Mak cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mak
Entrez Gene ID	25677
Full Name	male germ cell-associated kinase
General protein information	Preferred Names male germ cell-associated kinase Names serine/threonine-protein kinase MAK
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p13
Summary	kinase; may have an important role in spermatogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_013136.1	NP_037268.1	serine/threonine-protein kinase MAK

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	MAK	XP_001088297.1
Xenopus tropicalis (tropical clawed frog)	mak	NP_001072807.1
Rattus norvegicus (Norway rat)	Mak	NP_037268.1
Danio rerio (zebrafish)	mak	NP_956240.1
Pan troglodytes (chimpanzee)	MAK	XP_003950767.1
Bos taurus (cattle)	MAK	NP_001039880.2
Homo sapiens (human)	MAK	NP_001229886.1
Mus musculus (house mouse)	Mak	NP_001139275.1
Oryza sativa (rice)	Os03g0847600	NP_001051886.1
Canis lupus familiaris (dog)	MAK	XP_003434222.1
Gallus gallus (chicken)	MAK	XP_418948.3
Arabidopsis thaliana (thale cress)	MHK	NP_001190712.1

Gene Ontology
Bibliography

Related articles in PubMed

Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.
Wang LY, Kung HJ
Oncogene31(24)2907-18(2012 Jun)

Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa.
Tucker BA, Scheetz TE, Mullins RF, DeLuca AP, Hoffmann JM, Johnston RM, Jacobson SG, Sheffield VC, Stone EM
Proceedings of the National Academy of Sciences of the United States of America108(34)E569-76(2011 Aug)

Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.
Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T
Proceedings of the National Academy of Sciences of the United States of America107(52)22671-6(2010 Dec)

Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ
Cancer research66(17)8439-47(2006 Sep)

High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome research14(4)750-7(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Mak gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mak cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02106	NM_013136.1 Latest version!	Rattus norvegicus male germ cell-associated kinase (Mak), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mak ( NM_013136.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_037268.1 Rattus norvegicus male germ cell-associated kinase (Mak), mRNA.

Price & Availability↑

CloneID	ORa02106
Clone ID Related Accession (Same CDS sequence)	NM_013136.1
Accession Version	NM_013136.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1869bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	serine/threonine-protein kinase MAK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M35862.1. ##Evidence-Data-START## Transcript exon combination :: M35862.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAACCGAT ATACAACCAT GAGGCAGCTG GGGGACGGCA CGTACGGGAG TGTGCTTATG 
GGCAAGAGCA ATGAGTCTGG GGAGCTGGTG GCAATCAAGA GGATGAAGAG AAAGTTCTAT 
TCTTGGGATG AGTGTATGAA CTTGCGAGAA GTTAAGTCCC TGAAGAAACT CAATCATGCC 
AATGTGATTA AACTAAAAGA AGTTATCAGA GAAAATGACC ATCTTTATTT TATATTTGAA 
TATATGAAAG AAAACCTCTA TCAGCTAATG AAAGACAGAA ACAAACTGTT CCCTGAGTCA 
GTCATCAGAA ATATTATGTA TCAAATACTA CAGGGGCTGG CATTTATCCA CAAACATGGC 
TTTTTTCACA GGGACATGAA ACCTGAGAAT TTGCTTTGCA TGGGTCCAGA GCTGGTGAAG 
ATTGCTGATT TTGGACTTGC GAGAGAATTA AGATCACAGC CACCATATAC TGACTATGTG 
TCTACCAGAT GGTACCGTGC TCCTGAAGTT TTGCTAAGGT CTTCAGTGTA CAGCTCTCCC 
ATTGACGTGT GGGCCGTGGG AAGTATAATG GCCGAGCTAT ATACGTTTAG ACCGCTTTTC 
CCAGGGACCA GTGAAGTTGA TGAGATCTTT AAAATTTGCC AAGTGTTAGG GACTCCCAAG 
AAAAGTGACT GGCCGGAGGG GTACCAGCTG GCATCCTCCA TGAACTTCCG CTTTCCCCAG 
TGCATTCCTA TAAACCTGAA AACTCTCATT CCCAATGCCA GTAGTGAGGC TATTCAGCTT 
ATGACAGAAA TGCTTAACTG GGATCCAAAG AAACGGCCAA CTGCAAGCCA GGCACTGAAG 
CACCCATATT TTCAAGTCGG TCAGGTATTG GGCCCTTCTG CACACCATCT GGATGCAAAA 
CAGACTTTGC ACAAGCAGCT GCAGCCTCCA GAGCCAAAGC CATCTTCCTC TGAACGGGAT 
CCTAAGCCTT TGCCAAACAT CCTTGATCAG CCTGCCGGGC AGCCCCAGCC AAAACAGGGC 
CACCAACCAC TGCAGGCCAT TCAGCCACCA CAGAACACAG TGGTTCAGCC ACCTCCAAAG 
CAGCAGGGTC ACCATAAGCA ACCACAAACG ATGTTTCCAA GTATCGTCAA AACCATACCA 
ACGAATCCAG TCAGCACAGT AGGCCATAAG GGGGCCCGGA GACGGTGGGG TCAGACAGTC 
TTCAAGTCTG GAGACAGCTG TGACAACATC GAGGACTGCG ACTTGGGAGC CTCCCACTCC 
AAGAAGCCGA GCATGGATGC CTTCAAGGAA AAAAAGAAGA AGGAGTCTCC ATTTCGGTTT 
CCAGAAGCAG GACTCCCAGT CTCCAACCAC TTGAAGGGGG AAAATAGAAA TTTACATGCA 
TCCTTAAAAT CTGACACAAA CTTGTCAACT GCTTCAACCG CTAAGCAGTA CTATTTGAAA 
CAATCAAGAT ACCTTCCGGG TGTGAACCCC AAGAACGTGT CTTTGGTAGC TGGCGGCAAG 
GATATAAATT CACACTCTTG GAATAATCAG CTATTTCCTA AGTCTCTGGG ATCCATGGGG 
GCGGACCTCG CTTTCAAGAG GAGTAACGCA GCAGGGAACC TTGGGAGCTA CAGCGCTTAC 
AGCCAGACGG GATGCGTGCC TTCCTTTCTC AAGAAAGAAG TGGGATCAGC TGGCCAGAGG 
ATCCACTTGG CGCCTCTGGG TGCGTCGGCT GCCGACTATA CCTGGAGCAC AAAAACTGGC 
CGAGGCCAGT TTTCAGGACG AACTTACAAT CCCACAGCCA AAAATCTCAA TATTGTGAAC 
CGCACACAGC CAGTCCCCTC GGTGCACGGG AGGACAGACT GGGTGGCTAA GTACGGAGGC 
CACCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_037268.1
CDS	237..2105
Translation	MNRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAFIHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRSSVYSSPIDVWAVGSIMAELYTFRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCIPINLKTLIPNASSEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSAHHLDAKQTLHKQLQPPEPKPSSSERDPKPLPNILDQPAGQPQPKQGHQPLQAIQPPQNTVVQPPPKQQGHHKQPQTMFPSIVKTIPTNPVSTVGHKGARRRWGQTVFKSGDSCDNIEDCDLGASHSKKPSMDAFKEKKKKESPFRFPEAGLPVSNHLKGENRNLHASLKSDTNLSTASTAKQYYLKQSRYLPGVNPKNVSLVAGGKDINSHSWNNQLFPKSLGSMGADLAFKRSNAAGNLGSYSAYSQTGCVPSFLKKEVGSAGQRIHLAPLGASAADYTWSTKTGRGQFSGRTYNPTAKNLNIVNRTQPVPSVHGRTDWVAKYGGHR

Target ORF information:

RefSeq Version	NM_013136.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus male germ cell-associated kinase (Mak), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013136.1

ORF Insert Sequence:

ATGAACCGAT ATACAACCAT GAGGCAGCTG GGGGACGGCA CGTACGGGAG TGTGCTTATG 
GGCAAGAGCA ATGAGTCTGG GGAGCTGGTG GCAATCAAGA GGATGAAGAG AAAGTTCTAT 
TCTTGGGATG AGTGTATGAA CTTGCGAGAA GTTAAGTCCC TGAAGAAACT CAATCATGCC 
AATGTGATTA AACTAAAAGA AGTTATCAGA GAAAATGACC ATCTTTATTT TATATTTGAA 
TATATGAAAG AAAACCTCTA TCAGCTAATG AAAGACAGAA ACAAACTGTT CCCTGAGTCA 
GTCATCAGAA ATATTATGTA TCAAATACTA CAGGGGCTGG CATTTATCCA CAAACATGGC 
TTTTTTCACA GGGACATGAA ACCTGAGAAT TTGCTTTGCA TGGGTCCAGA GCTGGTGAAG 
ATTGCTGATT TTGGACTTGC GAGAGAATTA AGATCACAGC CACCATATAC TGACTATGTG 
TCTACCAGAT GGTACCGTGC TCCTGAAGTT TTGCTAAGGT CTTCAGTGTA CAGCTCTCCC 
ATTGACGTGT GGGCCGTGGG AAGTATAATG GCCGAGCTAT ATACGTTTAG ACCGCTTTTC 
CCAGGGACCA GTGAAGTTGA TGAGATCTTT AAAATTTGCC AAGTGTTAGG GACTCCCAAG 
AAAAGTGACT GGCCGGAGGG GTACCAGCTG GCATCCTCCA TGAACTTCCG CTTTCCCCAG 
TGCATTCCTA TAAACCTGAA AACTCTCATT CCCAATGCCA GTAGTGAGGC TATTCAGCTT 
ATGACAGAAA TGCTTAACTG GGATCCAAAG AAACGGCCAA CTGCAAGCCA GGCACTGAAG 
CACCCATATT TTCAAGTCGG TCAGGTATTG GGCCCTTCTG CACACCATCT GGATGCAAAA 
CAGACTTTGC ACAAGCAGCT GCAGCCTCCA GAGCCAAAGC CATCTTCCTC TGAACGGGAT 
CCTAAGCCTT TGCCAAACAT CCTTGATCAG CCTGCCGGGC AGCCCCAGCC AAAACAGGGC 
CACCAACCAC TGCAGGCCAT TCAGCCACCA CAGAACACAG TGGTTCAGCC ACCTCCAAAG 
CAGCAGGGTC ACCATAAGCA ACCACAAACG ATGTTTCCAA GTATCGTCAA AACCATACCA 
ACGAATCCAG TCAGCACAGT AGGCCATAAG GGGGCCCGGA GACGGTGGGG TCAGACAGTC 
TTCAAGTCTG GAGACAGCTG TGACAACATC GAGGACTGCG ACTTGGGAGC CTCCCACTCC 
AAGAAGCCGA GCATGGATGC CTTCAAGGAA AAAAAGAAGA AGGAGTCTCC ATTTCGGTTT 
CCAGAAGCAG GACTCCCAGT CTCCAACCAC TTGAAGGGGG AAAATAGAAA TTTACATGCA 
TCCTTAAAAT CTGACACAAA CTTGTCAACT GCTTCAACCG CTAAGCAGTA CTATTTGAAA 
CAATCAAGAT ACCTTCCGGG TGTGAACCCC AAGAACGTGT CTTTGGTAGC TGGCGGCAAG 
GATATAAATT CACACTCTTG GAATAATCAG CTATTTCCTA AGTCTCTGGG ATCCATGGGG 
GCGGACCTCG CTTTCAAGAG GAGTAACGCA GCAGGGAACC TTGGGAGCTA CAGCGCTTAC 
AGCCAGACGG GATGCGTGCC TTCCTTTCTC AAGAAAGAAG TGGGATCAGC TGGCCAGAGG 
ATCCACTTGG CGCCTCTGGG TGCGTCGGCT GCCGACTATA CCTGGAGCAC AAAAACTGGC 
CGAGGCCAGT TTTCAGGACG AACTTACAAT CCCACAGCCA AAAATCTCAA TATTGTGAAC 
CGCACACAGC CAGTCCCCTC GGTGCACGGG AGGACAGACT GGGTGGCTAA GTACGGAGGC 
CACCGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.
Oncogene31(24)2907-18(2012 Jun)
Wang LY,Kung HJ

Exome sequencing and analysis of induced pluripotent stem cells identify the cilia-related gene male germ cell-associated kinase (MAK) as a cause of retinitis pigmentosa.
Proceedings of the National Academy of Sciences of the United States of America108(34)E569-76(2011 Aug)
Tucker BA,Scheetz TE,Mullins RF,DeLuca AP,Hoffmann JM,Johnston RM,Jacobson SG,Sheffield VC,Stone EM

Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.
Proceedings of the National Academy of Sciences of the United States of America107(52)22671-6(2010 Dec)
Omori Y,Chaya T,Katoh K,Kajimura N,Sato S,Muraoka K,Ueno S,Koyasu T,Kondo M,Furukawa T

Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.
Cancer research66(17)8439-47(2006 Sep)
Ma AH,Xia L,Desai SJ,Boucher DL,Guan Y,Shih HM,Shi XB,deVere White RW,Chen HW,Tepper CG,Kung HJ

High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Genome research14(4)750-7(2004 Apr)
Kwitek AE,Gullings-Handley J,Yu J,Carlos DC,Orlebeke K,Nie J,Eckert J,Lemke A,Andrae JW,Bromberg S,Pasko D,Chen D,Scheetz TE,Casavant TL,Soares MB,Sheffield VC,Tonellato PJ,Jacob HJ

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Mak cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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