| Gene Symbol | Unc119 |
| Entrez Gene ID | 29402 |
| Full Name | unc-119 lipid binding chaperone |
| Synonyms | RRG4,Uncl19 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | a retinal specific gene [RGD, Feb 2006]. |
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Unc119 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Unc119 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Unc119 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa03175 Clone ID Related Accession (Same CDS sequence) NM_017188.1 Accession Version NM_017188.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 723bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1569168000000 Organism Rattus norvegicus(Norway rat) Product protein unc-119 homolog A Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U40999.1. ##Evidence-Data-START## Transcript exon combination :: U40999.1, BC062057.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601
661
721ATGAAGGTGA AGAAGGGCGG CGGCGGGACC GGACCGGGGG CGGAGCCCGT TCCTGGGGCC
TCGAACCGGA GCGTGGAGCC CACGCGGGAG CCTGGGGCGG AAGCCGAGTC CGGGTCCGAG
TCGGAGCCGG AGCCAGGCCC GGGGCCCAGA CTGGGGCCGC TGCAGGGCAA GCAGCCCATC
GGGCCGGAGG ACGTGCTGGG GCTGCAGCGG ATCACCGGCG ACTACCTGTG CTCCCCTGAG
GAAAATATCT ACAAGATTGA CTTCGTCAGG TTCAAGATCC GGGACATGGA CTCAGGGACT
GTTCTTTTTG AAATCAAGAA GCCCCCTGTT TCCGAACGGT TGCCCATCAA CCGGCGGGAC
CTGGACCCCA ATGCAGGGCG CTTTGTTCGA TACCAGTTCA CACCTGCCTT CCTCCGCCTA
AGGCAGGTGG GAGCCACGGT GGAGTTCACA GTGGGAGACA AGCCGGTCAA CAACTTCCGC
ATGATTGAGA GGCACTACTT TCGAAACCAG CTCCTCAAAA GCTTCGACTT CCACTTTGGC
TTCTGCATTC CCAGCAGCAA GAACACCTGT GAGCACATCT ATGACTTCCC GCCTCTCTCC
GAGGAGCTAA TCAGTGAGAT GATTCGTCAT CCGTATGAGA CACAGTCTGA CAGCTTCTAC
TTCGTGGATG ATCGGCTGGT GATGCACAAC AAGGCAGACT ATTCCTACAG CGGGACCCCC
TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_058884.1 CDS 35..757 Translation 
Target ORF information:
RefSeq Version NM_017188.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus unc-119 lipid binding chaperone (Unc119), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_017188.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601
661
721ATGAAGGTGA AGAAGGGCGG CGGCGGGACC GGACCGGGGG CGGAGCCCGT TCCTGGGGCC
TCGAACCGGA GCGTGGAGCC CACGCGGGAG CCTGGGGCGG AAGCCGAGTC CGGGTCCGAG
TCGGAGCCGG AGCCAGGCCC GGGGCCCAGA CTGGGGCCGC TGCAGGGCAA GCAGCCCATC
GGGCCGGAGG ACGTGCTGGG GCTGCAGCGG ATCACCGGCG ACTACCTGTG CTCCCCTGAG
GAAAATATCT ACAAGATTGA CTTCGTCAGG TTCAAGATCC GGGACATGGA CTCAGGGACT
GTTCTTTTTG AAATCAAGAA GCCCCCTGTT TCCGAACGGT TGCCCATCAA CCGGCGGGAC
CTGGACCCCA ATGCAGGGCG CTTTGTTCGA TACCAGTTCA CACCTGCCTT CCTCCGCCTA
AGGCAGGTGG GAGCCACGGT GGAGTTCACA GTGGGAGACA AGCCGGTCAA CAACTTCCGC
ATGATTGAGA GGCACTACTT TCGAAACCAG CTCCTCAAAA GCTTCGACTT CCACTTTGGC
TTCTGCATTC CCAGCAGCAA GAACACCTGT GAGCACATCT ATGACTTCCC GCCTCTCTCC
GAGGAGCTAA TCAGTGAGAT GATTCGTCAT CCGTATGAGA CACAGTCTGA CAGCTTCTAC
TTCGTGGATG ATCGGCTGGT GATGCACAAC AAGGCAGACT ATTCCTACAG CGGGACCCCC
TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa57275 Clone ID Related Accession (Same CDS sequence) XM_017597170.1 Accession Version XM_017597170.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 573bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product protein unc-119 homolog A isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301
361
421
481
541ATGCTGGAAG CTTCCACTAG GCAGGAGGTC CAGTTGTCCG AAGGATGCAT GCCAACCTTG
CAAAGCCGAG ACTACCTGTG CTCCCCTGAG GAAAATATCT ACAAGATTGA CTTCGTCAGG
TTCAAGATCC GGGACATGGA CTCAGGGACT GTTCTTTTTG AAATCAAGAA GCCCCCTGTT
TCCGAACGGT TGCCCATCAA CCGGCGGGAC CTGGACCCCA ATGCAGGGCG CTTTGTTCGA
TACCAGTTCA CACCTGCCTT CCTCCGCCTA AGGCAGGTGG GAGCCACGGT GGAGTTCACA
GTGGGAGACA AGCCGGTCAA CAACTTCCGC ATGATTGAGA GGCACTACTT TCGAAACCAG
CTCCTCAAAA GCTTCGACTT CCACTTTGGC TTCTGCATTC CCAGCAGCAA GAACACCTGT
GAGCACATCT ATGACTTCCC GCCTCTCTCC GAGGAGCTAA TCAGTGAGAT GATTCGTCAT
CCGTATGAGA CACAGTCTGA CAGCTTCTAC TTCGTGGATG ATCGGCTGGT GATGCACAAC
AAGGCAGACT ATTCCTACAG CGGGACCCCC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_017452659.1 CDS 1622..2194 Translation
Target ORF information:
RefSeq Version XM_017597170.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus unc-119 lipid binding chaperone (Unc119), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017597170.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541ATGCTGGAAG CTTCCACTAG GCAGGAGGTC CAGTTGTCCG AAGGATGCAT GCCAACCTTG
CAAAGCCGAG ACTACCTGTG CTCCCCTGAG GAAAATATCT ACAAGATTGA CTTCGTCAGG
TTCAAGATCC GGGACATGGA CTCAGGGACT GTTCTTTTTG AAATCAAGAA GCCCCCTGTT
TCCGAACGGT TGCCCATCAA CCGGCGGGAC CTGGACCCCA ATGCAGGGCG CTTTGTTCGA
TACCAGTTCA CACCTGCCTT CCTCCGCCTA AGGCAGGTGG GAGCCACGGT GGAGTTCACA
GTGGGAGACA AGCCGGTCAA CAACTTCCGC ATGATTGAGA GGCACTACTT TCGAAACCAG
CTCCTCAAAA GCTTCGACTT CCACTTTGGC TTCTGCATTC CCAGCAGCAA GAACACCTGT
GAGCACATCT ATGACTTCCC GCCTCTCTCC GAGGAGCTAA TCAGTGAGAT GATTCGTCAT
CCGTATGAGA CACAGTCTGA CAGCTTCTAC TTCGTGGATG ATCGGCTGGT GATGCACAAC
AAGGCAGACT ATTCCTACAG CGGGACCCCC TGAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis.
Cell cycle (Georgetown, Tex.)12(8)1303-15(2013 Apr)
Lee Y,Chung S,Baek IK,Lee TH,Paik SY,Lee J
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Genes & development25(22)2347-60(2011 Nov)
Wright KJ,Baye LM,Olivier-Mason A,Mukhopadhyay S,Sang L,Kwong M,Wang W,Pretorius PR,Sheffield VC,Sengupta P,Slusarski DC,Jackson PK
UNC119 is required for G protein trafficking in sensory neurons.
Nature neuroscience14(7)874-80(2011 Jun)
Zhang H,Constantine R,Vorobiev S,Chen Y,Seetharaman J,Huang YJ,Xiao R,Montelione GT,Gerstner CD,Davis MW,Inana G,Whitby FG,Jorgensen EM,Hill CP,Tong L,Baehr W
UNC119 inhibits dynamin and dynamin-dependent endocytic processes.
Cellular signalling22(1)128-37(2010 Jan)
Karim Z,Vepachedu R,Gorska M,Alam R
Unc119, a novel activator of Lck/Fyn, is essential for T cell activation.
The Journal of experimental medicine199(3)369-79(2004 Feb)
Gorska MM,Stafford SJ,Cen O,Sur S,Alam R
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