Abcc2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcc2
Entrez Gene ID	25303
Full Name	ATP binding cassette subfamily C member 2
Synonyms	Cmoat,Mrp2,cMRP,mrp
General protein information	Preferred Names ATP binding cassette subfamily C member 2 Names canalicular multispecific organic anion transporter 1 ATP-binding cassette sub-family C member 2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 cMrp2/cMoat canalicular apical conjugate export pump calicular multispecific organic anion transporter canalicular multidrug resistance protein multidrug resistance-associated protein 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q54
Summary	multispecific organic anion transporter; mutation may be responsible for conjugated hyperbilirubinemia in the TR- rat, which is a model for human Dubin-Johnson syndrome [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012833.2	NP_036965.1	canalicular multispecific organic anion transporter 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Abcc2	NP_038834.2
Arabidopsis thaliana (thale cress)	MRP2	NP_001189675.1
Danio rerio (zebrafish)	abcc2	NP_956883.2
Arabidopsis thaliana (thale cress)	MRP12	NP_174331.2
Homo sapiens (human)	ABCC2	NP_000383.1
Macaca mulatta (Rhesus monkey)	ABCC2	NP_001028019.1
Arabidopsis thaliana (thale cress)	MRP1	NP_174329.1
Canis lupus familiaris (dog)	ABCC2	NP_001003081.1
Gallus gallus (chicken)	ABCC2	XP_421698.4
Bos taurus (cattle)	ABCC2	XP_002698533.1
Rattus norvegicus (Norway rat)	Abcc2	NP_036965.1
Arabidopsis thaliana (thale cress)	MRP13	NP_174330.3
Xenopus tropicalis (tropical clawed frog)	abcc2	XP_004915926.1

Gene Ontology
Bibliography

Related articles in PubMed

Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.
Tocchetti GN, Arias A, Arana MR, Rigalli JP, Domínguez CJ, Zecchinati F, Ruiz ML, Villanueva SSM, Mottino AD
Archives of toxicology92(2)777-788(2018 Feb)

Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.
Qu X, Zhang Y, Zhang S, Zhai J, Gao H, Tao L, Song Y
Biological & pharmaceutical bulletin41(8)1211-1218(2018)

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.
Arana MR, Tocchetti GN, Zecchinati F, Londero AS, Dominguez C, Perdomo V, Rigalli JP, Villanueva SSM, Mottino AD
Toxicology39022-31(2017 09)

Pre-Hepatectomy Assessment of Bile Transporter Expression by Gadoxetic Acid-Enhanced MRI in a Rat Model of Liver Cirrhosis.
Kim J, Kim T, Hong KS, Moon H, Oh IK, Lee SM, Hohenwalter MD, Zimmerman MA, Cronin DC, Hong JC
Journal of investigative surgery : the official journal of the Academy of Surgical Research30(4)265-271(2017 Aug)

Nrf2 signaling increases expression of ATP-binding cassette subfamily C mRNA transcripts at the blood-brain barrier following hypoxia-reoxygenation stress.
Ibbotson K, Yell J, Ronaldson PT
Fluids and barriers of the CNS14(1)6(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Abcc2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcc2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01078	NM_012833.2 Latest version!	Rattus norvegicus ATP binding cassette subfamily C member 2 (Abcc2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$811.30 $1159.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcc2 ( NM_012833.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036965.1 Rattus norvegicus ATP binding cassette subfamily C member 2 (Abcc2), mRNA.

Price & Availability↑

CloneID	ORa01078
Clone ID Related Accession (Same CDS sequence)	NM_012833.2
Accession Version	NM_012833.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4626bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577376000000
Organism	Rattus norvegicus(Norway rat)
Product	canalicular multispecific organic anion transporter 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AABR07006900.1, L49379.1 and X96393.1. On Aug 27, 2014 this sequence version replaced NM_012833.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X96393.1, L49379.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 17065236 ##RefSeq-Attributes-END##

ATGGACAAGT TCTGCAACTC TACTTTTTGG GATCTCTCAT TACTGGAAAG TCCAGAGGCT 
GACCTGCCTC TTTGTTTTGA GCAAACTGTT CTGGTGTGGA TTCCCTTGGG CTTTCTTTGG 
CTCCTGGCTC CTTGGCAACT TTACAGCGTG TACAGATCCA GGACCAAGAG ATCTTCTATA 
ACCAAATTCT ACCTTGCCAA GCAGGTGTTC GTCGTGTTTC TTCTTATTTT AGCAGCCATA 
GACCTGTCTC TTGCGCTCAC AGAAGATACT GGACAAGCCA CAGTTCCTCC TGTCAGATAT 
ACGAATCCAA TCCTCTACCT GTGCACATGG CTCCTGGTTT TGGCAGTCCA GCACAGCAGG 
CAATGGTGTG TACGAAAGAA CTCTTGGTTC CTGTCTCTGT TCTGGATCCT CTCGGTCTTA 
TGCGGCGTAT TCCAGTTTCA GACTCTGATA CGAGCACTCC TGAAGGACAG CAAGTCCAAC 
ATGGCCTACT CCTACCTGTT CTTCGTCTCC TACGGTTTCC AGATTGTCCT CCTGATTCTT 
ACAGCCTTTT CAGGACCAAG TGACTCAACA CAAACTCCAT CAGTCACGGC TTCCTTTCTG 
AGTAGCATTA CATTTAGTTG GTATGACAGG ACTGTTCTGA AAGGTTACAA GCATCCACTG 
ACACTAGAAG ATGTCTGGGA TATCGATGAA GGGTTTAAAA CAAGGTCAGT CACCAGCAAG 
TTTGAGGCGG CCATGACAAA GGACCTGCAG AAAGCCAGGC AGGCTTTTCA GAGGCGGCTG 
CAGAAGTCCC AGCGGAAACC TGAGGCCACA CTACACGGAC TGAACAAGAA GCAGAGTCAG 
AGCCAAGACG TTCTCGTCCT GGAAGAAGCG AAAAAGAAGT CTGAGAAGAC CACCAAAGAC 
TATCCCAAAT CGTGGTTGAT CAAGTCTCTC TTCAAAACCT TCCACGTAGT GATCCTGAAA 
TCATTTATAC TGAAATTAAT ACATGACCTT TTGGTGTTTC TGAATCCTCA GCTGCTGAAG 
TTGCTGATCG GTTTCGTGAA GAGCTCTAAC TCATACGTGT GGTTTGGCTA TATCTGTGCA 
ATCCTAATGT TTGCTGTGAC TCTCATCCAA TCTTTCTGCC TTCAGTCTTA CTTTCAACAT 
TGTTTTGTGT TGGGAATGTG CGTACGGACA ACCGTCATGT CTTCGATATA TAAGAAGGCA 
TTGACCCTAT CTAACTTGGC TAGGAAGCAG TACACCATTG GAGAGACGGT GAACTTGATG 
TCTGTAGATT CCCAGAAGCT AATGGATGCG ACCAACTACA TGCAGTTGGT GTGGTCAAGT 
GTTATACAGA TTACTTTGTC CATCTTCTTC CTGTGGAGAG AGTTGGGACC GTCCATCTTA 
GCAGGTGTTG GGGTTATGGT TCTCCTAATC CCAGTTAATG GAGTTCTGGC TACCAAGATC 
AGAAATATTC AGGTCCAAAA TATGAAGAAT AAAGACAAAC GTTTAAAAAT CATGAATGAG 
ATTCTCAGTG GAATCAAGAT CCTGAAATAC TTTGCCTGGG AACCTTCATT TCAAGAGCAA 
GTCCAGGGCA TTCGGAAGAA AGAACTCAAG AACTTGCTGC GGTTCGGCCA GCTGCAGAGT 
CTGCTGATCT TCATTTTACA GATAACTCCA ATCCTGGTGT CTGTGGTCAC ATTTTCTGTC 
TATGTCCTGG TGGATAGCGC CAATGTTTTG AATGCGGAGA AGGCATTTAC CTCCATCACC 
CTCTTCAATA TCCTACGCTT CCCTCTGTCC ATGCTTCCCA TGGTGACCTC ATCGATCCTC 
CAGGCCAGTG TTTCTGTGGA CCGGCTGGAG AGGTATTTGG GAGGAGACGA TTTAGACACA 
TCTGCCATTC GCCGCGTCAG CAATTTTGAT AAAGCTGTGA AGTTTTCAGA GGCCTCTTTT 
ACTTGGGACC CGGACTTGGA AGCCACAATC CAAGATGTGA ACCTGGACAT AAAGCCAGGC 
CAACTGGTGG CTGTGGTGGG CACTGTAGGC TCTGGGAAAT CCTCTTTGGT ATCAGCCATG 
CTGGGAGAAA TGGAAAACGT TCACGGGCAC ATCACCATCC AGGGATCCAC AGCCTATGTC 
CCTCAGCAGT CCTGGATTCA GAATGGAACC ATCAAAGACA ACATCCTGTT TGGGTCCGAA 
TACAATGAAA AGAAGTACCA GCAAGTTCTC AAAGCATGCG CTCTCCTCCC AGACTTGGAA 
ATATTGCCTG GAGGAGACAT GGCTGAGATC GGAGAGAAGG GGATAAATCT CAGTGGTGGT 
CAGAAGCAGC GAGTCAGCCT GGCCAGAGCT GCCTATCAAG ATGCTGACAT CTATATTCTG 
GACGATCCCC TGTCGGCTGT GGATGCTCAT GTGGGAAAAC ACATTTTCAA CAAGGTTGTG 
GGCCCCAACG GCCTGTTGGC TGGCAAGACG AGAATCTTTG TTACTCATGG TATTCACTTC 
CTTCCCCAAG TGGATGAGAT TGTAGTTCTG GGGAAAGGCA CCATCTTAGA GAAAGGATCC 
TATCGTGACC TGTTGGACAA GAAGGGAGTG TTTGCTAGGA ACTGGAAGAC CTTCATGAAG 
CATTCAGGGC CTGAAGGAGA GGCCACAGTC AATAATGACA GTGAGGCGGA AGACGACGAT 
GATGGGCTGA TTCCCACCAT GGAGGAAATC CCTGAGGATG CAGCTTCCTT GGCCATGAGA 
AGAGAAAATA GTCTTCGCCG TACACTGAGC CGCAGCTCTA GGTCCAGCAG CCGACGTGGG 
AAGTCCCTCA AAAACTCCTT GAAGATTAAA AATGTGAATG TCTTGAAGGA GAAGGAAAAA 
GAAGTGGAAG GACAAAAACT AATTAAGAAA GAATTTGTGG AAACCGGGAA GGTCAAGTTC 
TCCATCTACC TGAAGTATCT ACAGGCAGTA GGGTGGTGGT CCATACTTTT CATCATCCTT 
TTCTACGGAT TGAATAATGT TGCTTTTATC GGCTCTAACC TCTGGCTGAG TGCTTGGACC 
AGTGACTCTG ACAACTTGAA TGGGACCAAC AATTCGTCTT CTCATAGGGA CATGAGAATT 
GGGGTCTTTG GAGCTCTGGG ATTAGCACAA GGTATATGTT TGCTTATTTC AACTCTGTGG 
AGCATATATG CTTGCAGAAA TGCATCAAAA GCTTTGCACG GGCAGCTGTT AACCAACATC 
CTCCGGGCAC CCATGAGGTT TTTTGACACA ACTCCCACAG GCCGGATTGT GAACAGATTT 
TCTGGTGATA TTTCTACTGT GGACGACTTG CTCCCCCAGA CACTTCGAAG CTGGATGATG 
TGTTTCTTTG GCATCGCTGG CACTCTTGTC ATGATCTGCA TGGCCACCCC AGTCTTCGCT 
ATCATCATCA TTCCTCTCAG CATTCTTTAT ATTTCGGTGC AGGTTTTTTA TGTGGCTACT 
TCCCGCCAGC TGAGACGGTT GGATTCTGTC ACCAAATCTC CGATCTATTC TCACTTCAGT 
GAGACTGTCA CAGGTTTGCC CATTATCCGT GCCTTTGAGC ACCAGCAGCG ATTTCTAGCT 
TGGAATGAGA AGCAGATTGA CATCAACCAG AAATGTGTCT TTTCCTGGAT TACCTCCAAC 
AGGTGGCTTG CAATTCGGCT GGAGCTGGTT GGAAACTTGG TCGTCTTCTG TTCCGCCTTG 
CTGCTGGTTA TTTATAGAAA AACCTTAACC GGGGACGTTG TGGGCTTTGT TCTGTCCAAC 
GCCCTCAATA TCACACAAAC CTTGAACTGG CTAGTGAGGA TGACGTCAGA AGCAGAGACC 
AACATTGTGG CAGTTGAGCG AATAAGTGAA TACATAAATG TAGAGAATGA GGCGCCCTGG 
GTGACTGACA AGAGGCCTCC GGCAGACTGG CCCAGACATG GTGAGATCCA GTTTAACAAC 
TATCAAGTGC GGTATCGGCC GGAGCTGGAT CTGGTACTGA AAGGGATCAC TTGTAACATC 
AAGAGCGGAG AGAAGGTCGG CGTAGTGGGC AGGACTGGGG CTGGGAAATC ATCCCTCACA 
AACTGCCTCT TCAGAATCTT AGAGTCTGCG GGGGGCCAGA TCATCATTGA TGGGATAGAT 
GTTGCCTCCA TTGGACTGCA CGACCTTCGA GAGAGGCTGA CCATCATTCC CCAGGACCCC 
ATTTTGTTCT CGGGGAGTCT GAGGATGAAT CTCGACCCTT TCAACAAATA TTCAGATGAG 
GAGGTTTGGA GGGCCCTGGA GTTGGCTCAC CTCAGATCCT TTGTGTCTGG CCTACAGCTT 
GGGTTGTTAT CCGAAGTGAC AGAGGGTGGT GACAACCTGA GCATAGGGCA GAGGCAGCTC 
CTATGCCTGG GCAGGGCTGT GCTTCGAAAA TCCAAAATCC TGGTCCTGGA TGAAGCCACG 
GCTGCAGTGG ATCTCGAGAC GGATAGCCTC ATTCAGACGA CCATCCGAAA GGAGTTCTCC 
CAGTGCACGG TCATCACCAT CGCTCACAGG CTGCACACCA TCATGGACAG TGACAAGATA 
ATGGTCCTAG ACAACGGGAA GATTGTCGAG TATGGCAGTC CTGAAGAACT GCTGTCCAAC 
AGAGGTTCCT TCTATCTGAT GGCCAAGGAA GCCGGCATTG AAAATGTGAA TCACACAGAG 
CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036965.1
CDS	214..4839
Translation	MDKFCNSTFWDLSLLESPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYSVYRSRTKRSSITKFYLAKQVFVVFLLILAAIDLSLALTEDTGQATVPPVRYTNPILYLCTWLLVLAVQHSRQWCVRKNSWFLSLFWILSVLCGVFQFQTLIRALLKDSKSNMAYSYLFFVSYGFQIVLLILTAFSGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLERYLGGDDLDTSAIRRVSNFDKAVKFSEASFTWDPDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKEAGIENVNHTEL

Target ORF information:

RefSeq Version	NM_012833.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ATP binding cassette subfamily C member 2 (Abcc2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012833.2

ORF Insert Sequence:

ATGGACAAGT TCTGCAACTC TACTTTTTGG GATCTCTCAT TACTGGAAAG TCCAGAGGCT 
GACCTGCCTC TTTGTTTTGA GCAAACTGTT CTGGTGTGGA TTCCCTTGGG CTTTCTTTGG 
CTCCTGGCTC CTTGGCAACT TTACAGCGTG TACAGATCCA GGACCAAGAG ATCTTCTATA 
ACCAAATTCT ACCTTGCCAA GCAGGTGTTC GTCGTGTTTC TTCTTATTTT AGCAGCCATA 
GACCTGTCTC TTGCGCTCAC AGAAGATACT GGACAAGCCA CAGTTCCTCC TGTCAGATAT 
ACGAATCCAA TCCTCTACCT GTGCACATGG CTCCTGGTTT TGGCAGTCCA GCACAGCAGG 
CAATGGTGTG TACGAAAGAA CTCTTGGTTC CTGTCTCTGT TCTGGATCCT CTCGGTCTTA 
TGCGGCGTAT TCCAGTTTCA GACTCTGATA CGAGCACTCC TGAAGGACAG CAAGTCCAAC 
ATGGCCTACT CCTACCTGTT CTTCGTCTCC TACGGTTTCC AGATTGTCCT CCTGATTCTT 
ACAGCCTTTT CAGGACCAAG TGACTCAACA CAAACTCCAT CAGTCACGGC TTCCTTTCTG 
AGTAGCATTA CATTTAGTTG GTATGACAGG ACTGTTCTGA AAGGTTACAA GCATCCACTG 
ACACTAGAAG ATGTCTGGGA TATCGATGAA GGGTTTAAAA CAAGGTCAGT CACCAGCAAG 
TTTGAGGCGG CCATGACAAA GGACCTGCAG AAAGCCAGGC AGGCTTTTCA GAGGCGGCTG 
CAGAAGTCCC AGCGGAAACC TGAGGCCACA CTACACGGAC TGAACAAGAA GCAGAGTCAG 
AGCCAAGACG TTCTCGTCCT GGAAGAAGCG AAAAAGAAGT CTGAGAAGAC CACCAAAGAC 
TATCCCAAAT CGTGGTTGAT CAAGTCTCTC TTCAAAACCT TCCACGTAGT GATCCTGAAA 
TCATTTATAC TGAAATTAAT ACATGACCTT TTGGTGTTTC TGAATCCTCA GCTGCTGAAG 
TTGCTGATCG GTTTCGTGAA GAGCTCTAAC TCATACGTGT GGTTTGGCTA TATCTGTGCA 
ATCCTAATGT TTGCTGTGAC TCTCATCCAA TCTTTCTGCC TTCAGTCTTA CTTTCAACAT 
TGTTTTGTGT TGGGAATGTG CGTACGGACA ACCGTCATGT CTTCGATATA TAAGAAGGCA 
TTGACCCTAT CTAACTTGGC TAGGAAGCAG TACACCATTG GAGAGACGGT GAACTTGATG 
TCTGTAGATT CCCAGAAGCT AATGGATGCG ACCAACTACA TGCAGTTGGT GTGGTCAAGT 
GTTATACAGA TTACTTTGTC CATCTTCTTC CTGTGGAGAG AGTTGGGACC GTCCATCTTA 
GCAGGTGTTG GGGTTATGGT TCTCCTAATC CCAGTTAATG GAGTTCTGGC TACCAAGATC 
AGAAATATTC AGGTCCAAAA TATGAAGAAT AAAGACAAAC GTTTAAAAAT CATGAATGAG 
ATTCTCAGTG GAATCAAGAT CCTGAAATAC TTTGCCTGGG AACCTTCATT TCAAGAGCAA 
GTCCAGGGCA TTCGGAAGAA AGAACTCAAG AACTTGCTGC GGTTCGGCCA GCTGCAGAGT 
CTGCTGATCT TCATTTTACA GATAACTCCA ATCCTGGTGT CTGTGGTCAC ATTTTCTGTC 
TATGTCCTGG TGGATAGCGC CAATGTTTTG AATGCGGAGA AGGCATTTAC CTCCATCACC 
CTCTTCAATA TCCTACGCTT CCCTCTGTCC ATGCTTCCCA TGGTGACCTC ATCGATCCTC 
CAGGCCAGTG TTTCTGTGGA CCGGCTGGAG AGGTATTTGG GAGGAGACGA TTTAGACACA 
TCTGCCATTC GCCGCGTCAG CAATTTTGAT AAAGCTGTGA AGTTTTCAGA GGCCTCTTTT 
ACTTGGGACC CGGACTTGGA AGCCACAATC CAAGATGTGA ACCTGGACAT AAAGCCAGGC 
CAACTGGTGG CTGTGGTGGG CACTGTAGGC TCTGGGAAAT CCTCTTTGGT ATCAGCCATG 
CTGGGAGAAA TGGAAAACGT TCACGGGCAC ATCACCATCC AGGGATCCAC AGCCTATGTC 
CCTCAGCAGT CCTGGATTCA GAATGGAACC ATCAAAGACA ACATCCTGTT TGGGTCCGAA 
TACAATGAAA AGAAGTACCA GCAAGTTCTC AAAGCATGCG CTCTCCTCCC AGACTTGGAA 
ATATTGCCTG GAGGAGACAT GGCTGAGATC GGAGAGAAGG GGATAAATCT CAGTGGTGGT 
CAGAAGCAGC GAGTCAGCCT GGCCAGAGCT GCCTATCAAG ATGCTGACAT CTATATTCTG 
GACGATCCCC TGTCGGCTGT GGATGCTCAT GTGGGAAAAC ACATTTTCAA CAAGGTTGTG 
GGCCCCAACG GCCTGTTGGC TGGCAAGACG AGAATCTTTG TTACTCATGG TATTCACTTC 
CTTCCCCAAG TGGATGAGAT TGTAGTTCTG GGGAAAGGCA CCATCTTAGA GAAAGGATCC 
TATCGTGACC TGTTGGACAA GAAGGGAGTG TTTGCTAGGA ACTGGAAGAC CTTCATGAAG 
CATTCAGGGC CTGAAGGAGA GGCCACAGTC AATAATGACA GTGAGGCGGA AGACGACGAT 
GATGGGCTGA TTCCCACCAT GGAGGAAATC CCTGAGGATG CAGCTTCCTT GGCCATGAGA 
AGAGAAAATA GTCTTCGCCG TACACTGAGC CGCAGCTCTA GGTCCAGCAG CCGACGTGGG 
AAGTCCCTCA AAAACTCCTT GAAGATTAAA AATGTGAATG TCTTGAAGGA GAAGGAAAAA 
GAAGTGGAAG GACAAAAACT AATTAAGAAA GAATTTGTGG AAACCGGGAA GGTCAAGTTC 
TCCATCTACC TGAAGTATCT ACAGGCAGTA GGGTGGTGGT CCATACTTTT CATCATCCTT 
TTCTACGGAT TGAATAATGT TGCTTTTATC GGCTCTAACC TCTGGCTGAG TGCTTGGACC 
AGTGACTCTG ACAACTTGAA TGGGACCAAC AATTCGTCTT CTCATAGGGA CATGAGAATT 
GGGGTCTTTG GAGCTCTGGG ATTAGCACAA GGTATATGTT TGCTTATTTC AACTCTGTGG 
AGCATATATG CTTGCAGAAA TGCATCAAAA GCTTTGCACG GGCAGCTGTT AACCAACATC 
CTCCGGGCAC CCATGAGGTT TTTTGACACA ACTCCCACAG GCCGGATTGT GAACAGATTT 
TCTGGTGATA TTTCTACTGT GGACGACTTG CTCCCCCAGA CACTTCGAAG CTGGATGATG 
TGTTTCTTTG GCATCGCTGG CACTCTTGTC ATGATCTGCA TGGCCACCCC AGTCTTCGCT 
ATCATCATCA TTCCTCTCAG CATTCTTTAT ATTTCGGTGC AGGTTTTTTA TGTGGCTACT 
TCCCGCCAGC TGAGACGGTT GGATTCTGTC ACCAAATCTC CGATCTATTC TCACTTCAGT 
GAGACTGTCA CAGGTTTGCC CATTATCCGT GCCTTTGAGC ACCAGCAGCG ATTTCTAGCT 
TGGAATGAGA AGCAGATTGA CATCAACCAG AAATGTGTCT TTTCCTGGAT TACCTCCAAC 
AGGTGGCTTG CAATTCGGCT GGAGCTGGTT GGAAACTTGG TCGTCTTCTG TTCCGCCTTG 
CTGCTGGTTA TTTATAGAAA AACCTTAACC GGGGACGTTG TGGGCTTTGT TCTGTCCAAC 
GCCCTCAATA TCACACAAAC CTTGAACTGG CTAGTGAGGA TGACGTCAGA AGCAGAGACC 
AACATTGTGG CAGTTGAGCG AATAAGTGAA TACATAAATG TAGAGAATGA GGCGCCCTGG 
GTGACTGACA AGAGGCCTCC GGCAGACTGG CCCAGACATG GTGAGATCCA GTTTAACAAC 
TATCAAGTGC GGTATCGGCC GGAGCTGGAT CTGGTACTGA AAGGGATCAC TTGTAACATC 
AAGAGCGGAG AGAAGGTCGG CGTAGTGGGC AGGACTGGGG CTGGGAAATC ATCCCTCACA 
AACTGCCTCT TCAGAATCTT AGAGTCTGCG GGGGGCCAGA TCATCATTGA TGGGATAGAT 
GTTGCCTCCA TTGGACTGCA CGACCTTCGA GAGAGGCTGA CCATCATTCC CCAGGACCCC 
ATTTTGTTCT CGGGGAGTCT GAGGATGAAT CTCGACCCTT TCAACAAATA TTCAGATGAG 
GAGGTTTGGA GGGCCCTGGA GTTGGCTCAC CTCAGATCCT TTGTGTCTGG CCTACAGCTT 
GGGTTGTTAT CCGAAGTGAC AGAGGGTGGT GACAACCTGA GCATAGGGCA GAGGCAGCTC 
CTATGCCTGG GCAGGGCTGT GCTTCGAAAA TCCAAAATCC TGGTCCTGGA TGAAGCCACG 
GCTGCAGTGG ATCTCGAGAC GGATAGCCTC ATTCAGACGA CCATCCGAAA GGAGTTCTCC 
CAGTGCACGG TCATCACCAT CGCTCACAGG CTGCACACCA TCATGGACAG TGACAAGATA 
ATGGTCCTAG ACAACGGGAA GATTGTCGAG TATGGCAGTC CTGAAGAACT GCTGTCCAAC 
AGAGGTTCCT TCTATCTGAT GGCCAAGGAA GCCGGCATTG AAAATGTGAA TCACACAGAG 
CTCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.
Archives of toxicology92(2)777-788(2018 Feb)
Tocchetti GN,Arias A,Arana MR,Rigalli JP,Domínguez CJ,Zecchinati F,Ruiz ML,Villanueva SSM,Mottino AD

Dysregulation of BSEP and MRP2 May Play an Important Role in Isoniazid-Induced Liver Injury via the SIRT1/FXR Pathway in Rats and HepG2 Cells.
Biological & pharmaceutical bulletin41(8)1211-1218(2018)
Qu X,Zhang Y,Zhang S,Zhai J,Gao H,Tao L,Song Y

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