| Gene Symbol | Cryba1 |
| Entrez Gene ID | 25583 |
| Full Name | crystallin, beta A1 |
| Synonyms | BA3A1C,beta-A3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | a lens structural component [RGD, Feb 2006]. |
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Cryba1 cDNA ORF clone, Rattus norvegicus(Norway rat)
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Gene
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Clones
gRNAs
The following Cryba1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cryba1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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Reference Sequences (Refseq)
CloneID ORa01802 Clone ID Related Accession (Same CDS sequence) NM_013056.1 Accession Version NM_013056.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 648bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector 
User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1569254400000 Organism Rattus norvegicus(Norway rat) Product beta-crystallin A3 Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07030057.1. On or before Sep 1, 2012 this sequence version replaced XM_001080813.3, XM_340846.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA997738.1, DV214089.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##
1
61
121
181
241
301
361
421
481
541
601ATGGAGACCC AGACTGTGCA GCGGGAGCTG GAAACTCTTC CAACCACCAA GATGGCTCAG
ACCAACCCTA TGCCAGGGTC CATGGGGCCA TGGAAGATAA CCATCTATGA TCAGGAGAAC
TTCCAGGGCA AGAGGATGGA GTTCACCAGC TCCTGCCCAA ATGTCTCTGA ACGTAGTTTT
GATAATGTCC GGTCACTTAA GGTGGAGTGT GGCGCCTGGA TTGGTTATGA GCACACCAGC
TTCTGTGGGC AACAGTTCAT CCTGGAGAGA GGAGAATACC CTCGATGGGA TGCCTGGAGT
GGGAGCAATG CCTATCATAT TGAGCGTCTC ATGTCCTTCC GACCCATCTG TTCTGCTAAT
CATAAAGAGT CTAAGATCAC CATCTTTGAG AAAGAGAACT TTATTGGACG CCAGTGGGAG
ATCTGTGATG ACTACCCTTC CTTACAAGCC ATGGGTTGGT TCAACAATGA AGTGGGTTCC
ATGAAGATAC AGTGTGGAGC TTGGGTTTGC TACCAGTATC CTGGATATCG TGGTTATCAG
TATATCTTGG AATGTGACCA TCACGGAGGA GACTACAAAC ACTGGAGAGA GTGGGGAACT
CATGCTCAGA CTTCTCAGAT CCAATCAATT CGCCGAATAC AACAATAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq NP_037188.1 CDS 6..653 Translation 
Target ORF information:
RefSeq Version NM_013056.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus crystallin, beta A1 (Cryba1), mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK 
NM_013056.1
ORF Insert Sequence:
1
61
121
181
241
301
361
421
481
541
601ATGGAGACCC AGACTGTGCA GCGGGAGCTG GAAACTCTTC CAACCACCAA GATGGCTCAG
ACCAACCCTA TGCCAGGGTC CATGGGGCCA TGGAAGATAA CCATCTATGA TCAGGAGAAC
TTCCAGGGCA AGAGGATGGA GTTCACCAGC TCCTGCCCAA ATGTCTCTGA ACGTAGTTTT
GATAATGTCC GGTCACTTAA GGTGGAGTGT GGCGCCTGGA TTGGTTATGA GCACACCAGC
TTCTGTGGGC AACAGTTCAT CCTGGAGAGA GGAGAATACC CTCGATGGGA TGCCTGGAGT
GGGAGCAATG CCTATCATAT TGAGCGTCTC ATGTCCTTCC GACCCATCTG TTCTGCTAAT
CATAAAGAGT CTAAGATCAC CATCTTTGAG AAAGAGAACT TTATTGGACG CCAGTGGGAG
ATCTGTGATG ACTACCCTTC CTTACAAGCC ATGGGTTGGT TCAACAATGA AGTGGGTTCC
ATGAAGATAC AGTGTGGAGC TTGGGTTTGC TACCAGTATC CTGGATATCG TGGTTATCAG
TATATCTTGG AATGTGACCA TCACGGAGGA GACTACAAAC ACTGGAGAGA GTGGGGAACT
CATGCTCAGA CTTCTCAGAT CCAATCAATT CGCCGAATAC AACAATAGThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID ORa57200 Clone ID Related Accession (Same CDS sequence) XM_017597045.1 Accession Version XM_017597045.1 Latest version! Documents for ORF clone product in default vector Sequence Information ORF Nucleotide Sequence (Length: 342bp)
Protein sequence
SNPVector pcDNA3.1-C-(k)DYK or customized vector User ManualClone information Clone Map MSDSTag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags ORF Insert Method CloneEZ™ Seamless cloning technology Insert Structure linear Update Date 1469376000000 Organism Rattus norvegicus(Norway rat) Product beta-crystallin A3 isoform X1 Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##
1
61
121
181
241
301ATGGAGACCC AGACTGTGCA GCGGGAGCTG GAAACTCTTC CAACCACCAA GATGGCTCAG
ACCAACCCTA TGCCAGGGTC CATGGGGCCA TGGAAGATAA CCATCTATGA TCAGGAGAAC
TTCCAGGGCA AGAGGATGGA GTTCACCAGC TCCTGCCCAA ATGTCTCTGA ACGTAGTTTT
GATAATGTCC GGTCACTTAA GGTGGAGTGT GGCGCAATCA TAAAGAGTCT AAGATCACCA
TCTTTGAGAA AGAGAACTTT ATTGGACGCC AGTGGGAGAT CTGTGATGAC TACCCTTCCT
TACAAGCCAT GGGTTGGTTC AACAATGAAG TGGGTTCCAT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq XP_017452534.1 CDS 381..722 Translation
Target ORF information:
RefSeq Version XM_017597045.1 Organism Rattus norvegicus(Norway rat) Definition Rattus norvegicus crystallin, beta A1 (Cryba1), transcript variant X1, mRNA. Target ORF information:
Epitope DYKDDDDK Bacterial selection AMPR Mammalian selection NeoR Vector pcDNA3.1+/C-(K)DYK XM_017597045.1
ORF Insert Sequence:
1
61
121
181
241
301ATGGAGACCC AGACTGTGCA GCGGGAGCTG GAAACTCTTC CAACCACCAA GATGGCTCAG
ACCAACCCTA TGCCAGGGTC CATGGGGCCA TGGAAGATAA CCATCTATGA TCAGGAGAAC
TTCCAGGGCA AGAGGATGGA GTTCACCAGC TCCTGCCCAA ATGTCTCTGA ACGTAGTTTT
GATAATGTCC GGTCACTTAA GGTGGAGTGT GGCGCAATCA TAAAGAGTCT AAGATCACCA
TCTTTGAGAA AGAGAACTTT ATTGGACGCC AGTGGGAGAT CTGTGATGAC TACCCTTCCT
TACAAGCCAT GGGTTGGTTC AACAATGAAG TGGGTTCCAT GAThe stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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PubMed
Establishment of a recessive mutant small-eye rat with lens involution and retinal detachment associated with partial deletion and rearrangement of the Cryba1 gene.
The Biochemical journal471(2)293-305(2015 Oct)
Yamada T,Nanashima N,Shimizu T,Nakazawa Y,Nakazawa M,Tsuchida S
βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.
Scientific reports58755(2015 Mar)
Valapala M,Edwards M,Hose S,Hu J,Wawrousek E,Lutty GA,Zigler JS Jr,Qian J,Sinha D
Differential proteomics analysis of proteins from human diabetic and age-related cataractous lenses.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences18(11)984-9(2013 Nov)
Zhu J,Shao J,Yao Y,Chu ZD,Yu QQ,Zhao W,Lin Q,Zhang ZY
Congenital polymorphic cataract associated with a G to A splice site mutation in the human beta-crystallin gene CRYβA3/A1.
Molecular vision182213-20(2012)
Yu Y,Li J,Xu J,Wang Q,Yu Y,Yao K
A novel T→G splice site mutation of CRYBA1/A3 associated with autosomal dominant nuclear cataracts in a Chinese family.
Molecular vision181283-8(2012)
Yang Z,Su D,Li Q,Yang F,Ma Z,Zhu S,Ma X
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