Kcnq3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnq3
Entrez Gene ID	29682
Full Name	potassium voltage-gated channel subfamily Q member 3
General protein information	Preferred Names potassium voltage-gated channel subfamily Q member 3 Names potassium voltage-gated channel subfamily KQT member 3 KQT-like 3 potassium channel subunit alpha KvLQT3 potassium channel, voltage-gated KQT-like subfamily Q, member 3 potassium voltage-gated channel, KQT-like subfamily, member 3 voltage-gated potassium channel subunit Kv7.3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	potassium channel involved in regulating neuronal excitability [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031597.4	NP_113785.3	potassium voltage-gated channel subfamily KQT member 3

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	KCNQ3	XP_001089122.1
Xenopus tropicalis (tropical clawed frog)	kcnq3	XP_004915103.1
Canis lupus familiaris (dog)	KCNQ3	XP_532334.3
Gallus gallus (chicken)	KCNQ3	XP_003640915.2
Danio rerio (zebrafish)	kcnq3	XP_003197981.1
Bos taurus (cattle)	KCNQ3	NP_776799.1
Homo sapiens (human)	KCNQ3	NP_004510.1
Pan troglodytes (chimpanzee)	KCNQ3	XP_519963.2
Mus musculus (house mouse)	Kcnq3	NP_690887.2
Rattus norvegicus (Norway rat)	Kcnq3	NP_113785.3

Gene Ontology
Bibliography

Related articles in PubMed

Suppression of KV7/KCNQ potassium channel enhances neuronal differentiation of PC12 cells.
Zhou N, Huang S, Li L, Huang D, Yan Y, Du X, Zhang H
Neuroscience333356-67(2016 10)

Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.
Strulovich R, Tobelaim WS, Attali B, Hirsch JA
Biochemistry55(38)5353-65(2016 09)

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
Anta B, Martín-Rodríguez C, Gomis-Perez C, Calvo L, López-Benito S, Calderón-García AA, Vicente-García C, Villarroel Á, Arévalo JC
The Journal of biological chemistry291(36)19132-45(2016 09)

Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.
Li C, Lu Q, Huang P, Fu T, Li C, Guo L, Xu X
Neuropharmacology95154-67(2015 Aug)

Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.
Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH
The Journal of neuroscience : the official journal of the Society for Neuroscience34(10)3719-32(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Kcnq3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnq3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13333	NM_031597.4 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily Q member 3 (Kcnq3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnq3 ( NM_031597.4 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113785.3 Rattus norvegicus potassium voltage-gated channel subfamily Q member 3 (Kcnq3), mRNA.

Price & Availability↑

CloneID	ORa13333
Clone ID Related Accession (Same CDS sequence)	NM_031597.4
Accession Version	NM_031597.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2739bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1569254400000
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily KQT member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07058255.1 and AABR07058254.1. On Mar 20, 2013 this sequence version replaced NM_031597.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCATTGG AGTTCCCGGG CTTGCAGCCG CCGCCGCCGC CTCGTCCCGT ACCCCAAGCG 
CTCCTTCTTC CCGGAGCAGC AGCGGAGAAG GCGAAGCGCC CGGTGGGGGC GAGGCAGATG 
GGGCTCAAGG CTCGCAGGGC GGCGGGGGCG GCCGGCGGGG GCGGCGGCGA AGGGGGCGGA 
GGAGGCGGCG GGGCGGCTAA CCCGGCTGGA GGGGACTCGG CAGTGGCCGG CGACGAGGAG 
CGGAAAGTGG GGCTGGCGCC AGGAGACGTG GAGCAAGTCA CCTTGGCGCT AGGGACCGGA 
GCCGACAAAG ACGGGACCCT GCTGCTGGAG GGCGGTGGCC GCGAAGAGGG GCAGAGGAGG 
ACCCCGCAGG GCATCGGGCT CCTGGCAAAG ACCCCCCTGA GCCGTCCAGT TAAGAGGAAC 
AACGCCAAGT ACAGGCGCAT CCAAACTTTG ATCTATGACG CCCTGGAGAG ACCGAGGGGC 
TGGGCGCTGC TCTACCACGC GCTTGTGTTC CTGATTGTCC TGGGATGCTT GATTCTGGCC 
GTGCTCACCA CTTTCAAGGA GTATGAGACT GTGTCTGGAG ACTGGCTTTT GCTGCTGGAA 
ACATTTGCTA TTTTCATCTT TGGAGCTGAG TTTGCTTTGA GGATCTGGGC TGCAGGATGT 
TGCTGTCGAT ACAAAGGCTG GCGTGGACGG CTGAAGTTTG CCAGGAAGCC CCTGTGCATG 
TTGGATATCT TCGTGCTGAT TGCTTCTGTG CCAGTGGTTG CCGTGGGAAA CCAGGGCAAT 
GTCCTGGCTA CCTCTCTGCG AAGCCTCCGC TTCCTGCAGA TCCTGCGCAT GCTTCGAATG 
GATAGGAGGG GTGGCACCTG GAAGCTCCTG GGCTCAGCTA TCTGTGCCCA CAGCAAAGAA 
CTCATCACCG CCTGGTACAT CGGCTTCCTG ACACTCATCC TTTCTTCATT TCTTGTCTAC 
CTGGTGGAGA AGGATGTGCC AGAGATGGAT GCCCAAGGAG AGGAAATGAA AGAGGAGTTT 
GAGACCTATG CTGATGCCCT GTGGTGGGGC CTGATCACAC TGGCCACCAT TGGTTATGGA 
GACAAGACAC CTAAAACCTG GGAAGGACGT CTGATTGCTG CCACCTTTTC TTTAATCGGC 
GTCTCCTTTT TTGCTCTTCC GGCAGGCATC CTTGGCTCAG GACTGGCATT GAAGGTTCAG 
GAACAGCACC GTCAGAAGCA CTTTGAGAAG AGAAGGAAGC CAGCTGCTGA ACTCATCCAG 
GCTGCCTGGA GATATTATGC TACCAACCCC AACAGGCTTG ACCTGGTGGC AACCTGGAGA 
TTTTATGAAT CAGTTGTCTC TTTCCCATTC TTCAGGAAAG AACAACTGGA AGCAGCAGCC 
AGCCAAAAGC TGGGTCTCTT GGATCGGGTT CGCCTTTCTA ATCCTCGTGG TAGCAATACT 
AAAGGAAAGC TATTTACCCC TCTGAATGTA GATGCCATAG AAGAAAGCCC TTCCAAAGAG 
CCAAAGCCCG TTGGCTTAAA CAATAAAGAG CGTTTCCGCA CCGCCTTCCG CATGAAAGCC 
TACGCTTTCT GGCAGAGTTC TGAAGATGCC GGGACAGGAG ACCCCATGAC AGAAGACAGG 
GGCTATGGAA ATGACTTCCT CATTGAAGAC ATGATCCCCA CCCTAAAGGC TGCCATCCGA 
GCTGTCAGAA TTCTACAATT CCGTCTGTAT AAAAAAAAAT TCAAGGAGAC ATTGAGGCCT 
TATGATGTAA AAGATGTAAT TGAGCAGTAT TCTGCTGGAC ATCTTGACAT GCTTTCCAGG 
ATAAAGTACC TTCAGACAAG AATAGATATG ATTTTCACCC CTGGACCTCC ATCCACTCCA 
AAACATAAGA AGTCTCAGAA AGGGTCAGCA TTTACCTACC CATCCCAGCA GTCTCCAAGG 
AATGAACCAT ATGTAGCCAG GGCAGCCACA TCAGAAACTG AAGACCAAAG CATGATGGGG 
AAGTTTGTAA AAGTTGAAAG ACAGGTTCAC GACATGGGGA AGAAACTGGA CTTCCTCGTG 
GACATGCACA TGCAGCATAT GGAGCGTCTG CAGGTGCACG TCACCGAGTA CTACCCAACA 
AAGGGGGCCT CCTCCCCAGC AGAAGGGGAG AAGAAAGAGG ACAACAGGTA TTCTGACTTG 
AAAACCATCA TCTGTAACTA CTCAGAATCA GGCCCCCCCG ACCCACCCTA CAGCTTCCAC 
CAGGTGCCCA TCGACAGAGT TGGCCCCTAT GGGTTTTTTG CACATGACCC CGTGAAACTG 
ACCAGAGGGG GACCCAGTTC TACAAAGGCT CAGGCCAACC TTCCCTCCTC GGGAAGTACA 
TATGCAGAGA GGCCCACAGT CCTGCCCATC TTGACTCTTC TGGACTCATG TGTGAGCTAC 
CACTCCCAGA CAGAACTGCA AGGCCCCTAT TCGGACCACA TCTCACCCCG CCAGAGACGC 
AGCATCACTA GGGACAGTGA CACACCACTG TCCCTCATGT CCGTCAACCA CGAGGAACTG 
GAACGGTCTC CAAGTGGCTT CAGCATCTCC CAAGACAGAG ATGATTATGT ATTTGGCCCC 
AGTGGGGGTT CGAGCTGGAT GAGGGAAAAG CGGTACCTGG CTGAAGGAGA AACAGACACA 
GATACAGACC CCTTCACGCC CAGTGGATCC ATGCCTATGT CATCTACTGG AGATGGTATT 
TCAGATTCCA TATGGACCCC TTCCAACAAG CCCACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113785.3
CDS	310..3048
Translation	MALEFPGLQPPPPPRPVPQALLLPGAAAEKAKRPVGARQMGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKVGLAPGDVEQVTLALGTGADKDGTLLLEGGGREEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPNRLDLVATWRFYESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMTEDRGYGNDFLIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPRNEPYVARAATSETEDQSMMGKFVKVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGEKKEDNRYSDLKTIICNYSESGPPDPPYSFHQVPIDRVGPYGFFAHDPVKLTRGGPSSTKAQANLPSSGSTYAERPTVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPSGGSSWMREKRYLAEGETDTDTDPFTPSGSMPMSSTGDGISDSIWTPSNKPT

Target ORF information:

RefSeq Version	NM_031597.4
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily Q member 3 (Kcnq3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031597.4

ORF Insert Sequence:

ATGGCATTGG AGTTCCCGGG CTTGCAGCCG CCGCCGCCGC CTCGTCCCGT ACCCCAAGCG 
CTCCTTCTTC CCGGAGCAGC AGCGGAGAAG GCGAAGCGCC CGGTGGGGGC GAGGCAGATG 
GGGCTCAAGG CTCGCAGGGC GGCGGGGGCG GCCGGCGGGG GCGGCGGCGA AGGGGGCGGA 
GGAGGCGGCG GGGCGGCTAA CCCGGCTGGA GGGGACTCGG CAGTGGCCGG CGACGAGGAG 
CGGAAAGTGG GGCTGGCGCC AGGAGACGTG GAGCAAGTCA CCTTGGCGCT AGGGACCGGA 
GCCGACAAAG ACGGGACCCT GCTGCTGGAG GGCGGTGGCC GCGAAGAGGG GCAGAGGAGG 
ACCCCGCAGG GCATCGGGCT CCTGGCAAAG ACCCCCCTGA GCCGTCCAGT TAAGAGGAAC 
AACGCCAAGT ACAGGCGCAT CCAAACTTTG ATCTATGACG CCCTGGAGAG ACCGAGGGGC 
TGGGCGCTGC TCTACCACGC GCTTGTGTTC CTGATTGTCC TGGGATGCTT GATTCTGGCC 
GTGCTCACCA CTTTCAAGGA GTATGAGACT GTGTCTGGAG ACTGGCTTTT GCTGCTGGAA 
ACATTTGCTA TTTTCATCTT TGGAGCTGAG TTTGCTTTGA GGATCTGGGC TGCAGGATGT 
TGCTGTCGAT ACAAAGGCTG GCGTGGACGG CTGAAGTTTG CCAGGAAGCC CCTGTGCATG 
TTGGATATCT TCGTGCTGAT TGCTTCTGTG CCAGTGGTTG CCGTGGGAAA CCAGGGCAAT 
GTCCTGGCTA CCTCTCTGCG AAGCCTCCGC TTCCTGCAGA TCCTGCGCAT GCTTCGAATG 
GATAGGAGGG GTGGCACCTG GAAGCTCCTG GGCTCAGCTA TCTGTGCCCA CAGCAAAGAA 
CTCATCACCG CCTGGTACAT CGGCTTCCTG ACACTCATCC TTTCTTCATT TCTTGTCTAC 
CTGGTGGAGA AGGATGTGCC AGAGATGGAT GCCCAAGGAG AGGAAATGAA AGAGGAGTTT 
GAGACCTATG CTGATGCCCT GTGGTGGGGC CTGATCACAC TGGCCACCAT TGGTTATGGA 
GACAAGACAC CTAAAACCTG GGAAGGACGT CTGATTGCTG CCACCTTTTC TTTAATCGGC 
GTCTCCTTTT TTGCTCTTCC GGCAGGCATC CTTGGCTCAG GACTGGCATT GAAGGTTCAG 
GAACAGCACC GTCAGAAGCA CTTTGAGAAG AGAAGGAAGC CAGCTGCTGA ACTCATCCAG 
GCTGCCTGGA GATATTATGC TACCAACCCC AACAGGCTTG ACCTGGTGGC AACCTGGAGA 
TTTTATGAAT CAGTTGTCTC TTTCCCATTC TTCAGGAAAG AACAACTGGA AGCAGCAGCC 
AGCCAAAAGC TGGGTCTCTT GGATCGGGTT CGCCTTTCTA ATCCTCGTGG TAGCAATACT 
AAAGGAAAGC TATTTACCCC TCTGAATGTA GATGCCATAG AAGAAAGCCC TTCCAAAGAG 
CCAAAGCCCG TTGGCTTAAA CAATAAAGAG CGTTTCCGCA CCGCCTTCCG CATGAAAGCC 
TACGCTTTCT GGCAGAGTTC TGAAGATGCC GGGACAGGAG ACCCCATGAC AGAAGACAGG 
GGCTATGGAA ATGACTTCCT CATTGAAGAC ATGATCCCCA CCCTAAAGGC TGCCATCCGA 
GCTGTCAGAA TTCTACAATT CCGTCTGTAT AAAAAAAAAT TCAAGGAGAC ATTGAGGCCT 
TATGATGTAA AAGATGTAAT TGAGCAGTAT TCTGCTGGAC ATCTTGACAT GCTTTCCAGG 
ATAAAGTACC TTCAGACAAG AATAGATATG ATTTTCACCC CTGGACCTCC ATCCACTCCA 
AAACATAAGA AGTCTCAGAA AGGGTCAGCA TTTACCTACC CATCCCAGCA GTCTCCAAGG 
AATGAACCAT ATGTAGCCAG GGCAGCCACA TCAGAAACTG AAGACCAAAG CATGATGGGG 
AAGTTTGTAA AAGTTGAAAG ACAGGTTCAC GACATGGGGA AGAAACTGGA CTTCCTCGTG 
GACATGCACA TGCAGCATAT GGAGCGTCTG CAGGTGCACG TCACCGAGTA CTACCCAACA 
AAGGGGGCCT CCTCCCCAGC AGAAGGGGAG AAGAAAGAGG ACAACAGGTA TTCTGACTTG 
AAAACCATCA TCTGTAACTA CTCAGAATCA GGCCCCCCCG ACCCACCCTA CAGCTTCCAC 
CAGGTGCCCA TCGACAGAGT TGGCCCCTAT GGGTTTTTTG CACATGACCC CGTGAAACTG 
ACCAGAGGGG GACCCAGTTC TACAAAGGCT CAGGCCAACC TTCCCTCCTC GGGAAGTACA 
TATGCAGAGA GGCCCACAGT CCTGCCCATC TTGACTCTTC TGGACTCATG TGTGAGCTAC 
CACTCCCAGA CAGAACTGCA AGGCCCCTAT TCGGACCACA TCTCACCCCG CCAGAGACGC 
AGCATCACTA GGGACAGTGA CACACCACTG TCCCTCATGT CCGTCAACCA CGAGGAACTG 
GAACGGTCTC CAAGTGGCTT CAGCATCTCC CAAGACAGAG ATGATTATGT ATTTGGCCCC 
AGTGGGGGTT CGAGCTGGAT GAGGGAAAAG CGGTACCTGG CTGAAGGAGA AACAGACACA 
GATACAGACC CCTTCACGCC CAGTGGATCC ATGCCTATGT CATCTACTGG AGATGGTATT 
TCAGATTCCA TATGGACCCC TTCCAACAAG CCCACTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Suppression of KV7/KCNQ potassium channel enhances neuronal differentiation of PC12 cells.
Neuroscience333356-67(2016 10)
Zhou N,Huang S,Li L,Huang D,Yan Y,Du X,Zhang H

Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.
Biochemistry55(38)5353-65(2016 09)
Strulovich R,Tobelaim WS,Attali B,Hirsch JA

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
The Journal of biological chemistry291(36)19132-45(2016 09)
Anta B,Martín-Rodríguez C,Gomis-Perez C,Calvo L,López-Benito S,Calderón-García AA,Vicente-García C,Villarroel Á,Arévalo JC

Activity-dependent downregulation of M-Type (Kv7) K⁺ channels surface expression requires the activation of iGluRs/Ca²⁺/PKC signaling pathway in hippocampal neuron.
Neuropharmacology95154-67(2015 Aug)
Li C,Lu Q,Huang P,Fu T,Li C,Guo L,Xu X

Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(10)3719-32(2014 Mar)
Battefeld A,Tran BT,Gavrilis J,Cooper EC,Kole MH

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Kcnq3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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