGT 
TATCCACGCC GGAGGCGGCC ACTGGATTCT GTAGTCCTAC AGCAGGGTCT GGCTGACCGA 
ATTGTTAAAG ATATCCGAGA ATTTATTGAT AATCCCAAGT GGTACATTGA CAGAGGCATC 
CCCTACAGAC GTGGCTACCT TCTTTATGGG CCCCCTGGTT GTGGAAAGAG CAGTTTTATA 
ACAGCTCTGG CTGGAGAACT GGAACACAGC ATCTGCCTGC TAAGTCTCAC AGACTCTAGC 
CTCTCGGACG ACCGGCTCAA CCATCTACTA AGCGTAGCAC CCCAGCAGAG CCTGGTGCTC 
CTGGAAGATG TAGATGCTGC TTTTCTCAGT AGAGACTTGG CCGTGGAGAA CCCTGTAAAG 
TACCAAGGAT TAGGTCGCCT CACCTTCAGC GGACTGCTTA ATGCTTTGGA TGGTGTAGCC 
TCTACCGAGG CTCGAATTGT GTTCATGACC ACTAACCACA TTGACAGGCT GGATCCTGCC 
CTGATACGTC CTGGGCGAGT AGATCTGAAG GAGTATGTGG GCTACTGCTC ACACTGGCAG 
CTGACCCAGA TGTTCCAGAG GTTCTATCCA GGACAAGCGC CTTCTTTGGC TGAGAATTTT 
GCTGAACATG TCCTTAAAGC TACATCCCAG ATTAGTCCTG CCCAGGTGCA AGGCTACTTC 
ATGCTGTATA AAAATGACCC CATGGGGGCC ATTCACAATG TCGAATCTCT GAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy.
Hepatology (Baltimore, Md.)53(2)437-47(2011 Feb)
Levéen P,Kotarsky H,Mörgelin M,Karikoski R,Elmér E,Fellman V

Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.
Journal of cell science121(Pt 15)2588-600(2008 Aug)
Tamai S,Iida H,Yokota S,Sayano T,Kiguchiya S,Ishihara N,Hayashi J,Mihara K,Oka T

GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L.
American journal of human genetics71(4)863-76(2002 Oct)
Visapää I,Fellman V,Vesa J,Dasvarma A,Hutton JL,Kumar V,Payne GS,Makarow M,Van Coster R,Taylor RW,Turnbull DM,Suomalainen A,Peltonen L

A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure.
Nature genetics29(1)57-60(2001 Sep)
de Lonlay P,Valnot I,Barrientos A,Gorbatyuk M,Tzagoloff A,Taanman JW,Benayoun E,Chrétien D,Kadhom N,Lombès A,de Baulny HO,Niaudet P,Munnich A,Rustin P,Rötig A

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Bcs1l cDNA ORF clone, Rattus norvegicus(Norway rat)

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ORF Insert Sequence:

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