Syk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Syk
Entrez Gene ID	25155
Full Name	spleen associated tyrosine kinase
Synonyms	p72syk
General protein information	Preferred Names spleen associated tyrosine kinase Names tyrosine-protein kinase SYK spleen tyrosine kinase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17p14
Summary	plays a role in cCbl-mediated ubiquitination and down-regulation by protein degradation of FcepsilonRI, a high affinity receptor for IgE [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_012758.1	NP_036890.1	tyrosine-protein kinase SYK

Pathways from BioSystems

Homologies

Macaca mulatta (Rhesus monkey)	SYK	XP_001100834.1
Xenopus tropicalis (tropical clawed frog)	syk	XP_002937073.2
Canis lupus familiaris (dog)	SYK	XP_005616010.1
Gallus gallus (chicken)	SYK	NP_001026601.1
Homo sapiens (human)	SYK	NP_001167638.1
Mus musculus (house mouse)	Syk	NP_001185906.1
Pan troglodytes (chimpanzee)	SYK	XP_520123.4
Bos taurus (cattle)	SYK	NP_001032542.1
Rattus norvegicus (Norway rat)	Syk	NP_036890.1
Danio rerio (zebrafish)	syk	NP_998008.1

Gene Ontology
Bibliography

Related articles in PubMed

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
Li S, Liu R, Xue M, Qiao Y, Chen Y, Long G, Tian X, Hu Y, Zhou P, Dong X, Qi Z, Cui Y, Shen Y
International journal of molecular medicine43(6)2481-2490(2019 Jun)

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.
Qiao Y, Tian X, Men L, Li S, Chen Y, Xue M, Hu Y, Zhou P, Long G, Shi Y, Liu R, Liu Y, Qi Z, Cui Y, Shen Y
Molecular medicine reports18(2)1995-2008(2018 Aug)

Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.
Buyanravjikh S, Han S, Lee S, Jeong AL, Ka HI, Park JY, Boldbaatar A, Lim JS, Lee MS, Yang Y
Molecular medicine reports18(1)1095-1103(2018 Jul)

SYK kinase mediates brown fat differentiation and activation.
Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF
Nature communications8(1)2115(2017 12)

Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, Hida Y, Ishizuka T, Sada K
Scientific reports746064(2017 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Syk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Syk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa00855	NM_012758.1 Latest version!	Rattus norvegicus spleen associated tyrosine kinase (Syk), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Syk ( NM_012758.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036890.1 Rattus norvegicus spleen associated tyrosine kinase (Syk), mRNA.

Price & Availability↑

CloneID	ORa00855
Clone ID Related Accession (Same CDS sequence)	NM_012758.1
Accession Version	NM_012758.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	1566748800000
Organism	Rattus norvegicus(Norway rat)
Product	tyrosine-protein kinase SYK
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U21684.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U21684.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGGCA ATGCTGTGGA CAATGCCAAC CACCTGACCT ACTTTTTTGG CAACATCACC 
CGGGAAGAGG CCGAAGACTA CCTGGTCCAG GGAGGCATGA CCGATGGGCT CTACCTGCTA 
CGCCAGAGCC GCAATTACCT GGGTGGTTTT GCTTTGTCGG TGGCACACAA CAGGAAGGCA 
CACCACTACA CTATCGAGAG AGAACTTAAC GGCACCTACG CCATCTCCGG GGGCAGGGCC 
CATGCCAGCC CGGCAGACCT CTGCCATTAC CACTCCCAGG AACCCGAAGG CCTGGTCTGC 
CTCCTCAAGA AGCCCTTCAA CCGGCCCCCG GGGGTACAGC CCAAGACTGG ACCCTTTGAG 
GACCTGAAGG AGAACCTCAT CAGGGAATAT GTGAAACAGA CCTGGAACCT TCAGGGCCAG 
GCTCTGGAGC AAGCCATCAT AAGTCAGAAG CCCCAACTGG AGAAGTTGAT CGCCACGACG 
GCTCATGAGA AGATGCCCTG GTTCCATGGC AACATCTCCA GAGACGAGTC AGAGCAGACG 
GTCCTCATAG GGTCAAAGAC CAACGGAAAA TTCCTGATCA GGGCCAGAGA CAACAACGGC 
TCCTTTGCAC TGTGCCTGCT GCACGAAGGG AAGGTATTAC ACTATCGCAT CGACAGGGAC 
AAGACCGGGA AGCTTTCCAT CCCCGAGGGG AAGAAGTTTG ACACCCTCTG GCAGCTAGTG 
GAACATTACT CTTACAAGCC AGATGGGCTA TTAAGAGTCC TCACGGTACC ATGTCAAAAG 
ATTGGCGTGC AGATGGGCCA CCCAGGAAGT TCAAATGCCC ATCCTGTGAC TTGGTCACCA 
GGTGGAATAA TCTCAAGAAT CAAATCCTAC TCCTTCCCAA AGCCTGGCCA CAAAAAGCCT 
CCCCCACCCC AAGGGAGCCG TCCGGAGAGC ACCGTGTCCT TCAATCCCTA TGAGCCAACG 
GGAGGGGCCT GGGGCCCAGA CAGAGGCCTT CAGAGAGAAG CCCTGCCCAT GGACACCGAG 
GTATATGAGA GTCCTTACGC TGACCCTGAA GAGATCCGGC CCAAAGAGGT CTACCTGGAC 
AGGAAACTGC TGACCCTGGA GGACAATGAA CTGGGCTCTG GCAACTTCGG GACTGTGAAA 
AAGGGATACT ACCAAATGAA AAAAGTTGTA AAAACAGTGG CTGTGAAAAT CCTGAAGAAT 
GAGGCCAACG ACCCGGCTCT GAAGGACGAG CTGCTGGCGG AGGCCAACGT CATGCAGCAG 
CTGGACAACC CCTACATTGT GCGCATGATC GGAATCTGTG AGGCGGAGTC GTGGATGCTG 
GTGATGGAGA TGGCGGCATG GGGGCCCCTC AACAAGTACC TGCAGCAGAA CAGGCACATC 
AAGGATAAGA ACATCATCGA GCTGGTTCAC CAGGTTTCCA TGGGAATGAA GTATTTGGAG 
GAGAGCAATT TTGTGCACAG AGATCTGGCC GCGAGGAACG TGCTTCTGGT CACCCAGCAC 
TACGCCAAGA TCAGTGACTT CGGTCTTTCC AAAGCCCTCC GTGCTGATGA AAACTACTAC 
AAGGCCCAGA CCCACGGGAA GTGGCCGGTG AAGTGGTACG CCCCCGAATG CATCAACTAC 
TTTAAGTTCT CCAGTAAGAG TGATGTCTGG AGCTTCGGAG TCCTGATGTG GGAAGCGTTC 
TCCTACGGGC AGAAGCCATA CAGAGGGATG AAAGGGAGCG AAGTGACTGC CATGCTGGAG 
AAAGGAGAGC GGATGGGGTG CCCTCCAGGA TGCCCGAGAG AGATGTACGA CTTGATGTTC 
CTATGCTGGA CTTACGATGT GGAGAACAGG CCAGGATTCG CGGCTGTGGA ACTGCGGCTT 
CGCAATTACT ACTACGACGT GGTTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036890.1
CDS	323..2212
Translation	MAGNAVDNANHLTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAISGGRAHASPADLCHYHSQEPEGLVCLLKKPFNRPPGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGNISRDESEQTVLIGSKTNGKFLIRARDNNGSFALCLLHEGKVLHYRIDRDKTGKLSIPEGKKFDTLWQLVEHYSYKPDGLLRVLTVPCQKIGVQMGHPGSSNAHPVTWSPGGIISRIKSYSFPKPGHKKPPPPQGSRPESTVSFNPYEPTGGAWGPDRGLQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAAWGPLNKYLQQNRHIKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPPGCPREMYDLMFLCWTYDVENRPGFAAVELRLRNYYYDVVN

Target ORF information:

RefSeq Version	NM_012758.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus spleen associated tyrosine kinase (Syk), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012758.1

ORF Insert Sequence:

ATGGCGGGCA ATGCTGTGGA CAATGCCAAC CACCTGACCT ACTTTTTTGG CAACATCACC 
CGGGAAGAGG CCGAAGACTA CCTGGTCCAG GGAGGCATGA CCGATGGGCT CTACCTGCTA 
CGCCAGAGCC GCAATTACCT GGGTGGTTTT GCTTTGTCGG TGGCACACAA CAGGAAGGCA 
CACCACTACA CTATCGAGAG AGAACTTAAC GGCACCTACG CCATCTCCGG GGGCAGGGCC 
CATGCCAGCC CGGCAGACCT CTGCCATTAC CACTCCCAGG AACCCGAAGG CCTGGTCTGC 
CTCCTCAAGA AGCCCTTCAA CCGGCCCCCG GGGGTACAGC CCAAGACTGG ACCCTTTGAG 
GACCTGAAGG AGAACCTCAT CAGGGAATAT GTGAAACAGA CCTGGAACCT TCAGGGCCAG 
GCTCTGGAGC AAGCCATCAT AAGTCAGAAG CCCCAACTGG AGAAGTTGAT CGCCACGACG 
GCTCATGAGA AGATGCCCTG GTTCCATGGC AACATCTCCA GAGACGAGTC AGAGCAGACG 
GTCCTCATAG GGTCAAAGAC CAACGGAAAA TTCCTGATCA GGGCCAGAGA CAACAACGGC 
TCCTTTGCAC TGTGCCTGCT GCACGAAGGG AAGGTATTAC ACTATCGCAT CGACAGGGAC 
AAGACCGGGA AGCTTTCCAT CCCCGAGGGG AAGAAGTTTG ACACCCTCTG GCAGCTAGTG 
GAACATTACT CTTACAAGCC AGATGGGCTA TTAAGAGTCC TCACGGTACC ATGTCAAAAG 
ATTGGCGTGC AGATGGGCCA CCCAGGAAGT TCAAATGCCC ATCCTGTGAC TTGGTCACCA 
GGTGGAATAA TCTCAAGAAT CAAATCCTAC TCCTTCCCAA AGCCTGGCCA CAAAAAGCCT 
CCCCCACCCC AAGGGAGCCG TCCGGAGAGC ACCGTGTCCT TCAATCCCTA TGAGCCAACG 
GGAGGGGCCT GGGGCCCAGA CAGAGGCCTT CAGAGAGAAG CCCTGCCCAT GGACACCGAG 
GTATATGAGA GTCCTTACGC TGACCCTGAA GAGATCCGGC CCAAAGAGGT CTACCTGGAC 
AGGAAACTGC TGACCCTGGA GGACAATGAA CTGGGCTCTG GCAACTTCGG GACTGTGAAA 
AAGGGATACT ACCAAATGAA AAAAGTTGTA AAAACAGTGG CTGTGAAAAT CCTGAAGAAT 
GAGGCCAACG ACCCGGCTCT GAAGGACGAG CTGCTGGCGG AGGCCAACGT CATGCAGCAG 
CTGGACAACC CCTACATTGT GCGCATGATC GGAATCTGTG AGGCGGAGTC GTGGATGCTG 
GTGATGGAGA TGGCGGCATG GGGGCCCCTC AACAAGTACC TGCAGCAGAA CAGGCACATC 
AAGGATAAGA ACATCATCGA GCTGGTTCAC CAGGTTTCCA TGGGAATGAA GTATTTGGAG 
GAGAGCAATT TTGTGCACAG AGATCTGGCC GCGAGGAACG TGCTTCTGGT CACCCAGCAC 
TACGCCAAGA TCAGTGACTT CGGTCTTTCC AAAGCCCTCC GTGCTGATGA AAACTACTAC 
AAGGCCCAGA CCCACGGGAA GTGGCCGGTG AAGTGGTACG CCCCCGAATG CATCAACTAC 
TTTAAGTTCT CCAGTAAGAG TGATGTCTGG AGCTTCGGAG TCCTGATGTG GGAAGCGTTC 
TCCTACGGGC AGAAGCCATA CAGAGGGATG AAAGGGAGCG AAGTGACTGC CATGCTGGAG 
AAAGGAGAGC GGATGGGGTG CCCTCCAGGA TGCCCGAGAG AGATGTACGA CTTGATGTTC 
CTATGCTGGA CTTACGATGT GGAGAACAGG CCAGGATTCG CGGCTGTGGA ACTGCGGCTT 
CGCAATTACT ACTACGACGT GGTTAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy.
International journal of molecular medicine43(6)2481-2490(2019 Jun)
Li S,Liu R,Xue M,Qiao Y,Chen Y,Long G,Tian X,Hu Y,Zhou P,Dong X,Qi Z,Cui Y,Shen Y

Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome‑mediated IL‑1β secretion via c‑Jun N‑terminal kinase activation and cell apoptosis during diabetic nephropathy.
Molecular medicine reports18(2)1995-2008(2018 Aug)
Qiao Y,Tian X,Men L,Li S,Chen Y,Xue M,Hu Y,Zhou P,Long G,Shi Y,Liu R,Liu Y,Qi Z,Cui Y,Shen Y

Cryptotanshinone inhibits IgE‑mediated degranulation through inhibition of spleen tyrosine kinase and tyrosine‑protein kinase phosphorylation in mast cells.
Molecular medicine reports18(1)1095-1103(2018 Jul)
Buyanravjikh S,Han S,Lee S,Jeong AL,Ka HI,Park JY,Boldbaatar A,Lim JS,Lee MS,Yang Y

SYK kinase mediates brown fat differentiation and activation.
Nature communications8(1)2115(2017 12)
Knoll M,Winther S,Natarajan A,Yang H,Jiang M,Thiru P,Shahsafaei A,Chavarria TE,Lamming DW,Sun L,Hansen JB,Lodish HF

Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk.
Scientific reports746064(2017 04)
Honjoh C,Chihara K,Yoshiki H,Yamauchi S,Takeuchi K,Kato Y,Hida Y,Ishizuka T,Sada K

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Syk cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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