Elac2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Elac2
Entrez Gene ID	282826
Full Name	elaC ribonuclease Z 2
General protein information	Preferred Names elaC ribonuclease Z 2 Names zinc phosphodiesterase ELAC protein 2 RNase Z 2 elaC homolog 2 elaC homolog protein 2 ribonuclease Z 2 tRNA 3 endonuclease 2 tRNase Z 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	human homolog is a tRNA 3 processing endoribonuclease and is associated with prostate cancer susceptibility [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_172326.1	NP_758829.1	zinc phosphodiesterase ELAC protein 2

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	JhI-1	NP_724916.1
Xenopus tropicalis (tropical clawed frog)	elac2	NP_001039086.1
Oryza sativa (rice)	Os01g0232300	NP_001042502.1
Homo sapiens (human)	ELAC2	NP_060597.4
Rattus norvegicus (Norway rat)	Elac2	NP_758829.1
Danio rerio (zebrafish)	elac2	NP_001243133.1
Arabidopsis thaliana (thale cress)	TRZ4	NP_188247.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009743	XP_318827.4
Schizosaccharomyces pombe (fission yeast)	trz1	NP_593023.1
Pan troglodytes (chimpanzee)	ELAC2	NP_001009034.1
Bos taurus (cattle)	ELAC2	NP_001179994.1
Caenorhabditis elegans (roundworm)	hoe-1	NP_001023109.1
Arabidopsis thaliana (thale cress)	TRZ3	NP_175628.2
Canis lupus familiaris (dog)	ELAC2	XP_546630.2
Mus musculus (house mouse)	Elac2	NP_075968.2
Gallus gallus (chicken)	ELAC2	XP_415584.4

Gene Ontology
Bibliography

Related articles in PubMed

Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.
Bogenhagen DF, Martin DW, Koller A
Cell metabolism19(4)618-29(2014 Apr)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.
Brzezniak LK, Bijata M, Szczesny RJ, Stepien PP
RNA biology8(4)616-26(2011 Jul-Aug)

3' processing of eukaryotic precursor tRNAs.
Maraia RJ, Lamichhane TN
Wiley interdisciplinary reviews. RNA2(3)362-75(2011 May-Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Elac2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elac2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03295	NM_172326.1 Latest version!	Rattus norvegicus elaC ribonuclease Z 2 (Elac2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Elac2 ( NM_172326.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_758829.1 Rattus norvegicus elaC ribonuclease Z 2 (Elac2), mRNA.

Price & Availability↑

CloneID	ORa03295
Clone ID Related Accession (Same CDS sequence)	NM_172326.1
Accession Version	NM_172326.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2484bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	zinc phosphodiesterase ELAC protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY149902.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY149902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGTGGGCCC TCCGCTCGCT GCTGCGTCCC CTTGGCCTGC GCACCATGTC GCAGGGTTCG 
GCTCGCCGGC CGCGGCCTCC CAAAGACCCA CTGCGACACC TGCGCACGAG GGAGAAGCGC 
GGCCCGGGTT GGGGTCCCGG GGGCCCGAAC ACCGTGTACC TGCAGGTGGT GGCGGCGGGC 
GGCCGGGACG CGGCGGCTGC TCTCTACGTC TTCTCGGAAT ACAACAGGTA CCTTTTTAAC 
TGCGGAGAAG GCGTCCAACG ACTTATGCAG GAACACAAAC TGAAAGTCGC TCGCTTGGAC 
AACATATTTC TCACTCGGAT GCATTGGTCA AATGTTGGGG GTTTGTGTGG AATGATTTTA 
ACTTTAAAGG AAACCGGGCT TCCCAAATGC GTTCTGTCTG GACCTCCACA ACTGGAGAAA 
TATCTAGAAG CAATCAAAAT ATTTTCTGGT CCATTGAAAG GAATAGACCT GGCTGTGCGG 
CCTCACTCTG CACCAGAATA CAAGGATGAG ACCATGACTG TTTACCAGGT CCCTATCCAC 
AGTGAACGGA GGTGTGGAGA GCAAGAGCCA TCACGGAGCC CCAAAAGATC TCCCAACAGG 
CTCAGTCCCA AACAGTCGTC CTCAGACCCT GGATCCGCTG AAAATGGGCA GTGCCTTCCA 
GAGGGCAGCA GTGCAGGTGT CAACGGGAAA GCATGGGGCA GGGACCCCTC CTTAGTGGTA 
GCTTTTGTCT GCAAGCTTCA CTTGAGGAAA GGAAACTTCT TGGTGCTCAA AGCAAAGGAG 
CTGGGCCTTC CTGTTGGGAC GGCCGCCATT GCACCCATCA TTGCTGCTGT CAAGGACGGG 
AAGAGTATCA CTTATGAAGG AAGGGAGATT GCTGCTGAAG AGCTTTGTAC ACCACCAGAT 
CCTGGTCTCG TGTTCATCGT GGTAGAGTGT CCCGATGAAG GATTCATCCA GCCCATCTGT 
GAGAATGACA CCTTTCAAAG GTACCAGGGA GAGGCCGATG CACCTGTGGC AGTGGTGGTC 
CACATAGCCC CAGAATCTGT ACTCATCGAC AGCAGGTACC AGCAGTGGAT GGAGAGGTTC 
GGGCCTGACA CACAGCATCT GATTCTGAAT GAGAACTGCC CCTCAGTCCA CAACCTGCGC 
AGCCACAAGA TTCAGACTCA GCTCAGCCTC ATCCACCCGG ACATCTTCCC TCAGCTCACC 
AGCTTCCACA GTAAGGAGGA AGGTTCTACC TTCAGCTTGC CGACAGTTCG GGGTGAATGC 
CTTCTCAAGT ATCACGTCCG CCCCAAGAGA GAGTGGCAGA GGGACACCAC ACTCGACTGC 
AATACTGATG AATTCATAGC TGAGGCCTTG GAGCTCCCCA ATTTCCAGGA GAGTGTGGAG 
GAGTACAGGA AGAATATGCA GGCCAGCCCA GCCCCAGCAG AGAAAAGAAG CCAGTATCCT 
GAAATTGTCT TCCTGGGTAC GGGGTCTGCC ATCCCAATGA AGATCCGAAA TGTCAGTTCC 
ACACTCGTCA ACCTAAGCCC TGACAAGTCT GTGCTGCTGG ATTGTGGAGA AGGCACTTTT 
GGGCAGTTAT GCCGTCATTA TGGACAGCAA ATAGACAGAG TCCTCTGCAA CCTTACTGCT 
GTGTTTGTGT CCCACCTGCA TGCGGACCAC CACACGGGCT TGTTGAATAT CTTGCTGCAG 
AGGGAGCATG CGCTGGCGTC TCTGGGGAAA CCTTTTCAGC CCTTGCTAGT GGTGGCCCCT 
ACCCAGCTCA GGGCCTGGCT GCAGCAGTAT CACAATCAGT GCCAGGAGAT TCTGCATCAC 
ATCAGTATGA TTCCTGCCAA ATGCCTTCAG AAAGGAGCAG AGGTCCCCAG TCCCCCAGTT 
GAAAGGCTGA TCAGCTTGCT GTTGGAAACA TGTGACTTAC AAGAATTTCA GACCTGCCTG 
GTACGTCACT GCAAGCATGC TTTTGGCTGT GCGCTGGTGC ATTCATCTGG CTGGAAAGTG 
GTCTACTCAG GGGACACCAT GCCCTGTGAG GCTCTGGTCC AGATGGGGAA AGATGCCACC 
CTCCTGATAC ACGAAGCCAC TCTGGAGGAT GGCTTGGAAG AGGAAGCAGT GGAGAAGACG 
CATAGTACCA CCTCCCAGGC TATTGGTGTG GGGATGCGGA TGAATGCTGA GTTCATCATG 
CTGAACCACT TCAGTCAGCG GTACGCCAAG ATCCCCCTTT TCAGCCCTGA CTTCAATGAG 
AAAGTTGGCA TCGCCTTTGA CCACATGAAG GTCTGCTTTG GAGACTTCCC GACAGTGCCC 
AAGCTTATTC CTCCGCTGAA GGCCCTGTTT GCAGATGACA TTGAAGAGAT GGTGGAACGC 
AGGGAGAAGA GGGAGCTACG GCTGGTGCGG GCAGCCCTCC TGACTCAGCA GGCAGACAGC 
TCAGAGGACA GAGAACCCCA CCAGAAGCGG GCCCACTCAG AGGAACCACA CAGCCCACAG 
AGCAAGAAGG TCAGAGCCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758829.1
CDS	60..2543
Translation	MWALRSLLRPLGLRTMSQGSARRPRPPKDPLRHLRTREKRGPGWGPGGPNTVYLQVVAAGGRDAAAALYVFSEYNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLCGMILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIDLAVRPHSAPEYKDETMTVYQVPIHSERRCGEQEPSRSPKRSPNRLSPKQSSSDPGSAENGQCLPEGSSAGVNGKAWGRDPSLVVAFVCKLHLRKGNFLVLKAKELGLPVGTAAIAPIIAAVKDGKSITYEGREIAAEELCTPPDPGLVFIVVECPDEGFIQPICENDTFQRYQGEADAPVAVVVHIAPESVLIDSRYQQWMERFGPDTQHLILNENCPSVHNLRSHKIQTQLSLIHPDIFPQLTSFHSKEEGSTFSLPTVRGECLLKYHVRPKREWQRDTTLDCNTDEFIAEALELPNFQESVEEYRKNMQASPAPAEKRSQYPEIVFLGTGSAIPMKIRNVSSTLVNLSPDKSVLLDCGEGTFGQLCRHYGQQIDRVLCNLTAVFVSHLHADHHTGLLNILLQREHALASLGKPFQPLLVVAPTQLRAWLQQYHNQCQEILHHISMIPAKCLQKGAEVPSPPVERLISLLLETCDLQEFQTCLVRHCKHAFGCALVHSSGWKVVYSGDTMPCEALVQMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAIGVGMRMNAEFIMLNHFSQRYAKIPLFSPDFNEKVGIAFDHMKVCFGDFPTVPKLIPPLKALFADDIEEMVERREKRELRLVRAALLTQQADSSEDREPHQKRAHSEEPHSPQSKKVRAQ

Target ORF information:

RefSeq Version	NM_172326.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus elaC ribonuclease Z 2 (Elac2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172326.1

ORF Insert Sequence:

ATGTGGGCCC TCCGCTCGCT GCTGCGTCCC CTTGGCCTGC GCACCATGTC GCAGGGTTCG 
GCTCGCCGGC CGCGGCCTCC CAAAGACCCA CTGCGACACC TGCGCACGAG GGAGAAGCGC 
GGCCCGGGTT GGGGTCCCGG GGGCCCGAAC ACCGTGTACC TGCAGGTGGT GGCGGCGGGC 
GGCCGGGACG CGGCGGCTGC TCTCTACGTC TTCTCGGAAT ACAACAGGTA CCTTTTTAAC 
TGCGGAGAAG GCGTCCAACG ACTTATGCAG GAACACAAAC TGAAAGTCGC TCGCTTGGAC 
AACATATTTC TCACTCGGAT GCATTGGTCA AATGTTGGGG GTTTGTGTGG AATGATTTTA 
ACTTTAAAGG AAACCGGGCT TCCCAAATGC GTTCTGTCTG GACCTCCACA ACTGGAGAAA 
TATCTAGAAG CAATCAAAAT ATTTTCTGGT CCATTGAAAG GAATAGACCT GGCTGTGCGG 
CCTCACTCTG CACCAGAATA CAAGGATGAG ACCATGACTG TTTACCAGGT CCCTATCCAC 
AGTGAACGGA GGTGTGGAGA GCAAGAGCCA TCACGGAGCC CCAAAAGATC TCCCAACAGG 
CTCAGTCCCA AACAGTCGTC CTCAGACCCT GGATCCGCTG AAAATGGGCA GTGCCTTCCA 
GAGGGCAGCA GTGCAGGTGT CAACGGGAAA GCATGGGGCA GGGACCCCTC CTTAGTGGTA 
GCTTTTGTCT GCAAGCTTCA CTTGAGGAAA GGAAACTTCT TGGTGCTCAA AGCAAAGGAG 
CTGGGCCTTC CTGTTGGGAC GGCCGCCATT GCACCCATCA TTGCTGCTGT CAAGGACGGG 
AAGAGTATCA CTTATGAAGG AAGGGAGATT GCTGCTGAAG AGCTTTGTAC ACCACCAGAT 
CCTGGTCTCG TGTTCATCGT GGTAGAGTGT CCCGATGAAG GATTCATCCA GCCCATCTGT 
GAGAATGACA CCTTTCAAAG GTACCAGGGA GAGGCCGATG CACCTGTGGC AGTGGTGGTC 
CACATAGCCC CAGAATCTGT ACTCATCGAC AGCAGGTACC AGCAGTGGAT GGAGAGGTTC 
GGGCCTGACA CACAGCATCT GATTCTGAAT GAGAACTGCC CCTCAGTCCA CAACCTGCGC 
AGCCACAAGA TTCAGACTCA GCTCAGCCTC ATCCACCCGG ACATCTTCCC TCAGCTCACC 
AGCTTCCACA GTAAGGAGGA AGGTTCTACC TTCAGCTTGC CGACAGTTCG GGGTGAATGC 
CTTCTCAAGT ATCACGTCCG CCCCAAGAGA GAGTGGCAGA GGGACACCAC ACTCGACTGC 
AATACTGATG AATTCATAGC TGAGGCCTTG GAGCTCCCCA ATTTCCAGGA GAGTGTGGAG 
GAGTACAGGA AGAATATGCA GGCCAGCCCA GCCCCAGCAG AGAAAAGAAG CCAGTATCCT 
GAAATTGTCT TCCTGGGTAC GGGGTCTGCC ATCCCAATGA AGATCCGAAA TGTCAGTTCC 
ACACTCGTCA ACCTAAGCCC TGACAAGTCT GTGCTGCTGG ATTGTGGAGA AGGCACTTTT 
GGGCAGTTAT GCCGTCATTA TGGACAGCAA ATAGACAGAG TCCTCTGCAA CCTTACTGCT 
GTGTTTGTGT CCCACCTGCA TGCGGACCAC CACACGGGCT TGTTGAATAT CTTGCTGCAG 
AGGGAGCATG CGCTGGCGTC TCTGGGGAAA CCTTTTCAGC CCTTGCTAGT GGTGGCCCCT 
ACCCAGCTCA GGGCCTGGCT GCAGCAGTAT CACAATCAGT GCCAGGAGAT TCTGCATCAC 
ATCAGTATGA TTCCTGCCAA ATGCCTTCAG AAAGGAGCAG AGGTCCCCAG TCCCCCAGTT 
GAAAGGCTGA TCAGCTTGCT GTTGGAAACA TGTGACTTAC AAGAATTTCA GACCTGCCTG 
GTACGTCACT GCAAGCATGC TTTTGGCTGT GCGCTGGTGC ATTCATCTGG CTGGAAAGTG 
GTCTACTCAG GGGACACCAT GCCCTGTGAG GCTCTGGTCC AGATGGGGAA AGATGCCACC 
CTCCTGATAC ACGAAGCCAC TCTGGAGGAT GGCTTGGAAG AGGAAGCAGT GGAGAAGACG 
CATAGTACCA CCTCCCAGGC TATTGGTGTG GGGATGCGGA TGAATGCTGA GTTCATCATG 
CTGAACCACT TCAGTCAGCG GTACGCCAAG ATCCCCCTTT TCAGCCCTGA CTTCAATGAG 
AAAGTTGGCA TCGCCTTTGA CCACATGAAG GTCTGCTTTG GAGACTTCCC GACAGTGCCC 
AAGCTTATTC CTCCGCTGAA GGCCCTGTTT GCAGATGACA TTGAAGAGAT GGTGGAACGC 
AGGGAGAAGA GGGAGCTACG GCTGGTGCGG GCAGCCCTCC TGACTCAGCA GGCAGACAGC 
TCAGAGGACA GAGAACCCCA CCAGAAGCGG GCCCACTCAG AGGAACCACA CAGCCCACAG 
AGCAAGAAGG TCAGAGCCCA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.
Cell metabolism19(4)618-29(2014 Apr)
Bogenhagen DF,Martin DW,Koller A

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanhäusser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.
RNA biology8(4)616-26(2011 Jul-Aug)
Brzezniak LK,Bijata M,Szczesny RJ,Stepien PP

3' processing of eukaryotic precursor tRNAs.
Wiley interdisciplinary reviews. RNA2(3)362-75(2011 May-Jun)
Maraia RJ,Lamichhane TN

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Elac2 cDNA ORF clone, Rattus norvegicus(Norway rat)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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