Dclre1c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dclre1c
Entrez Gene ID	259171
Full Name	DNA cross-link repair 1C
Synonyms	Snm1l
General protein information	Preferred Names DNA cross-link repair 1C Names protein artemis DNA cross-link repair 1C protein SNM1-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.3
Summary	mouse homolog plays a role in non-homologous end joining DNA repair during VDJ recombination [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017600460.1	XP_017455949.1	protein artemis isoform X1
NM_147145.2	NP_671486.2	protein artemis

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DCLRE1C	NP_001093847.1
Gallus gallus (chicken)	DCLRE1C	NP_001026765.1
Macaca mulatta (Rhesus monkey)	DCLRE1C	XP_002805614.1
Rattus norvegicus (Norway rat)	Dclre1c	NP_671486.2
Danio rerio (zebrafish)	dclre1c	NP_001038566.1
Xenopus tropicalis (tropical clawed frog)	dclre1c	XP_002935298.1
Homo sapiens (human)	DCLRE1C	NP_001029027.1
Pan troglodytes (chimpanzee)	DCLRE1C	XP_001147049.1
Mus musculus (house mouse)	Dclre1c	NP_666226.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000597	XP_310480.2
Canis lupus familiaris (dog)	DCLRE1C	XP_544251.2

Gene Ontology
Bibliography

Related articles in PubMed

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.
Volk T, Pannicke U, Reisli I, Bulashevska A, Ritter J, Björkman A, Schäffer AA, Fliegauf M, Sayar EH, Salzer U, Fisch P, Pfeifer D, Di Virgilio M, Cao H, Yang F, Zimmermann K, Keles S, Caliskaner Z, Güner SÜ, Schindler D, Hammarström L, Rizzi M, Hummel M, Pan-Hammarström Q, Schwarz K, Grimbacher B
Human molecular genetics24(25)7361-72(2015 Dec)

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K, Malewicz M
Cell death and differentiation22(6)890-7(2015 Jun)

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP
Molecular and cellular biology33(18)3568-79(2013 Sep)

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
Lieber MR
Annual review of biochemistry79181-211(2010)

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
Rooney S, Alt FW, Lombard D, Whitlow S, Eckersdorff M, Fleming J, Fugmann S, Ferguson DO, Schatz DG, Sekiguchi J
The Journal of experimental medicine197(5)553-65(2003 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Dclre1c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dclre1c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02818	NM_147145.2 Latest version!	Rattus norvegicus DNA cross-link repair 1C (Dclre1c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
ORa58999	XM_017600460.1 Latest version!	Rattus norvegicus DNA cross-link repair 1C (Dclre1c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dclre1c ( NM_147145.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_671486.2 Rattus norvegicus DNA cross-link repair 1C (Dclre1c), mRNA.

Price & Availability↑

CloneID	ORa02818
Clone ID Related Accession (Same CDS sequence)	NM_147145.2
Accession Version	NM_147145.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2097bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577203200000
Organism	Rattus norvegicus(Norway rat)
Product	protein artemis
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083546.1. On Dec 7, 2007 this sequence version replaced NM_147145.1. ##Evidence-Data-START## Transcript exon combination :: BC083546.1, AF395746.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGTTCTT TCCAGGGACA GATGGAGGAA TATCCAACCA TCTCCATTGA CCGCTTCGAC 
AGAGAGAACC TGAAAGCCCG TGCCTACTTC CTTTCGCACT GCCACAAGGA TCACATGAAA 
GGATTAAGGG CTCCTTCCAT GAAAAGAAGG CTGGAATGCA GTTTGAAGGT CTTCCTGTAC 
TGTTCTCCAG TCACTAAGGA GCTGCTCTTA ACCAGCCCAA AGTACAAGTT CTGGGAAAAC 
CGAATTATAG CAATTGAAAT TGAAACTCCT ACCCAGGTAT CTTTAGTTGA TGAGGCATCG 
GGTGAGAAGG AAGAAGTTGT TGTGACTCTC TTACCAGCTG GTCACTGCCC AGGTTCAGTT 
ATGTTTCTAT TTCAGGGCAG TAATGGAACT GTCTTATACA CAGGAGACTT CAGACTGGCG 
AAAGGAGAAG TTTCCAGAAT GGAGCTTCTG CACTCTGGGG GCAGAGTAAA AGACATCCAA 
AGTGTATATT TAGACACCAC TTTCTGTGAC CCAAGGTTTT ATCAAATTCC AAGTCGTGAG 
GAGTGCTTGA GGGGCGTTCT GGAGCTGGTT CGGAGCTGGA TCACGAGGAG TCCGAAGCAC 
GTCGTGTGGC TGAACTGCAA GGCCGCCTAC GGCTATGAGT ACTTATTCAC CAACCTGAGT 
GAGGAGCTGG GAGTCCAGGT TCATGTGGAC AAGCTGGACA TGTTTAAAAA CATGCCTGAT 
ATCCTGCACC ATCTCACAAC GGATCGAAAC ACCCAGATCC ACGCCTGCCG CCACCCGAAG 
GCAGAAGAGT ATTTTCAGTG GAATAAGTTA CCCTGTGGCA TGGCTTCCAA AACTAAAACT 
GTACTCCACA CAATCAGCAT CAAGCCATCT ACCATGTGGT TTGGAGAGAG GACCAGAAAA 
ACAAACGTGA TTGTGAGAAC CGGAGAGAGC TCATACAGAG CTTGCTTCTC TTTCCACTCC 
TCCTACAGTG AGATTAAAGA TTTTTTGAGC TACATCTGCC CAGTGAATGC GTATCCAAAT 
GTCATTCCGA TCGGCCTCAC TGTGGATAAG GTCATGGACT TTTTAAAGCC TCTGTGCCGC 
TCTTCCCAAT GTGCTGAACC AAAGTACAAG CCCCTCGGGA AACTGAAGAG AGCTAGAACA 
GTTCACCTTG ACTCAGAGGA AGATGATGAT CTCTTTGATG ACCCTCTACT AACACATTCA 
AGGCGCAAAG TTCCGTACCA AGTAACTCTT CACCCTGAGG TATTTTCAAT GAAGGCACTA 
CCGCTAGATC AGCCTGAACT GGGACAAAGC CCCGGATGCT GTAAAGCAGA GAGTATGCCG 
AGTCCTTCTT TGGCCAACTT TGTGGACTGT GACGAGTCCA ACAGTGACAG TGAAGGAGAG 
TTAGAGACCC CGCCTTCTCT GCAGGGAGGT CTCGGCCCCA CAACACTCCC ACAGCAAAAC 
GCTGATCCGG ATGTGGATGT ACCTCGGTGG GAAGTATTCT TCAAAAGAAA AGATGAAATC 
ACAGATGAAT GTTTGGAAAA CTTACCTTCC TCCATAGAGA CAGGGGGATC GCAGTCACCA 
AAGCGTTTCA GTGACTCACC AAAGCTGGGC AGTGACTCTG ATGGAGAATC CACCCATATC 
TCTTCCCAGA ATTCATCTCA GTCAACCCAC ATAACGGATC AAGGAAGCCA AGGCTGGGAC 
AGCCAGTGTG ATACCGTTTT GTTATCTTCC CAAGAGAAAA GTGGTGGGGA TAGCACCTCT 
TTGAACAAGG ATACCTACAA ACCAAAACCC AAAGATAGTA TTTCTGCCTC CCAAATAGAA 
CAGAATGCAC TTTGTCCACA GGATACTCAC TGTGATTTGA AAAGCGGAGC TGAAGTAAAT 
GGAGTCCCTT GTATTGAAGA ACCAGACACT GTGAGTGGCA GGAAATCTTC ACCTGAGAAA 
ACATCGCTAA CCAGCACACA GGCAGACTCA CAGAGCTCCT CTGACTTTGA AATCCCCTCA 
ACTCCAGAAG CTGAGCTTCC CAAGCCAGAG CATTTACAGT TCTTATATGG AAAGCTGGCA 
ACAGGTGAGA GTATAGTGTT GAAAAAAGAA AATGTTCACT CCCAGATATT TAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_671486.2
CDS	24..2120
Translation	MSSFQGQMEEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRAPSMKRRLECSLKVFLYCSPVTKELLLTSPKYKFWENRIIAIEIETPTQVSLVDEASGEKEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEVSRMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLRGVLELVRSWITRSPKHVVWLNCKAAYGYEYLFTNLSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEEYFQWNKLPCGMASKTKTVLHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYICPVNAYPNVIPIGLTVDKVMDFLKPLCRSSQCAEPKYKPLGKLKRARTVHLDSEEDDDLFDDPLLTHSRRKVPYQVTLHPEVFSMKALPLDQPELGQSPGCCKAESMPSPSLANFVDCDESNSDSEGELETPPSLQGGLGPTTLPQQNADPDVDVPRWEVFFKRKDEITDECLENLPSSIETGGSQSPKRFSDSPKLGSDSDGESTHISSQNSSQSTHITDQGSQGWDSQCDTVLLSSQEKSGGDSTSLNKDTYKPKPKDSISASQIEQNALCPQDTHCDLKSGAEVNGVPCIEEPDTVSGRKSSPEKTSLTSTQADSQSSSDFEIPSTPEAELPKPEHLQFLYGKLATGESIVLKKENVHSQIFK

Target ORF information:

RefSeq Version	NM_147145.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA cross-link repair 1C (Dclre1c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_147145.2

ORF Insert Sequence:

ATGAGTTCTT TCCAGGGACA GATGGAGGAA TATCCAACCA TCTCCATTGA CCGCTTCGAC 
AGAGAGAACC TGAAAGCCCG TGCCTACTTC CTTTCGCACT GCCACAAGGA TCACATGAAA 
GGATTAAGGG CTCCTTCCAT GAAAAGAAGG CTGGAATGCA GTTTGAAGGT CTTCCTGTAC 
TGTTCTCCAG TCACTAAGGA GCTGCTCTTA ACCAGCCCAA AGTACAAGTT CTGGGAAAAC 
CGAATTATAG CAATTGAAAT TGAAACTCCT ACCCAGGTAT CTTTAGTTGA TGAGGCATCG 
GGTGAGAAGG AAGAAGTTGT TGTGACTCTC TTACCAGCTG GTCACTGCCC AGGTTCAGTT 
ATGTTTCTAT TTCAGGGCAG TAATGGAACT GTCTTATACA CAGGAGACTT CAGACTGGCG 
AAAGGAGAAG TTTCCAGAAT GGAGCTTCTG CACTCTGGGG GCAGAGTAAA AGACATCCAA 
AGTGTATATT TAGACACCAC TTTCTGTGAC CCAAGGTTTT ATCAAATTCC AAGTCGTGAG 
GAGTGCTTGA GGGGCGTTCT GGAGCTGGTT CGGAGCTGGA TCACGAGGAG TCCGAAGCAC 
GTCGTGTGGC TGAACTGCAA GGCCGCCTAC GGCTATGAGT ACTTATTCAC CAACCTGAGT 
GAGGAGCTGG GAGTCCAGGT TCATGTGGAC AAGCTGGACA TGTTTAAAAA CATGCCTGAT 
ATCCTGCACC ATCTCACAAC GGATCGAAAC ACCCAGATCC ACGCCTGCCG CCACCCGAAG 
GCAGAAGAGT ATTTTCAGTG GAATAAGTTA CCCTGTGGCA TGGCTTCCAA AACTAAAACT 
GTACTCCACA CAATCAGCAT CAAGCCATCT ACCATGTGGT TTGGAGAGAG GACCAGAAAA 
ACAAACGTGA TTGTGAGAAC CGGAGAGAGC TCATACAGAG CTTGCTTCTC TTTCCACTCC 
TCCTACAGTG AGATTAAAGA TTTTTTGAGC TACATCTGCC CAGTGAATGC GTATCCAAAT 
GTCATTCCGA TCGGCCTCAC TGTGGATAAG GTCATGGACT TTTTAAAGCC TCTGTGCCGC 
TCTTCCCAAT GTGCTGAACC AAAGTACAAG CCCCTCGGGA AACTGAAGAG AGCTAGAACA 
GTTCACCTTG ACTCAGAGGA AGATGATGAT CTCTTTGATG ACCCTCTACT AACACATTCA 
AGGCGCAAAG TTCCGTACCA AGTAACTCTT CACCCTGAGG TATTTTCAAT GAAGGCACTA 
CCGCTAGATC AGCCTGAACT GGGACAAAGC CCCGGATGCT GTAAAGCAGA GAGTATGCCG 
AGTCCTTCTT TGGCCAACTT TGTGGACTGT GACGAGTCCA ACAGTGACAG TGAAGGAGAG 
TTAGAGACCC CGCCTTCTCT GCAGGGAGGT CTCGGCCCCA CAACACTCCC ACAGCAAAAC 
GCTGATCCGG ATGTGGATGT ACCTCGGTGG GAAGTATTCT TCAAAAGAAA AGATGAAATC 
ACAGATGAAT GTTTGGAAAA CTTACCTTCC TCCATAGAGA CAGGGGGATC GCAGTCACCA 
AAGCGTTTCA GTGACTCACC AAAGCTGGGC AGTGACTCTG ATGGAGAATC CACCCATATC 
TCTTCCCAGA ATTCATCTCA GTCAACCCAC ATAACGGATC AAGGAAGCCA AGGCTGGGAC 
AGCCAGTGTG ATACCGTTTT GTTATCTTCC CAAGAGAAAA GTGGTGGGGA TAGCACCTCT 
TTGAACAAGG ATACCTACAA ACCAAAACCC AAAGATAGTA TTTCTGCCTC CCAAATAGAA 
CAGAATGCAC TTTGTCCACA GGATACTCAC TGTGATTTGA AAAGCGGAGC TGAAGTAAAT 
GGAGTCCCTT GTATTGAAGA ACCAGACACT GTGAGTGGCA GGAAATCTTC ACCTGAGAAA 
ACATCGCTAA CCAGCACACA GGCAGACTCA CAGAGCTCCT CTGACTTTGA AATCCCCTCA 
ACTCCAGAAG CTGAGCTTCC CAAGCCAGAG CATTTACAGT TCTTATATGG AAAGCTGGCA 
ACAGGTGAGA GTATAGTGTT GAAAAAAGAA AATGTTCACT CCCAGATATT TAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Dclre1c ( XM_017600460.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017455949.1 Rattus norvegicus DNA cross-link repair 1C (Dclre1c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa58999
Clone ID Related Accession (Same CDS sequence)	XM_017600460.1
Accession Version	XM_017600460.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	protein artemis isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005116.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAATCAG AAGTGCTTCT CTACTTACTC TCTTTTCAGA TAGCAATTGA AATTGAAACT 
CCTACCCAGG TATCTTTAGT TGATGAGGCA TCGGGTGAGA AGGAAGAAGT TGTTGTGACT 
CTCTTACCAG CTGGTCACTG CCCAGGTTCA GTTATGTTTC TATTTCAGGG CAGTAATGGA 
ACTGTCTTAT ACACAGGAGA CTTCAGACTG GCGAAAGGAG AAGTTTCCAG AATGGAGCTT 
CTGCACTCTG GGGGCAGAGT AAAAGACATC CAAAGTGTAT ATTTAGACAC CACTTTCTGT 
GACCCAAGGT TTTATCAAAT TCCAAGTCGT GAGGAGTGCT TGAGGGGCGT TCTGGAGCTG 
GTTCGGAGCT GGATCACGAG GAGTCCGAAG CACGTCGTGT GGCTGAACTG CAAGGCCGCC 
TACGGCTATG AGTACTTATT CACCAACCTG AGTGAGGAGC TGGGAGTCCA GGTTCATGTG 
GACAAGCTGG ACATGTTTAA AAACATGCCT GATATCCTGC ACCATCTCAC AACGGATCGA 
AACACCCAGA TCCACGCCTG CCGCCACCCG AAGGCAGAAG AGTATTTTCA GTGGAATAAG 
TTACCCTGTG GCATGGCTTC CAAAACTAAA ACTGTACTCC ACACAATCAG CATCAAGCCA 
TCTACCATGT GGTTTGGAGA GAGGACCAGA AAAACAAACG TGATTGTGAG AACCGGAGAG 
AGCTCATACA GAGCTTGCTT CTCTTTCCAC TCCTCCTACA GTGAGATTAA AGATTTTTTG 
AGCTACATCT GCCCAGTGAA TGCGTATCCA AATGTCATTC CGATCGGCCT CACTGTGGAT 
AAGGTCATGG ACTTTTTAAA GCCTCTGTGC CGCTCTTCCC AATGTGCTGA ACCAAAGTAC 
AAGCCCCTCG GGAAACTGAA GAGAGCTAGA ACAGTTCACC TTGACTCAGA GGAAGATGAT 
GATCTCTTTG ATGACCCTCT ACTAACACAT TCAAGGCGCA AAGTTCCGTA CCAAGTAACT 
CTTCACCCTG AGGTATTTTC AATGAAGGCA CTACCGCTAG ATCAGCCTGA ACTGGGACAA 
AGCCCCGGAT GCTGTAAAGC AGAGAGTATG CCGAGTCCTT CTTTGGCCAA CTTTGTGGAC 
TGTGACGAGT CCAACAGTGA CAGTGAAGGA GAGTTAGAGA CCCCGCCTTC TCTGCAGGGA 
GGTCTCGGCC CCACAACACT CCCACAGCAA AACGCTGATC CGGATGTGGA TGTACCTCGG 
TGGGAAGTAT TCTTCAAAAG AAAAGATGAA ATCACAGATG AATGTTTGGA AAACTTACCT 
TCCTCCATAG AGACAGGGGG ATCGCAGTCA CCAAAGCGTT TCAGTGACTC ACCAAAGCTG 
GGCAGTGACT CTGATGGAGA ATCCACCCAT ATCTCTTCCC AGAATTCATC TCAGTCAACC 
CACATAACGG ATCAAGGAAG CCAAGGCTGG GACAGCCAGT GTGATACCGT TTTGTTATCT 
TCCCAAGAGA AAAGTGGTGG GGATAGCACC TCTTTGAACA AGGATACCTA CAAACCAAAA 
CCCAAAGATA GTATTTCTGC CTCCCAAATA GAACAGAATG CACTTTGTCC ACAGGATACT 
CACTGTGATT TGAAAAGCGG AGCTGAAGTA AATGGAGTCC CTTGTATTGA AGAACCAGAC 
ACTGTGAGTG GCAGGAAATC TTCACCTGAG AAAACATCGC TAACCAGCAC ACAGGCAGAC 
TCACAGAGCT CCTCTGACTT TGAAATCCCC TCAACTCCAG AAGCTGAGCT TCCCAAGCCA 
GAGCATTTAC AGTTCTTATA TGGAAAGCTG GCAACAGGTG AGAGTATAGT GTTGAAAAAA 
GAAAATGTTC ACTCCCAGAT ATTTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017455949.1
CDS	1429..3318
Translation	MKSEVLLYLLSFQIAIEIETPTQVSLVDEASGEKEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEVSRMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLRGVLELVRSWITRSPKHVVWLNCKAAYGYEYLFTNLSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEEYFQWNKLPCGMASKTKTVLHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYICPVNAYPNVIPIGLTVDKVMDFLKPLCRSSQCAEPKYKPLGKLKRARTVHLDSEEDDDLFDDPLLTHSRRKVPYQVTLHPEVFSMKALPLDQPELGQSPGCCKAESMPSPSLANFVDCDESNSDSEGELETPPSLQGGLGPTTLPQQNADPDVDVPRWEVFFKRKDEITDECLENLPSSIETGGSQSPKRFSDSPKLGSDSDGESTHISSQNSSQSTHITDQGSQGWDSQCDTVLLSSQEKSGGDSTSLNKDTYKPKPKDSISASQIEQNALCPQDTHCDLKSGAEVNGVPCIEEPDTVSGRKSSPEKTSLTSTQADSQSSSDFEIPSTPEAELPKPEHLQFLYGKLATGESIVLKKENVHSQIFK

Target ORF information:

RefSeq Version	XM_017600460.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus DNA cross-link repair 1C (Dclre1c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017600460.1

ORF Insert Sequence:

ATGAAATCAG AAGTGCTTCT CTACTTACTC TCTTTTCAGA TAGCAATTGA AATTGAAACT 
CCTACCCAGG TATCTTTAGT TGATGAGGCA TCGGGTGAGA AGGAAGAAGT TGTTGTGACT 
CTCTTACCAG CTGGTCACTG CCCAGGTTCA GTTATGTTTC TATTTCAGGG CAGTAATGGA 
ACTGTCTTAT ACACAGGAGA CTTCAGACTG GCGAAAGGAG AAGTTTCCAG AATGGAGCTT 
CTGCACTCTG GGGGCAGAGT AAAAGACATC CAAAGTGTAT ATTTAGACAC CACTTTCTGT 
GACCCAAGGT TTTATCAAAT TCCAAGTCGT GAGGAGTGCT TGAGGGGCGT TCTGGAGCTG 
GTTCGGAGCT GGATCACGAG GAGTCCGAAG CACGTCGTGT GGCTGAACTG CAAGGCCGCC 
TACGGCTATG AGTACTTATT CACCAACCTG AGTGAGGAGC TGGGAGTCCA GGTTCATGTG 
GACAAGCTGG ACATGTTTAA AAACATGCCT GATATCCTGC ACCATCTCAC AACGGATCGA 
AACACCCAGA TCCACGCCTG CCGCCACCCG AAGGCAGAAG AGTATTTTCA GTGGAATAAG 
TTACCCTGTG GCATGGCTTC CAAAACTAAA ACTGTACTCC ACACAATCAG CATCAAGCCA 
TCTACCATGT GGTTTGGAGA GAGGACCAGA AAAACAAACG TGATTGTGAG AACCGGAGAG 
AGCTCATACA GAGCTTGCTT CTCTTTCCAC TCCTCCTACA GTGAGATTAA AGATTTTTTG 
AGCTACATCT GCCCAGTGAA TGCGTATCCA AATGTCATTC CGATCGGCCT CACTGTGGAT 
AAGGTCATGG ACTTTTTAAA GCCTCTGTGC CGCTCTTCCC AATGTGCTGA ACCAAAGTAC 
AAGCCCCTCG GGAAACTGAA GAGAGCTAGA ACAGTTCACC TTGACTCAGA GGAAGATGAT 
GATCTCTTTG ATGACCCTCT ACTAACACAT TCAAGGCGCA AAGTTCCGTA CCAAGTAACT 
CTTCACCCTG AGGTATTTTC AATGAAGGCA CTACCGCTAG ATCAGCCTGA ACTGGGACAA 
AGCCCCGGAT GCTGTAAAGC AGAGAGTATG CCGAGTCCTT CTTTGGCCAA CTTTGTGGAC 
TGTGACGAGT CCAACAGTGA CAGTGAAGGA GAGTTAGAGA CCCCGCCTTC TCTGCAGGGA 
GGTCTCGGCC CCACAACACT CCCACAGCAA AACGCTGATC CGGATGTGGA TGTACCTCGG 
TGGGAAGTAT TCTTCAAAAG AAAAGATGAA ATCACAGATG AATGTTTGGA AAACTTACCT 
TCCTCCATAG AGACAGGGGG ATCGCAGTCA CCAAAGCGTT TCAGTGACTC ACCAAAGCTG 
GGCAGTGACT CTGATGGAGA ATCCACCCAT ATCTCTTCCC AGAATTCATC TCAGTCAACC 
CACATAACGG ATCAAGGAAG CCAAGGCTGG GACAGCCAGT GTGATACCGT TTTGTTATCT 
TCCCAAGAGA AAAGTGGTGG GGATAGCACC TCTTTGAACA AGGATACCTA CAAACCAAAA 
CCCAAAGATA GTATTTCTGC CTCCCAAATA GAACAGAATG CACTTTGTCC ACAGGATACT 
CACTGTGATT TGAAAAGCGG AGCTGAAGTA AATGGAGTCC CTTGTATTGA AGAACCAGAC 
ACTGTGAGTG GCAGGAAATC TTCACCTGAG AAAACATCGC TAACCAGCAC ACAGGCAGAC 
TCACAGAGCT CCTCTGACTT TGAAATCCCC TCAACTCCAG AAGCTGAGCT TCCCAAGCCA 
GAGCATTTAC AGTTCTTATA TGGAAAGCTG GCAACAGGTG AGAGTATAGT GTTGAAAAAA 
GAAAATGTTC ACTCCCAGAT ATTTAAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.
Human molecular genetics24(25)7361-72(2015 Dec)
Volk T,Pannicke U,Reisli I,Bulashevska A,Ritter J,Björkman A,Schäffer AA,Fliegauf M,Sayar EH,Salzer U,Fisch P,Pfeifer D,Di Virgilio M,Cao H,Yang F,Zimmermann K,Keles S,Caliskaner Z,Güner SÜ,Schindler D,Hammarström L,Rizzi M,Hummel M,Pan-Hammarström Q,Schwarz K,Grimbacher B

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Cell death and differentiation22(6)890-7(2015 Jun)
Craxton A,Somers J,Munnur D,Jukes-Jones R,Cain K,Malewicz M

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.
Molecular and cellular biology33(18)3568-79(2013 Sep)
Lee BS,Gapud EJ,Zhang S,Dorsett Y,Bredemeyer A,George R,Callen E,Daniel JA,Osipovich O,Oltz EM,Bassing CH,Nussenzweig A,Lees-Miller S,Hammel M,Chen BP,Sleckman BP

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
Annual review of biochemistry79181-211(2010)
Lieber MR

Defective DNA repair and increased genomic instability in Artemis-deficient murine cells.
The Journal of experimental medicine197(5)553-65(2003 Mar)
Rooney S,Alt FW,Lombard D,Whitlow S,Eckersdorff M,Fleming J,Fugmann S,Ferguson DO,Schatz DG,Sekiguchi J

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Dclre1c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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