Chrm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Chrm1
Entrez Gene ID	25229
Full Name	cholinergic receptor, muscarinic 1
General protein information	Preferred Names cholinergic receptor, muscarinic 1 Names muscarinic acetylcholine receptor M1 Cholinergic receptor, muscarin 1 m1 muscarinic acetylcholine receptor protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q43
Summary	plays a role in acetylcholine receptor signaling and neuromuscular synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_080773.1	NP_542951.1	muscarinic acetylcholine receptor M1
XM_008760215.2	XP_008758437.1	muscarinic acetylcholine receptor M1 isoform X1
XM_006230974.3	XP_006231036.1	muscarinic acetylcholine receptor M1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CHRM1	NP_000729.2
Pan troglodytes (chimpanzee)	CHRM1	XP_508508.2
Mus musculus (house mouse)	Chrm1	NP_001106167.1
Rattus norvegicus (Norway rat)	Chrm1	NP_542951.1
Canis lupus familiaris (dog)	CHRM1	XP_005631654.1
Caenorhabditis elegans (roundworm)	gar-3	NP_001024236.1
Xenopus tropicalis (tropical clawed frog)	LOC100490434	XP_004913718.1
Anopheles gambiae (African malaria mosquito)	GPRMAC1	XP_314486.1
Macaca mulatta (Rhesus monkey)	CHRM1	NP_001028117.1
Bos taurus (cattle)	CHRM1	NP_001231538.1
Drosophila melanogaster (fruit fly)	mAcR-60C	NP_726440.1

Gene Ontology
Bibliography

Related articles in PubMed

PKC delta activation increases neonatal rat retinal cells survival in vitro: Involvement of neurotrophins and M1 muscarinic receptors.
Braga LEG, Miranda RL, Granja MG, Giestal-de-Araujo E, Dos Santos AA
Biochemical and biophysical research communications500(4)917-923(2018 06)

Linking muscarinic receptor activation to UPS-mediated object memory destabilization: Implications for long-term memory modification and storage.
Stiver ML, Cloke JM, Nightingale N, Rizos J, Messer WS Jr, Winters BD
Neurobiology of learning and memory145151-164(2017 Nov)

Hippocampal and striatal M
Aitken P, Benoit A, Zheng Y, Philoxene B, Le Gall A, Denise P, Besnard S, Smith PF
Hippocampus26(12)1509-1514(2016 12)

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Dennis SH, Pasqui F, Colvin EM, Sanger H, Mogg AJ, Felder CC, Broad LM, Fitzjohn SM, Isaac JT, Mellor JR
Cerebral cortex (New York, N.Y. : 1991)26(1)414-26(2016 Jan)

M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.
Garcia RC, Dati LM, Torres LH, da Silva MA, Udo MS, Abdalla FM, da Costa JL, Gorjão R, Afeche SC, Yonamine M, Niswender CM, Conn PJ, Camarini R, Sandoval MR, Marcourakis T
Scientific reports517555(2015 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Chrm1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Chrm1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa13341	NM_080773.1 Latest version!	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa13341	XM_008760215.2 Latest version!	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
ORa13341	XM_006230974.3 Latest version!	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Chrm1 ( NM_080773.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_542951.1 Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), mRNA.

Price & Availability↑

CloneID	ORa13341
Clone ID Related Accession (Same CDS sequence)	NM_080773.1 , XM_008760215.2 , XM_006230974.3
Accession Version	NM_080773.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1577289600000
Organism	Rattus norvegicus(Norway rat)
Product	muscarinic acetylcholine receptor M1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M16406.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_542951.1
CDS	1..1383
Translation	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Target ORF information:

RefSeq Version	NM_080773.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_080773.1

ORF Insert Sequence:

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Chrm1 ( XM_008760215.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008758437.1 Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa13341
Clone ID Related Accession (Same CDS sequence)	NM_080773.1 , XM_008760215.2 , XM_006230974.3
Accession Version	XM_008760215.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	muscarinic acetylcholine receptor M1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008760215.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008758437.1
CDS	517..1899
Translation	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Target ORF information:

RefSeq Version	XM_008760215.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008760215.2

ORF Insert Sequence:

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Chrm1 ( XM_006230974.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006231036.1 Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa13341
Clone ID Related Accession (Same CDS sequence)	NM_080773.1 , XM_008760215.2 , XM_006230974.3
Accession Version	XM_006230974.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1383bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1469376000000
Organism	Rattus norvegicus(Norway rat)
Product	muscarinic acetylcholine receptor M1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230974.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006231036.1
CDS	694..2076
Translation	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

Target ORF information:

RefSeq Version	XM_006230974.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cholinergic receptor, muscarinic 1 (Chrm1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230974.3

ORF Insert Sequence:

ATGAACACCT CAGTGCCCCC TGCTGTCAGT CCCAACATCA CTGTCTTGGC ACCAGGAAAG 
GGTCCCTGGC AGGTGGCCTT CATCGGGATC ACCACAGGCC TCCTGTCTCT AGCTACAGTG 
ACAGGCAACC TACTGGTACT CATCTCCTTC AAGGTCAACA CCGAGCTCAA GACAGTCAAC 
AACTACTTCC TGCTGAGCCT GGCCTGTGCT GACCTCATCA TTGGCACCTT CTCCATGAAC 
CTCTATACCA CGTACCTGCT CATGGGCCAC TGGGCTCTGG GCACACTGGC CTGTGACCTC 
TGGCTGGCCC TGGACTATGT GGCCAGCAAC GCCTCTGTCA TGAATCTTCT GCTCATCAGC 
TTTGACCGTT ACTTCTCGGT GACCCGACCC CTGAGCTACC GAGCCAAGCG CACTCCCCGA 
AGGGCAGCTC TGATGATTGG CCTAGCATGG CTGGTTTCCT TCGTTCTCTG GGCCCCAGCC 
ATCCTCTTCT GGCAATACCT AGTTGGGGAG CGGACAGTGC TGGCTGGGCA GTGCTACATC 
CAGTTCCTCT CCCAACCCAT CATCACTTTT GGCACAGCCA TGGCCGCCTT CTACCTCCCT 
GTCACGGTCA TGTGTACACT GTACTGGCGC ATCTACCGGG AGACAGAAAA CCGAGCCCGG 
GAGCTGGCCG CCCTGCAGGG CTCTGAGACA CCAGGCAAAG GTGGTGGCAG CAGCAGCAGC 
TCAGAGAGGT CACAGCCAGG GGCTGAAGGC TCACCCGAGT CGCCTCCAGG CCGCTGCTGC 
CGCTGTTGCC GGGCACCCAG GCTCCTGCAG GCCTACAGCT GGAAGGAAGA AGAAGAGGAG 
GATGAAGGCT CCATGGAGTC CCTCACATCC TCCGAAGGTG AGGAGCCTGG CTCAGAAGTG 
GTGATCAAGA TGCCCATGGT AGATTCTGAA GCACAGGCAC CCACCAAGCA GCCTCCCAAA 
AGCTCCCCAA ATACAGTCAA GAGGCCCACC AAGAAAGGCC GAGACCGAGG CGGCAAGGGC 
CAAAAACCCC GAGGGAAGGA ACAGCTGGCC AAGAGAAAGA CCTTCTCACT GGTCAAGGAG 
AAGAAGGCAG CTCGGACCCT GAGTGCCATC CTGCTGGCCT TCATCCTCAC CTGGACACCA 
TATAACATCA TGGTGCTGGT ATCTACCTTC TGCAAGGACT GTGTTCCTGA AACCCTGTGG 
GAGCTGGGCT ACTGGCTATG CTACGTCAAC AGCACTGTCA ACCCCATGTG CTATGCACTG 
TGCAACAAAG CCTTCCGGGA CACGTTCCGC CTGCTGCTGC TCTGCCGCTG GGACAAGAGG 
CGCTGGCGCA AGATCCCCAA GCGCCCTGGC TCTGTGCACC GCACCCCCTC CCGCCAATGC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PKC delta activation increases neonatal rat retinal cells survival in vitro: Involvement of neurotrophins and M1 muscarinic receptors.
Biochemical and biophysical research communications500(4)917-923(2018 06)
Braga LEG,Miranda RL,Granja MG,Giestal-de-Araujo E,Dos Santos AA

Linking muscarinic receptor activation to UPS-mediated object memory destabilization: Implications for long-term memory modification and storage.
Neurobiology of learning and memory145151-164(2017 Nov)
Stiver ML,Cloke JM,Nightingale N,Rizos J,Messer WS Jr,Winters BD

Hippocampal and striatal M
Hippocampus26(12)1509-1514(2016 12)
Aitken P,Benoit A,Zheng Y,Philoxene B,Le Gall A,Denise P,Besnard S,Smith PF

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.
Cerebral cortex (New York, N.Y. : 1991)26(1)414-26(2016 Jan)
Dennis SH,Pasqui F,Colvin EM,Sanger H,Mogg AJ,Felder CC,Broad LM,Fitzjohn SM,Isaac JT,Mellor JR

M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product.
Scientific reports517555(2015 Dec)
Garcia RC,Dati LM,Torres LH,da Silva MA,Udo MS,Abdalla FM,da Costa JL,Gorjão R,Afeche SC,Yonamine M,Niswender CM,Conn PJ,Camarini R,Sandoval MR,Marcourakis T

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Chrm1 cDNA ORF clone, Rattus norvegicus(Norway rat)

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