Rabggtb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rabggtb
Entrez Gene ID	25533
Full Name	Rab geranylgeranyltransferase, beta subunit
General protein information	Preferred Names Rab geranylgeranyltransferase, beta subunit Names geranylgeranyl transferase type-2 subunit beta GGTase-II-beta Rab geranylgeranyl transferase componenet, subunit beta geranylgeranyl transferase type II subunit beta rab GG transferase beta rab GGTase beta rab geranyl-geranyltransferase subunit beta rab geranylgeranyltransferase subunit beta type II protein geranyl-geranyltransferase subunit beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q45
Summary	subunit of Rab geranylgeranyl transferase, which catalyses the transfer of geranylgeranyl groups to Rab protein cysteine residues [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138708.2	NP_619715.1	geranylgeranyl transferase type-2 subunit beta

Pathways from BioSystems

Homologies

Schizosaccharomyces pombe (fission yeast)	ptb1	NP_593383.1
Canis lupus familiaris (dog)	RABGGTB	XP_005622111.1
Saccharomyces cerevisiae (baker's yeast)	BET2	NP_015502.1
Oryza sativa (rice)	Os08g0512300	NP_001062217.1
Eremothecium gossypii	AGOS_AEL268W	NP_984592.1
Magnaporthe oryzae (rice blast fungus)	MGG_09304	XP_003709954.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP013277	XP_003435802.1
Kluyveromyces lactis	KLLA0E04797g	XP_454162.1
Macaca mulatta (Rhesus monkey)	RABGGTB	XP_001101556.1
Bos taurus (cattle)	RABGGTB	NP_001015646.1
Drosophila melanogaster (fruit fly)	betaggt-II	NP_524894.1
Caenorhabditis elegans (roundworm)	ggtb-1	NP_498559.1
Arabidopsis thaliana (thale cress)	RGTB1	NP_568259.1
Arabidopsis thaliana (thale cress)	RGTB2	NP_850567.1
Pan troglodytes (chimpanzee)	RABGGTB	XP_003308209.1
Homo sapiens (human)	RABGGTB	NP_004573.2
Gallus gallus (chicken)	RABGGTB	XP_422548.2
Danio rerio (zebrafish)	rabggtb	NP_998277.2
Mus musculus (house mouse)	Rabggtb	NP_001156950.1
Rattus norvegicus (Norway rat)	Rabggtb	NP_619715.1
Neurospora crassa	NCU07509	XP_965056.1
Xenopus tropicalis (tropical clawed frog)	rabggtb	NP_001106636.1

Gene Ontology
Bibliography

Related articles in PubMed

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells.
Arora DK, Syed I, Machhadieh B, McKenna CE, Kowluru A
Islets4(5)354-8(2012 Sep-Oct)

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W
The EMBO journal27(18)2444-56(2008 Sep)

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Pylypenko O, Rak A, Reents R, Niculae A, Sidorovitch V, Cioaca MD, Bessolitsyna E, Thomä NH, Waldmann H, Schlichting I, Goody RS, Alexandrov K
Molecular cell11(2)483-94(2003 Feb)

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Zhang H, Seabra MC, Deisenhofer J
Structure (London, England : 1993)8(3)241-51(2000 Mar)

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.
Armstrong SA, Seabra MC, Südhof TC, Goldstein JL, Brown MS
The Journal of biological chemistry268(16)12221-9(1993 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Rabggtb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rabggtb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01654	NM_138708.2 Latest version!	Rattus norvegicus Rab geranylgeranyltransferase subunit beta (Rabggtb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rabggtb ( NM_138708.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_619715.1 Rattus norvegicus Rab geranylgeranyltransferase subunit beta (Rabggtb), mRNA.

Price & Availability↑

CloneID	ORa01654
Clone ID Related Accession (Same CDS sequence)	NM_138708.2
Accession Version	NM_138708.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 996bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1568908800000
Organism	Rattus norvegicus(Norway rat)
Product	geranylgeranyl transferase type-2 subunit beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L10416.1. On Jun 3, 2003 this sequence version replaced NM_138708.1. ##Evidence-Data-START## Transcript exon combination :: L10416.1, BC078683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMN01906349 [ECO:0000348] ##Evidence-Data-END##

ATGGGCACAC AGCAGAAGGA CGTCACCATC AAGTCAGATG CGCCTGACAC CCTGCTGCTC 
GAGAAGCATG CTGATTATAT CGCCTCGTAC GGCTCAAAGA AAGATGATTA TGAATACTGC 
ATGTCCGAAT ACTTGAGAAT GAGCGGCGTC TACTGGGGCC TGACAGTGAT GGACCTCATG 
GGGCAGCTTC ATCGGATGAA TAAAGAGGAG ATACTGGTGT TTATCAAGTC GTGCCAGCAT 
GAGTGTGGGG GAGTCAGTGC CAGCATCGGG CACGACCCCC ACCTTCTCTA CACGCTCAGT 
GCTGTCCAGA TTCTCACTCT GTATGATAGC ATCCATGTAA TCAACGTAGA CAAAGTGGTA 
GCCTATGTTC AGAGTCTACA GAAAGAAGAT GGTTCCTTTG CTGGAGACAT CTGGGGAGAA 
ATCGATACAA GATTCTCATT TTGTGCAGTG GCAACTTTGG CTCTCTTGGG CAAACTTGAT 
GCTATTAATG TGGAAAAGGC CATTGAATTT GTTTTGTCCT GTATGAACTT TGATGGTGGA 
TTTGGGTGCA GACCAGGCTC TGAATCTCAC GCCGGACAGA TCTATTGTTG CACAGGATTC 
CTGGCCATAA CTAGTCAGTT GCATCAAGTG AACTCCGACC TACTTGGTTG GTGGCTTTGT 
GAACGACAGT TGCCCTCTGG CGGACTCAAT GGAAGACCCG AGAAGTTACC AGATGTGTGC 
TATTCCTGGT GGGTGTTGGC CTCCTTAAAG ATAATCGGGA GGCTTCATTG GATTGACAGA 
GAAAAGCTTC GAAGCTTCAT CTTGGCATGT CAAGATGAAG AGACAGGAGG GTTTGCAGAC 
AGGCCAGGAG ACATGGTGGA TCCCTTTCAC ACCTTGTTTG GCATTGCTGG ATTGTCACTT 
CTGGGGGAAG AGCAGATCAA GCCTGTCAGC CCTGTCTTTT GCATGCCTGA AGAAGTGCTA 
CAGAGGGTGA ATGTCCAGCC TGAACTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619715.1
CDS	13..1008
Translation	MGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS

Target ORF information:

RefSeq Version	NM_138708.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Rab geranylgeranyltransferase subunit beta (Rabggtb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138708.2

ORF Insert Sequence:

ATGGGCACAC AGCAGAAGGA CGTCACCATC AAGTCAGATG CGCCTGACAC CCTGCTGCTC 
GAGAAGCATG CTGATTATAT CGCCTCGTAC GGCTCAAAGA AAGATGATTA TGAATACTGC 
ATGTCCGAAT ACTTGAGAAT GAGCGGCGTC TACTGGGGCC TGACAGTGAT GGACCTCATG 
GGGCAGCTTC ATCGGATGAA TAAAGAGGAG ATACTGGTGT TTATCAAGTC GTGCCAGCAT 
GAGTGTGGGG GAGTCAGTGC CAGCATCGGG CACGACCCCC ACCTTCTCTA CACGCTCAGT 
GCTGTCCAGA TTCTCACTCT GTATGATAGC ATCCATGTAA TCAACGTAGA CAAAGTGGTA 
GCCTATGTTC AGAGTCTACA GAAAGAAGAT GGTTCCTTTG CTGGAGACAT CTGGGGAGAA 
ATCGATACAA GATTCTCATT TTGTGCAGTG GCAACTTTGG CTCTCTTGGG CAAACTTGAT 
GCTATTAATG TGGAAAAGGC CATTGAATTT GTTTTGTCCT GTATGAACTT TGATGGTGGA 
TTTGGGTGCA GACCAGGCTC TGAATCTCAC GCCGGACAGA TCTATTGTTG CACAGGATTC 
CTGGCCATAA CTAGTCAGTT GCATCAAGTG AACTCCGACC TACTTGGTTG GTGGCTTTGT 
GAACGACAGT TGCCCTCTGG CGGACTCAAT GGAAGACCCG AGAAGTTACC AGATGTGTGC 
TATTCCTGGT GGGTGTTGGC CTCCTTAAAG ATAATCGGGA GGCTTCATTG GATTGACAGA 
GAAAAGCTTC GAAGCTTCAT CTTGGCATGT CAAGATGAAG AGACAGGAGG GTTTGCAGAC 
AGGCCAGGAG ACATGGTGGA TCCCTTTCAC ACCTTGTTTG GCATTGCTGG ATTGTCACTT 
CTGGGGGAAG AGCAGATCAA GCCTGTCAGC CCTGTCTTTT GCATGCCTGA AGAAGTGCTA 
CAGAGGGTGA ATGTCCAGCC TGAACTAGTG AGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells.
Islets4(5)354-8(2012 Sep-Oct)
Arora DK,Syed I,Machhadieh B,McKenna CE,Kowluru A

Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.
The EMBO journal27(18)2444-56(2008 Sep)
Guo Z,Wu YW,Das D,Delon C,Cramer J,Yu S,Thuns S,Lupilova N,Waldmann H,Brunsveld L,Goody RS,Alexandrov K,Blankenfeldt W

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.
Molecular cell11(2)483-94(2003 Feb)
Pylypenko O,Rak A,Reents R,Niculae A,Sidorovitch V,Cioaca MD,Bessolitsyna E,Thomä NH,Waldmann H,Schlichting I,Goody RS,Alexandrov K

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure (London, England : 1993)8(3)241-51(2000 Mar)
Zhang H,Seabra MC,Deisenhofer J

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.
The Journal of biological chemistry268(16)12221-9(1993 Jun)
Armstrong SA,Seabra MC,Südhof TC,Goldstein JL,Brown MS

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Rabggtb cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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