Psma3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psma3
Entrez Gene ID	29670
Full Name	proteasome subunit alpha 3
Synonyms	Psma3l
General protein information	Preferred Names proteasome subunit alpha 3 Names proteasome subunit alpha type-3 macropain subunit C8 multicatalytic endopeptidase complex subunit C8 multicatalytic proteinase subunit K proteasome (prosome, macropain) subunit, alpha type 3 proteasome component C8 proteasome subunit C8 proteasome subunit K
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q24
Summary	component of the proteasome multicatalytic proteinase complex [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017594059.1	XP_017449548.1	proteasome subunit alpha type-3 isoform X1
NM_017280.2	NP_058976.1	proteasome subunit alpha type-3

Pathways from BioSystems

Homologies

Neurospora crassa	NCU02493	XP_965087.1
Macaca mulatta (Rhesus monkey)	PSMA3	XP_001091541.1
Arabidopsis thaliana (thale cress)	PAG1	NP_180270.1
Kluyveromyces lactis	KLLA0A03487g	XP_451153.2
Pan troglodytes (chimpanzee)	PSMA3	XP_001164848.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001973	XP_003435981.1
Schizosaccharomyces pombe (fission yeast)	pre10	NP_588040.1
Bos taurus (cattle)	PSMA3	NP_001029407.1
Drosophila melanogaster (fruit fly)	Prosalpha7	NP_724834.1
Caenorhabditis elegans (roundworm)	pas-7	NP_496177.2
Magnaporthe oryzae (rice blast fungus)	MGG_07727	XP_003712933.1
Canis lupus familiaris (dog)	PSMA3	XP_537460.2
Mus musculus (house mouse)	Psma3	NP_035314.3
Rattus norvegicus (Norway rat)	Psma3	NP_058976.1
Gallus gallus (chicken)	PSMA3	NP_001006491.1
Saccharomyces cerevisiae (baker's yeast)	PRE10	NP_015007.1
Oryza sativa (rice)	Os01g0811100	NP_001044588.1
Homo sapiens (human)	PSMA3	NP_002779.1
Danio rerio (zebrafish)	psma3	NP_001025358.1
Xenopus tropicalis (tropical clawed frog)	psma3	NP_001011257.1
Eremothecium gossypii	AGOS_ADR401C	NP_984496.1

Gene Ontology
Bibliography

Related articles in PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
Brehm A, Liu Y, Sheikh A, Marrero B, Omoyinmi E, Zhou Q, Montealegre G, Biancotto A, Reinhardt A, Almeida de Jesus A, Pelletier M, Tsai WL, Remmers EF, Kardava L, Hill S, Kim H, Lachmann HJ, Megarbane A, Chae JJ, Brady J, Castillo RD, Brown D, Casano AV, Gao L, Chapelle D, Huang Y, Stone D, Chen Y, Sotzny F, Lee CC, Kastner DL, Torrelo A, Zlotogorski A, Moir S, Gadina M, McCoy P, Wesley R, Rother KI, Rother K, Hildebrand PW, Brogan P, Krüger E, Aksentijevich I, Goldbach-Mansky R
The Journal of clinical investigation125(11)4196-211(2015 Nov)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Sasaki K, Hamazaki J, Koike M, Hirano Y, Komatsu M, Uchiyama Y, Tanaka K, Murata S
Molecular and cellular biology30(15)3864-74(2010 Aug)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Parfitt DA, Michael GJ, Vermeulen EG, Prodromou NV, Webb TR, Gallo JM, Cheetham ME, Nicoll WS, Blatch GL, Chapple JP
Human molecular genetics18(9)1556-65(2009 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Psma3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psma3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03524	NM_017280.2 Latest version!	Rattus norvegicus proteasome 20S subunit alpha 3 (Psma3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
ORa61568	XM_017594059.1 Latest version!	Rattus norvegicus proteasome subunit alpha 3 (Psma3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psma3 ( NM_017280.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058976.1 Rattus norvegicus proteasome 20S subunit alpha 3 (Psma3), mRNA.

Price & Availability↑

CloneID	ORa03524
Clone ID Related Accession (Same CDS sequence)	NM_017280.2
Accession Version	NM_017280.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577116800000
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit alpha type-3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC081817.1. On Sep 19, 2004 this sequence version replaced NM_017280.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC081817.1, FQ224319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTCCA TTGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGATGGAAGA 
GTTTTCCAAG TTGAATATGC TATGAAGGCT GTGGAAAACA GTAGTACAGC TATTGGGATC 
AGATGTAAAG ATGGTGTTGT GTTTGGGGTA GAAAAACTAG TCCTTTCTAA ACTTTATGAA 
GAAGGCTCCA ATAAACGTCT TTTCAATGTT GATCGACATG TTGGAATGGC AGTGGCAGGT 
TTGTTGGCAG ATGCTCGTTC CTTGGCAGAC ATAGCAAGAG AAGAAGCGTC CAACTTTAGG 
TCTAACTTTG GCTATAACAT TCCTCTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTA 
CACGCGTATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTGGGGTCT 
TACAGTGTGA ATGATGGTGC ACAGCTCTAT ATGATCGATC CATCAGGTGT TTCATATGGT 
TACTGGGGCT GTGCCATTGG CAAAGCCAGG CAAGCTGCAA AGACAGAAAT AGAAAAGCTT 
CAGATGAAGG AAATGACCTG CCGTGATGTA GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGATG AAGTTAAGGA TAAAGCTTTT GAACTAGAGC TCAGCTGGGT TGGTGAATTA 
ACTAAAGGAA GACATGAAAT TGTTCCCAAA GACGTAAGAG AGGAAGCAGA GAAATATGCC 
AAGGAATCTT TGAAGGAAGA AGATGAATCA GATGACGACA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058976.1
CDS	3..770
Translation	MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM

Target ORF information:

RefSeq Version	NM_017280.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome 20S subunit alpha 3 (Psma3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017280.2

ORF Insert Sequence:

ATGAGCTCCA TTGGCACTGG GTATGACCTG TCAGCCTCTA CATTCTCTCC TGATGGAAGA 
GTTTTCCAAG TTGAATATGC TATGAAGGCT GTGGAAAACA GTAGTACAGC TATTGGGATC 
AGATGTAAAG ATGGTGTTGT GTTTGGGGTA GAAAAACTAG TCCTTTCTAA ACTTTATGAA 
GAAGGCTCCA ATAAACGTCT TTTCAATGTT GATCGACATG TTGGAATGGC AGTGGCAGGT 
TTGTTGGCAG ATGCTCGTTC CTTGGCAGAC ATAGCAAGAG AAGAAGCGTC CAACTTTAGG 
TCTAACTTTG GCTATAACAT TCCTCTAAAA CATCTTGCAG ACAGAGTGGC CATGTATGTA 
CACGCGTATA CACTCTACAG TGCTGTTAGA CCTTTTGGCT GCAGTTTCAT GTTGGGGTCT 
TACAGTGTGA ATGATGGTGC ACAGCTCTAT ATGATCGATC CATCAGGTGT TTCATATGGT 
TACTGGGGCT GTGCCATTGG CAAAGCCAGG CAAGCTGCAA AGACAGAAAT AGAAAAGCTT 
CAGATGAAGG AAATGACCTG CCGTGATGTA GTTAAAGAAG TTGCAAAAAT AATTTACATA 
GTACATGATG AAGTTAAGGA TAAAGCTTTT GAACTAGAGC TCAGCTGGGT TGGTGAATTA 
ACTAAAGGAA GACATGAAAT TGTTCCCAAA GACGTAAGAG AGGAAGCAGA GAAATATGCC 
AAGGAATCTT TGAAGGAAGA AGATGAATCA GATGACGACA ATATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Psma3 ( XM_017594059.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017449548.1 Rattus norvegicus proteasome subunit alpha 3 (Psma3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa61568
Clone ID Related Accession (Same CDS sequence)	XM_017594059.1
Accession Version	XM_017594059.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 543bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	proteasome subunit alpha type-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGTGG CAGGTTTGTT GGCAGATGCT CGTTCCTTGG CAGACATAGC AAGAGAAGAA 
GCGTCCAACT TTAGGTCTAA CTTTGGCTAT AACATTCCTC TAAAACATCT TGCAGACAGA 
GTGGCCATGT ATGTACACGC GTATACACTC TACAGTGCTG TTAGACCTTT TGGCTGCAGT 
TTCATGTTGG GGTCTTACAG TGTGAATGAT GGTGCACAGC TCTATATGAT CGATCCATCA 
GGTGTTTCAT ATGGTTACTG GGGCTGTGCC ATTGGCAAAG CCAGGCAAGC TGCAAAGACA 
GAAATAGAAA AGCTTCAGAT GAAGGAAATG ACCTGCCGTG ATGTAGTTAA AGAAGTTGCA 
AAAATAATTT ACATAGTACA TGATGAAGTT AAGGATAAAG CTTTTGAACT AGAGCTCAGC 
TGGGTTGGTG AATTAACTAA AGGAAGACAT GAAATTGTTC CCAAAGACGT AAGAGAGGAA 
GCAGAGAAAT ATGCCAAGGA ATCTTTGAAG GAAGAAGATG AATCAGATGA CGACAATATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017449548.1
CDS	201..743
Translation	MAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM

Target ORF information:

RefSeq Version	XM_017594059.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus proteasome subunit alpha 3 (Psma3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017594059.1

ORF Insert Sequence:

ATGGCAGTGG CAGGTTTGTT GGCAGATGCT CGTTCCTTGG CAGACATAGC AAGAGAAGAA 
GCGTCCAACT TTAGGTCTAA CTTTGGCTAT AACATTCCTC TAAAACATCT TGCAGACAGA 
GTGGCCATGT ATGTACACGC GTATACACTC TACAGTGCTG TTAGACCTTT TGGCTGCAGT 
TTCATGTTGG GGTCTTACAG TGTGAATGAT GGTGCACAGC TCTATATGAT CGATCCATCA 
GGTGTTTCAT ATGGTTACTG GGGCTGTGCC ATTGGCAAAG CCAGGCAAGC TGCAAAGACA 
GAAATAGAAA AGCTTCAGAT GAAGGAAATG ACCTGCCGTG ATGTAGTTAA AGAAGTTGCA 
AAAATAATTT ACATAGTACA TGATGAAGTT AAGGATAAAG CTTTTGAACT AGAGCTCAGC 
TGGGTTGGTG AATTAACTAA AGGAAGACAT GAAATTGTTC CCAAAGACGT AAGAGAGGAA 
GCAGAGAAAT ATGCCAAGGA ATCTTTGAAG GAAGAAGATG AATCAGATGA CGACAATATG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
The Journal of clinical investigation125(11)4196-211(2015 Nov)
Brehm A,Liu Y,Sheikh A,Marrero B,Omoyinmi E,Zhou Q,Montealegre G,Biancotto A,Reinhardt A,Almeida de Jesus A,Pelletier M,Tsai WL,Remmers EF,Kardava L,Hill S,Kim H,Lachmann HJ,Megarbane A,Chae JJ,Brady J,Castillo RD,Brown D,Casano AV,Gao L,Chapelle D,Huang Y,Stone D,Chen Y,Sotzny F,Lee CC,Kastner DL,Torrelo A,Zlotogorski A,Moir S,Gadina M,McCoy P,Wesley R,Rother KI,Rother K,Hildebrand PW,Brogan P,Krüger E,Aksentijevich I,Goldbach-Mansky R

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballescà JL,Oliva R

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis.
Molecular and cellular biology30(15)3864-74(2010 Aug)
Sasaki K,Hamazaki J,Koike M,Hirano Y,Komatsu M,Uchiyama Y,Tanaka K,Murata S

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1.
Human molecular genetics18(9)1556-65(2009 May)
Parfitt DA,Michael GJ,Vermeulen EG,Prodromou NV,Webb TR,Gallo JM,Cheetham ME,Nicoll WS,Blatch GL,Chapple JP

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Psma3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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