Mtrr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mtrr
Entrez Gene ID	290947
Full Name	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Synonyms	MSR
General protein information	Preferred Names 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Names methionine synthase reductase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1p11

mRNA and Protein(s)

mRNA	Protein	Name
XM_006227814.2	XP_006227876.1	methionine synthase reductase isoform X2
XM_006227813.3	XP_006227875.1	methionine synthase reductase isoform X1
NM_001039003.1	NP_001034092.1	methionine synthase reductase

Pathways from BioSystems

Homologies

Homo sapiens (human)	MTRR	NP_076915.2
Canis lupus familiaris (dog)	MTRR	XP_005639737.1
Mus musculus (house mouse)	Mtrr	NP_766068.1
Caenorhabditis elegans (roundworm)	mtrr-1	NP_495978.1
Xenopus tropicalis (tropical clawed frog)	mtrr	XP_002942769.2
Bos taurus (cattle)	MTRR	NP_001025470.1
Gallus gallus (chicken)	MTRR	XP_004935186.1
Macaca mulatta (Rhesus monkey)	MTRR	XP_002804366.1
Pan troglodytes (chimpanzee)	MTRR	XP_001145250.1
Rattus norvegicus (Norway rat)	Mtrr	NP_001034092.1
Danio rerio (zebrafish)	mtrr	XP_689157.2

Gene Ontology
Bibliography

Related articles in PubMed

Functional variant in methionine synthase reductase intron-1 is associated with pleiotropic congenital malformations.
Cheng H, Li H, Bu Z, Zhang Q, Bai B, Zhao H, Li RK, Zhang T, Xie J
Molecular and cellular biochemistry407(1-2)51-6(2015 Sep)

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase.
Gherasim C, Yadav PK, Kabil O, Niu WN, Banerjee R
PloS one9(1)e85544(2014)

Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.
Padmanabhan N, Jia D, Geary-Joo C, Wu X, Ferguson-Smith AC, Fung E, Bieda MC, Snyder FF, Gravel RA, Cross JC, Watson ED
Cell155(1)81-93(2013 Sep)

Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.
Lautner-Csorba O, Gézsi A, Erdélyi DJ, Hullám G, Antal P, Semsei ÁF, Kutszegi N, Kovács G, Falus A, Szalai C
PloS one8(8)e69843(2013)

Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population.
Zhao JY, Yang XY, Gong XH, Gu ZY, Duan WY, Wang J, Ye ZZ, Shen HB, Shi KH, Hou J, Huang GY, Jin L, Qiao B, Wang HY
Circulation125(3)482-90(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mtrr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mtrr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08350	NM_001039003.1 Latest version!	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
ORa22104	XM_006227813.3 Latest version!	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa22105	XM_006227814.2 Latest version!	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mtrr ( NM_001039003.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001034092.1 Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), mRNA.

Price & Availability↑

CloneID	ORa08350
Clone ID Related Accession (Same CDS sequence)	NM_001039003.1
Accession Version	NM_001039003.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1521bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1563724800000
Organism	Rattus norvegicus(Norway rat)
Product	methionine synthase reductase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100107.1. On Jan 12, 2006 this sequence version replaced XM_225078.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689603, SAMN02642599 [ECO:0000348] ##Evidence-Data-END##

ATGAGAAGGT TTTTGTTACT GTATGCTACA CAGCGAGGGC AGGCAAAGGC CATAGCTGAA 
GAAATAAGTG AGCAGGCTCT GTCACACGGG TTTTCCGCAG ATCTTCACTG CGTCAGTGAG 
TCAGAAAAGA GCTCTCTAAG TATTCCTGCT GTGTCCCCAG AATATTTGGA GGTCTATCTT 
CAGGAGTCTC TTGGCCAGGA TGAAAACCAA GCATCTGTGC CACCATCAGT CGATCCAATT 
TTTCAAGTTC CAATTTCAAA AGCTGTTGAG CTGACTACAA ACGATGCCAT AAAGACCACT 
CTGCTGTTGG AATTGGACAT CTCAAAAGTA GAGTTTTCCC ATCAACCTGG AGATTCCTTC 
AATGTGATCT GTCCAAACAG TGGTTCTGAA GTAGAAGACT TGCTGCAAAG GCTGCAGCTG 
GCTGACAAAC AAGCACACCG GGTCATCCTG AAAATTAAGA TGGACACCAA GAAGAAAGGA 
GCTTCTCTGC CCCAGCATGT GCCTGAGGGG AGTTCTCTCC AGTTCATCTT CACCTGGTGT 
CTTGAAATAC GAGCAGTTCC TAAAAAGGCT TTTTTGAGGG CCCTTTCGGA TTACACCAGC 
GATGCCACTG AAAAGCGGAG GCTTCAGGAG CTCTGCAGTA AGCAGGGAGC AGCTGATTAC 
AACCGCTTCA TCCGAGATGC CAGTGTCTGC CTGCTAGACC TCCTGCTTAC CTTCCCATCC 
TGCCAGCCTC CGCTCAACCT CCTGCTGGAG CACCTTCCTA AACTCCAGCC TCGACCATAC 
TCGTGCGCAA GCTCCAGCTT ACTCCATCCA GACAAGCTTC ACTTTGTGTT TAACATCGTA 
GAGCTTCCGT CGAACACCAC TGCAGCCTCA CTGCGGAAGG GAGTGTGCAC AGGCTGGCTA 
GCCACATTGG TTGCTCCATT TCTTCAGCCA AACACAGAAG TTTTGACTGC AGACCATAGT 
GATGCTCTGG CTCCTGAGAT ACTTATCTCT CCTCGGGCAA CAAATTCCTT CCACTTACCA 
GATGACCTGT CGGCCCCCAT CATAATGGTG GGTCCAGGAA CTGGTGTAGC CCCCTTTGTT 
GGCTTCCTGC AGCACAGAGA AAAACTCCAA GAACAACACC CAGACGGAAA CTTTGGAGCA 
ATGTGGCTGT TTTTTGGCTG CAGACATAAG GACAGAGACT ATTTGTTCAG GGAGGAGCTC 
AGGCATTTCC TCAAGACTGG GGTCTTGACT CACCTGAAGG TCTCATTCTC AAGAGATGCT 
GCGCCTGAGG AAGAGGAGGA GGCCCCAGCA AAGTATGTGC AAGACAACCT CCAGCATCAC 
AGCCAGCAGG TGGCCAGGAC CCTCCTTCAG GAGAATGGCT ACATTTACGT GTGTGGAGAC 
GCCAAGAATA TGGCTAAGGA TGTACACGAC GCCCTTGTAG AAATCATAAG CAAAGAAGCT 
GGAGTTGACA AACTAGAAGC AATGAAGACA CTGGCAACCT TAAAGCAAGA AAAGCGGTAT 
CTGCAGGATA TCTGGTCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034092.1
CDS	77..1597
Translation	MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS

Target ORF information:

RefSeq Version	NM_001039003.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039003.1

ORF Insert Sequence:

ATGAGAAGGT TTTTGTTACT GTATGCTACA CAGCGAGGGC AGGCAAAGGC CATAGCTGAA 
GAAATAAGTG AGCAGGCTCT GTCACACGGG TTTTCCGCAG ATCTTCACTG CGTCAGTGAG 
TCAGAAAAGA GCTCTCTAAG TATTCCTGCT GTGTCCCCAG AATATTTGGA GGTCTATCTT 
CAGGAGTCTC TTGGCCAGGA TGAAAACCAA GCATCTGTGC CACCATCAGT CGATCCAATT 
TTTCAAGTTC CAATTTCAAA AGCTGTTGAG CTGACTACAA ACGATGCCAT AAAGACCACT 
CTGCTGTTGG AATTGGACAT CTCAAAAGTA GAGTTTTCCC ATCAACCTGG AGATTCCTTC 
AATGTGATCT GTCCAAACAG TGGTTCTGAA GTAGAAGACT TGCTGCAAAG GCTGCAGCTG 
GCTGACAAAC AAGCACACCG GGTCATCCTG AAAATTAAGA TGGACACCAA GAAGAAAGGA 
GCTTCTCTGC CCCAGCATGT GCCTGAGGGG AGTTCTCTCC AGTTCATCTT CACCTGGTGT 
CTTGAAATAC GAGCAGTTCC TAAAAAGGCT TTTTTGAGGG CCCTTTCGGA TTACACCAGC 
GATGCCACTG AAAAGCGGAG GCTTCAGGAG CTCTGCAGTA AGCAGGGAGC AGCTGATTAC 
AACCGCTTCA TCCGAGATGC CAGTGTCTGC CTGCTAGACC TCCTGCTTAC CTTCCCATCC 
TGCCAGCCTC CGCTCAACCT CCTGCTGGAG CACCTTCCTA AACTCCAGCC TCGACCATAC 
TCGTGCGCAA GCTCCAGCTT ACTCCATCCA GACAAGCTTC ACTTTGTGTT TAACATCGTA 
GAGCTTCCGT CGAACACCAC TGCAGCCTCA CTGCGGAAGG GAGTGTGCAC AGGCTGGCTA 
GCCACATTGG TTGCTCCATT TCTTCAGCCA AACACAGAAG TTTTGACTGC AGACCATAGT 
GATGCTCTGG CTCCTGAGAT ACTTATCTCT CCTCGGGCAA CAAATTCCTT CCACTTACCA 
GATGACCTGT CGGCCCCCAT CATAATGGTG GGTCCAGGAA CTGGTGTAGC CCCCTTTGTT 
GGCTTCCTGC AGCACAGAGA AAAACTCCAA GAACAACACC CAGACGGAAA CTTTGGAGCA 
ATGTGGCTGT TTTTTGGCTG CAGACATAAG GACAGAGACT ATTTGTTCAG GGAGGAGCTC 
AGGCATTTCC TCAAGACTGG GGTCTTGACT CACCTGAAGG TCTCATTCTC AAGAGATGCT 
GCGCCTGAGG AAGAGGAGGA GGCCCCAGCA AAGTATGTGC AAGACAACCT CCAGCATCAC 
AGCCAGCAGG TGGCCAGGAC CCTCCTTCAG GAGAATGGCT ACATTTACGT GTGTGGAGAC 
GCCAAGAATA TGGCTAAGGA TGTACACGAC GCCCTTGTAG AAATCATAAG CAAAGAAGCT 
GGAGTTGACA AACTAGAAGC AATGAAGACA CTGGCAACCT TAAAGCAAGA AAAGCGGTAT 
CTGCAGGATA TCTGGTCGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mtrr ( XM_006227813.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006227875.1 Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa22104
Clone ID Related Accession (Same CDS sequence)	XM_006227813.3
Accession Version	XM_006227813.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2103bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	methionine synthase reductase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227813.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAAGGT TTTTGTTACT GTATGCTACA CAGCGAGGGC AGGCAAAGGC CATAGCTGAA 
GAAATAAGTG AGCAGGCTCT GTCACACGGG TTTTCCGCAG ATCTTCACTG CGTCAGTGAG 
TCAGAAAAGT ATGATCTGAA AACCGAAACT GGCCCTCTGG TGATGGTTGT ATCTACCACG 
GGTACTGGAG ACCCACCCGA CACAGCCCGC AAGTTTGTGA AAGAAATACA CAACAAGACA 
CTACCCACAG ACTTCTTTGC TCACCTGTGG TATGGATTAT TGGGTTTGGG TGACTCAGAA 
TACACATACT TCTGCAATGG AGGGAAAGTA ATTGATAAAC GACTTCAGGA GCTTGGAGCC 
CAGCATTTCT ATGACACTGG ACATGCCGAT GACTGCGTAG GTTTAGAGCT CGTGGTAGAA 
CCATGGATTG ATGGACTCTG GCCTGCTCTC ACAAAGCACT TTAAGTCACT CGGAGGACAA 
GAAGACATGA GTGACAGTGA CACACTCGCA CAGGCATCAG ATGCCCCCTT GAGTATGGCC 
ATGAAGCCAG AGTTGTTGCA CATCCAGTCA CAAGTTGAAC TTCTAAGTTT AGAAGACGTG 
GGGAAAAGGG ATTCTGAGCT TCAGGAACAA AATGAGACCA ACAAGAATCA GCCAAGTCGG 
ATCGAAGACT TTGACTCTTC GCTTGTTAAC TCGGTTCCCC CACTCTCACA GAGCTCTCTA 
AGTATTCCTG CTGTGTCCCC AGAATATTTG GAGGTCTATC TTCAGGAGTC TCTTGGCCAG 
GATGAAAACC AAGCATCTGT GCCACCATCA GTCGATCCAA TTTTTCAAGT TCCAATTTCA 
AAAGCTGTTG AGCTGACTAC AAACGATGCC ATAAAGACCA CTCTGCTGTT GGAATTGGAC 
ATCTCAAAAG TAGAGTTTTC CCATCAACCT GGAGATTCCT TCAATGTGAT CTGTCCAAAC 
AGTGGTTCTG AAGTAGAAGA CTTGCTGCAA AGGCTGCAGC TGGCTGACAA ACAAGCACAC 
CGGGTCATCC TGAAAATTAA GATGGACACC AAGAAGAAAG GAGCTTCTCT GCCCCAGCAT 
GTGCCTGAGG GGAGTTCTCT CCAGTTCATC TTCACCTGGT GTCTTGAAAT ACGAGCAGTT 
CCTAAAAAGG CTTTTTTGAG GGCCCTTTCG GATTACACCA GCGATGCCAC TGAAAAGCGG 
AGGCTTCAGG AGCTCTGCAG TAAGCAGGGA GCAGCTGATT ACAACCGCTT CATCCGAGAT 
GCCAGTGTCT GCCTGCTAGA CCTCCTGCTT ACCTTCCCAT CCTGCCAGCC TCCGCTCAAC 
CTCCTGCTGG AGCACCTTCC TAAACTCCAG CCTCGACCAT ACTCGTGCGC AAGCTCCAGC 
TTACTCCATC CAGACAAGCT TCACTTTGTG TTTAACATCG TAGAGCTTCC GTCGAACACC 
ACTGCAGCCT CACTGCGGAA GGGAGTGTGC ACAGGCTGGC TAGCCACATT GGTTGCTCCA 
TTTCTTCAGC CAAACACAGA AGTTTTGACT GCAGACCATA GTGATGCTCT GGCTCCTGAG 
ATACTTATCT CTCCTCGGGC AACAAATTCC TTCCACTTAC CAGATGACCT GTCGGCCCCC 
ATCATAATGG TGGGTCCAGG AACTGGTGTA GCCCCCTTTG TTGGCTTCCT GCAGCACAGA 
GAAAAACTCC AAGAACAACA CCCAGACGGA AACTTTGGAG CAATGTGGCT GTTTTTTGGC 
TGCAGACATA AGGACAGAGA CTATTTGTTC AGGGAGGAGC TCAGGCATTT CCTCAAGACT 
GGGGTCTTGA CTCACCTGAA GGTCTCATTC TCAAGAGATG CTGCGCCTGA GGAAGAGGAG 
GAGGCCCCAG CAAAGTATGT GCAAGACAAC CTCCAGCATC ACAGCCAGCA GGTGGCCAGG 
ACCCTCCTTC AGGAGAATGG CTACATTTAC GTGTGTGGAG ACGCCAAGAA TATGGCTAAG 
GATGTACACG ACGCCCTTGT AGAAATCATA AGCAAAGAAG CTGGAGTTGA CAAACTAGAA 
GCAATGAAGA CACTGGCAAC CTTAAAGCAA GAAAAGCGGT ATCTGCAGGA TATCTGGTCG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006227875.1
CDS	135..2237
Translation	MRRFLLLYATQRGQAKAIAEEISEQALSHGFSADLHCVSESEKYDLKTETGPLVMVVSTTGTGDPPDTARKFVKEIHNKTLPTDFFAHLWYGLLGLGDSEYTYFCNGGKVIDKRLQELGAQHFYDTGHADDCVGLELVVEPWIDGLWPALTKHFKSLGGQEDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSELQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS

Target ORF information:

RefSeq Version	XM_006227813.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006227813.3

ORF Insert Sequence:

ATGAGAAGGT TTTTGTTACT GTATGCTACA CAGCGAGGGC AGGCAAAGGC CATAGCTGAA 
GAAATAAGTG AGCAGGCTCT GTCACACGGG TTTTCCGCAG ATCTTCACTG CGTCAGTGAG 
TCAGAAAAGT ATGATCTGAA AACCGAAACT GGCCCTCTGG TGATGGTTGT ATCTACCACG 
GGTACTGGAG ACCCACCCGA CACAGCCCGC AAGTTTGTGA AAGAAATACA CAACAAGACA 
CTACCCACAG ACTTCTTTGC TCACCTGTGG TATGGATTAT TGGGTTTGGG TGACTCAGAA 
TACACATACT TCTGCAATGG AGGGAAAGTA ATTGATAAAC GACTTCAGGA GCTTGGAGCC 
CAGCATTTCT ATGACACTGG ACATGCCGAT GACTGCGTAG GTTTAGAGCT CGTGGTAGAA 
CCATGGATTG ATGGACTCTG GCCTGCTCTC ACAAAGCACT TTAAGTCACT CGGAGGACAA 
GAAGACATGA GTGACAGTGA CACACTCGCA CAGGCATCAG ATGCCCCCTT GAGTATGGCC 
ATGAAGCCAG AGTTGTTGCA CATCCAGTCA CAAGTTGAAC TTCTAAGTTT AGAAGACGTG 
GGGAAAAGGG ATTCTGAGCT TCAGGAACAA AATGAGACCA ACAAGAATCA GCCAAGTCGG 
ATCGAAGACT TTGACTCTTC GCTTGTTAAC TCGGTTCCCC CACTCTCACA GAGCTCTCTA 
AGTATTCCTG CTGTGTCCCC AGAATATTTG GAGGTCTATC TTCAGGAGTC TCTTGGCCAG 
GATGAAAACC AAGCATCTGT GCCACCATCA GTCGATCCAA TTTTTCAAGT TCCAATTTCA 
AAAGCTGTTG AGCTGACTAC AAACGATGCC ATAAAGACCA CTCTGCTGTT GGAATTGGAC 
ATCTCAAAAG TAGAGTTTTC CCATCAACCT GGAGATTCCT TCAATGTGAT CTGTCCAAAC 
AGTGGTTCTG AAGTAGAAGA CTTGCTGCAA AGGCTGCAGC TGGCTGACAA ACAAGCACAC 
CGGGTCATCC TGAAAATTAA GATGGACACC AAGAAGAAAG GAGCTTCTCT GCCCCAGCAT 
GTGCCTGAGG GGAGTTCTCT CCAGTTCATC TTCACCTGGT GTCTTGAAAT ACGAGCAGTT 
CCTAAAAAGG CTTTTTTGAG GGCCCTTTCG GATTACACCA GCGATGCCAC TGAAAAGCGG 
AGGCTTCAGG AGCTCTGCAG TAAGCAGGGA GCAGCTGATT ACAACCGCTT CATCCGAGAT 
GCCAGTGTCT GCCTGCTAGA CCTCCTGCTT ACCTTCCCAT CCTGCCAGCC TCCGCTCAAC 
CTCCTGCTGG AGCACCTTCC TAAACTCCAG CCTCGACCAT ACTCGTGCGC AAGCTCCAGC 
TTACTCCATC CAGACAAGCT TCACTTTGTG TTTAACATCG TAGAGCTTCC GTCGAACACC 
ACTGCAGCCT CACTGCGGAA GGGAGTGTGC ACAGGCTGGC TAGCCACATT GGTTGCTCCA 
TTTCTTCAGC CAAACACAGA AGTTTTGACT GCAGACCATA GTGATGCTCT GGCTCCTGAG 
ATACTTATCT CTCCTCGGGC AACAAATTCC TTCCACTTAC CAGATGACCT GTCGGCCCCC 
ATCATAATGG TGGGTCCAGG AACTGGTGTA GCCCCCTTTG TTGGCTTCCT GCAGCACAGA 
GAAAAACTCC AAGAACAACA CCCAGACGGA AACTTTGGAG CAATGTGGCT GTTTTTTGGC 
TGCAGACATA AGGACAGAGA CTATTTGTTC AGGGAGGAGC TCAGGCATTT CCTCAAGACT 
GGGGTCTTGA CTCACCTGAA GGTCTCATTC TCAAGAGATG CTGCGCCTGA GGAAGAGGAG 
GAGGCCCCAG CAAAGTATGT GCAAGACAAC CTCCAGCATC ACAGCCAGCA GGTGGCCAGG 
ACCCTCCTTC AGGAGAATGG CTACATTTAC GTGTGTGGAG ACGCCAAGAA TATGGCTAAG 
GATGTACACG ACGCCCTTGT AGAAATCATA AGCAAAGAAG CTGGAGTTGA CAAACTAGAA 
GCAATGAAGA CACTGGCAAC CTTAAAGCAA GAAAAGCGGT ATCTGCAGGA TATCTGGTCG 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mtrr ( XM_006227814.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006227876.1 Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa22105
Clone ID Related Accession (Same CDS sequence)	XM_006227814.2
Accession Version	XM_006227814.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	methionine synthase reductase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006227814.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTTCTT GTTGTGGTTT TGTTTTGACC AGTTTAGAGC TCGTGGTAGA ACCATGGATT 
GATGGACTCT GGCCTGCTCT CACAAAGCAC TTTAAGTCAC TCGGAGGACA AGAAGACATG 
AGTGACAGTG ACACACTCGC ACAGGCATCA GATGCCCCCT TGAGTATGGC CATGAAGCCA 
GAGTTGTTGC ACATCCAGTC ACAAGTTGAA CTTCTAAGTT TAGAAGACGT GGGGAAAAGG 
GATTCTGAGC TTCAGGAACA AAATGAGACC AACAAGAATC AGCCAAGTCG GATCGAAGAC 
TTTGACTCTT CGCTTGTTAA CTCGGTTCCC CCACTCTCAC AGAGCTCTCT AAGTATTCCT 
GCTGTGTCCC CAGAATATTT GGAGGTCTAT CTTCAGGAGT CTCTTGGCCA GGATGAAAAC 
CAAGCATCTG TGCCACCATC AGTCGATCCA ATTTTTCAAG TTCCAATTTC AAAAGCTGTT 
GAGCTGACTA CAAACGATGC CATAAAGACC ACTCTGCTGT TGGAATTGGA CATCTCAAAA 
GTAGAGTTTT CCCATCAACC TGGAGATTCC TTCAATGTGA TCTGTCCAAA CAGTGGTTCT 
GAAGTAGAAG ACTTGCTGCA AAGGCTGCAG CTGGCTGACA AACAAGCACA CCGGGTCATC 
CTGAAAATTA AGATGGACAC CAAGAAGAAA GGAGCTTCTC TGCCCCAGCA TGTGCCTGAG 
GGGAGTTCTC TCCAGTTCAT CTTCACCTGG TGTCTTGAAA TACGAGCAGT TCCTAAAAAG 
GCTTTTTTGA GGGCCCTTTC GGATTACACC AGCGATGCCA CTGAAAAGCG GAGGCTTCAG 
GAGCTCTGCA GTAAGCAGGG AGCAGCTGAT TACAACCGCT TCATCCGAGA TGCCAGTGTC 
TGCCTGCTAG ACCTCCTGCT TACCTTCCCA TCCTGCCAGC CTCCGCTCAA CCTCCTGCTG 
GAGCACCTTC CTAAACTCCA GCCTCGACCA TACTCGTGCG CAAGCTCCAG CTTACTCCAT 
CCAGACAAGC TTCACTTTGT GTTTAACATC GTAGAGCTTC CGTCGAACAC CACTGCAGCC 
TCACTGCGGA AGGGAGTGTG CACAGGCTGG CTAGCCACAT TGGTTGCTCC ATTTCTTCAG 
CCAAACACAG AAGTTTTGAC TGCAGACCAT AGTGATGCTC TGGCTCCTGA GATACTTATC 
TCTCCTCGGG CAACAAATTC CTTCCACTTA CCAGATGACC TGTCGGCCCC CATCATAATG 
GTGGGTCCAG GAACTGGTGT AGCCCCCTTT GTTGGCTTCC TGCAGCACAG AGAAAAACTC 
CAAGAACAAC ACCCAGACGG AAACTTTGGA GCAATGTGGC TGTTTTTTGG CTGCAGACAT 
AAGGACAGAG ACTATTTGTT CAGGGAGGAG CTCAGGCATT TCCTCAAGAC TGGGGTCTTG 
ACTCACCTGA AGGTCTCATT CTCAAGAGAT GCTGCGCCTG AGGAAGAGGA GGAGGCCCCA 
GCAAAGTATG TGCAAGACAA CCTCCAGCAT CACAGCCAGC AGGTGGCCAG GACCCTCCTT 
CAGGAGAATG GCTACATTTA CGTGTGTGGA GACGCCAAGA ATATGGCTAA GGATGTACAC 
GACGCCCTTG TAGAAATCAT AAGCAAAGAA GCTGGAGTTG ACAAACTAGA AGCAATGAAG 
ACACTGGCAA CCTTAAAGCA AGAAAAGCGG TATCTGCAGG ATATCTGGTC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006227876.1
CDS	274..2007
Translation	MFSCCGFVLTSLELVVEPWIDGLWPALTKHFKSLGGQEDMSDSDTLAQASDAPLSMAMKPELLHIQSQVELLSLEDVGKRDSELQEQNETNKNQPSRIEDFDSSLVNSVPPLSQSSLSIPAVSPEYLEVYLQESLGQDENQASVPPSVDPIFQVPISKAVELTTNDAIKTTLLLELDISKVEFSHQPGDSFNVICPNSGSEVEDLLQRLQLADKQAHRVILKIKMDTKKKGASLPQHVPEGSSLQFIFTWCLEIRAVPKKAFLRALSDYTSDATEKRRLQELCSKQGAADYNRFIRDASVCLLDLLLTFPSCQPPLNLLLEHLPKLQPRPYSCASSSLLHPDKLHFVFNIVELPSNTTAASLRKGVCTGWLATLVAPFLQPNTEVLTADHSDALAPEILISPRATNSFHLPDDLSAPIIMVGPGTGVAPFVGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFREELRHFLKTGVLTHLKVSFSRDAAPEEEEEAPAKYVQDNLQHHSQQVARTLLQENGYIYVCGDAKNMAKDVHDALVEIISKEAGVDKLEAMKTLATLKQEKRYLQDIWS

Target ORF information:

RefSeq Version	XM_006227814.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (Mtrr), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006227814.2

ORF Insert Sequence:

ATGTTTTCTT GTTGTGGTTT TGTTTTGACC AGTTTAGAGC TCGTGGTAGA ACCATGGATT 
GATGGACTCT GGCCTGCTCT CACAAAGCAC TTTAAGTCAC TCGGAGGACA AGAAGACATG 
AGTGACAGTG ACACACTCGC ACAGGCATCA GATGCCCCCT TGAGTATGGC CATGAAGCCA 
GAGTTGTTGC ACATCCAGTC ACAAGTTGAA CTTCTAAGTT TAGAAGACGT GGGGAAAAGG 
GATTCTGAGC TTCAGGAACA AAATGAGACC AACAAGAATC AGCCAAGTCG GATCGAAGAC 
TTTGACTCTT CGCTTGTTAA CTCGGTTCCC CCACTCTCAC AGAGCTCTCT AAGTATTCCT 
GCTGTGTCCC CAGAATATTT GGAGGTCTAT CTTCAGGAGT CTCTTGGCCA GGATGAAAAC 
CAAGCATCTG TGCCACCATC AGTCGATCCA ATTTTTCAAG TTCCAATTTC AAAAGCTGTT 
GAGCTGACTA CAAACGATGC CATAAAGACC ACTCTGCTGT TGGAATTGGA CATCTCAAAA 
GTAGAGTTTT CCCATCAACC TGGAGATTCC TTCAATGTGA TCTGTCCAAA CAGTGGTTCT 
GAAGTAGAAG ACTTGCTGCA AAGGCTGCAG CTGGCTGACA AACAAGCACA CCGGGTCATC 
CTGAAAATTA AGATGGACAC CAAGAAGAAA GGAGCTTCTC TGCCCCAGCA TGTGCCTGAG 
GGGAGTTCTC TCCAGTTCAT CTTCACCTGG TGTCTTGAAA TACGAGCAGT TCCTAAAAAG 
GCTTTTTTGA GGGCCCTTTC GGATTACACC AGCGATGCCA CTGAAAAGCG GAGGCTTCAG 
GAGCTCTGCA GTAAGCAGGG AGCAGCTGAT TACAACCGCT TCATCCGAGA TGCCAGTGTC 
TGCCTGCTAG ACCTCCTGCT TACCTTCCCA TCCTGCCAGC CTCCGCTCAA CCTCCTGCTG 
GAGCACCTTC CTAAACTCCA GCCTCGACCA TACTCGTGCG CAAGCTCCAG CTTACTCCAT 
CCAGACAAGC TTCACTTTGT GTTTAACATC GTAGAGCTTC CGTCGAACAC CACTGCAGCC 
TCACTGCGGA AGGGAGTGTG CACAGGCTGG CTAGCCACAT TGGTTGCTCC ATTTCTTCAG 
CCAAACACAG AAGTTTTGAC TGCAGACCAT AGTGATGCTC TGGCTCCTGA GATACTTATC 
TCTCCTCGGG CAACAAATTC CTTCCACTTA CCAGATGACC TGTCGGCCCC CATCATAATG 
GTGGGTCCAG GAACTGGTGT AGCCCCCTTT GTTGGCTTCC TGCAGCACAG AGAAAAACTC 
CAAGAACAAC ACCCAGACGG AAACTTTGGA GCAATGTGGC TGTTTTTTGG CTGCAGACAT 
AAGGACAGAG ACTATTTGTT CAGGGAGGAG CTCAGGCATT TCCTCAAGAC TGGGGTCTTG 
ACTCACCTGA AGGTCTCATT CTCAAGAGAT GCTGCGCCTG AGGAAGAGGA GGAGGCCCCA 
GCAAAGTATG TGCAAGACAA CCTCCAGCAT CACAGCCAGC AGGTGGCCAG GACCCTCCTT 
CAGGAGAATG GCTACATTTA CGTGTGTGGA GACGCCAAGA ATATGGCTAA GGATGTACAC 
GACGCCCTTG TAGAAATCAT AAGCAAAGAA GCTGGAGTTG ACAAACTAGA AGCAATGAAG 
ACACTGGCAA CCTTAAAGCA AGAAAAGCGG TATCTGCAGG ATATCTGGTC GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional variant in methionine synthase reductase intron-1 is associated with pleiotropic congenital malformations.
Molecular and cellular biochemistry407(1-2)51-6(2015 Sep)
Cheng H,Li H,Bu Z,Zhang Q,Bai B,Zhao H,Li RK,Zhang T,Xie J

Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase.
PloS one9(1)e85544(2014)
Gherasim C,Yadav PK,Kabil O,Niu WN,Banerjee R

Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.
Cell155(1)81-93(2013 Sep)
Padmanabhan N,Jia D,Geary-Joo C,Wu X,Ferguson-Smith AC,Fung E,Bieda MC,Snyder FF,Gravel RA,Cross JC,Watson ED

Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.
PloS one8(8)e69843(2013)
Lautner-Csorba O,Gézsi A,Erdélyi DJ,Hullám G,Antal P,Semsei ÁF,Kutszegi N,Kovács G,Falus A,Szalai C

Functional variant in methionine synthase reductase intron-1 significantly increases the risk of congenital heart disease in the Han Chinese population.
Circulation125(3)482-90(2012 Jan)
Zhao JY,Yang XY,Gong XH,Gu ZY,Duan WY,Wang J,Ye ZZ,Shen HB,Shi KH,Hou J,Huang GY,Jin L,Qiao B,Wang HY

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Mtrr cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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