Grhl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Grhl3
Entrez Gene ID	298555
Full Name	grainyhead-like transcription factor 3
Synonyms	Tfcp2l4
General protein information	Preferred Names grainyhead-like transcription factor 3 Names grainyhead-like protein 3 homolog grainyhead-like 3 transcription factor CP2-like 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36

mRNA and Protein(s)

mRNA	Protein	Name
XM_006239149.3	XP_006239211.1	grainyhead-like protein 3 homolog isoform X2
XM_008764216.2	XP_008762438.1	grainyhead-like protein 3 homolog isoform X1
NM_001106690.1	NP_001100160.1	grainyhead-like protein 3 homolog

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Grhl3	NP_001100160.1
Xenopus tropicalis (tropical clawed frog)	grhl3	NP_001005642.1
Macaca mulatta (Rhesus monkey)	LOC711881	XP_001105395.2
Homo sapiens (human)	GRHL3	NP_937816.1
Canis lupus familiaris (dog)	GRHL3	XP_005617861.1
Bos taurus (cattle)	GRHL3	XP_002685819.3
Mus musculus (house mouse)	Grhl3	NP_001013778.1
Danio rerio (zebrafish)	grhl3	XP_005158615.1
Pan troglodytes (chimpanzee)	GRHL3	XP_513205.4
Gallus gallus (chicken)	GRHL3	XP_417842.3

Gene Ontology
Bibliography

Related articles in PubMed

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.
Gordon WM, Zeller MD, Klein RH, Swindell WR, Ho H, Espetia F, Gudjonsson JE, Baldi PF, Andersen B
The Journal of clinical investigation124(12)5205-18(2014 Dec)

Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo.
Haendeler J, Mlynek A, Büchner N, Lukosz M, Graf M, Guettler C, Jakob S, Farrokh S, Kunze K, Goy C, Guardiola-Serrano F, Schaal H, Cortese-Krott M, Deenen R, Köhrer K, Winkler C, Altschmied J
Arteriosclerosis, thrombosis, and vascular biology33(7)1639-46(2013 Jul)

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.
Brouns MR, De Castro SC, Terwindt-Rouwenhorst EA, Massa V, Hekking JW, Hirst CS, Savery D, Munts C, Partridge D, Lamers W, Köhler E, van Straaten HW, Copp AJ, Greene ND
Human molecular genetics20(8)1536-46(2011 Apr)

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.
Boglev Y, Wilanowski T, Caddy J, Parekh V, Auden A, Darido C, Hislop NR, Cangkrama M, Ting SB, Jane SM
Developmental biology349(2)512-22(2011 Jan)

Regional neural tube closure defined by the Grainy head-like transcription factors.
Rifat Y, Parekh V, Wilanowski T, Hislop NR, Auden A, Ting SB, Cunningham JM, Jane SM
Developmental biology345(2)237-45(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Grhl3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Grhl3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa04921	NM_001106690.1 Latest version!	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa28738	XM_006239149.3 Latest version!	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa45537	XM_008764216.2 Latest version!	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Grhl3 ( NM_001106690.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100160.1 Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), mRNA.

Price & Availability↑

CloneID	ORa04921
Clone ID Related Accession (Same CDS sequence)	NM_001106690.1
Accession Version	NM_001106690.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1650bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1527350400000
Organism	Rattus norvegicus(Norway rat)
Product	grainyhead-like protein 3 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473968.1. On or before Oct 4, 2007 this sequence version replaced XM_233561.4, XM_001068377.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAC GACTTTGAGT ACACCCTGGG CTCCCCCAAA 
GCCATTCACA TCAAAGCGGG GGAGTCACCC ATGGCCTACC TCAACAAGGG TCAGTTCTAC 
CCGGTCACCC TACGCACCCC AGCGGGAGGA AAAGGCCTCT CTCTGTCCTC CAGCAAAGTC 
AAGAGCGTGG TGATGATTGT GTTCGATAAT GACAAGGTTC CAGTGGAGCA GCTGCGCTTC 
TGGAGGCACT GGCATTCCCG GCAGCCTACC GCCAAGCAGC GTGTCATCGA CGTAGCCGAC 
TGTAAGGAAA ACTTCAACAC AGTCCAGCAC ATCGAGGAGG TGGCCTATAA CGCACTGTCC 
TTTGTGTGGA ATGTTAACGA GGAGGCTAAG GTGTTCATCG GTGTCAACTG TCTGAGCACA 
GACTTCTCCT CGCAGAAGGG GGTGAAGGGT GTCCCCCTCA ACTTGCAAAT TGACACTTAT 
GACTGTGGAG CAGGCACTGA GCGCCTGGGT GCCGAGAGGA AGATGCGCGA TGATGAACGG 
AAGCAGTTTC GAAGGAAGGT CAAGTGCCCA GACTCCAGTA ACAATGGCAT CAAGGGCTGC 
CTGCTGTCCG GCTTCAGGGG CAATGAGACC ACATACTTGC GGCCAGAAGC GGACCTGGAG 
ACCCAGCCTG TGTTGTTCAT CCCCAACCTG CATTTCTCCA GCCTACAACG CCCAGGAGGG 
GTTGTCCCCT CAGCAGGACA CAGCAGCTCT GACAGGTTGC CTCTGAAGCG AACCTGCTCG 
CCCTTTGCTG AGGAGTTTGA GCCTCTCCCC TCCAAACAGG CCAAGGAAGA TGACCTTCAG 
AGAGTTCTGC TGTATGTGAG GAGGGAGACA GAGGAGGTGT TTGACGCACT CATGTTGAAG 
ACCCCGGACT TGAAGGGGCT GAGGAATGCG ATCTCTGAGA AGTATGGCTT CCCTGAGGAG 
AATATCTGCA AAGTCTACAA GAAATGCAAG CGAGGAATCC TGGTCAACAT GGACAACAAC 
ATCATCCAGC ATTACAGCAA CCACGTGGCC TTCCTGCTGG ACATGGGTGA GCTGGATGGC 
AAGATTCAGA TTATCCTGAA GGAGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100160.1
CDS	77..1726
Translation	MSNELDFRSVRLLKNDPVSFQKFPYNNEDEAWKTYLENPLTAATKAIMRVNGDDESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKYYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGALPTPGKTSTLPPGPSKLEAGSMDSYLLPTSDMYDNSSLNSLFESIHGVPPTHDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLSLSSSKVKSVVMIVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLGAERKMRDDERKQFRRKVKCPDSSNNGIKGCLLSGFRGNETTYLRPEADLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL

Target ORF information:

RefSeq Version	NM_001106690.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106690.1

ORF Insert Sequence:

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAC GACTTTGAGT ACACCCTGGG CTCCCCCAAA 
GCCATTCACA TCAAAGCGGG GGAGTCACCC ATGGCCTACC TCAACAAGGG TCAGTTCTAC 
CCGGTCACCC TACGCACCCC AGCGGGAGGA AAAGGCCTCT CTCTGTCCTC CAGCAAAGTC 
AAGAGCGTGG TGATGATTGT GTTCGATAAT GACAAGGTTC CAGTGGAGCA GCTGCGCTTC 
TGGAGGCACT GGCATTCCCG GCAGCCTACC GCCAAGCAGC GTGTCATCGA CGTAGCCGAC 
TGTAAGGAAA ACTTCAACAC AGTCCAGCAC ATCGAGGAGG TGGCCTATAA CGCACTGTCC 
TTTGTGTGGA ATGTTAACGA GGAGGCTAAG GTGTTCATCG GTGTCAACTG TCTGAGCACA 
GACTTCTCCT CGCAGAAGGG GGTGAAGGGT GTCCCCCTCA ACTTGCAAAT TGACACTTAT 
GACTGTGGAG CAGGCACTGA GCGCCTGGGT GCCGAGAGGA AGATGCGCGA TGATGAACGG 
AAGCAGTTTC GAAGGAAGGT CAAGTGCCCA GACTCCAGTA ACAATGGCAT CAAGGGCTGC 
CTGCTGTCCG GCTTCAGGGG CAATGAGACC ACATACTTGC GGCCAGAAGC GGACCTGGAG 
ACCCAGCCTG TGTTGTTCAT CCCCAACCTG CATTTCTCCA GCCTACAACG CCCAGGAGGG 
GTTGTCCCCT CAGCAGGACA CAGCAGCTCT GACAGGTTGC CTCTGAAGCG AACCTGCTCG 
CCCTTTGCTG AGGAGTTTGA GCCTCTCCCC TCCAAACAGG CCAAGGAAGA TGACCTTCAG 
AGAGTTCTGC TGTATGTGAG GAGGGAGACA GAGGAGGTGT TTGACGCACT CATGTTGAAG 
ACCCCGGACT TGAAGGGGCT GAGGAATGCG ATCTCTGAGA AGTATGGCTT CCCTGAGGAG 
AATATCTGCA AAGTCTACAA GAAATGCAAG CGAGGAATCC TGGTCAACAT GGACAACAAC 
ATCATCCAGC ATTACAGCAA CCACGTGGCC TTCCTGCTGG ACATGGGTGA GCTGGATGGC 
AAGATTCAGA TTATCCTGAA GGAGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grhl3 ( XM_006239149.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239211.1 Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa28738
Clone ID Related Accession (Same CDS sequence)	XM_006239149.3
Accession Version	XM_006239149.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1809bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	grainyhead-like protein 3 homolog isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239149.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAG CGCTGGCAGC CAGACAGCAC CTTCAAAGAC 
GACCCACAGG AGTCGCTGCT CTTCCCTGAT ATCCTGAAGA CATCCCCGGA AGCCCCATGT 
CCAGAGGATT ATCCAAGCCT CAAGAGCGAC TTTGAGTACA CCCTGGGCTC CCCCAAAGCC 
ATTCACATCA AAGCGGGGGA GTCACCCATG GCCTACCTCA ACAAGGGTCA GTTCTACCCG 
GTCACCCTAC GCACCCCAGC GGGAGGAAAA GGCCTCTCTC TGTCCTCCAG CAAAGTCAAG 
AGCGTGGTGA TGATTGTGTT CGATAATGAC AAGGTTCCAG TGGAGCAGCT GCGCTTCTGG 
AGGCACTGGC ATTCCCGGCA GCCTACCGCC AAGCAGCGTG TCATCGACGT AGCCGACTGT 
AAGGAAAACT TCAACACAGT CCAGCACATC GAGGAGGTGG CCTATAACGC ACTGTCCTTT 
GTGTGGAATG TTAACGAGGA GGCTAAGGTG TTCATCGGTG TCAACTGTCT GAGCACAGAC 
TTCTCCTCGC AGAAGGGGGT GAAGGGTGTC CCCCTCAACT TGCAAATTGA CACTTATGAC 
TGTGGAGCAG GCACTGAGCG CCTGGTGCAC CGTGCTGTCT GCCAAATCAA GATCTTCTGT 
GACAAGGGTG CCGAGAGGAA GATGCGCGAT GATGAACGGA AGCAGTTTCG AAGGAAGGTC 
AAGTGCCCAG ACTCCAGTAA CAATGGCATC AAGGGCTGCC TGCTGTCCGG CTTCAGGGGC 
AATGAGACCA CATACTTGCG GCCAGAAGCG GACCTGGAGA CCCAGCCTGT GTTGTTCATC 
CCCAACCTGC ATTTCTCCAG CCTACAACGC CCAGGAGGGG TTGTCCCCTC AGCAGGACAC 
AGCAGCTCTG ACAGGTTGCC TCTGAAGCGA ACCTGCTCGC CCTTTGCTGA GGAGTTTGAG 
CCTCTCCCCT CCAAACAGGC CAAGGAAGAT GACCTTCAGA GAGTTCTGCT GTATGTGAGG 
AGGGAGACAG AGGAGGTGTT TGACGCACTC ATGTTGAAGA CCCCGGACTT GAAGGGGCTG 
AGGAATGCGA TCTCTGAGAA GTATGGCTTC CCTGAGGAGA ATATCTGCAA AGTCTACAAG 
AAATGCAAGC GAGGAATCCT GGTCAACATG GACAACAACA TCATCCAGCA TTACAGCAAC 
CACGTGGCCT TCCTGCTGGA CATGGGTGAG CTGGATGGCA AGATTCAGAT TATCCTGAAG 
GAGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239211.1
CDS	226..2034
Translation	MSNELDFRSVRLLKNDPVSFQKFPYNNEDEAWKTYLENPLTAATKAIMRVNGDDESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKYYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGALPTPGKTSTLPPGPSKLEAGSMDSYLLPTSDMYDNSSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPEAPCPEDYPSLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLSLSSSKVKSVVMIVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNGIKGCLLSGFRGNETTYLRPEADLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL

Target ORF information:

RefSeq Version	XM_006239149.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239149.3

ORF Insert Sequence:

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAG CGCTGGCAGC CAGACAGCAC CTTCAAAGAC 
GACCCACAGG AGTCGCTGCT CTTCCCTGAT ATCCTGAAGA CATCCCCGGA AGCCCCATGT 
CCAGAGGATT ATCCAAGCCT CAAGAGCGAC TTTGAGTACA CCCTGGGCTC CCCCAAAGCC 
ATTCACATCA AAGCGGGGGA GTCACCCATG GCCTACCTCA ACAAGGGTCA GTTCTACCCG 
GTCACCCTAC GCACCCCAGC GGGAGGAAAA GGCCTCTCTC TGTCCTCCAG CAAAGTCAAG 
AGCGTGGTGA TGATTGTGTT CGATAATGAC AAGGTTCCAG TGGAGCAGCT GCGCTTCTGG 
AGGCACTGGC ATTCCCGGCA GCCTACCGCC AAGCAGCGTG TCATCGACGT AGCCGACTGT 
AAGGAAAACT TCAACACAGT CCAGCACATC GAGGAGGTGG CCTATAACGC ACTGTCCTTT 
GTGTGGAATG TTAACGAGGA GGCTAAGGTG TTCATCGGTG TCAACTGTCT GAGCACAGAC 
TTCTCCTCGC AGAAGGGGGT GAAGGGTGTC CCCCTCAACT TGCAAATTGA CACTTATGAC 
TGTGGAGCAG GCACTGAGCG CCTGGTGCAC CGTGCTGTCT GCCAAATCAA GATCTTCTGT 
GACAAGGGTG CCGAGAGGAA GATGCGCGAT GATGAACGGA AGCAGTTTCG AAGGAAGGTC 
AAGTGCCCAG ACTCCAGTAA CAATGGCATC AAGGGCTGCC TGCTGTCCGG CTTCAGGGGC 
AATGAGACCA CATACTTGCG GCCAGAAGCG GACCTGGAGA CCCAGCCTGT GTTGTTCATC 
CCCAACCTGC ATTTCTCCAG CCTACAACGC CCAGGAGGGG TTGTCCCCTC AGCAGGACAC 
AGCAGCTCTG ACAGGTTGCC TCTGAAGCGA ACCTGCTCGC CCTTTGCTGA GGAGTTTGAG 
CCTCTCCCCT CCAAACAGGC CAAGGAAGAT GACCTTCAGA GAGTTCTGCT GTATGTGAGG 
AGGGAGACAG AGGAGGTGTT TGACGCACTC ATGTTGAAGA CCCCGGACTT GAAGGGGCTG 
AGGAATGCGA TCTCTGAGAA GTATGGCTTC CCTGAGGAGA ATATCTGCAA AGTCTACAAG 
AAATGCAAGC GAGGAATCCT GGTCAACATG GACAACAACA TCATCCAGCA TTACAGCAAC 
CACGTGGCCT TCCTGCTGGA CATGGGTGAG CTGGATGGCA AGATTCAGAT TATCCTGAAG 
GAGCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Grhl3 ( XM_008764216.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008762438.1 Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa45537
Clone ID Related Accession (Same CDS sequence)	XM_008764216.2
Accession Version	XM_008764216.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	grainyhead-like protein 3 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008764216.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAG CGCTGGCAGC CAGACAGCAC CTTCAAAGAC 
GACCCACAGG AGTCGCTGCT CTTCCCTGAT ATCCTGAAGA CATCCCCGGA AGCCCCATGT 
CCAGAGGATT ATCCAAGCCT CAAGAGCGAC TTTGAGTACA CCCTGGGCTC CCCCAAAGCC 
ATTCACATCA AAGCGGGGGA GTCACCCATG GCCTACCTCA ACAAGGGTCA GTTCTACCCG 
GTCACCCTAC GCACCCCAGC GGGAGGAAAA GGCCTCTCTC TGTCCTCCAG CAAAGTCAAG 
AGCGTGGTGA TGATTGTGTT CGATAATGAC AAGGTTCCAG TGGAGCAGCT GCGCTTCTGG 
AGGCACTGGC ATTCCCGGCA GCCTACCGCC AAGCAGCGTG TCATCGACGT AGCCGACTGT 
AAGGAAAACT TCAACACAGT CCAGCACATC GAGGAGGTGG CCTATAACGC ACTGTCCTTT 
GTGTGGAATG TTAACGAGGA GGCTAAGGTG TTCATCGGTG TCAACTGTCT GAGCACAGAC 
TTCTCCTCGC AGAAGGGGGT GAAGGGTGTC CCCCTCAACT TGCAAATTGA CACTTATGAC 
TGTGGAGCAG GCACTGAGCG CCTGGTGCAC CGTGCTGTCT GCCAAATCAA GATCTTCTGT 
GACAAGGGTG CCGAGAGGAA GATGCGCGAT GATGAACGGA AGCAGTTTCG AAGGAAGGTC 
AAGTGCCCAG ACTCCAGTAA CAATGCAGGC ATCAAGGGCT GCCTGCTGTC CGGCTTCAGG 
GGCAATGAGA CCACATACTT GCGGCCAGAA GCGGACCTGG AGACCCAGCC TGTGTTGTTC 
ATCCCCAACC TGCATTTCTC CAGCCTACAA CGCCCAGGAG GGGTTGTCCC CTCAGCAGGA 
CACAGCAGCT CTGACAGGTT GCCTCTGAAG CGAACCTGCT CGCCCTTTGC TGAGGAGTTT 
GAGCCTCTCC CCTCCAAACA GGCCAAGGAA GATGACCTTC AGAGAGTTCT GCTGTATGTG 
AGGAGGGAGA CAGAGGAGGT GTTTGACGCA CTCATGTTGA AGACCCCGGA CTTGAAGGGG 
CTGAGGAATG CGATCTCTGA GAAGTATGGC TTCCCTGAGG AGAATATCTG CAAAGTCTAC 
AAGAAATGCA AGCGAGGAAT CCTGGTCAAC ATGGACAACA ACATCATCCA GCATTACAGC 
AACCACGTGG CCTTCCTGCT GGACATGGGT GAGCTGGATG GCAAGATTCA GATTATCCTG 
AAGGAGCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008762438.1
CDS	226..2037
Translation	MSNELDFRSVRLLKNDPVSFQKFPYNNEDEAWKTYLENPLTAATKAIMRVNGDDESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKYYHSMDYEPDLAPLESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGALPTPGKTSTLPPGPSKLEAGSMDSYLLPTSDMYDNSSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPEAPCPEDYPSLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLSLSSSKVKSVVMIVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPEADLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL

Target ORF information:

RefSeq Version	XM_008764216.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008764216.2

ORF Insert Sequence:

ATGTCGAATG AACTTGATTT CAGGTCTGTG CGGCTGCTGA AAAATGACCC CGTGAGCTTC 
CAGAAGTTTC CCTACAATAA TGAGGATGAG GCCTGGAAGA CATACCTGGA GAACCCTTTG 
ACAGCCGCCA CCAAGGCCAT AATGAGAGTC AATGGGGACG ATGAGAGTGT CGCTGCTCTG 
AGCTTTCTCT ATGACTACTA TATGGGTCCC AAGGAGAAGC GGATACTGTC CTCCAGCACT 
GGTGGCCGGA ATGACCAAGG AAAGAAGTAC TACCACAGCA TGGACTATGA GCCGGATCTT 
GCCCCGCTTG AGAGCCCCAC GCACCTCATG AAATTTCTGA CAGAGAACGT GTCTGGAAGC 
CCAGACTACA CAGACCAGCT CAAGAAGAAC AACCTGCTAG GCTTGGAGGG GGCTCTACCC 
ACCCCCGGCA AGACCAGTAC CCTGCCCCCA GGTCCAAGTA AGCTGGAAGC CGGCTCCATG 
GACAGCTACC TCTTGCCCAC CAGTGACATG TATGACAACA GCTCCCTCAA CTCACTATTT 
GAGAGCATTC ATGGCGTTCC ACCCACACAG CGCTGGCAGC CAGACAGCAC CTTCAAAGAC 
GACCCACAGG AGTCGCTGCT CTTCCCTGAT ATCCTGAAGA CATCCCCGGA AGCCCCATGT 
CCAGAGGATT ATCCAAGCCT CAAGAGCGAC TTTGAGTACA CCCTGGGCTC CCCCAAAGCC 
ATTCACATCA AAGCGGGGGA GTCACCCATG GCCTACCTCA ACAAGGGTCA GTTCTACCCG 
GTCACCCTAC GCACCCCAGC GGGAGGAAAA GGCCTCTCTC TGTCCTCCAG CAAAGTCAAG 
AGCGTGGTGA TGATTGTGTT CGATAATGAC AAGGTTCCAG TGGAGCAGCT GCGCTTCTGG 
AGGCACTGGC ATTCCCGGCA GCCTACCGCC AAGCAGCGTG TCATCGACGT AGCCGACTGT 
AAGGAAAACT TCAACACAGT CCAGCACATC GAGGAGGTGG CCTATAACGC ACTGTCCTTT 
GTGTGGAATG TTAACGAGGA GGCTAAGGTG TTCATCGGTG TCAACTGTCT GAGCACAGAC 
TTCTCCTCGC AGAAGGGGGT GAAGGGTGTC CCCCTCAACT TGCAAATTGA CACTTATGAC 
TGTGGAGCAG GCACTGAGCG CCTGGTGCAC CGTGCTGTCT GCCAAATCAA GATCTTCTGT 
GACAAGGGTG CCGAGAGGAA GATGCGCGAT GATGAACGGA AGCAGTTTCG AAGGAAGGTC 
AAGTGCCCAG ACTCCAGTAA CAATGCAGGC ATCAAGGGCT GCCTGCTGTC CGGCTTCAGG 
GGCAATGAGA CCACATACTT GCGGCCAGAA GCGGACCTGG AGACCCAGCC TGTGTTGTTC 
ATCCCCAACC TGCATTTCTC CAGCCTACAA CGCCCAGGAG GGGTTGTCCC CTCAGCAGGA 
CACAGCAGCT CTGACAGGTT GCCTCTGAAG CGAACCTGCT CGCCCTTTGC TGAGGAGTTT 
GAGCCTCTCC CCTCCAAACA GGCCAAGGAA GATGACCTTC AGAGAGTTCT GCTGTATGTG 
AGGAGGGAGA CAGAGGAGGT GTTTGACGCA CTCATGTTGA AGACCCCGGA CTTGAAGGGG 
CTGAGGAATG CGATCTCTGA GAAGTATGGC TTCCCTGAGG AGAATATCTG CAAAGTCTAC 
AAGAAATGCA AGCGAGGAAT CCTGGTCAAC ATGGACAACA ACATCATCCA GCATTACAGC 
AACCACGTGG CCTTCCTGCT GGACATGGGT GAGCTGGATG GCAAGATTCA GATTATCCTG 
AAGGAGCTAT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia.
The Journal of clinical investigation124(12)5205-18(2014 Dec)
Gordon WM,Zeller MD,Klein RH,Swindell WR,Ho H,Espetia F,Gudjonsson JE,Baldi PF,Andersen B

Two isoforms of Sister-Of-Mammalian Grainyhead have opposing functions in endothelial cells and in vivo.
Arteriosclerosis, thrombosis, and vascular biology33(7)1639-46(2013 Jul)
Haendeler J,Mlynek A,Büchner N,Lukosz M,Graf M,Guettler C,Jakob S,Farrokh S,Kunze K,Goy C,Guardiola-Serrano F,Schaal H,Cortese-Krott M,Deenen R,Köhrer K,Winkler C,Altschmied J

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.
Human molecular genetics20(8)1536-46(2011 Apr)
Brouns MR,De Castro SC,Terwindt-Rouwenhorst EA,Massa V,Hekking JW,Hirst CS,Savery D,Munts C,Partridge D,Lamers W,Köhler E,van Straaten HW,Copp AJ,Greene ND

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.
Developmental biology349(2)512-22(2011 Jan)
Boglev Y,Wilanowski T,Caddy J,Parekh V,Auden A,Darido C,Hislop NR,Cangkrama M,Ting SB,Jane SM

Regional neural tube closure defined by the Grainy head-like transcription factors.
Developmental biology345(2)237-45(2010 Sep)
Rifat Y,Parekh V,Wilanowski T,Hislop NR,Auden A,Ting SB,Cunningham JM,Jane SM

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Grhl3 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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