Tubb2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tubb2b
Entrez Gene ID	291081
Full Name	tubulin, beta 2B class IIb
Synonyms	RGD1309427,Tubb2
General protein information	Preferred Names tubulin, beta 2B class IIb Names tubulin beta-2B chain beta-tubulin T beta15 (aa 1-445) t beta-15 tubulin, beta 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013886.2	NP_001013908.2	tubulin beta-2B chain

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os03g0661300	NP_001050825.1
Bos taurus (cattle)	TUBB2B	NP_001003900.1
Homo sapiens (human)	TUBB2B	NP_821080.1
Pan troglodytes (chimpanzee)	TUBB2B	XP_001162039.1
Macaca mulatta (Rhesus monkey)	TUBB2B	XP_001092923.1
Canis lupus familiaris (dog)	TUBB2B	XP_856151.2
Mus musculus (house mouse)	Tubb2b	NP_076205.1
Gallus gallus (chicken)	LOC768337	XP_001231210.2
Caenorhabditis elegans (roundworm)	mec-7	NP_509313.1
Rattus norvegicus (Norway rat)	Tubb2b	NP_001013908.2
Drosophila melanogaster (fruit fly)	betaTub85D	NP_524290.2
Xenopus tropicalis (tropical clawed frog)	tubb2b	NP_989275.1
Gallus gallus (chicken)	TUBB2B	NP_001004400.1
Arabidopsis thaliana (thale cress)	TUB2	NP_568959.1
Danio rerio (zebrafish)	zgc:123194	NP_001032487.1
Arabidopsis thaliana (thale cress)	TUB3	NP_568960.1
Arabidopsis thaliana (thale cress)	TUB8	NP_001190373.1

Gene Ontology
Bibliography

Related articles in PubMed

A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization.
Stottmann RW, Driver A, Gutierrez A, Skelton MR, Muntifering M, Stepien C, Knudson L, Kofron M, Vorhees CV, Williams MT
Genes, brain, and behavior16(2)250-259(2017 02)

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.
Breuss MW, Nguyen T, Srivatsan A, Leca I, Tian G, Fritz T, Hansen AH, Musaev D, McEvoy-Venneri J, James KN, Rosti RO, Scott E, Tan U, Kolodner RD, Cowan NJ, Keays DA, Gleeson JG
Human molecular genetics26(2)258-269(2017 01)

De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.
Laquerriere A, Gonzales M, Saillour Y, Cavallin M, Joyē N, Quēlin C, Bidat L, Dommergues M, Plessis G, Encha-Razavi F, Chelly J, Bahi-Buisson N, Poirier K
European journal of medical genetics59(4)249-56(2016 Apr)

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).
Sheldon KL, Gurnev PA, Bezrukov SM, Sackett DL
The Journal of biological chemistry290(44)26784-9(2015 Oct)

An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.
Cederquist GY, Luchniak A, Tischfield MA, Peeva M, Song Y, Menezes MP, Chan WM, Andrews C, Chew S, Jamieson RV, Gomes L, Flaherty M, Grant PE, Gupta ML Jr, Engle EC
Human molecular genetics21(26)5484-99(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Tubb2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tubb2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04085	NM_001013886.2 Latest version!	Rattus norvegicus tubulin, beta 2B class IIb (Tubb2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tubb2b ( NM_001013886.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013908.2 Rattus norvegicus tubulin, beta 2B class IIb (Tubb2b), mRNA.

Price & Availability↑

CloneID	ORa04085
Clone ID Related Accession (Same CDS sequence)	NM_001013886.2
Accession Version	NM_001013886.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1338bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	tubulin beta-2B chain
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC105754.1. On Jul 14, 2006 this sequence version replaced NM_001013886.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC105754.1, EV769742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCGAGAGA TCGTGCACAT TCAGGCGGGC CAGTGCGGCA ACCAGATCGG TGCCAAGTTT 
TGGGAGGTCA TCAGTGATGA GCATGGTATC GATCCCACTG GAAGTTACCA TGGAGACAGT 
GATTTGCAAC TGGAAAGAAT CAATGTATAC TACAACGAAG CAACTGGTAA TAAATATGTG 
CCTCGGGCCA TCCTGGTGGA CCTGGAGCCT GGCACCATGG ACTCTGTCAG ATCCGGACCA 
TTTGGGCAGA TCTTCAGGCC AGACAACTTC GTGTTCGGCC AGAGTGGTGC AGGAAATAAC 
TGGGCAAAGG GCCACTACAC AGAGGGTGCC GAGCTGGTGG ACTCTGTCCT GGACGTGGTA 
AGGAAGGAGT CAGAAAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCACTGGGG 
GGAGGCACTG GCTCAGGCAT GGGGACCCTG CTCATCAGCA AGATCAGAGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTCTCTGA CACTGTGGTG 
GAGCCCTATA ATGCCACCCT CTCCGTGCAC CAGCTGGTAG AGAACACAGA TGAAACCTAC 
TGCATCGACA ATGAGGCTCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACACCC 
ACCTATGGCG ATCTCAACCA CCTGGTGTCA GCCACCATGA GTGGAGTGAC CACCTGCCTG 
CGCTTCCCTG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CTGTGAACAT GGTGCCTTTC 
CCACGCCTGC ACTTCTTCAT GCCAGGCTTC GCACCTCTGA CCAGCAGGGG CAGCCAGCAG 
TACCGAGCCC TGACAGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCTGCCTGCG ACCCACGCCA TGGCCGCTAC CTGACCGTAG CCGCCATTTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAATGTGAAG ACGGCCGTGT GTGACATCCC TCCTCGTGGC 
CTCAAGATGT CAGCCACCTT CATTGGCAAC AGCACCGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCGGAGC AGTTCACTGC CATGTTCAGG CGCAAGGCTT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCGGAGAGCA ACATGAATGA CCTGGTGTCT 
GAGTACCAGC AGTACCAGGA TGCCACGGCT GATGAGCAGG GCGAGTTCGA GGAGGAGGAG 
GGCGAGGATG AGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013908.2
CDS	100..1437
Translation	MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

Target ORF information:

RefSeq Version	NM_001013886.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus tubulin, beta 2B class IIb (Tubb2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013886.2

ORF Insert Sequence:

ATGCGAGAGA TCGTGCACAT TCAGGCGGGC CAGTGCGGCA ACCAGATCGG TGCCAAGTTT 
TGGGAGGTCA TCAGTGATGA GCATGGTATC GATCCCACTG GAAGTTACCA TGGAGACAGT 
GATTTGCAAC TGGAAAGAAT CAATGTATAC TACAACGAAG CAACTGGTAA TAAATATGTG 
CCTCGGGCCA TCCTGGTGGA CCTGGAGCCT GGCACCATGG ACTCTGTCAG ATCCGGACCA 
TTTGGGCAGA TCTTCAGGCC AGACAACTTC GTGTTCGGCC AGAGTGGTGC AGGAAATAAC 
TGGGCAAAGG GCCACTACAC AGAGGGTGCC GAGCTGGTGG ACTCTGTCCT GGACGTGGTA 
AGGAAGGAGT CAGAAAGCTG TGACTGTCTC CAGGGCTTCC AGCTGACCCA CTCACTGGGG 
GGAGGCACTG GCTCAGGCAT GGGGACCCTG CTCATCAGCA AGATCAGAGA AGAGTACCCA 
GACCGCATCA TGAACACCTT CAGCGTCATG CCCTCACCCA AGGTCTCTGA CACTGTGGTG 
GAGCCCTATA ATGCCACCCT CTCCGTGCAC CAGCTGGTAG AGAACACAGA TGAAACCTAC 
TGCATCGACA ATGAGGCTCT GTATGACATC TGCTTCCGCA CCCTGAAGCT GACCACACCC 
ACCTATGGCG ATCTCAACCA CCTGGTGTCA GCCACCATGA GTGGAGTGAC CACCTGCCTG 
CGCTTCCCTG GCCAGCTGAA CGCAGACCTG CGCAAGCTGG CTGTGAACAT GGTGCCTTTC 
CCACGCCTGC ACTTCTTCAT GCCAGGCTTC GCACCTCTGA CCAGCAGGGG CAGCCAGCAG 
TACCGAGCCC TGACAGTGCC CGAGCTCACC CAGCAGATGT TCGACTCCAA GAACATGATG 
GCTGCCTGCG ACCCACGCCA TGGCCGCTAC CTGACCGTAG CCGCCATTTT CCGGGGCCGC 
ATGTCCATGA AGGAGGTGGA TGAGCAGATG CTCAACGTGC AGAACAAGAA CAGCAGCTAC 
TTCGTGGAGT GGATCCCCAA CAATGTGAAG ACGGCCGTGT GTGACATCCC TCCTCGTGGC 
CTCAAGATGT CAGCCACCTT CATTGGCAAC AGCACCGCCA TCCAGGAGCT GTTCAAGCGC 
ATCTCGGAGC AGTTCACTGC CATGTTCAGG CGCAAGGCTT TCCTGCACTG GTACACGGGC 
GAGGGCATGG ACGAGATGGA GTTCACCGAG GCGGAGAGCA ACATGAATGA CCTGGTGTCT 
GAGTACCAGC AGTACCAGGA TGCCACGGCT GATGAGCAGG GCGAGTTCGA GGAGGAGGAG 
GGCGAGGATG AGGCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization.
Genes, brain, and behavior16(2)250-259(2017 02)
Stottmann RW,Driver A,Gutierrez A,Skelton MR,Muntifering M,Stepien C,Knudson L,Kofron M,Vorhees CV,Williams MT

Uner Tan syndrome caused by a homozygous TUBB2B mutation affecting microtubule stability.
Human molecular genetics26(2)258-269(2017 01)
Breuss MW,Nguyen T,Srivatsan A,Leca I,Tian G,Fritz T,Hansen AH,Musaev D,McEvoy-Venneri J,James KN,Rosti RO,Scott E,Tan U,Kolodner RD,Cowan NJ,Keays DA,Gleeson JG

De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy.
European journal of medical genetics59(4)249-56(2016 Apr)
Laquerriere A,Gonzales M,Saillour Y,Cavallin M,Joyē N,Quēlin C,Bidat L,Dommergues M,Plessis G,Encha-Razavi F,Chelly J,Bahi-Buisson N,Poirier K

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).
The Journal of biological chemistry290(44)26784-9(2015 Oct)
Sheldon KL,Gurnev PA,Bezrukov SM,Sackett DL

An inherited TUBB2B mutation alters a kinesin-binding site and causes polymicrogyria, CFEOM and axon dysinnervation.
Human molecular genetics21(26)5484-99(2012 Dec)
Cederquist GY,Luchniak A,Tischfield MA,Peeva M,Song Y,Menezes MP,Chan WM,Andrews C,Chew S,Jamieson RV,Gomes L,Flaherty M,Grant PE,Gupta ML Jr,Engle EC

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Tubb2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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