Clrn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Clrn1
Entrez Gene ID	261738
Full Name	clarin 1
Synonyms	Ush3,Ush3a
General protein information	Preferred Names clarin 1 Names clarin-1 Usher syndrome 3A homolog Usher syndrome type III A usher syndrome type-3 protein homolog
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q26
Summary	gene associated with Usher syndrome type III is an autosomal recessive disorder characterized by progressive sensorineural hearing loss, vestibular dysfunction, and retinitis pigmentosa [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_153299.2	NP_695211.2	clarin-1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CLRN1	NP_001182723.1
Mus musculus (house mouse)	Clrn1	NP_700434.1
Gallus gallus (chicken)	CLRN1	XP_004943634.1
Canis lupus familiaris (dog)	CLRN1	XP_854563.1
Danio rerio (zebrafish)	clrn1	NP_001002671.1
Xenopus tropicalis (tropical clawed frog)	clrn1	XP_002937147.2
Pan troglodytes (chimpanzee)	CLRN1	XP_003310099.1
Bos taurus (cattle)	CLRN1	NP_001179030.1
Rattus norvegicus (Norway rat)	Clrn1	NP_695211.2
Macaca mulatta (Rhesus monkey)	CLRN1	XP_001107584.1

Gene Ontology
Bibliography

Related articles in PubMed

Genes and mutations causing retinitis pigmentosa.
Daiger SP, Sullivan LS, Bowne SJ
Clinical genetics84(2)132-41(2013 Aug)

Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors.
Zallocchi M, Meehan DT, Delimont D, Askew C, Garige S, Gratton MA, Rothermund-Franklin CA, Cosgrove D
Hearing research255(1-2)109-20(2009 Sep)

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation.
Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG
Human molecular genetics18(15)2748-60(2009 Aug)

Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton.
Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y
The Journal of biological chemistry284(28)18980-93(2009 Jul)

Two truncating USH3A mutations, including one novel, in a German family with Usher syndrome.
Ebermann I, Wilke R, Lauhoff T, Lübben D, Zrenner E, Bolz HJ
Molecular vision131539-47(2007 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Clrn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clrn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02949	NM_153299.2 Latest version!	Rattus norvegicus clarin 1 (Clrn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Clrn1 ( NM_153299.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_695211.2 Rattus norvegicus clarin 1 (Clrn1), mRNA.

Price & Availability↑

CloneID	ORa02949
Clone ID Related Accession (Same CDS sequence)	NM_153299.2
Accession Version	NM_153299.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 699bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1550764800000
Organism	Rattus norvegicus(Norway rat)
Product	clarin-1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07010718.1 and AABR07010717.1. On May 11, 2012 this sequence version replaced NM_153299.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF482698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCAAGCC AGCAGAAGAA GATCATCTTT TGCATGGCTG GCGTATTGAG CTTTCTCTGT 
GCTCTCGGAG TGGTGACCGC AGTGGGAACC CCACTGTGGG TGAAAGCCAC TATCCTCTGC 
AAAACAGGGG CTCTGCTTGT CAATGCGTCA GGGAAGGAGC TGGACAAGTT CATGGGCGAG 
ATGCAGTATG GTCTTTTCCA CGGAGAAGGC GTAAGGCAAT GCGGGTTAGG AGCAAGGCCT 
TTCCGGTTCT CATTCTTCCC AGATTTGGTT CAAGCCATCC CTGTAAGCAT CCACGTCAAT 
ATTATTCTCT TCTCCATGAT TCTTGTCGTC TTAACCATGG TGGGGACAGC CTTCTTCATG 
TACAATGCTT TTGGCAAGCC CTTTGAAACT CTGCATGGAC CACTGGGGCT CTATCTGGTC 
AGCTTCATTT CAGGATCCTG TGGCTGTCTT GTCATGATAC TGTTTGCCTC TGAAGTGAAA 
ATCCACCGCC TTTCAGAGAA AATTGCAAAT TTTAAAGAAG GGACCTATGC CTACAAAACG 
CAAAACGAAA ACTATACCAC CTCATTCTGG GTTGTTTTCA TTTGCTTTTT TGTTCATTTT 
TTGAATGGGC TCCTGATACG ACTTGCTGGA TTTCAGTTCC CTTTCACAAA ATCTAAAGAA 
ACAGAGACCA CTAACGTAGC TTCAGATTTA ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_695211.2
CDS	45..743
Translation	MPSQQKKIIFCMAGVLSFLCALGVVTAVGTPLWVKATILCKTGALLVNASGKELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLVQAIPVSIHVNIILFSMILVVLTMVGTAFFMYNAFGKPFETLHGPLGLYLVSFISGSCGCLVMILFASEVKIHRLSEKIANFKEGTYAYKTQNENYTTSFWVVFICFFVHFLNGLLIRLAGFQFPFTKSKETETTNVASDLMY

Target ORF information:

RefSeq Version	NM_153299.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus clarin 1 (Clrn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153299.2

ORF Insert Sequence:

ATGCCAAGCC AGCAGAAGAA GATCATCTTT TGCATGGCTG GCGTATTGAG CTTTCTCTGT 
GCTCTCGGAG TGGTGACCGC AGTGGGAACC CCACTGTGGG TGAAAGCCAC TATCCTCTGC 
AAAACAGGGG CTCTGCTTGT CAATGCGTCA GGGAAGGAGC TGGACAAGTT CATGGGCGAG 
ATGCAGTATG GTCTTTTCCA CGGAGAAGGC GTAAGGCAAT GCGGGTTAGG AGCAAGGCCT 
TTCCGGTTCT CATTCTTCCC AGATTTGGTT CAAGCCATCC CTGTAAGCAT CCACGTCAAT 
ATTATTCTCT TCTCCATGAT TCTTGTCGTC TTAACCATGG TGGGGACAGC CTTCTTCATG 
TACAATGCTT TTGGCAAGCC CTTTGAAACT CTGCATGGAC CACTGGGGCT CTATCTGGTC 
AGCTTCATTT CAGGATCCTG TGGCTGTCTT GTCATGATAC TGTTTGCCTC TGAAGTGAAA 
ATCCACCGCC TTTCAGAGAA AATTGCAAAT TTTAAAGAAG GGACCTATGC CTACAAAACG 
CAAAACGAAA ACTATACCAC CTCATTCTGG GTTGTTTTCA TTTGCTTTTT TGTTCATTTT 
TTGAATGGGC TCCTGATACG ACTTGCTGGA TTTCAGTTCC CTTTCACAAA ATCTAAAGAA 
ACAGAGACCA CTAACGTAGC TTCAGATTTA ATGTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genes and mutations causing retinitis pigmentosa.
Clinical genetics84(2)132-41(2013 Aug)
Daiger SP,Sullivan LS,Bowne SJ

Localization and expression of clarin-1, the Clrn1 gene product, in auditory hair cells and photoreceptors.
Hearing research255(1-2)109-20(2009 Sep)
Zallocchi M,Meehan DT,Delimont D,Askew C,Garige S,Gratton MA,Rothermund-Franklin CA,Cosgrove D

Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation.
Human molecular genetics18(15)2748-60(2009 Aug)
Geng R,Geller SF,Hayashi T,Ray CA,Reh TA,Bermingham-McDonogh O,Jones SM,Wright CG,Melki S,Imanishi Y,Palczewski K,Alagramam KN,Flannery JG

Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton.
The Journal of biological chemistry284(28)18980-93(2009 Jul)
Tian G,Zhou Y,Hajkova D,Miyagi M,Dinculescu A,Hauswirth WW,Palczewski K,Geng R,Alagramam KN,Isosomppi J,Sankila EM,Flannery JG,Imanishi Y

Two truncating USH3A mutations, including one novel, in a German family with Usher syndrome.
Molecular vision131539-47(2007 Aug)
Ebermann I,Wilke R,Lauhoff T,Lübben D,Zrenner E,Bolz HJ

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Clrn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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