Spta1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Spta1
Entrez Gene ID	289257
Full Name	spectrin, alpha, erythrocytic 1
Synonyms	Spna1
General protein information	Preferred Names spectrin, alpha, erythrocytic 1 Names spectrin alpha chain, erythrocytic 1 erythroid spectrin alpha spectrin alpha chain, erythrocyte spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011908.3	NP_001011908.2	spectrin alpha chain, erythrocytic 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	SPTA1	NP_003117.2
Macaca mulatta (Rhesus monkey)	SPTA1	XP_001117115.1
Bos taurus (cattle)	SPTA1	NP_001193517.1
Mus musculus (house mouse)	Spta1	NP_035595.2
Pan troglodytes (chimpanzee)	SPTA1	XP_001169940.1
Canis lupus familiaris (dog)	SPTA1	XP_545733.3
Rattus norvegicus (Norway rat)	Spta1	NP_001011908.2

Gene Ontology
Bibliography

Related articles in PubMed

The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.
Korsgren C, Lux SE
Blood116(14)2600-7(2010 Oct)

The small GTPase Rac1 regulates auditory hair cell morphogenesis.
Grimsley-Myers CM, Sipe CW, Géléoc GS, Lu X
The Journal of neuroscience : the official journal of the Society for Neuroscience29(50)15859-69(2009 Dec)

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Robledo RF, Ciciotte SL, Gwynn B, Sahr KE, Gilligan DM, Mohandas N, Peters LL
Blood112(10)4298-307(2008 Nov)

Different impacts of alleles alphaLEPRA and alphaLELY as assessed versus a novel, virtually null allele of the SPTA1 gene in trans.
Delaunay J, Nouyrigat V, Proust A, Schischmanoff PO, Cynober T, Yvart J, Gaillard C, Danos O, Tchernia G
British journal of haematology127(1)118-22(2004 Oct)

Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene.
Wandersee NJ, Birkenmeier CS, Gifford EJ, Mohandas N, Barker JE
The hematology journal : the official journal of the European Haematology Association1(4)235-42(2000)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Spta1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spta1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01495	NM_001011908.3 Latest version!	Rattus norvegicus spectrin, alpha, erythrocytic 1 (Spta1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	29-31	$1301.30 $1859.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Spta1 ( NM_001011908.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001011908.2 Rattus norvegicus spectrin, alpha, erythrocytic 1 (Spta1), mRNA.

Price & Availability↑

CloneID	ORa01495
Clone ID Related Accession (Same CDS sequence)	NM_001011908.3
Accession Version	NM_001011908.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7251bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1506700800000
Organism	Rattus norvegicus(Norway rat)
Product	spectrin alpha chain, erythrocytic 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY238342.1, EB480501.1, DY314141.1, CA504635.1 and AI639523.1. On Nov 26, 2008 this sequence version replaced NM_001011908.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMN01906347, SAMN01906348 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAAACTC CAAAGGAAAC TGCTGTTGAA AGCAGTGGAC CAAAGGTTCT AGAAACAGCA 
GAAGAAATCC AGCACAGGAG GCAGGAGGTG TTAGACCAAT ACCAGAGGTT CAAGGAGCGC 
GTGGCCGAGA GGGGTCAGAA GCTTGAGGAA TCTTATCACT ATCAAGTTTT CAGGAGAGAT 
GCAGACGACC TGGAGAAGTG GATCATGGAG AAGCTTGAAA TTACAAAAGA TAAGACATAT 
GAACCCACAA ATATACAGGG GAAATATCAG AAGCACGAAT CCTTTGTATC AGAGGTGCAA 
GCCAAATCAA GAGTGCTTCC TGAGCTGGAG GAAATCAGGG AGGCTCGATT TGCAGAAGAT 
CATTTTGCCC ATGAAGCCAC CAAGACGCAT CTGAAGGAAC TTCGCCACTT GTGGGATCTG 
CTGTTGGAGT TGACCCAAGA GAAAAGTGAC ATCCTGCTGA GGGCACTGAA GTTCTATCAG 
TACTGTCAGG AGTGTGAAGA CATCTTGGAG TGGGTCAAAG AGAAGGAAGC TATAGTGACA 
TTAGTGGAGC TGGGAGATGA CTGGGAACGA ACAGAGGTCC TGCATAAGAA GTTTGAAGAA 
TTCCAGGAAG AACTGACAGC TCGGAAAGGA AAAGTGGACA GAGTGAACCA ATATGCTAAT 
GAGTGTGCCC AGGAGCAACA CCCTAAGTTG CCTGAGATAA AGGCAAAACA AGATGAAGTC 
AATGCTGCCT GGGATCGTCT CTGGAGCCTG GCTCTCAAGA GACGAGAAAG TCTATCAAAT 
GCTGCAGACC TCCAGCGCTT TAAAAGGGAT GTCAATGAAG CCATCCAGTG GATGGAGGAG 
AAGGAGCCTC TACTCACCTC TGAGGACTAT GGCAAAGATC TTGTTAGTTC TGAGGCTCTG 
TTTCACAGTC ACAAGAGGCT CGAGAGGAAT CTTGCTGTCA TGGATGACAA GGTGAAGGAG 
CTTTGTGCCA AAGCAGACAA GCTGATGGTT TCCCACTCTG CAGATGCACC TCAGATCCAG 
CAGATGAAAA TGGATCTAGT CTCCAACTGG GAACTCATCC GCGCCTTGGC CACTAACAGA 
TATGCAAAGC TGAAGGCTTC TTATGGGTAC CATCGGTTCT TATCTGACTA TGATGAGCTC 
ACAGGCTGGA TGGAGGAAAA GACAGCTCTG ATCAATGCTG ATGAGCTGCC AACAGATGTG 
GCCAGTGGGG AAGCCCTGCT AGCCAGGCAC CAGCAGCATA AGCATGAGAT TGACTCCTAT 
GATGATCGAT TTCAAACTGC TGAGGCAACT GGTCAAGATC TGCTGGATGG CAATCACGAA 
GCCTCGGATG AAATTCGAGA GAAGATGACA ATACTTGCCC ATGACTGGGC TGCCCTGCGG 
GAACTCTGGA ACAAGTGTCA GCATCAGTAC CGCCAGAGTC TGGATTTCCA CCTCTTCTAC 
CGAGACAGCG AACAAGTGGA TAGTTGGATG AGCAGACAAG AGGCTTTTCT GGAAAATGAA 
GACCTGGGAA ACTCAGTGGG TAGCGTGGAA GCCCTTCTTC AGAAGCATGA TGACTTTGAA 
GAAGCATTCA CTGCCCAGGA AGAAAAGATT ATAACCTTGG ATGAGACTGC GACCAAGCTC 
ATAGACAATG ACCACTATGA CTCCGAGAAC ATTGCTGCTA TCCGTGATGG GCTCCTGGCC 
AGACGTGATG CCCTGCGTGA AAGGGCTGCC ACCAGAAGAA AATTGTTGGT AGATTCACAA 
CTTCTCCAAC AACTGTATCA AGACTCAGAT GACCTAAAAA CCTGGATCAA TAAGAAGAAG 
AAGTTAGCTG ATGATGAAGA TTACAAGGAT GTACAGAACT TGAAGAGCCG GGTTCAGAAG 
CAACAGGACT TTGAAGAGGA ATTGGCAGCA AATGAGATTA TGCTCAACAA CCTGGAGAGA 
ACTGGCCAGG ACATGATTGA GAATGATCAC TATGCCTCTG ATGCTGTGGC TGCTCGCATG 
AGCGAGGTCG CCAACCTCTG GAAGGAGTTG CTGGAAGCAA CAGCACAAAA AGGGACACAG 
CTGTATGAAG CCAACCAGCT GCTACAATTT GAGAACAATG CGGAAGACCT GAAGCGCTGG 
CTGGAGGAGG TGGAGCGGCA GGTTGCCTCT GAGGATTATG GGAAAGGTCT GGCCGATGTG 
CAGAATCTAC TGAGAAAACA TGGCCTCCTA GAGTCAGCTG TGCTTGCTCG CCAGGATCAA 
GTGGACACCC TCACAGACAT GGCTGCACAT TTTGAAGAAA TAGGACATCC TGACTCTGAG 
AATATATGTG CAAGGCAAGA ATCCTTGCTT TCTCGTTTTG AGGCTCTGAA AGAGCCACTG 
GCCACTCGGA AGAAGAAACT CATTGACCTA CTCAAGCTAC AGCAGATTTG CAGAGACTCA 
GAAGATGAGG AGGCCTGGAT CCAGGAGACT GAGCCCTCAG CAGCTTCCAC TCATCTTGGC 
AAGGACTTGG TTGCAGCCAA GAATCTTCTA AACAGACATG AAGTCATTTT GGCAGACATT 
GCCAGCCATG AACCACGGAT TCAAACCATA ACAGAGAGGG GAAACAAAAT GGTGGAGGAA 
GGACACTTCG CTTCAGAAGA CATAGCATCT AGGGTTGAGA GCTTGAACAA AAATATGGAG 
TCTCTCCGTG CTCGTGCTAT TAGACGGGAG AATGACCTTA AGGCCAATGT CCAGCTCCAA 
CAGTACCTGG CAGATCTGCA TGAAGCAGAA GCATGGATTA AAGAGAAAGA ACCCATTGTA 
GACAACAAAA ATTATGGAGC TGATGAAGAA GCAGCTGGGG CCCTTCTCAA AAAGCATGAG 
GCCTTCCTGG TGGACCTCAA CGCATTTGGA AACAGCATAA AGGCTCTGGG GGATCAGGCA 
GAGGCCTGCC AGCAACAACA GGCAGCACCA GTGGATGAGG CTGGTCGAGA AGCTAGGGTC 
ATAGCTCTGT ATGACTTTGA GGCTCGCAGC CGTAGAGAGG TCAGCATGAA GAAGAATGAT 
GTCTTAACTC TGCTCAGTTC CATCAACAAG GACTGGTGGA AGGTTGAAGC TGACGATCAC 
CAGGGCTTTG TGCCAGCGGT CTATGTCAGG AAACTGGCAC ACGATGAACT CCCAGGGTTC 
CCACAGCAAC GGCGAGAGGA ACCAGTCAAC ATCCCTCAGC TCCAGGAGCA GATCGAGACC 
CTGTACCACT CCCTCCTAGA TCGGGCAGAA GAACGCAGGC GTCGCCTGCT GCAGCGGTAC 
AATGAGTTTC TGCTAGCCTA TGAGGCAGGA GACATGTTGG AGTGGATCCA AGAGAAAAAG 
ACAGAAAACA CTGGGGTGGA ACTGGATGAT GTTTGGGAAC TGCAGAAGAA ATTTGACGAG 
TTCCAGAGGG ATCTGAAGAG CAACGAGCCT CGGTTAAAAG ATATCAATAA GGTGGCTGAT 
GAACTGCTCT TTGAAGACCT CCTAACCCCA GAAGGATCTC ACATACGGCA GGAGTTGAAC 
ACCCGCTGGA GTTCCTTGAA GAGGCTGGCA GATGAGCAGT ATCAGCTGCT GAGCAGTGCA 
CATGCCGTTG AGATGTTTCT CAGAGAAGCA GATGATGTCA AGGAACAGAT TGATAAGAAA 
TGCCAGGCTC TCAATGCTGC TGACCCTGGC TCTGACCTGC TCAGTGTCCA GGCCCTCCAG 
AGGCAGCATG AGGTCTTTGA GAGAGACATC ATCCCCCTGG GAGAAAAGGT GACGACACTG 
GGGGAGACAG CTGAGCGTCT CTGTGAATCA CACCCCGATG CCACTGAGGA CTTACAGAAG 
CAGCGAACAG AGCTGAATGA GGCTTGGGAT ACGCTACAAG GTCTTACCAG TGATCGAAAG 
GAGAGTCTGA ATGAAGCTCA TAAATTCTTC CTCTTCCTTA GCAAGGCCAG TGATCTAGAG 
AATTGGATCA AGGCCATTGG TGGTGTAATA TCATCACCTG AGCTGGCTGA GGACTTAACT 
GGCACAGAGA TCTTGCTGGA GCGACACCAG GAGCATTATG ATGACATAAA AAGAGAAGAC 
CCCACTTTCC AAGCCTTAGA AGACTTTGGT AGAGAACTTA TAGACAGAGG CCACCGTAAT 
AGCCACGAAA TTGAAACTAC TCTCCAGGAT ATTAAATTAA AGAGAGACGA TTTGGAAAAG 
AATTGGGAAA ACCGCAAGAA GATGCTAGAC CAGTGCCTAG AACTGCAGCT GTTCCGAGGG 
AAGTGTGAAC AGGTTGAGAG CTGGATGGTG GCACGTGAGA ATTCCCTGAG GTCAGATGAC 
AGGGATCACT TAAACAGTCT ACAGGCTTTG ATGAAAAAAC GGGATGACCT GGACAAAGCA 
ATCGCTGCTC AGGAAGGGAA GATTGCTGAC CTAGAGAACC ATGCCACAAG GCTCATGGAC 
AATGACCACT ATGCTAAGGA AGAGATTGCT GCTCGCCTCC AACGTGTACT AGACAGGTGG 
AAGGATCTCA AAACACAGCT GCTTGCTGAA CTGGGAAAGC TAGGAGACTA TGCCGACCTG 
AAACAGTTCT ATCGTGACCT CGAGGACCTG GAGGAATGGA TCAGTGAGAT GCTGCCCGTA 
GCCTGTGATG AATCTTACAA AGATCCCACT AATATCCAGC AAAGGAAATA TCTGAAACAT 
CAAGCCTTTG AAAATGAAGT CAATGGCCGT GCCGAGCAGG TGGAAGGGGT CATCAACCTG 
GGGAAATCCC TGATTGAGCG CAGAGTGTGT GATGGGGATG AAGAGAACAT GCAGGAGCAA 
CTGGACAAAC TAAAGGAGAA CTGGGACTAT CTCCTAGAGA GAACAACTGA CAAAGGGCAG 
AAGCTCAACG AGGCCAGTCG GCAGCAAAGG TTCAACACAA GTATCCGGGA CTTTGAGTTC 
TGGCTTTCAG AGGCAGAAGG CTTGCTGGCC ATGAAGGATC AGGCCAGGGA CTTAACTTCA 
GCAGGAAACC TACTTAAGAA GCATCAGCTA TTGGAAGCAG AGATGTTGGC ACGAGAGGAC 
CCTCTCAAAG ATCTGAATGG TCTGGCTAAG GAGCTGATCT CCAGTGGGAC TTTCAACATT 
GAGCAGATAG AAGAGAAAAT GAATGGTGTC AATGAGCGTT TCAAAAATGT CCAGAGTTTG 
GCAGCTGCAC ACCATGAGAA ACTGAAAGAG ACCTATGCCT TATTCCAGTT CTTCCAAGAC 
CTGGATGATG AGGAAGCCTG GATAGAGGAG AAGTTGCTAC GAGTGAGCTC CCAGGACTGT 
GGGAGGGATC TTCAGAGTGT TCAGAACTTA CTGAAAAAAC ACAGACGCCT AGAGGGGGAG 
CTGGTGGCAC ATGAACCTGC TGTCCAGAAT GTGCTGGATA CAGCAGAAAG CCTGAAAGAC 
AAGGCTGCTG TAGGGAAAGA GGAGATCCAG GAGCGACTGG CTCAGTTTGT CCAGCATTGG 
GAAAAGCTCA AAGAATTGGC GAAGACACGA GGGGTGAATT TGGAGGAGTC TCTTCAGTAT 
CTGCAATTCA TGGAGAATGC AGAGGAAGAA GAAGCATGGC TGGGTGAAAA GGATGCACTG 
GTTAGCCGAG GAGATTCTGG AGACACACTG GCTGCTACTC AGAGTTTGCT AAAGAAGCAC 
GAAGCTTTGG AGAATGACTT TGCTGTACAC AAGAACCGGG TACAAGATGT TTGTGCACAA 
GGAGAAGACA TTCTCAGTAA GGAAGAAACT CAAAACAAGG ATAAGATTTC CACCAAGATT 
GAAGTTCTGA ATGAAAAGAC AGCATCTCTG ACCAAGGCCT TAGCTGCTTG GAAGTCACAG 
CTGGACGAAG TGCATGCCTT TCAGCAGTTT AACTGGAAGG CTGATGTCGT GGAATCCTGG 
ATAGGTGAGA AGGAGGCAAG CCTGAAGACC AAGAGCAATG GTGCAGACCT CACTGCCTTC 
CTCACACTCC TGGCAAAGCA AGACACGCTG GATGCCAGTC TTCAGAGCTT CCAGCAAGAA 
AGGCTTTCTG AAATCACTGA TCTGAAGGAC GAGCTGCTGG CTGCTGAGCA CAGCCAAAGC 
AAAGCCATTG AGGAACGGCA CGCAGCCCTG CTGAGGCGCT GGGAACAACT GCTGGAGGCA 
TGTAGAGTTC ACAGGCAGAA GCTATTGGAG AAGCAGCTGC CTCTACAGAA GGCTGAGGAG 
CTATTCATGG AATTTGCACA CAAAGCTTCA GCCTTCAACA ACTGGTGTGA GAACGCTGAA 
GAGGACTTGT CAGAACCTGT GCATTGTGTC TCTCTAAATG AGATCCGGCA GCTGCAGAAG 
GAGCATGAAG CCTTCTTGGC CTCTATGGTT GGGGCTCAAG AGGATTTCAA CTATTTGTTG 
GCACTAGACC AGCAAATTAA AGCCTTAAAT GTGTCCTCCA GTCCTTATAC CTGGTTAACA 
GTGGATGTGC TGGGCAGGAT CTGGAAGCAC CTACCTGAAA TCATCAAGGA ACGGGAGCAG 
GAGCTACAGA AAGAAGAGGC TAGGCAGATC AAGAATTTTG AAATGTGCCA GGAGTTTGAA 
CAGAATGCCA GTGCCTTCCT TCAGTGGATC CAGGAGACCA GGGCTTATTT TCTGGATGGA 
TCGTTGCTCA AGGAAACAGG AACTCTGGAA TCCCAACTTG AAGCAAATAA AAGGAAGCAG 
AAGGAGATTC AAGCAATGAA GCGTCATCTC ACCAAGATTG AAGACCTGGG GGACAGCATG 
GAAGAGGCTT TGATCCTTGA TATCAAATAC AGCACCATTG GACTGGCCCA GCAGTGGGAT 
CAGCTGCACC AGCTGGGGAT GCGAATGCAG CACAATTTGG AGCAACAGAT TCAAGCCAAA 
GACACCATAG GTGTGAGTGA GGAGACACTG AAAGAATTTA GCACCACATA TAAACACTTC 
GATGAGAATT TGACAGGGCG ATTGACTCAC AAAGAGTTCC GGTCATGCCT GAGAGGACTC 
AACTACTATT TGCCTATGGT TGAGGAAGGT GAACCTGAGC CCAAGTTTGA GAAATTTCTG 
AATGCTGTGG ATCCAGGGAG GAAAGGCTAT GTGTCACTGG AGGACTACAC ATCATTCCTG 
ATTGACAAGG AGTCAGAGAA TATCAAGACA AGTGATGACA TAGAGAGTGG ATTCCAAGCC 
CTGGCAGAAG GCAAGGCCTA CATTACCAAG GAGGACATGA AACAGGCTCT AACCCCAGAA 
CAAGTGTCAT TCTGTACCAT ACATATGCAG CAATATATGG ACCCGCGGGG TCGGAGCCAA 
CCTGCTGGCT ACGACTATGT TGGCTTCACC AATTCATTCT TTGGCAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011908.2
CDS	181..7431
Translation	METPKETAVESSGPKVLETAEEIQHRRQEVLDQYQRFKERVAERGQKLEESYHYQVFRRDADDLEKWIMEKLEITKDKTYEPTNIQGKYQKHESFVSEVQAKSRVLPELEEIREARFAEDHFAHEATKTHLKELRHLWDLLLELTQEKSDILLRALKFYQYCQECEDILEWVKEKEAIVTLVELGDDWERTEVLHKKFEEFQEELTARKGKVDRVNQYANECAQEQHPKLPEIKAKQDEVNAAWDRLWSLALKRRESLSNAADLQRFKRDVNEAIQWMEEKEPLLTSEDYGKDLVSSEALFHSHKRLERNLAVMDDKVKELCAKADKLMVSHSADAPQIQQMKMDLVSNWELIRALATNRYAKLKASYGYHRFLSDYDELTGWMEEKTALINADELPTDVASGEALLARHQQHKHEIDSYDDRFQTAEATGQDLLDGNHEASDEIREKMTILAHDWAALRELWNKCQHQYRQSLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSVGSVEALLQKHDDFEEAFTAQEEKIITLDETATKLIDNDHYDSENIAAIRDGLLARRDALRERAATRRKLLVDSQLLQQLYQDSDDLKTWINKKKKLADDEDYKDVQNLKSRVQKQQDFEEELAANEIMLNNLERTGQDMIENDHYASDAVAARMSEVANLWKELLEATAQKGTQLYEANQLLQFENNAEDLKRWLEEVERQVASEDYGKGLADVQNLLRKHGLLESAVLARQDQVDTLTDMAAHFEEIGHPDSENICARQESLLSRFEALKEPLATRKKKLIDLLKLQQICRDSEDEEAWIQETEPSAASTHLGKDLVAAKNLLNRHEVILADIASHEPRIQTITERGNKMVEEGHFASEDIASRVESLNKNMESLRARAIRRENDLKANVQLQQYLADLHEAEAWIKEKEPIVDNKNYGADEEAAGALLKKHEAFLVDLNAFGNSIKALGDQAEACQQQQAAPVDEAGREARVIALYDFEARSRREVSMKKNDVLTLLSSINKDWWKVEADDHQGFVPAVYVRKLAHDELPGFPQQRREEPVNIPQLQEQIETLYHSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKTENTGVELDDVWELQKKFDEFQRDLKSNEPRLKDINKVADELLFEDLLTPEGSHIRQELNTRWSSLKRLADEQYQLLSSAHAVEMFLREADDVKEQIDKKCQALNAADPGSDLLSVQALQRQHEVFERDIIPLGEKVTTLGETAERLCESHPDATEDLQKQRTELNEAWDTLQGLTSDRKESLNEAHKFFLFLSKASDLENWIKAIGGVISSPELAEDLTGTEILLERHQEHYDDIKREDPTFQALEDFGRELIDRGHRNSHEIETTLQDIKLKRDDLEKNWENRKKMLDQCLELQLFRGKCEQVESWMVARENSLRSDDRDHLNSLQALMKKRDDLDKAIAAQEGKIADLENHATRLMDNDHYAKEEIAARLQRVLDRWKDLKTQLLAELGKLGDYADLKQFYRDLEDLEEWISEMLPVACDESYKDPTNIQQRKYLKHQAFENEVNGRAEQVEGVINLGKSLIERRVCDGDEENMQEQLDKLKENWDYLLERTTDKGQKLNEASRQQRFNTSIRDFEFWLSEAEGLLAMKDQARDLTSAGNLLKKHQLLEAEMLAREDPLKDLNGLAKELISSGTFNIEQIEEKMNGVNERFKNVQSLAAAHHEKLKETYALFQFFQDLDDEEAWIEEKLLRVSSQDCGRDLQSVQNLLKKHRRLEGELVAHEPAVQNVLDTAESLKDKAAVGKEEIQERLAQFVQHWEKLKELAKTRGVNLEESLQYLQFMENAEEEEAWLGEKDALVSRGDSGDTLAATQSLLKKHEALENDFAVHKNRVQDVCAQGEDILSKEETQNKDKISTKIEVLNEKTASLTKALAAWKSQLDEVHAFQQFNWKADVVESWIGEKEASLKTKSNGADLTAFLTLLAKQDTLDASLQSFQQERLSEITDLKDELLAAEHSQSKAIEERHAALLRRWEQLLEACRVHRQKLLEKQLPLQKAEELFMEFAHKASAFNNWCENAEEDLSEPVHCVSLNEIRQLQKEHEAFLASMVGAQEDFNYLLALDQQIKALNVSSSPYTWLTVDVLGRIWKHLPEIIKEREQELQKEEARQIKNFEMCQEFEQNASAFLQWIQETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRHLTKIEDLGDSMEEALILDIKYSTIGLAQQWDQLHQLGMRMQHNLEQQIQAKDTIGVSEETLKEFSTTYKHFDENLTGRLTHKEFRSCLRGLNYYLPMVEEGEPEPKFEKFLNAVDPGRKGYVSLEDYTSFLIDKESENIKTSDDIESGFQALAEGKAYITKEDMKQALTPEQVSFCTIHMQQYMDPRGRSQPAGYDYVGFTNSFFGN

Target ORF information:

RefSeq Version	NM_001011908.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus spectrin, alpha, erythrocytic 1 (Spta1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011908.3

ORF Insert Sequence:

ATGGAAACTC CAAAGGAAAC TGCTGTTGAA AGCAGTGGAC CAAAGGTTCT AGAAACAGCA 
GAAGAAATCC AGCACAGGAG GCAGGAGGTG TTAGACCAAT ACCAGAGGTT CAAGGAGCGC 
GTGGCCGAGA GGGGTCAGAA GCTTGAGGAA TCTTATCACT ATCAAGTTTT CAGGAGAGAT 
GCAGACGACC TGGAGAAGTG GATCATGGAG AAGCTTGAAA TTACAAAAGA TAAGACATAT 
GAACCCACAA ATATACAGGG GAAATATCAG AAGCACGAAT CCTTTGTATC AGAGGTGCAA 
GCCAAATCAA GAGTGCTTCC TGAGCTGGAG GAAATCAGGG AGGCTCGATT TGCAGAAGAT 
CATTTTGCCC ATGAAGCCAC CAAGACGCAT CTGAAGGAAC TTCGCCACTT GTGGGATCTG 
CTGTTGGAGT TGACCCAAGA GAAAAGTGAC ATCCTGCTGA GGGCACTGAA GTTCTATCAG 
TACTGTCAGG AGTGTGAAGA CATCTTGGAG TGGGTCAAAG AGAAGGAAGC TATAGTGACA 
TTAGTGGAGC TGGGAGATGA CTGGGAACGA ACAGAGGTCC TGCATAAGAA GTTTGAAGAA 
TTCCAGGAAG AACTGACAGC TCGGAAAGGA AAAGTGGACA GAGTGAACCA ATATGCTAAT 
GAGTGTGCCC AGGAGCAACA CCCTAAGTTG CCTGAGATAA AGGCAAAACA AGATGAAGTC 
AATGCTGCCT GGGATCGTCT CTGGAGCCTG GCTCTCAAGA GACGAGAAAG TCTATCAAAT 
GCTGCAGACC TCCAGCGCTT TAAAAGGGAT GTCAATGAAG CCATCCAGTG GATGGAGGAG 
AAGGAGCCTC TACTCACCTC TGAGGACTAT GGCAAAGATC TTGTTAGTTC TGAGGCTCTG 
TTTCACAGTC ACAAGAGGCT CGAGAGGAAT CTTGCTGTCA TGGATGACAA GGTGAAGGAG 
CTTTGTGCCA AAGCAGACAA GCTGATGGTT TCCCACTCTG CAGATGCACC TCAGATCCAG 
CAGATGAAAA TGGATCTAGT CTCCAACTGG GAACTCATCC GCGCCTTGGC CACTAACAGA 
TATGCAAAGC TGAAGGCTTC TTATGGGTAC CATCGGTTCT TATCTGACTA TGATGAGCTC 
ACAGGCTGGA TGGAGGAAAA GACAGCTCTG ATCAATGCTG ATGAGCTGCC AACAGATGTG 
GCCAGTGGGG AAGCCCTGCT AGCCAGGCAC CAGCAGCATA AGCATGAGAT TGACTCCTAT 
GATGATCGAT TTCAAACTGC TGAGGCAACT GGTCAAGATC TGCTGGATGG CAATCACGAA 
GCCTCGGATG AAATTCGAGA GAAGATGACA ATACTTGCCC ATGACTGGGC TGCCCTGCGG 
GAACTCTGGA ACAAGTGTCA GCATCAGTAC CGCCAGAGTC TGGATTTCCA CCTCTTCTAC 
CGAGACAGCG AACAAGTGGA TAGTTGGATG AGCAGACAAG AGGCTTTTCT GGAAAATGAA 
GACCTGGGAA ACTCAGTGGG TAGCGTGGAA GCCCTTCTTC AGAAGCATGA TGACTTTGAA 
GAAGCATTCA CTGCCCAGGA AGAAAAGATT ATAACCTTGG ATGAGACTGC GACCAAGCTC 
ATAGACAATG ACCACTATGA CTCCGAGAAC ATTGCTGCTA TCCGTGATGG GCTCCTGGCC 
AGACGTGATG CCCTGCGTGA AAGGGCTGCC ACCAGAAGAA AATTGTTGGT AGATTCACAA 
CTTCTCCAAC AACTGTATCA AGACTCAGAT GACCTAAAAA CCTGGATCAA TAAGAAGAAG 
AAGTTAGCTG ATGATGAAGA TTACAAGGAT GTACAGAACT TGAAGAGCCG GGTTCAGAAG 
CAACAGGACT TTGAAGAGGA ATTGGCAGCA AATGAGATTA TGCTCAACAA CCTGGAGAGA 
ACTGGCCAGG ACATGATTGA GAATGATCAC TATGCCTCTG ATGCTGTGGC TGCTCGCATG 
AGCGAGGTCG CCAACCTCTG GAAGGAGTTG CTGGAAGCAA CAGCACAAAA AGGGACACAG 
CTGTATGAAG CCAACCAGCT GCTACAATTT GAGAACAATG CGGAAGACCT GAAGCGCTGG 
CTGGAGGAGG TGGAGCGGCA GGTTGCCTCT GAGGATTATG GGAAAGGTCT GGCCGATGTG 
CAGAATCTAC TGAGAAAACA TGGCCTCCTA GAGTCAGCTG TGCTTGCTCG CCAGGATCAA 
GTGGACACCC TCACAGACAT GGCTGCACAT TTTGAAGAAA TAGGACATCC TGACTCTGAG 
AATATATGTG CAAGGCAAGA ATCCTTGCTT TCTCGTTTTG AGGCTCTGAA AGAGCCACTG 
GCCACTCGGA AGAAGAAACT CATTGACCTA CTCAAGCTAC AGCAGATTTG CAGAGACTCA 
GAAGATGAGG AGGCCTGGAT CCAGGAGACT GAGCCCTCAG CAGCTTCCAC TCATCTTGGC 
AAGGACTTGG TTGCAGCCAA GAATCTTCTA AACAGACATG AAGTCATTTT GGCAGACATT 
GCCAGCCATG AACCACGGAT TCAAACCATA ACAGAGAGGG GAAACAAAAT GGTGGAGGAA 
GGACACTTCG CTTCAGAAGA CATAGCATCT AGGGTTGAGA GCTTGAACAA AAATATGGAG 
TCTCTCCGTG CTCGTGCTAT TAGACGGGAG AATGACCTTA AGGCCAATGT CCAGCTCCAA 
CAGTACCTGG CAGATCTGCA TGAAGCAGAA GCATGGATTA AAGAGAAAGA ACCCATTGTA 
GACAACAAAA ATTATGGAGC TGATGAAGAA GCAGCTGGGG CCCTTCTCAA AAAGCATGAG 
GCCTTCCTGG TGGACCTCAA CGCATTTGGA AACAGCATAA AGGCTCTGGG GGATCAGGCA 
GAGGCCTGCC AGCAACAACA GGCAGCACCA GTGGATGAGG CTGGTCGAGA AGCTAGGGTC 
ATAGCTCTGT ATGACTTTGA GGCTCGCAGC CGTAGAGAGG TCAGCATGAA GAAGAATGAT 
GTCTTAACTC TGCTCAGTTC CATCAACAAG GACTGGTGGA AGGTTGAAGC TGACGATCAC 
CAGGGCTTTG TGCCAGCGGT CTATGTCAGG AAACTGGCAC ACGATGAACT CCCAGGGTTC 
CCACAGCAAC GGCGAGAGGA ACCAGTCAAC ATCCCTCAGC TCCAGGAGCA GATCGAGACC 
CTGTACCACT CCCTCCTAGA TCGGGCAGAA GAACGCAGGC GTCGCCTGCT GCAGCGGTAC 
AATGAGTTTC TGCTAGCCTA TGAGGCAGGA GACATGTTGG AGTGGATCCA AGAGAAAAAG 
ACAGAAAACA CTGGGGTGGA ACTGGATGAT GTTTGGGAAC TGCAGAAGAA ATTTGACGAG 
TTCCAGAGGG ATCTGAAGAG CAACGAGCCT CGGTTAAAAG ATATCAATAA GGTGGCTGAT 
GAACTGCTCT TTGAAGACCT CCTAACCCCA GAAGGATCTC ACATACGGCA GGAGTTGAAC 
ACCCGCTGGA GTTCCTTGAA GAGGCTGGCA GATGAGCAGT ATCAGCTGCT GAGCAGTGCA 
CATGCCGTTG AGATGTTTCT CAGAGAAGCA GATGATGTCA AGGAACAGAT TGATAAGAAA 
TGCCAGGCTC TCAATGCTGC TGACCCTGGC TCTGACCTGC TCAGTGTCCA GGCCCTCCAG 
AGGCAGCATG AGGTCTTTGA GAGAGACATC ATCCCCCTGG GAGAAAAGGT GACGACACTG 
GGGGAGACAG CTGAGCGTCT CTGTGAATCA CACCCCGATG CCACTGAGGA CTTACAGAAG 
CAGCGAACAG AGCTGAATGA GGCTTGGGAT ACGCTACAAG GTCTTACCAG TGATCGAAAG 
GAGAGTCTGA ATGAAGCTCA TAAATTCTTC CTCTTCCTTA GCAAGGCCAG TGATCTAGAG 
AATTGGATCA AGGCCATTGG TGGTGTAATA TCATCACCTG AGCTGGCTGA GGACTTAACT 
GGCACAGAGA TCTTGCTGGA GCGACACCAG GAGCATTATG ATGACATAAA AAGAGAAGAC 
CCCACTTTCC AAGCCTTAGA AGACTTTGGT AGAGAACTTA TAGACAGAGG CCACCGTAAT 
AGCCACGAAA TTGAAACTAC TCTCCAGGAT ATTAAATTAA AGAGAGACGA TTTGGAAAAG 
AATTGGGAAA ACCGCAAGAA GATGCTAGAC CAGTGCCTAG AACTGCAGCT GTTCCGAGGG 
AAGTGTGAAC AGGTTGAGAG CTGGATGGTG GCACGTGAGA ATTCCCTGAG GTCAGATGAC 
AGGGATCACT TAAACAGTCT ACAGGCTTTG ATGAAAAAAC GGGATGACCT GGACAAAGCA 
ATCGCTGCTC AGGAAGGGAA GATTGCTGAC CTAGAGAACC ATGCCACAAG GCTCATGGAC 
AATGACCACT ATGCTAAGGA AGAGATTGCT GCTCGCCTCC AACGTGTACT AGACAGGTGG 
AAGGATCTCA AAACACAGCT GCTTGCTGAA CTGGGAAAGC TAGGAGACTA TGCCGACCTG 
AAACAGTTCT ATCGTGACCT CGAGGACCTG GAGGAATGGA TCAGTGAGAT GCTGCCCGTA 
GCCTGTGATG AATCTTACAA AGATCCCACT AATATCCAGC AAAGGAAATA TCTGAAACAT 
CAAGCCTTTG AAAATGAAGT CAATGGCCGT GCCGAGCAGG TGGAAGGGGT CATCAACCTG 
GGGAAATCCC TGATTGAGCG CAGAGTGTGT GATGGGGATG AAGAGAACAT GCAGGAGCAA 
CTGGACAAAC TAAAGGAGAA CTGGGACTAT CTCCTAGAGA GAACAACTGA CAAAGGGCAG 
AAGCTCAACG AGGCCAGTCG GCAGCAAAGG TTCAACACAA GTATCCGGGA CTTTGAGTTC 
TGGCTTTCAG AGGCAGAAGG CTTGCTGGCC ATGAAGGATC AGGCCAGGGA CTTAACTTCA 
GCAGGAAACC TACTTAAGAA GCATCAGCTA TTGGAAGCAG AGATGTTGGC ACGAGAGGAC 
CCTCTCAAAG ATCTGAATGG TCTGGCTAAG GAGCTGATCT CCAGTGGGAC TTTCAACATT 
GAGCAGATAG AAGAGAAAAT GAATGGTGTC AATGAGCGTT TCAAAAATGT CCAGAGTTTG 
GCAGCTGCAC ACCATGAGAA ACTGAAAGAG ACCTATGCCT TATTCCAGTT CTTCCAAGAC 
CTGGATGATG AGGAAGCCTG GATAGAGGAG AAGTTGCTAC GAGTGAGCTC CCAGGACTGT 
GGGAGGGATC TTCAGAGTGT TCAGAACTTA CTGAAAAAAC ACAGACGCCT AGAGGGGGAG 
CTGGTGGCAC ATGAACCTGC TGTCCAGAAT GTGCTGGATA CAGCAGAAAG CCTGAAAGAC 
AAGGCTGCTG TAGGGAAAGA GGAGATCCAG GAGCGACTGG CTCAGTTTGT CCAGCATTGG 
GAAAAGCTCA AAGAATTGGC GAAGACACGA GGGGTGAATT TGGAGGAGTC TCTTCAGTAT 
CTGCAATTCA TGGAGAATGC AGAGGAAGAA GAAGCATGGC TGGGTGAAAA GGATGCACTG 
GTTAGCCGAG GAGATTCTGG AGACACACTG GCTGCTACTC AGAGTTTGCT AAAGAAGCAC 
GAAGCTTTGG AGAATGACTT TGCTGTACAC AAGAACCGGG TACAAGATGT TTGTGCACAA 
GGAGAAGACA TTCTCAGTAA GGAAGAAACT CAAAACAAGG ATAAGATTTC CACCAAGATT 
GAAGTTCTGA ATGAAAAGAC AGCATCTCTG ACCAAGGCCT TAGCTGCTTG GAAGTCACAG 
CTGGACGAAG TGCATGCCTT TCAGCAGTTT AACTGGAAGG CTGATGTCGT GGAATCCTGG 
ATAGGTGAGA AGGAGGCAAG CCTGAAGACC AAGAGCAATG GTGCAGACCT CACTGCCTTC 
CTCACACTCC TGGCAAAGCA AGACACGCTG GATGCCAGTC TTCAGAGCTT CCAGCAAGAA 
AGGCTTTCTG AAATCACTGA TCTGAAGGAC GAGCTGCTGG CTGCTGAGCA CAGCCAAAGC 
AAAGCCATTG AGGAACGGCA CGCAGCCCTG CTGAGGCGCT GGGAACAACT GCTGGAGGCA 
TGTAGAGTTC ACAGGCAGAA GCTATTGGAG AAGCAGCTGC CTCTACAGAA GGCTGAGGAG 
CTATTCATGG AATTTGCACA CAAAGCTTCA GCCTTCAACA ACTGGTGTGA GAACGCTGAA 
GAGGACTTGT CAGAACCTGT GCATTGTGTC TCTCTAAATG AGATCCGGCA GCTGCAGAAG 
GAGCATGAAG CCTTCTTGGC CTCTATGGTT GGGGCTCAAG AGGATTTCAA CTATTTGTTG 
GCACTAGACC AGCAAATTAA AGCCTTAAAT GTGTCCTCCA GTCCTTATAC CTGGTTAACA 
GTGGATGTGC TGGGCAGGAT CTGGAAGCAC CTACCTGAAA TCATCAAGGA ACGGGAGCAG 
GAGCTACAGA AAGAAGAGGC TAGGCAGATC AAGAATTTTG AAATGTGCCA GGAGTTTGAA 
CAGAATGCCA GTGCCTTCCT TCAGTGGATC CAGGAGACCA GGGCTTATTT TCTGGATGGA 
TCGTTGCTCA AGGAAACAGG AACTCTGGAA TCCCAACTTG AAGCAAATAA AAGGAAGCAG 
AAGGAGATTC AAGCAATGAA GCGTCATCTC ACCAAGATTG AAGACCTGGG GGACAGCATG 
GAAGAGGCTT TGATCCTTGA TATCAAATAC AGCACCATTG GACTGGCCCA GCAGTGGGAT 
CAGCTGCACC AGCTGGGGAT GCGAATGCAG CACAATTTGG AGCAACAGAT TCAAGCCAAA 
GACACCATAG GTGTGAGTGA GGAGACACTG AAAGAATTTA GCACCACATA TAAACACTTC 
GATGAGAATT TGACAGGGCG ATTGACTCAC AAAGAGTTCC GGTCATGCCT GAGAGGACTC 
AACTACTATT TGCCTATGGT TGAGGAAGGT GAACCTGAGC CCAAGTTTGA GAAATTTCTG 
AATGCTGTGG ATCCAGGGAG GAAAGGCTAT GTGTCACTGG AGGACTACAC ATCATTCCTG 
ATTGACAAGG AGTCAGAGAA TATCAAGACA AGTGATGACA TAGAGAGTGG ATTCCAAGCC 
CTGGCAGAAG GCAAGGCCTA CATTACCAAG GAGGACATGA AACAGGCTCT AACCCCAGAA 
CAAGTGTCAT TCTGTACCAT ACATATGCAG CAATATATGG ACCCGCGGGG TCGGAGCCAA 
CCTGCTGGCT ACGACTATGT TGGCTTCACC AATTCATTCT TTGGCAACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding.
Blood116(14)2600-7(2010 Oct)
Korsgren C,Lux SE

The small GTPase Rac1 regulates auditory hair cell morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience29(50)15859-69(2009 Dec)
Grimsley-Myers CM,Sipe CW,Géléoc GS,Lu X

Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Blood112(10)4298-307(2008 Nov)
Robledo RF,Ciciotte SL,Gwynn B,Sahr KE,Gilligan DM,Mohandas N,Peters LL

Different impacts of alleles alphaLEPRA and alphaLELY as assessed versus a novel, virtually null allele of the SPTA1 gene in trans.
British journal of haematology127(1)118-22(2004 Oct)
Delaunay J,Nouyrigat V,Proust A,Schischmanoff PO,Cynober T,Yvart J,Gaillard C,Danos O,Tchernia G

Murine recessive hereditary spherocytosis, sph/sph, is caused by a mutation in the erythroid alpha-spectrin gene.
The hematology journal : the official journal of the European Haematology Association1(4)235-42(2000)
Wandersee NJ,Birkenmeier CS,Gifford EJ,Mohandas N,Barker JE

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Spta1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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